Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII

Blood

Volumn 97, Issue 4, 2001, Pages 966-972

  Van den Brink, E N ^a   Turenhout, E A M ^a   Bovenschen, N ^a   Heijnen, B G A D H ^a   Mertens, K ^a   Peters, M ^a   Voorberg, J ^a  

^a CENTRAL LABORATORY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 8 INHIBITOR; HYBRID PROTEIN;

AMINO ACID SEQUENCE; ANTIBODY PRODUCTION; ARTICLE; BINDING SITE; CASE REPORT; CONTROLLED STUDY; EPITOPE MAPPING; HEMOPHILIA A; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; SUBSTITUTION THERAPY;

EID: 0035865513     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.4.966     Document Type: Article

References (38)

1. Haemophilia A
2. Structure of human factor VIII
3. The life cycle of coagulation factor VIII in view of its structure and function
4. The inhibitor antibody response is more complex in hemophilia A patients than in most nonhemophiliacs with factor VIII autoantibodies
5. Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII
6. Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site
7. Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII
8. A human allo-antibody interferes with binding of factor IXa to the factor VIII light chain
9. Some human inhibitor antibodies interfere with factor VIII binding to factor IX
10. The sequence Glu1811-Lys818 of human blood coagulation factor VIII comprises a binding site for activated factor IX
11. Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules
12. The interaction between human blood-coagulation factor VIII and von Willebrand factor: Characterization of a high-affinity binding site on factor VIII
13. Sulfation of Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor
14. The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von Willebrand factor
15. Somatic generation of antibody diversity
16. The human immunoglobulin VH repertoire
17. The complete nucleotide sequence of the human immunoglobulin heavy chain variable region locus
18. Human antibodies with specificity for the C2 domain of factor VIII are derived from VH1 germline genes
19. Molecular analysis of human anti-factor VIII antibodies by V gene phage display identifies a new epitope in the acidic region following the A2 domain
20. 593→Cys is related to antibody formation in a patient with mild hemophilia A
21. Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII
22. The role of cleavage of the light chain at positions Arg1689 or Arg1721 in subunit interaction and activation of human blood coagulation factor VIII
23. Detection of the carrier state in hereditary coagulation disorders; II
24. A more uniform measurement of factor VIII inhibitors
25. A human monoclonal antibody specific for the leucine-33 (p1A1, HPA-1a) form of platelet glycoprotein IIIa from a V gene phage display library
26. By-passing immunization: Human antibodies from V-gene libraries displayed on phage
27. Phage antibodies: Filamentous phage displaying antibody variable domains
28. Isolation of high affinity human antibodies directly from large synthetic repertoires
29. In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library
30. A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin
31. Factor VIII-factor IX interactions: Molecular sites involved in enzyme-cofactor complex assembly
32. Mechanism and kinetics of factor VIII inactivation: Study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor
33. Cloning and characterization of single chain Fv of anti-factor VIII antibody derived from a hemophilia A patient with factor VIII inhibitor
34. + B cells
35. Genetic and immunological properties of phage-displayed human anti-Rh(D) antibodies: Implications for Rh(D) epitope topology
36. Three-dimensional structure of an antibody-antigen complex