A dominant-negative form of Serrate acts as a general antagonist of Notch activation

Development

Volumn 124, Issue 17, 1997, Pages 3427-3437

  Hukriede, Nell A ^a   Gu, Yi ^a   Fleming, Robert J ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Dominant negative; Drosophila; Notch; Serrate; Wing development

Indexed keywords

LIGAND; MEMBRANE PROTEIN; MUTANT PROTEIN;

ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DELETION MUTANT; DOMINANT GENE; EMBRYO POLARITY; FORELIMB; GENE ACTIVATION; GENE MUTATION; IMAGINAL DISC; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

ANIMALS; BASE SEQUENCE; CALCIUM-BINDING PROTEINS; DNA PRIMERS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MALE; MEMBRANE PROTEINS; MUTATION; PHENOTYPE; POLYMERASE CHAIN REACTION; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; WING;

EID: 0030869670     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Artavanis-Tsakonas, S., Matsuno, K. and Fortini, M.E. (1995). Notch signaling. Science 268, 225-232.
2. Brand, A.H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
3. Campos-Ortega, J.A., and Hartenstein, V. (1985). The Embryonic Development of Drosophila melanogaster. Berlin-Heidelberg-New York-Tokyo: Springer-Verlag.
4. Capdevila, J. and Guerrero, I. (1994). Targeted expression of the signalling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13, 4459-4468.
5. Chitnis, A., Henrique, D., Lewis, J., Ish-Horowicz, D. and Kinter, C. (1995). Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. Nature 375, 761-766.
6. Cohen, B., McGuffln, M.E., Pfeifle, C., Segal, D. and Cohen, S.M. (1992). apterous: a gene required for imaginai disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins. denes Dev. 6, 715-729.
7. Couso, J.P., Knust, E. and Martinez-Arias, A. (1995). Serrate and wingless cooperate to induce vestigial gene expression and wing formation. Curr. Biol. 5, 1437-1448.
8. de Cells, J.K., Garcia-Bellido, A. and Bray, S.J. (1996). Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 122, 359-369.
9. Diaz-Benjumea. F.J. and Cohen, S.M. (1995). Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development 121, 4215-4225.
10. Doherty, D., Feger, G., Younger-Shepard, S., Jan, I.,Y, and Jan, Y,N. (1996). Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev. 10, 421-434.
11. Fehon, R.G., Kooh, P.J., Rebay, I., Regan, C.L., Xu, T., Muskavitch, M.A.T., and Artavanis-Tsakonas, S. (1990). Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell 61, 523-534.
12. Fitzgerald, K. and Greenwald, I. (1995). Interchangeahility of Caenorhabditis elegans DSI. proteins and intrinsic signalling activity of their extracellular domains in vivo. Development 121, 4275-4282.
13. Fleming, R.J., Scottgale, T.N., Diederich, R J. and Artavanis-Tsakonas, S. (1990). The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev. 4, 2188-2201.
14. Fleming, R.J., Gu, Y. and Hukriede, N.A. (1997). Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginai disc. Development 124, 2973-2981.
15. Garcia-Bellido, A., Ripoll, P. and Morata, G. (1976). Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila. Dev. Biol. 48, 132-147.
16. Gu, Y., Hukriede, N.A. and Fleming, R.J. (1995). Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo. Development 121, 855-865.
17. Hinz, U., Giebel, B. and Campos-Ortega, J. (1994). The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76, 77-87.
18. Hukriede, N.A. and Fleming, R.J. (1997). Beaded of Goldschmidt. an antimorphic allele of Serrate, encodes a protein lacking transmembrane and intracellular domains. Genetics 145, 359-374.
19. Irvine, K. and Weischaus, E. (1994). fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 79, 595-606.
20. Jan, Y.L., and Jan, Y.N. (1982). Antibodies to horseradish peroxidase us specific neuronal markers in Drosophila and grasshopper embryos, Proc. Natl. Acatl. Sci. USA 79, 2700-2704.
21. Jönsson, F. and Knust, K. (1996). Distinct functions of the Drosophila genes Serrate and Delta revealed by ectopic expression during wing development. Dev. Genes. Evol. 206, 91-101.
22. Kim, J., Irvine, K.D. and Carroll, S.B. (1995). Cell recognition. signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell 82, 795-802.
23. Kim, J., Scoring, A., Esch, J., Kraus, M.E., Vorwerk, K., Magee, J. and Carroll, S.B. (1996) Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 382, 133-138.
24. Kolodziej, P.A. and Young, R.A. (1991). Epitopc tagging and protein surveillante. Meth. Unzymol. 194, 508-519.
25. Kornberg, T. B., Siden, I., O'Farrell, P. and Simon, M. (1985). The engrailed locus of Drosophila: in situ localisation of transcripts reveals compartment-specific expression. Cell 40, 45-53.
26. Lawrence, P.A. and Morata, G. (1977). The early development of mcsothoracic companments in Dmsophila. Otv. Biol. 56, 40-51.
27. Lawrence, P.A. and Struhl, G. (1996). Morphogens, compartments and pattern: Lessons from Drosophila? Cell 85, 951-961.
28. Lee, J-J., von Kessler, D.P., Parks, S. and Beachy, P.A. (1992). Secretion and localised transcription suggests a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33-50.
29. Lehmann, R., Jiménez, F., Dietrich, U. and Campos-Ortega, J.A. (1983). On the phenotype of mutants of early neurogenesis in Drosophila melanogaster. Roux's Arch Dev Biol. 192, 62-74.
30. Lindsley, D.L., and Zimm, G. G. (1992). The Genome of Drosophila melanogaster. San Diego, CA: Academic Press.
31. Neumann, C.J. and Cohen. S.M. (1996). A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122, 3477-3485.
32. Panin, V.M., Papayannopoulos, V., Wilson, R. and Irvine, K.D. (1997). Fringe modulates Notch-ligand interactions. Nature 387, 908-912.
33. Rebay, I., Fleming, R.J., Fehon, R.G., Cherbas, L., Cherbas, P., and Artavanis-Tsakonas, S. (1991). Specific EGF Repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor. Cell 67, 687-699.
34. Rulifson, E.J. and Blair, S.S. (1995). Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila. Development 121, 2813-2824.
35. Sanger, F., Nicklen, S. and Coulson, A.R. (1977). DNA sequencing with chain termination inhibitors. Proc. Nutl. Acad. Sci. USA 74, 5463-5467.
36. Sanicola, M., Sekelsky, J., Elson, S. and Gelbart, W.M. (1995). Drawing a stripe in Drosophila imaginai disks: negative regulation of decapentaplegic and patched expression by engrailed. Genetics 139, 745-756.
37. tsl, a conditional Notch lethal in Drosophila. Dev. Biol. 62, 432-446.
38. Shelton, C.A. and Wasserman, S.A. (1993). pelle encodes a protein kinase required to establish dorsovemral polarity in the Drosophila embryo. Cell 72, 515-525.
39. Simmonds, A.J., Brook, W.J., Cohen, S.M. and Bell, J.B. (1995). Distinguishable functions for engrailed and invected in anterior-posterior patterning in the Drosophila wing. Nature 376, 424-427.
40. Simpson, P. (1995). The Notch connection. Nature 375, 736-737.
41. Speicher, S.A., Thomas, U., Hinz, U and Knust, E.(1994). The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginai discs: control of cell proliferation. Development 120, 535-544.
42. Spradling. A.C. (1986). P element-mediated transformation. In Drosophila: A Practical Approach, (ed. D. B. Roberts). pp. 175-197. Oxford, England: IRI. Press.
43. Sun, X. and Artavanis-Tsakonas, S. (1996). The intrazellular deletions of DELTA and SERRATE define dominant-negative forms of the Drosophila Notch ligands. Development 122, 2465-2474.
44. Sun, X. and Artavanis-Tsakonas, S. (1997). Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development. 124, 3439-3448.
45. Tabata, T., Eaton, S. and Kornberg, T.B. (1992). The Drosophila hedgeehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation. Genes Dev. 6, 2635-2645.
46. Tabata, T., Schwartz, C., Gustavson, E., All, Z. and Kornberg, T. B. (1995). Creating a Drosophila wing dc novo, the role of engrailed, and the compartment border hypothesis. Development 121, 3359-3369.
47. Wilcox, M., Brown, N., Piovant, M., Smith, R.J. and White, R.A.H. (1984). The position-specific antigens are a family of cell surface glycoprotcin complexes, EMBO J. 3, 2307-2313.
48. Williams, J.A., Paddock, S.W., Vorwerk, K. and Carroll, S.B. (1994). Organisation of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary. Nature 368, 299-305.
49. Yuan, Y.P., Schultz, J., Mlodzik, M. and Bork, P. (1997). Secreted Fringe-like signaling molecules may be glycosyltransfcrascs. Cell 88, 9-11.
50. Zecca, M., Basler, K. and Struhl, G. (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development 21, 2265-2278.