Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration

Annual Review of Neuroscience

Volumn 26, Issue , 2003, Pages 565-597

  Selkoe, Dennis ^a   Kopan, Raphael ^b  

^a Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Alzbeimer's disease; Amyloid precursor protein; Cell fate decisions; Neurodegeneration; Proteases

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; GAMMA SECRETASE; MEMBRANE PROTEIN; MEMBRANE RECEPTOR; NOTCH RECEPTOR; PRESENILIN; PROTEINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ASSOCIATION CORTEX; BIOACCUMULATION; CELL COMMUNICATION; CELL DIVISION; CELL FATE; CELL TYPE; ENZYME SUBSTRATE; HUMAN; LIGAND BINDING; LIMBIC CORTEX; LIPID BILAYER; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; NERVOUS SYSTEM; NEURODEGENERATIVE DISEASES; PRESENILIN-1; PROTO-ONCOGENE PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; WNT PROTEINS; ZEBRAFISH PROTEINS;

EID: 0041355557     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.26.041002.131334     Document Type: Review

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