Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

Journal of Biological Chemistry

Volumn 272, Issue 45, 1997, Pages 28415-28422

  Thinakaran, Gopal ^a   Harris, Christie L ^a   Ratovitski, Tamara ^a   Davenport, Frances ^a   Slunt, Hilda H ^a   Price, Donald L ^a   Borchelt, David R ^a   Sisodia, Sangram S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; MOUSE; NERVE DEGENERATION; NEUROBLASTOMA CELL; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENILE PLAQUE; TUMOR CELL LINE;

ANIMALS; BINDING, COMPETITIVE; BRAIN CHEMISTRY; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MOLECULAR WEIGHT; MUTATION; NEUROBLASTOMA; PRESENILIN-1; PRESENILIN-2; TUMOR CELLS, CULTURED;

EID: 0030667426     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.45.28415     Document Type: Article

References (38)

1. Wisniewski, H. M., and Terry, R. D. (1973) in Progress in Neuropathology (Zimmerman, H., ed) Vol. II, pp. 1-26, Grune and Stratton, New York
2. Busfield, F., and Goate, A. M. (1995) in Pathology of Alzheimer's Disease (A. M. Gioate and F. Ashall, eds), pp. 59-75, Academic Press, San Diego
3. Sherrington, R., Froelich, S., Sorbi, S., Campion, D., Chi, H., Rogaeva, E. A., Levesque, G., Rogaev, E. I., Lin, C., Liang, Y., Ikeda, M., Mar, L., Brice, A., Agid, Y., Percy, M. E., Clerget-Darpoux, F., Piacentini, S., Marcon, G., Nacmias, B., Amaducci, L., Frebourg, T., Lannfelt, L., Rommens, J. M., and St. George-Hyslop, P. H. (1996) Hum. Mol. Genet. 5, 985-988
4. Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C. E., Jondro, P. D., Schmidt, S. D., Wang, K., Crowley, A. C., Fu, Y.-H., Guenette, S. Y., Galas, D., Nemens, E., Wijsman, E. M., Bird, T. D., Schellenberg, G. D., and Tanzi, R. E. (1995) Science 269, 973-977
5. Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Piacentini, S., Amaducci, L., Chumakov, I., Cohen, D., Lannfelt, L., Fraser, P. E., Rommens, J. M., and St. George-Hyslop, P. H. (1995) Nature 376, 775-778
6. Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., Larson, E., Levy-Lahad, E., Viitanen, M., Peskind, E., Poorkaj, P., Schellenberg, G., Tanzi, R., Wasco, W., Lannfelt, L., Selkoe, D., and Younkin, S. (1996) Nat. Med. 2, 864-870
7. Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C. M., Perez-Tur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D., Morgan, D., Gordon, M. N., Holcomb, L., Refolo, L., Zenk, B., Hardy, J., and Younkin, S. (1996) Nature 383, 710-713
8. Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitski, T., Prada, C. M., Kim, G., Seekins, S., Yager, D., Slunt, H. H., Wang, R., Seeger, M., Levey, A. I., Gandy, S. E., Copeland, N. G., Jenkins, N. A., Price, D. L., Younkin, S. G., and Sisodia, S. S. (1996) Neuron 17, 1005-1013
9. Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-Wood, K., Lee, M., Seubert, P., Davis, A., Kholodenko, D., Motter, R., Sherrington, R., Perry, B., Yao, H., Strome, R., Lieberburg, I., Rommens, J., Kim, S., Schenk, D., Fraser, P., St. George Hyslop, P., and Selkoe, D. J. (1997) Nat. Med. 3, 67-72
10. Tomita, T., Maruyama, K., Saido, T. C., Kume, H., Shinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grunberg, J., Haass, C., Iwatsubo, T., and Obata, K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2025-2030
11. Doan, A., Thinakaran, G., Borchelt, D. R., Slunt, H. H., Ratovitski, T., Podlisny, M., Selkoe, D. J., Seeger, M., Gandy, S. E., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 1023-1030
12. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitski, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190
13. Kim, T.-W., Pettingell, W. H., Hallmark, O. G., Moir, R. D., Wasco, W., and Tanzi, R. E. (1997) J. Biol. Chem. 272, 11006-11010
14. Perez-Tur, J., Froelich, S., Prihar, G., Crook, R., Baker, M., Duff, K., Wragg, M., Busfield, F., Lendon, C., Clark, R. F., Roques, P., Fuldner, R. A., Johnston, J., Cowburn, R., Forsell, C., Axelman, K., Lilius, L., Houlden, H., Karran, E., Roberts, G. W., Rossor, M., Adams, M. d., Hardy, J., Goate, A., Lannfelt, L., and Hutton, M. (1995) Neuroreport 7, 297-301
15. Thinakaran, G., Teplow, D. B., Siman, R., Greenberg, B., and Sisodia, S. S. (1996) J. Biol. Chem. 271, 9390-9397
16. Kovacs, D. M., Fausett, H. J., Page, K. J., Kim, T. W., Moir, R. D., Merriam, D. E., Hollister, R. D., Hallmark, O. G., Mancini, R., Felsenstein, K. M., Hyman, B. T., Tanzi, R. E., and Wasco, W. (1996) Nat. Med. 2, 224-229
17. Cook, D. G., Sung, J. C., Golde, T. E., Felsenstein, K. M., Wojczyk, B. S., Tanzi, R. E., Trojanowski, J. Q., Lee, V. M., and Doms, R. W. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9223-9228
18. Walter, J., Capell, A., Grunberg, J., Pesold, B., Schindzielorz, A., Prior, R., Podlisny, M. B., Fraser, P., Hyslop, P. S., Selkoe, D. J., and Haass, C. (1996) Mol. Med. 2, 673-691
19. De Strooper, B., Beullens, M., Contreras, B., Levesque, L., Craessaerts, K., Cordell, B., Moechars, D., Bollen, M., Fraser, P., St. George-Hyslop, P. H., and Van Leuven, F. (1997) J. Biol. Chem. 272, 3590-3598
20. Weidemann, A., Paliga, K., Dürrwang, U., Czech, C., Evin, G., Masters, C. L., and Beyreuther, K. (1997) Nat. Med. 3, 328-332
21. Podlisny, M. B., Citron, M., Amarante, P., Sherrington, R., Xia, W., Zhang, J., Diehl, T., Levesque, G., Fraser, P., Haass, C., Koo, E. H. M., Seubert, P., St. George-Hyslop, P., Teplow, D. B., and Selkoe, D. J. (1997) Neurobiol. Dis. 3, 325-337
22. Slunt, H. H., Thinakaran, G., Von Koch, C., Lo, A. C., Tanzi, R. E., and Sisodia, S. S. (1994) J. Biol. Chem. 269, 2637-2644
23. Thinakaran, G., Kitt, C. A., Roskams, A. J., Slunt, H. H., Masliah, E., von Koch, C., Ginsberg, S. D., Ronnett, G. V., Reed, R. R., Price, D. L., and Sisodia, S. S. (1995) J. Neurosci. 15, 6314-6326
24. Bergeron, J. J., Brenner, M. B., Thomas, D. Y., and Williams, D. B. (1994) Trends Biochem. Sci. 19, 124-128
25. Watowich, S. S., and Morimoto, R. I. (1988) Mol. Cell. Biol. 8, 393-405
26. Price, B. D., Mannheim-Rodman, L. A., and Calderwood, S. K. (1992) J. Cell. Physiol. 152, 545-552
27. Kozutsumi, Y., Segal, M., Normington, K., Gething, M. J., and Sambrook, J. (1988) Nature 332, 462-464
28. Lah, J. J., Heilman, C. J., Nash, N. R., Rees, H. D., Yi, H., Counts, S. E., and Levey, A. I. (1997) J. Neurosci. 17, 1971-1980
29. Lee, M. K., Borchelt, D. R., Kim, G., Thinakaran, G., Slunt, H. H., Ratovitski, T., Martin, L. J., Kittur, A., Gandy, S., Levey, A. I., Jenkins, N., Copeland, N., Price, D. L., and Sisodia, S. S. (1997) Nat. Med. 3, 756-760
30. Schellenberg, G. D. (1995) Proc. Natl. Acad. Sci. U. S.A. 92, 8552-8559
31. Lee, M. K., Slunt, H. H., Martin, L. J., Thinakaran, G., Kim, G., Gandy, S. E., Seeger, M., Koo, E., Price, D. L., and Sisodia, S. S. (1996) J. Neurosci. 16, 7513-7525
32. Li, X., and Greenwald, I. (1996) Neuron 17, 1015-1021
33. Ratovitski, T., Slunt, H. H., Thinakaran, G., Price, D. L., Sisodia, S. S., and Borchelt, D. R. (1997) J. Biol. Chem. 272, 24536-25541
34. Sisodia, S. S., Gay, D. A., and Cleveland, D. W. (1990) New Biol. 2, 66-76
35. Levitan, D., Doyle, T. G., Brousseau, D., Lee, M. K., Thinakaran, G., Slunt, H. H., Sisodia, S. S., and Greenwald, I. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14940-14944
36. Baumeister, R., Leimer, U., Zweekbronner, I., Jakubek, C., Grunberg, J., and Haass, C. (1997) Genes Funct. 1, 149-159
37. Sisodia, S. S., Koo, E. H., Hoffman, P. N., Perry, G., and Price, D. L. (1993) J. Neurosci. 13, 3136-3142
38. Chomczynski, P., and Sacchi, N. (1987) Anal. Biochem. 162, 156-159