SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Molecular and Cellular Biology

Volumn 21, Issue 21, 2001, Pages 7403-7415

  Wu, G ^a   Lyapina, S ^a   Das, I ^a   Li, J ^a   Gurney, M ^a   Pauley, A ^a   Chui, I ^a   Deshaies, R J ^a   Kitajewski, J ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; NOTCH RECEPTOR; PROTEIN; PROTEIN SEL 10; RECEPTOR PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034791336     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.21.7403-7415.2001     Document Type: Article

References (47)

1. β-Catenin is a target for the ubiquitin-proteasome pathway
2. Interaction between Wingless and Notch signaling pathways mediated by dishevelled
3. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
4. SCF and Cullin/Ring H2-based ubiquitin ligases
5. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
6. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
7. The suppressor of hairless protein participates in notch receptor signaling
8. LIN-12/Notch signaling: Lessons from worms and flies
9. Lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans
10. Sel-10, a negative regulator of lin-12 activity in C. elegans, encodes a member of the CDC4 family of proteins
11. Delta-1 activation of notch-1 signaling results in HES-1 transactivation
12. Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands
13. Notch3 mutations in CADASIL a hereditary adult-onset condition causing stroke and dementia
14. Q vectors, bicistronic retroviral vectors for gene transfer
15. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
16. How proteolysis drives the cell cycle
17. An F-box protein, FWDI, mediates ubiquitin-dependent proteolysis of beta-catenin
18. Epitope tagging and protein surveillance
19. The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin
20. Jagged: A mammalian ligand that activates Notch1
21. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
22. Carboxry-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans
23. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
24. Improved retroviral vectors for gene transfer and expression
25. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
26. Production of high-titer helper-free retroviruses by transient transfection
27. Recognition and ubiquitination of Notch by Itch, a Hect-type E3 ubiquitin ligase
28. PEST sequences and regulation by proteolysis
29. Mouse mammary tumor gene int-3: A member of the notch gene family transforms mammary, epithelial cells
30. A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription
31. Notchless encode s a novel WD40-repeat-containing protein that modulates Notch signaling activity
32. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
33. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
34. Nuclear access and action of notch in vivo
35. Presenilin is required for activity and nuclear access of Notch in Drosophila
36. Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans
37. Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila
38. Notch4 and Jagged-I induce microvessel differentiation of rat brain endothelial cells
39. Notch4/int-3, a mammary, proto-oncogene, is an endothelial cell-specific mammalian Notch gene
40. Notch4 and Wnt-1 proteins function to regulate branching morphogenesis of mammary epithelial cells in an opposing fashion
41. The NOTCH4 locus is associated with susceptibility to schizophrenia
42. Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision
43. A family of mammalian F-box proteins
44. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro
45. Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
46. Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
47. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants