Antibodies in diagnostics - From immunoassays to protein chips

Immunology Today

Volumn 21, Issue 8, 2000, Pages 379-382

  Borrebaeck, Carl A K ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; DIAGNOSTIC AGENT; DIAZEPAM; HYBRID PROTEIN; MONOCLONAL ANTIBODY; PROTEIN; PROTEOME; RECOMBINANT ANTIBODY; THEOPHYLLINE;

ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; BINDING SITE; BIOENGINEERING; CONTROLLED STUDY; GENE CONSTRUCT; GENE EXPRESSION; GENE LIBRARY; HUMAN; IMMUNOASSAY; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVIEW;

ANTIBODIES; ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; HUMANS; IMMUNOASSAY; POLYMERS; PROTEIN ENGINEERING; PROTEOME; RECOMBINANT PROTEINS;

EID: 0033858931     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01683-2     Document Type: Review

References (44)

1. Assay of plasma insulin in human subjects by immunological methods
2. Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G
3. Continuous culture of fused cells secreting antibody of predefined specificity
4. The development of monoclonal antibodies for the therapy of cancer
5. Solid-phase antigen-antibody systems
6. Enzyme-linked immunoassay for alpha fetoprotein by competitive and sandwich procedures
7. A sandwich method for enzyme immunoassay. I. Application to rat and human alpha fetoprotein
8. Phage antibodies: Filamentous phage displaying antibody variable domains
9. Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces
10. Man-made antibodies
11. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
12. DNA chips: State-of-the art
13. Clinically useful information provided by the flow cytometric immunophenotyping of hematological malignancies: Current status and future directions
14. Recent advances in flow cytometry: Application to the diagnosis of hematological malignancy
15. Application of cytometry to study acute leukemia: In vitro determination of drug sensitivity and detection of minimal residual disease
16. By-passing immunization: Building high affinity human antibodies by chain shuffling
17. Complementarity determining region (CDR) implantation: A theme of recombination
18. Light chain shuffling of a high affinity antibody results in a drift in epitope recognition
19. Fine tuning of an anti-testosterone antibody binding site by stepwise optimisation of the CDRs
20. Expression and secretion of aequorin as a chimeric antibody by means of a mammalian expression vector
21. Recombining germline-derived CDR sequences for creating diverse single framework antibody libraries
22. Specificity improvement of a recombinant anti-testosterone Fab fragment by CDRIII mutagenesis and phage display selection
23. Tapping the potential of molecular libraries in functional genomics
24. Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface
25. Exploiting recombination in single bacteria to make large phage antibody librares
26. Fully synthetic human combinatorial antibody libraries (HuCal) based on modular consensus frameworks and CDRs randomized with tri-nucleotides
27. Exploiting sequence space: Shuffling in vivo formed complementarity determining regions into a master framework
28. Antibody fragments from a 'single pot' phage display library as immunochemical reagents
29. Plastic antibodies: Developments and application
30. Towards artificial antibodies prepared by molecular imprinting
31. Drug assay using antibody mimics made by molecular imprinting
32. Rapid evolution of a protein in vitro by DNA shuffling
33. Protein evolution by molecular breeding
34. Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage
35. Binding proteins selected from combinatorial libraries of an α-helical bacterial receptor domain
36. Scaffolds for engineering novel binding sites in proteins
37. Ligand selected from combinatorial libraries of protein A for use in affinity capture of apolipoprotein A-1 and taq DNA polymerase
38. Affinity maturation of a Taq DNA Polymerase specific affibody by helix shuffling
39. Multispot, multianalyte immunoassay
40. Profiling of amyloid beta peptide variants using SELDI protein chip arrays
41. The role of cholesterol in the biosynthesis of beta-amyloid
42. High-throughput microarray-based enzyme-linked immunosorbent assay (ELISA)
43. Protein microarrays for gene expression and antibody screening