High affinity antibodies against Le(x) and sialyl Le(x) from a phage display library

Journal of Immunology

Volumn 157, Issue 2, 1996, Pages 732-738

  Dinh, Quang ^a   Weng, Nan Ping ^a,c   Kiso, Makoto ^b   Ishida, Hideharu ^b   Hasegawa, Akira ^b   Marcus, Donald M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b GIFU UNIVERSITY   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; OLIGOSACCHARIDE; STAGE SPECIFIC EMBRYO ANTIGEN 1;

ANTIBODY PRODUCTION; ANTIGEN RECOGNITION; ARTICLE; BACTERIAL INFECTION; BACTERIOPHAGE; CANCER IMMUNOTHERAPY; CARBOHYDRATE ANALYSIS; INFLAMMATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGENS, CD15; BACTERIOPHAGES; BASE SEQUENCE; CARBOHYDRATE SEQUENCE; CLONE CELLS; GENE LIBRARY; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; MICE; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES;

EID: 0029901753     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Couch, R. B. 1996. Vaccines. In Clinical Immunology Principles and Practice. R. R. Rich, T. A. Fleisher, B. D. Schwartz, W. T. Shearer, and W. Strobereds, eds. Mosby, St. Louis, p. 594.
2. Hakomori, S. 1989. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv. Cancer Res. 52:257.
3. Hellstrom, K. E., and I. Hellstrom. 1991. Principles of tumor immunity: tumor antigens. In Biologic Therapy of Cancer: Principles and Practice. V. T. DeVita. S. Hellman, and S. A. Rosenbergeds, eds. J. P. Lippincott Company, Philadelphia, p. 35.
4. LoBugglio, A. F., and M. N. Saleh. 1992. Advances in monoclonal antibody therapy of cancer. Am. J. Med. Sci. 304:214.
5. Wilson, I. A., and R. L. Stanfield. 1995. A trojan horse with a sweet tooth. Nature Structural Biology 2:433.
6. Bevilacqua, M. P., and R. M. Nelson. 1993. Selectins. J. Clin. Invest. 91:379.
7. Lasky, L. A. 1995. Selectin-carbohydrate interactions and the initiation of the inflammatory response. Annu. Rev. Biochem. 64:113.
8. Umeda, M., I. Diego, E. D. Ball, and D. M. Marcus. 1986. Idiotypic determinants of monoclonal antibodies that bind to 3-fucosyllactosamine. J. Immunol. 136: 2562.
9. Umeda, M., I. Diego, and D. M. Marcus. 1986. The occurrence of anti-3-fucosyllactosamine antibodies and their cross-reactive idiotopes in preimmune and immune mouse sera. J. Immunol. 137:3264.
10. Brockhaus, M., J. L. Magnani, and M. Herlyn. 1982. Monoclonal antibodies directed against the sugar sequence of lacto-N-fucopentaose III are obtained from mice immunized with human tumors. Arch. Biochem. Biophys. 217:647.
11. Huang, L. C., and M. Brockhaus. 1983. Many monoclonal antibodies with an apparent specificity for certain lung cancers are directed against a sugar sequence found in lacto-N-fucopentaose III. Arch. Biochem. Biophys. 220:318.
12. Hakomori, S. I. 1984. Monoclonal antibodies directed to cell-surface carbohydrates. In Monoclonal Antibodies and Functional Cell Lines. R. H. Kenneth, K. B. Bechtol, and T. J. McKearn, eds. Plenum Publishing Co., New York, p. 68.
13. Ball, E. D., R. F. Graziano, and M. W. Fanger. 1983. A unique antigen expressed on myeloid cells and acute leukemia blast cells defined by a monoclonal antibody. J. Immunol. 130:2937.
14. Ball, E. D., L. Mills, D. Hurd, R. McMillan, and R. Gringrich. 1992. Autologous bone marrow transplantation for acute myeloid leukemia using monoclonal antibody-purged bone marrow. Prog. Clin. Biol. Res. 377:97.
15. K genes by murine monoclonal antibodies against 3-fucosyllactosamine. Eur. J. Immunol. 19:1741.
16. x) and anti-galactosylgloboside antibodies. J. Immunol. 153:1161.
17. Huse, W. D., L. Sastry, S. A. Iverson, A. S. Kang, M. Alting-Mees, D. R. Burton, S. J. Benkovic, and R. A. Lerner. 1989. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 246:1275.
18. McCafferty, J., A. D. Griffiths, G. Winter, and D. J. Chiswell. 1990. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348: 552.
19. Barbas III, C. F., and R. A. Lerner. 1991. Combinatorial immunoglobulin libraries on the surface of phage (Phabs): rapid selection of antigen-specific Fabs. Methods. R. Lerner and D. Burton, eds. Academic Press, p. 119.
20. Clackson, T., H. R. Hoogenboom, A. D. Griffiths, and G. Winter. 1991. Making antibody fragments using phage display libraries. Nature 352:624.
21. Marks, J. D., H. R. Hoogenboom, T. P. Bonnert, J. McCafferty, A. D. Griffiths, and G. Winter. 1991. By-passing immunization of human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222:581.
22. Gram, H., L. Marconi, C. F. Barbas III, T. A. Collet, R. A. Lerner, and A. S. Kang. 1992. In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Proc. Natl. Acad. Sci. USA 89:3576.
23. Collet, T. A., P. Roben, R. O'Kennedy, C. F. Barbas III, D. R. Burton, and R. A. Lerner. 1992. A binary plasmid system for shuffling combinatorial antibody libraries. Proc. Natl. Acad. Sci. USA 89:100265.
24. Barbas III, C. F., A. S. Kang, R. A. Lerner, and S. J. Benkovic. 1991. Assembly of combinatorial antibody libraries on phage surfaces: the gene III site. Proc. Natl. Acad. Sci. USA 88:7978.
25. Kang, A. S., C. F. Barbas, K. D. Janda, S. J. Benkovic, and R. A. Lerner. 1991. Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces. Proc. Natl. Acad. Sci. USA 88:4363.
26. Yoshida, M., A. Uchimura, M. Kiso, and A. Hasegawa. 1993. Synthesis of chemically modified sialic acid-containing sialyl-Le X ganglioside analogues recognized by the selectin family. Glycoconj. J. 10:3.
27. Hasegawa, A., M. Kato, T. Ando, H. Ishida, and M. Kiso. 1995. Synthesis of sialyl Lewis X ganglioside analogues containing modified L-fucose residues. Carbohydr. Res. 274:165.
28. Hasegawa, A., K. Ito, H. Ishida, and M. Kiso. 1995. Synthesis of sialyl and sulfo Lewis X analogs containing a ceramide or 2-(tetradecyl) hexadecyl residue. J. Carbohydr. Chem. 14:353.
29. x ganglioside analogues to elucidate the structure necessitated for selectin recognition. Carbohydr. Res. In press.
30. Hasegawa, A., A. Uchimura, H. Ishida, and M. Koso. 1995. Synthesis of a sialyl Lewis X ganglioside analogue containing N-glycolyl in place of the N-acetyl group in the N-acetylneuraminic acid residue. Biosci. Biotech. Biochem. 59:1091.
31. T3 in the sera of patients with type I diabetes mellitus. J. Immunol. 142:3826.
32. Weng, N. 1993. Anti-ganglioside autoantibodies and peripheral neuropathy. Doctoral dissertation, Baylor College of Medicine.
33. Snyder, J. G., N. Weng, L. Yu-Lee, and D. M. Marcus. 1990. Heavy and light chain sequences of four monoclonal antibodies that bind galactosylgloboside (GalGb4). Eur. J. Immunol. 20:2673.
34. L regions of murine monoclonal antibodies against 3-fucosyllactosamine. J. Immunol. 140:1212.
35. Brockhaus, M., and J. L. Magnani. 1982. Monoclonal antibodies directed against the sugar sequence oflacto-N-fucopentaose III are obtained from mice immunized with human tumors. Arch. Biochem. Biophys. 217:647.
36. Ward, E. S., D. Gussow, A. D. Griffiths, P. T. Jones, and G. Winter. 1989. Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli. Nature 341:544.
37. Kimura, H., M. Umeda, and D. M. Marcus. 1989. Expression of a cross-reactive idiotope on naturally occurring murine antibodies against 3-fucosyllactosamine, levan, and dextran. J. Immunol. 142:3477.
38. Kabat, E. A., T. T. Wu, and C. Foeller. 1991. Sequences of Proteins of Immunological Interest, 5th ed. United States Department of Health and Human Services, National Institutes of Health, Bethesda, MD.
39. Cooper, L. J. N., A. R. Shikhman, D. D. Glass, D. Kangisser, M. W. Cunningham, and N. S. Greenspan. 1993. Role of heavy chain constant domains in antibody-antigen interaction. J. Immunol. 150:2231.
40. Smith-Gill, S. J., P. A. Hamel, M. H. Klein, S. Rudikoff, and K. J. 1986. Contribution of the Vk4 light chain to antibody specificity for lysozyme and β-(1-6) D-galactan. Mol. Immunol. 23:919.
41. Radic, M. Z., M. A. Masceli, J. Erikson, H. Shan, and M. Weiger. 1991. Ig H and L chain contributions to autoimmune specificities. J. Immunol. 146:176.
42. Kang, A. S., T. M. Jones, and D. R. Burton. 1991. Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries. Proc. Natl. Acad. Sci. USA 88:11120.
43. Jespers, L. S., A. Roberts, S. M. Mahler, G. Winter, and H. R. Hoogenboom. 1994. Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen. Biotechnology 12:899.
44. Burton, D. R., and C. F. Barbas III. 1994. Human antibodies from combinatorial libraries. Adv. Immunol. 57:191.
45. Bundle, D. R., E. Eichler, M. A. J. Gidney, M. Meldal, A. Ragauskas, B. W. Sigurskjold, B. Sinnott, D. C. Watson, M. Yaguchi, and N. M. Young. 1994. Molecular recognition of a Salmonella trisaccharide epitope by monoclonal antibody Sel 55-4. Biochemistry 33:5172.
46. Bundle, D. R., E. Altman, F.-I. Auzanneau, H. Baumann, E. Eichler, and B. W. Sigurskjold. 1994. The structure of oligosaccharide-antibody complexes and improved inhibitors of carbohydrate-protein binding. In Complex Carbohydrates Drug Research. Munksgard, Copenhagen: Alfred Benzon Symposium No. 36.
47. Brummel, D. A., V. P. Sharma, N. N. Anand, D. Bilous, G. Dubuc, J. Michniewicz, C. R. MacKenzie, J. Sadowska, B. W. Sigurskjold, B. Sinnott, et al. 1993. Probing the combining site of an anti-carbohydrate antibody by saturation-mutagenesis: role of the heavy-chain CDR3 residues. Biochemistry 32: 1180.
48. Bundle, D. R., H. Baumann, J. Brisson, S. M. Gagne, A. Zdanov, and M. Cygler. 1994. The solution structure of a trisaccharide-antibody complex: comparison of NMR measurements with a crystal structure. Biochemistry 33:5183.
49. Cygler, M., D. R. Rose, and D. R. Bundle. 1991. Recognition of a cell-surface oligosaccharide of pathogenic Salmonella by an antibody Fab fragment. Science 253:442.
50. Vyas, M. N., N. K. Vyas, P. J. Meikle, B. Sinnott, B. M. Pinto, D. R. Bundle, and F. A. Quiocho. 1993. Preliminary crystallographic analysis of a Fab specific for the O-antigen of Shigella flexneri cell surface lipopolysaccharide with and without bound saccharides. J. Mol. Biol. 231:133.
51. Vyas, N., M. Vyas, F. Quiocho, and D. Bundle. 1992. Atomic structures of anti-carbohydrate monoclonal antibody fragment (Fab) and cell surface carbohydrate epitope complexes. FASEB J. 6:A11.
52. Jeffrey, P. D., J. Bajorath, C. Y. Chang, D. Yelton, I. Hellstrom, K. E. Hellstrom, and S. Sheriff. 1995. The x-ray structure of an anti-tumour antibody in complex with antigen. Nature Structural Biology 2:466.
53. Padlan, E. A. Antibody-Antigen Complexes. 1994. R. G. Landes Company, Austin, TX.
54. DeFrees, S. A., W. Kosch, W. Wat, J. C. Paulson, S. Sabesan, R. L. Halcomb, D. Huang, Y. Ickikawa, and C. Wong. 1995. Ligand recognition by E-selectin: synthesis, inhibitory activity, and conformational analysis of bivalent sialyl Lewis X analogs. J. Am. Chem. Soc. 117:66.
55. Young, W. W., Jr., E. M. S. MacDonald, R. C. Nowinski, and S. Hakomori. 1979. Production of monoclonal antibodies specific for two distinct steric portions of the glycolipid ganglio-N-triosylceramide (ASIALO GM2). J. Exp. Med. 150: 1008.