Isoforms of vascular endothelial growth factor act in a coordinate fashion to recruit and expand tumor vasculature

Molecular and Cellular Biology

Volumn 20, Issue 19, 2000, Pages 7282-7291

  Grunstein, J ^a   Masbad, J J ^a   Hickey, R ^a   Giordano, F ^a   Johnson, R S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL PROLIFERATION; COMPLEX FORMATION; ENDOTHELIUM CELL; MOLECULAR CLONING; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR VASCULARIZATION;

ALTERNATIVE SPLICING; ANIMAL; CELL TRANSFORMATION, NEOPLASTIC; DNA, COMPLEMENTARY; ENDOTHELIAL GROWTH FACTORS; FIBROSARCOMA; GENE TARGETING; GENES, RAS; LYMPHOKINES; MICE; MICE, MUTANT STRAINS; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; OSMOLAR CONCENTRATION; PROTEIN ISOFORMS; RECOMBINANT FUSION PROTEINS;

EID: 0033830523     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.19.7282-7291.2000     Document Type: Article

References (38)

1. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
2. Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues
3. Therapeutic angiogenesis through intramuscular injection of the gene for vascular endothelial growth factor (VEGF)
4. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
5. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
6. Angiogenesis for the treatment of vascular diseases
7. Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189
8. Identification of a human VPF/VEGF 3' untranslated region mediating hypoxia-induced mRNA stability
9. Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms
10. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
11. The vascular endothelial growth factor family of polypeptides
12. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
13. Receptors for factors of the VEGF (vascular endothelial growth family)
14. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
15. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
16. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
17. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
18. Cellular transformation and malignancy induced by ras require c-jun
19. A requirement for neuropilin-1 in embryonic vessel formation
20. Vascular permeability factor, an endothelial cell mitogen related to PDGF
21. Regulation of the expression of the VEGF/VPS and its receptors: Role in tumor angiogenesis
22. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
23. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
24. Microvasculature architecture of small liver metastases in man. A correlation between microfil vascular preparations and histologic sections
25. Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer
26. Adenovirus-mediated increase of exogenous and inhibition of endogenous fosB gene expression in cultured pulmonary arterial smooth muscle cells
27. RAG-1-deficient mice have no mature B and T lymphocytes
28. Vascular endothelial growth factor (VEGF) and its receptors
29. Impact of oncogenes in tumor angiogenesis: Mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
30. Xenografts of human solid tumors frequently express cellular-associated isoform of vascular endothelial growth factor (VEGF) 189
31. The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
32. Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
33. HIF-1 alpha is required for solid tumor formation and embryonic vascularization
34. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
35. Hypoxic induction of vascular endothelial growth factor (VEGF) in human epithelial cells is mediated by increases in mRNA stability
36. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
37. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
38. VEGFs, receptors and angiogenesis