Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA

Chemistry and Biology

Volumn 8, Issue 1, 2001, Pages 1-7

  Braasch, Dwaine A ^a   Corey, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

DNA recognition; Gene expression control; Locked nucleic acid; RNA recognition

Indexed keywords

DNA; NUCLEIC ACID; PEPTIDE NUCLEIC ACID; RIBONUCLEASE H; RNA;

ANIMAL; BINDING SITE; CHEMISTRY; DNA MICROARRAY; DRUG STABILITY; ENZYME ACTIVATION; GENE EXPRESSION; GENETICS; IN VITRO STUDY; METABOLISM; SHORT SURVEY;

ANIMALS; BINDING SITES; DNA; DRUG STABILITY; ENZYME ACTIVATION; GENE EXPRESSION; NUCLEIC ACIDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDE NUCLEIC ACIDS; RIBONUCLEASE H, CALF THYMUS; RNA;

EID: 0035113736     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00058-2     Document Type: Short Survey

References (30)

1. Inhibition of Rous sarcoma virus replication and transformation by a specific oligonucleotide
2. First antisense drug will treat CMV retinitis
3. An antisense oligonucleotide primer
4. Keeping the biology of antisense in context
5. The ups and downs of nucleic acid duplex stability: Structure-stability studies on chemically-modified DNA:RNA duplexes
6. Antisense properties of peptide nucleic acids
7. Oligonucleotide N3′-P5′ phophoramidates as potential therapeutic agents
8. Solution structure of an HNA-RNA hybrid
9. Antiproliferative effects of steric blocking phosphoramidate morpholino antisense agents directed against c-myc
10. LNA (locked nucleic acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicylonucloside monomers, oligomerisation and unprecedented nucleic acid recognition
11. Novel convenient syntheses of LNA [2.2.1]bicyclo nucleosides
12. Stability and structural features of the duplexes containing the nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides
13. Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucletides containing 2′4′-C-bridged 2′-deoxynucleosides
14. Conformationally locked nucleosides. Synthesis and stereochemical assignments of 2′-C,4′-C-bridged bicyclonucleosides
15. Chemical etiology of nucleic acid structure: Comparing pentopyranosyl-(2′-4′) oligonucleotides with RNA
16. Solution structure of an LNA hybridized to DNA
17. Structural studies of LNA:RNA duplexes by NMR: Conformations and RNase H activity
18. Triplex formation by an oligonucleotide containing conformationally locked C-nucleoside, 5-(2-O,4-C-methylene-β-D-ribofuranosyl)oxazole
19. 2′-O, 4′-C-methylene bridge nucleic acid (2′, 4′-BNA) modification promotes pyrimidine motif triplex DNA formation at physiological pH: Thermodynamic and kinetic studies
20. Molecular mechanisms of antisense drugs: Human RNase H
21. Peptide nucleic acid: Its medical and biotechnical applications and promise for the future
22. Intracellular delivery and inhibition of gene expression by peptide nucleic acids
23. Hybrid oligonucleotides: Synthesis, biophysical properties, stability studies, and biological activity
24. 2′-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells
25. Up-regulation of luciferase gene expression with antisense oligonucleotides: Implications and applications in functional assay developments
26. Inhibition of telomerase leads to eroded telomeres, reduced proliferation, and cell death
27. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
28. The first analogues of LNA (locked nucleic acids): Phosphorothioate-LNA and 2′-thio LNA
29. Detection of the factor V Leiden mutation by direct allele-specific hybridization of PCR amplicons to photoimmobilized locked nucleic acids
30. LNA (locked nucleic acid): An RNA mimic forming exceedingly stable LNA:LNA duplexes