Microsensor-aided measurements of cellular signalling and metabolism on tumor cells. The cell monitoring system (CMS®)

Tumor Biology

Volumn 19, Issue 5, 1998, Pages 374-383

  Wolf, Bernhard ^a   Brischwein, Martin ^a   Baumann, Werner ^a   Ehret, Ralf ^a   Henning, Tobias ^a   Lehmann, Mirko ^a   Schwinde, Anne ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Biosensors, cellular; PhysioControl Microsystem; Signal transduction; Therapy, tumor

Indexed keywords

ARTICLE; BIOSENSOR; CANCER CELL CULTURE; CELL CULTURE; CELL METABOLISM; COLON CARCINOMA; HUMAN; HUMAN CELL; MEDICAL RESEARCH; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY;

EID: 0031880262     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000030030     Document Type: Article

References (26)

1. Chen LB: Fluorescent labeling of mitochondria. Methods Cell Biol 1989;29:103-114.
2. Negulescu PA, Reenstra W, Machen TE: Intracellular Ca-requirements for stimulus-secretion coupling in parietal cell. Am J Physiol 1989;256: C241-C251.
3. Wolf B, Bessler WG: Elektronen-Energieverlust-Spektroskopie (EELS) als Methode zur Lokalisierung von Antigenen und anderen Substanzen in Zellen und Geweben. Naturwissenschaften 1990;77:110-115.
4. Uhl B, Speth V, Wolf B, Bessler WG, Hauschildt S: Rapid alterations in the plasma membrane structure of macrophages stimulated with bacterial lipopeptides. Eur J Cell Biol 1992;58:90-98.
5. McConnell HM, Owicki JC, Parce JW, Miller DL, Baxter GT, Wada HG, Pitchford S: The cytosensor microphysiometer: Biological applications of silicon technology. Science 1992;257:1906-1912.
6. Gross GW, Rhoades BK, Azzazy HME, Wu M-Ch: The use of neuronal networks on multielectrode arrays as biosensors. Biosens Bioelectron 1995;10:553-567.
7. Kraus M, Wolf B: Structured Biological Modelling - A New Approach to Biophysical Cell Biology. Boca Raton. CRC Press, 1995.
8. Bray D: Intracellular signalling as a parallel distributed process. J Theor Biol 1990;143:215.
9. Wolf B, Müller E, Schwinde A: An ultrastructural morphometric analysis on ultrathin Epon and ultrathin cryosections of normal human gastric tissue and human gastric cancer. Virchows Arch 1985;407:209-219.
10. Wolf B, Bischoff E, Schwinde A: Preliminary investigations of a correlation between electron energy loss and morphometric analyses on ultrathin cryosections from normal and neoplastic gastric tissues. Virchows Arch 1986;408:665-676.
11. Wolf B, Dinger V, Weiler Ch, Schwinde A, Scheipers P, Kraus M: Drug targeting and metabolic investigations of cryoprepared tumour cells with analytical electron energy loss spectroscopy. Tumor Biol 1996; 17:234-250.
12. Ölssner W, Kaden H, Herrmann S: Miniaturized Basic Oxygen and pH Sensors for Electrochemical Measurements in Biological Systems. GBF Monograph, Weinheim, 1989, vol 13, pp 137-146.
13. Jobst G, Urban G, Jachimowicz A, Kohl F, Tilado O, Lettenbichler I, Nauer G: Thin-film Clark-type oxygen sensor based on novel polymer membrane systems for in vivo and biosensor applications. Biosens Bioelectron 1993;8:123-128.
14. Blackburn GF: Chemically sensitive field effect transistors; in Biosensors, Fundamentals and Applications. London, Oxford University Press, 1987: pp 481-530.
15. Shiono S, Hanazato Y, Nakako M: Advances in enzymatically coupled field effect transistor. Bioanal Appl Enzymes 1992;36:151-179.
16. Fromherz P, Offenhäuser A, Vetter T, Weis J: A neuron-silicon junction: A Retzius cell of the leech on an insulated-gate field-effect transistor. Science 1991;252:1290.
17. Baumann W: Entwicklung eines Messsystems zur zellulären Signal-analyse auf der Basis von Feldeffekttransistoren; Dissertation, University of Freiburg, 1996.
18. Lehmann M: Entwicklung und Testung von Biosensoren auf Halbleiterbasis; Diploma-Thesis Albert-Ludwigs-Universität Freiburg, 1996.
19. Foster KR, Schwan HP: Dielectric properties of tissues and biological materials: A critical review. Crit Rev Biomed Eng 1989;17:25-104.
20. Giaever I, Keese CR: A morphological biosensor for mammalian cells. Nature 1993;366:591-592.
21. Schwan HP: Determination of biological impedances: in Nastuk, WL (ed): Physical Techniques in Biological Research. New York. Academic Press, 1963; vol 6: pp 323-408.
22. Ehret R, Baumann W, Brischwein M, Schwinde A, Stegbauer K, Wolf B: Monitoring of cellular behaviour by impedance measurements on interdigitated electrode structures. Biosens Bioelectron 1997;12:29-40.
23. 1). Renal Physiol Biochem 1995;18:118-127.
24. Jones DP, Lash LH: Criteria for assessing normal and abnormal mitochondrial function; in Lash LH, Jones DP (eds): Methods in Toxicology, 1993, vol 2: Mitochondrial Dysfunction, New York, Academic Press, pp 1-7.
25. Wolf B, Kraus M, Sieben U: Potential of microsensor-based feedback bioactuators for biophysical cancer treatment. Biosens Bioelectron 1997;12:301-309.
26. Kraus M, Wolf B: Implications of acidic tumour microenvironment for neoplastic growth and cancer treatment: A computer analysis. Tumor Biol 1996;17:133-154.