Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage

Genes and Development

Volumn 12, Issue 8, 1998, Pages 1086-1091

  Zeng, Chaoyang ^a   Younger Shepherd, Susan ^a   Jan, Lily Y ^a   Jan, Yuh Nung ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Asymmetric cell divisions; Delta; Drosophila; Notch; Sensory organs; Serrate

Indexed keywords

ARTICLE; CELL DIVISION; CELL TRANSFORMATION; DROSOPHILA; GENETIC RECOMBINATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; SENSE ORGAN; SIGNAL TRANSDUCTION;

HEXAPODA;

EID: 0032522803     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.8.1086     Document Type: Article

References (38)

1. Artavanis-Tsakonas, S., K. Matsuno, and M.E. Fortini. 1995. Notch signaling. Science 268: 225-232.
2. Bodmer, R., R. Carretto, and Y.N. Jan. 1989. Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages. Neuron 3: 21-32.
3. Brand, A.H. and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
4. de Celis, J.F., S. Bray, and A. Garcia-Bellido. 1997. Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development 124: 1919-1928.
5. de Celis, J.F., M. Mari-Beffa, and A. Garcia-Bellido. 1991. Cell-autonomous role of Notch, an epidermal growth factor homologue, in sensory organ differentiation in Drosophila. Proc. Natl. Acad. Sci. 88: 632-636.
6. Diaz-Benjumea, F.J. and S.M. Cohen. 1995. Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121: 4215-4225,
7. Doherty, D., G. Feger, S. Younger-Shepherd, L.Y. Jan, and Y.N. Jan. 1996. Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes & Dev. 10: 421-434.
8. Fehon, R.G., P.J. Kooh, I. Rebay, C.L. Regan, T. Xu, M.A. Muskavitch, and S. Artavanis-Tsakonas. 1990. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61: 523-534.
9. Fleming, R.J., T.N. Scottgale, R.J. Diederich, and S. Artavanis-Tsakonas. 1990. The gene Serrate encodes a putative EGF-like transmembranc protein essential for proper ectodermal development in Drosophila melanogaster. Genes & Dev. 4: 2188-2201.
10. Fleming, R.J., Y. Gu, and N.A. Hukriede. 1997. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124: 2973-2981.
11. Frise, E., J.A. Knoblich, S. Younger-Shepherd, L.Y. Jan, and Y.N. Jan. 1996. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc. Natl. Acad. Sci. 93: 11925-11932.
12. Golic, K.G. and S. Lindquist. 1989. The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome. Cell 59: 499-509.
13. Gu, Y., N.A. Hukriede, and R.J. Fleming. 1995. Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development 121: 855-865.
14. Guo, M., L.Y. Jan, and Y.N. Jan. 1996. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 17: 27-41.
15. Hartenstein, V. and J.W. Posakony. 1989. Development of adult sensilla on the wing and notum of Drosophila melanogaster. Development 107: 389-405.
16. _. 1990. A dual function of the Notch gene in Drosophila sensillum development. Dev. Biol. 142: 13-30.
17. Heitzler, P. and P. Simpson. 1991. The choice of cell fate in the epidermis of Drosophila. Cell 64; 1083-1092.
18. _. 1993. Altered epidermal growth factor-like sequences provide evidence for a role of Notch as a receptor in cell fate decisions. Development 117: 1113-1123.
19. Heitzler, P., M. Bourouis, L. Ruel, C. Carteret, and P. Simpson. 1996. Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development 122: 161-171.
20. Hukriede, N.A., Y. Gu, and R.J. Fleming. 1997. A dominant-negative form of Serrate acts as a general antagonist of Notch activation. Development 124: 3427-3437.
21. Huppert, S.S., T.L. Jacobsen, and M.A.T. Muskavitch. 1997. Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. Development 124: 3283-3291.
22. Jan, Y.N. and L. Y. Jan. 1995. Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification. Neuron 14: 1-5.
23. Jonsson, F. and E. Knust. 1996. Distinct functions of the Drosophila genes Serrate and Delta revealed by ectopic expression during wing development. Dev. Genes Evol. 206: 91-101.
24. Lewis, J. 1996, Neurogenic genes and vertebrate neurogenesis. Curr. Opin. Neurobiol. 6: 3-10.
25. Micchelli, C.A., E.J. Rulifson, and S.S. Blair. 1997. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124: 1485-1495.
26. Nakao, K. and J.A. Campos-Ortega. 1996. Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila. Neuron 16: 275-286.
27. Panin, V.M., V. Papayannopoulos, R. Wilson, and K.D. Irvine. 1997. Fringe modulates Notch-ligand interactions. Nature 387: 908-912.
28. Parks, A.L. and M.A. Muskavitch. 1993. Delta function is required for bristle organ determination and morphogenesis in Drosophila. Dev. Biol. 157: 484-496.
29. Parks, A.L., S.S. Huppert, and M.A. Muskavitch. 1997. The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster. Mech. Dev. 63: 61-74.
30. Posakony, J.W. 1994. Nature versus nurture: Asymmetric cell divisions in Drosophila bristle development. Cell 76: 415-418.
31. Rhyu, M.S., L.Y. Jan, and Y.N. Jan. 1994. Asymmetric distribution of Numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76: 477-491.
32. Spana, E.P. and C.Q. Doe. 1996. Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron 17: 21-26.
33. Speicher, S.A., U. Thomas, U. Hinz, and E. Knust. 1994. The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginai discs: Control of cell proliferation. Development 120: 535-544.
34. Sturtevant, M.A. and E. Bier. 1995. Analysis of the genetic hierarchy guiding wing vein development in Drosophila. Development 121: 755-765.
35. Thomas, U., S.A. Speicher, and E. Knust. 1991. The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs. Development 111: 749-761.
36. Vaessin, H., E. Grell, E. Wolff, E. Bier, L.Y. Jan, and Y.N. Jan. 1991. Prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila. Cell 67: 941-953.
37. Wang, S., S. Younger-Shepherd, L.Y. Jan, and Y.N. Jan. 1997. Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless. Development 124: 4435-4446.
38. Xu, T. and G.M. Rubin. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.