Toward a catalog of human genes and proteins: Sequencing and analysis of 500 novel complete protein coding human cDNAs

Genome Research

Volumn 11, Issue 3, 2001, Pages 422-435

  Wiemann, Stefan ^a   Weil, Bernd ^a,b   Wellenreuther, Ruth ^a   Gassenhuber, Johannes ^a,b   Glassl, Sabine ^c   Ansorge, Wilhelm ^c   Böcher, Michael ^d   Blöcker, Helmut ^d   Bauersachs, Stefan ^e   Blum, Helmut ^e   Lauber, Jürgen ^f   Düsterhöft, Andreas ^f   Beyer, Andreas ^g   Köhrer, Karl ^g   Strack, Normann ^b   Mewes, Hans Werner ^b   Ottenwälder, Birgit ^h   Obermaier, Brigitte ^h   Tampe, Jens ⁱ   Heubner, Dagmar ^j   Wambutt, Rolf ^j   Korn, Bernhard ^a,k   Klein, Michaela ^a   Poustka, Annemarie ^a   more..

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f QIAGEN GMBH   (Germany)

^g HEINRICH HEINE UNIVERSITY   (Germany)

^h Medigenomix GmbH   (Germany)

ⁱ FRAUNHOFER GESELLSCHAFT   (Germany)

^j AGOWA GmbH   (Germany)

^k German Genome Resource Center RZPD   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN;

ACCURACY; AMINO ACID SEQUENCE; ARTICLE; CHROMOSOME 21; CHROMOSOME 22; CONTROLLED STUDY; DNA SEQUENCE; GENE ASSIGNMENT; GENETIC ANALYSIS; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UNINDEXED SEQUENCE;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; CHROMOSOMES, HUMAN, PAIR 21; CHROMOSOMES, HUMAN, PAIR 22; CLONING, MOLECULAR; DATABASES, FACTUAL; DNA, COMPLEMENTARY; GENE EXPRESSION PROFILING; GENE LIBRARY; GENES; HUMANS; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PROTEINS; SEQUENCE ANALYSIS, DNA;

EID: 0035078438     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.GR1547R     Document Type: Article

References (51)

1. Basic local alignment search tool
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. New goals for the U.S. Human Genome Project: 1998-2003
4. CpG islands and genes
5. The DNA sequence of human chromosome 22
6. Analysis of expressed sequence tags indicates 35,000 human genes
7. How many genes in the human genome?
8. PEDANTic genome analysis
9. Identification of protein coding regions by database similarity search
10. A simple and very efficient method for generating cDNA libraries
11. Primer design for large scale sequencing
12. Alternative splicing of human genes: More, the rule than the exception?
13. The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains
14. The DNA sequence of human chromosome 21. The chromosome 21 mapping and sequencing consortium
15. Increased coverage of protein families with the blocks database servers
16. Moonlighting proteins
17. One-megabase sequence analysis of the human immunoglobulin λ gene locus
18. Prediction of protein function from sequence properties. Discriminant analysis of a data base
19. ProSearch: Fast searching of protein sequences with regular expression patterns related to protein structure and function
20. Initiation of translation in prokaryotes and eukaryotes
21. Gene index analysis of the human genome estimates approximately 120, 000 genes
22. Predicting coiled coils from protein sequences
23. Evolutionary parameters of the transcribed mammalian genome: An analysis of 2,820 orthologous rodent and human sequences
24. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
25. The ancient regulatory-protein family of WD-repeat proteins
26. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites
27. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1
28. Zinc-dependent structure of a single-finger domain of yeast ADR1
29. Databases of mRNA untranslated regions for metazoa
30. UTRdb and UTRsite: Specialized databases of sequences and functional elements of 5′ and 3′ untranslated regions of eukaryotic mRNAs
31. Introducing RefSeq and LousLink: Curated human genome resources at the NCBI
32. GeneCards: A novel functional genomics compendium with automated data mining and query reformulation support
33. Estimate of human gene number provided by genome-wide analysis using Tetraodon nigroviridis DNA sequence
34. Pieces of the puzzle: Expressed sequence tags and the catalog of human genes
35. A gene map of the human genome
36. GeneSkipper: Integrated software environment for DNA sequence assembly and alignment
37. Systematic subcellular localization of novel proteins identified by large scale cDNA sequencing
38. Construction and characterization of a normalized cDNA library
39. Pfam: A comprehensive database of protein domain families based on seed alignments
40. The mammalian gene collection
41. Specific-primer-directed DNA sequencing
42. Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins
43. Alternative mRNA splicing: The Shaker gene
44. Statistical analysis of the 5′ untranslated region of human mRNA using "Oligo-Capped" cDNA libraries
45. Genome sequence of the nematode C. elegans: A platform for investigating biology
46. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
47. PATMAT: A searching and extraction program for sequence, pattern and block queries and databases
48. Simultaneous on-line DNA sequencing on both strands with two fluorescent dyes
49. Non-globular domains in protein sequences: Automated segmentation using complexity measures
50. Statistics of local complexity in amino acid sequences and sequence databases
51. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: Key sequence features controlling mRNA deadenylation and decay