Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides

Journal of Molecular Biology

Volumn 296, Issue 1, 2000, Pages 57-86

  Knappik, Achim ^a   Ge, Liming ^a   Honegger, Annemarie ^b   Pack, Peter ^a   Fischer, Melanie ^a   Wellnhofer, Günter ^a   Hoess, Adolf ^a   Wölle, Joachim ^a   Plückthun, Andreas ^b   Virnekäs, Bernhard ^a  

^a MORPHOSYS AG   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Antibody expression; Combinatorial immunoglobulin repertoire; Human antibodies; Phage display library; Trinucleotide mutagenesis

Indexed keywords

ANTIBODY; SYNTHETIC DNA; TRINUCLEOTIDE;

AMINO ACID SEQUENCE; ANTIBODY STRUCTURE; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONSENSUS SEQUENCE; CONTROLLED STUDY; GENE CASSETTE; GENE CONSTRUCT; GENE EXPRESSION; GENE FREQUENCY; MOLECULAR CLONING; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ESCHERICHIA COLI;

EID: 0034635335     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3444     Document Type: Article

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