Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Nature Medicine

Volumn 3, Issue 1, 1997, Pages 67-72

  Citron, Martin ^a   Westaway, David ^b   Xia, Weiming ^a   Carlson, George ^c   Diehl, Thekla ^a   Levesque, Georges ^b   Johnson Wood, Kelly ^d   Lee, Michael ^d   Seubert, Peter ^d   Davis, Angela ^c   Kholodenko, Dora ^d   Motter, Ruth ^d   Sherrington, Robin ^b   Perry, Billie ^c   Yao, Hong ^b   Strome, Robert ^b   Lieberburg, Ivan ^d   Rommens, Johanna ^b   Kim, Soyeon ^e   Schenk, Dale ^d   Fraser, Paul ^b   St George Hyslop, Peter ^b   Selkoe, Dennis J ^a   more..

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c McLauglin Research Institute   (United States)

^d Athena Neurosciences Inc   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENETIC VECTORS; HIPPOCAMPUS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; TRANSFECTION;

EID: 16944362157     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0197-67     Document Type: Article

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