A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

Journal of Neuroscience Research

Volumn 68, Issue 6, 2002, Pages 655-667

  Hicks, Carol ^a   Ladi, Ena ^a   Lindsell, Claire ^a   Hsieh, James J D ^b   Hayward, S Diane ^a,b   Collazo, Andres ^c   Weinmaster, Gerry ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOUSE EAR INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Activation; Delta; Inhibition; Jagged; Notch signaling

Indexed keywords

DELTA 1 FC FUSION PROTEIN; HYBRID PROTEIN; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL INTERACTION; HUMAN; HUMAN CELL; LIGAND BINDING; MORPHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANIMALS; CELL COMMUNICATION; MEMBRANE PROTEINS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0037097242     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10263     Document Type: Article

References (48)

1. Notch signaling: Cell fate control and signal integration in development
2. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling
3. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity
4. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
5. Ligand-induced signaling in the absence of furin processing of Notch1
6. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
7. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: Implications for notch function
8. Interchangeability of Caenorhabditis elgans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo
9. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc
10. Structure/function studies of lin-12/Notch proteins
11. Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells
12. Notch signaling in vertebrate development and disease
13. A soluble form of human delta-like-1 inhibits differentiation of hematopoietic progenitor cells
14. lag-2 May encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans
15. Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans
16. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
17. Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
18. Beaded of Goldschmidt, an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains
19. A dominant-negative form of Serrate acts as a general antagonist of Notch activation
20. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
21. Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells
22. Ligand-receptor interactions and transendocytosis of Delta, Serrate and Notch: Members of the Notch signalling pathway in Drosophila
23. Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development
24. Implications of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development
25. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1
26. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
27. Notch signaling: From the outside in
28. Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts
29. Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand Delta-1
30. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
31. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
32. Processing of the notch ligand delta by the metalloprotease Kuzbanian
33. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor
34. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling
35. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
36. Jagged2: A serrate-like gene expressed during rat embryogenesis
37. Mouse Jagged1 physically interacts with Notch2 and other notch receptors. Assessment by quantitative methods
38. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
39. Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
40. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs
41. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
42. Secreted forms of Delta and Serrate define antagonists of Notch signaling in Drosophila
43. The Notch ligand Jagged-1, influences the development of primitive hematopoietic precursor cells
44. Immobilization of Notch ligand Delta-1, is required for induction of notch signaling
45. Notch receptor activation inhibits oligodendrocyte differentiation
46. The ins and outs of notch signaling
47. Notch signal transduction: A real rip and more