Progression from extrinsic to intrinsic signaling in cell fate specification: A view from the nervous system

Cell

Volumn 96, Issue 2, 1999, Pages 211-224

  Edlund, Thomas ^a   Jessell, Thomas M ^b  

^a UMEÅ UNIVERSITY   (Sweden)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; GENETIC TRANSCRIPTION; HUMAN; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0033593304     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80561-9     Document Type: Review

References (141)

1. Anderson, D.U. (1989). The neural crest cell lineage problem: neuropoiesis? Neuron 3, 1-12.
2. Anderson, D.U., and Jan, Y.N. (1997). The determination of the neuronal phenotype. In Molecular and Cellular Approaches to Neural Development, W.M. Cowan, T.M. Jessell, and S.L. Zipursky, eds. (New York: Oxford University Press), pp. 26-63.
3. Artinger, K.B., and Bronner-Fraser, M. (1992). Partial restriction in the developmental potential of late emigrating avian neural crest cells. Dev. Biol. 749, 149-157.
4. Bartek, J., Bartkova, J., and Lukas, J. (1997). The retinoblastoma protein pathway in cell cycle control and cancer. Exp. Cell Res. 237, 1-6.
5. Belvin, M.P., Jin, Y., and Anderson, K.V. (1995). Cactus protein degradation mediates Drosophila dorsal-ventral signaling. Genes Dev. 9, 783-793.
6. Benveniste, R.J., Thor, S., Thomas, J.B., and Taghert, P.M. (1998). Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development 725, 4757-4765.
7. Bienz, M., and Muller, J. (1995). Transcriptional silencing of homeotic genes in Drosophila. Bioessays 77, 775-784.
8. Bohner, A.P., Akers, R.M., and McConnell, S.K. (1997). Induction of deep layer cortical neurons in vitro. Development 124, 915-923.
9. Boyes, J., Omischinski, J., Clark, D., Pikaart, M., and Felsenfeld, G. (1998). Perturbation of nucleosome structure by the erythroid transcription factor GATA-1. J. Mol. Biol. 279, 529-544.
10. Burrows, R.C., Wancio, D., Levitt, P., and Lillien, L. (1997). Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex. Neuron 79, 251-267.
11. Campbell, G., and Tomlinson, A. (1998). The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila. Development 725, 4483-4493.
12. Kip1. Genes Dev. 77, 2335-2346.
13. Castillo, S.O., Baffi, J.S., Palkovits, M., Goldstein, D.S., Kopin, I.J., Witta, J., Magnuson, M.A., and Nikodem, V.M. (1998). Dopamine biosynthesis is selectively abolished in substantia niga ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurrl Gene. Mol. Cell. Neurosci. 77, 36-46.
14. Cavalli, G., and Paro, R. (1998). The Drosophila Fab-7chromosomal element conveys epigenetic inheritance during mitosis and meiosis. Cell 93, 505-518.
15. Cepko, C.L., Fields-Berry, S., Ryder, E., Austin, C., and Golden, J. (1998). Lineage analysis using retroviral vectors. Curr. Top. Dev. Biol. 36, 51-74.
16. Chain, D.G., Hegde, A.N., Yamamoto, N., Liu-Marsh, B., and Schwartz, J.H. (1995). Persistent activation of cAM P-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia. J. Neurosci. 75, 7592-7603.
17. Chen, Z.F., Paquette, A.J., and Anderson, D.J. (1998). NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat. Genet. 20, 136-142.
18. Chien, C.T., Hsiao, C.D., Jan, L.Y., and Jan, Y.N. (1996). Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes. Proc. Natl. Acad. Sci. USA 93, 13239-13244.
19. Chong, J.A., Tapia-Ramirez, J., Kim, S., Toledo-Aral, J.J., Zheng, Y., Boutros, M.C., Altshuller, Y.M., Frohman, M.A., Kraner, S.D., and Mandel, G. (1995). REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80, 949-957.
20. Dale, J.K., Vesque, C., Lints, T.J., Sampath, T.K., Furley, A., Dodd, J., and Placzek, M. (1997). Cooperation of BMP7 and SHH in the induction of fore brain ventral midline cells by prechordal mesoderm. Cell 90, 257-269.
21. de Nooij, U.C., Letendre, M.A., and Hariharan, I.K. (1996). Acyclindependent kinase inhibitor, Dacapo, is necessary fortimely exit from the cell cycle during Drosophila embryogenesis. Cell 87, 1237-1247.
22. Dupin, E., Ziller, C., and Le Domain, N.M. (1998). The avian embryo as a model in developmental studies: chimeras and in vitro clonal analysis. Curr. Top. Dev. Biol. 36, 1-35.
23. Durand, B., Gao, F.B., and Raff, M. (1997). Accumulation of the cyclin-dependent kinase inhibitor p27 Kip1 and the timing of oligodendrocyte differentiation. EM BO J. 16, 306-317.
24. Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation. Curr. Biol. 8, 431-440.
25. Eagleson, K.L., Lillien, L, Chan, A.V., and Levitt, P. (1997). Mechanisms specifying area fate in cortex include cell-cycle-dependent decisions and the capacity of progenitors to express phenotype memory. Development 724, 1623-1630.
26. ElShamy, W.M., Fridvall, L.K., and Ernfors, P. (1998). Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3. Neuron 21, 1003-1015.
27. Ericson, J., Morton, S., Kawakami, A., Roelink, H., and Jessell, T.M. (1996). Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.
28. Ericson, J., Briscoe, J., Rashbass, P., van Heyningen, V., and Jessell, T.M. (1997). Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube. Cold Spring Harbor Symp. Quant. Biol. 62, 451-466.
29. Ezzeddine, Z.D., Yang, X., DeChiara, T., Yancopoulos, G., and Cepko, C.L (1997). Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development 724, 1055-1067.
30. Felsenfeld, G., Boyes, J., Chung, J., Clark, D., and Studitsky, V. (1996). Chromatin structure and gene expression. Proc. Natl. Acad. Sei. USA 93, 9384-9388.
31. Fowles, L.F., Martin, M.L., Nelsen, L., Stacey, K.J., Redd, D., Clark, Y.M., Nagamine, Y., McMahon, M., Hume, D.A., and Ostrowski, M.C. (1998). Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/c-fms signaling. Mol. Cell. Biol. 18, 5148-5156.
32. Frantz, G.D., and McConnell, S.K. (1996). Restriction of late cerebral cortical progenitors to an upper-layer fate. Neuron 77, 55-61.
33. Gage, F.H. (1998). Stem cells of the central nervous system. Curr. Opin. Neurobiol. 8, 671-676.
34. Gerasimova, T.I., and Corces, V.G. (1998). Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Cell 92, 511-521.
35. Gerber, A.N., Klesert, T.R., Bergstrom, D.A., and Tapscott, S.J. (1997). Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis. Genes Dev. 77, 436-450.
36. Ghosh, A., and Kolodkin, A.L. (1998). Specification of neuronal connectivity: ETS marks the spot. Cell 95, 303-306.
37. Gould, A. (1997). Functions of mammalian Polycomb group and trithorax group related genes. Curr. Opin. Genet. Dev. 7, 488-494.
38. Gould, A., Itasaki, N., and Krumlauf, R. (1998). Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway. Neuron 27, 39-51.
39. Groves, A.K., George, K.M., Tissier-Seta, J.P., Engel, J.D., Brunet, J.F., and Anderson, D.J. (1995). Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons. Development 727, 887-901.
40. Gurdon, J.B., Dyson, S., and St. Johnston, D. (1998). Cells' perception of position in a concentration gradient. Cell 95, 159-162.
41. Habecker, B.A., and Landis, S.C. (1994). Noradrenergic regulation of cholinergic differentiation. Science 264, 1602-1604.
42. Habecker, B.A., Symes, A.J., Stahl, N., Francis, N.J., Economides, A., Fink, J.S., Yancopoulos, G.D., and Landis, S.C. (1997). A sweat gland-derived differentiation activity acts through known cytokine signaling pathways. J. Biol. Chem. 272, 30421-30428.
43. Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y., and Krasnow, M.A. (1998). sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 92, 253-263.
44. Halevy, O., Novitch, E.G., Spicer, D.B., Skapek, S.X., Rhee, J., Hannon, G.J., Beach, D., and Lassar, A.B. (1995). Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267, 1018-1021.
45. Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A.B., and Joyner, A.L. (1995). Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679-682.
46. Harper, J.W. (1997). Cyclin dependent kinase inhibitors. Cancer Surv. 29, 91-107.
47. Harris, W.A., and Hartenstein, V. (1991). Neuronal determination without cell division in Xenopus embryos. Neuron 6, 400-515.
48. Henrique, D., Tyler, D., Kintner, C., Heath, J.K., Lewis, J.H., IshHorowicz, D., and Storey, K.G. (1997). Cash4, a novel achaete-scute homolog induced by Hensen's node during generation of the posterior nervous system. Genes Dev. 11, 603-615.
49. Hirsch, M.R., Tieron, M.C., Guillemot, F., Burnet, J.F., and Goridis, C. (1998). Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development 725, 599-608.
50. Hollyday, M. (1983). Development of motor innervation of chick limbs. Prog. Clin. Biol. Res. 770, 183-193.
51. Hong, Y., Roy, R., and Ambros, V. (1998). Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in caenorhabditis elegans. Development 725, 3585-3597.
52. Horsfield, J., Penton, A., Secombe, J., Huffman, F.M., and Richardson, H. (1998). Decapentaplegic is required for arrest in G1 phase during Drosophila eye development. Development 725, 5069-5078.
53. Hsu, D.R., Economides, A.N., Wang, X., Eimon, P.M., and Harland, R.M. (1998). The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol. Cell 7, 673-683.
54. Jacobs, D., Beitel, G.J., Clark, S.G., Horvits, H.R., and Kornfield, K. (1998). Gain-of-function mutations in the Caenorhabditis elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase. Genetics 749, 1809-1822.
55. Jarman, A.P., and Ahmed, I. (1998). The specificity of proneural genes in determining drosophila sense organ identity. Mech. Dev. 76, 117-125.
56. Johnson, W.A., and Hirsh, J. (1990). Binding of a Drosophila POUdomain protein to a sequence element regulating gene expression in specific dopaminergic neurons. Nature 343, 467-470.
57. Kanekar, S., Perron, M., Dorsky, R., Harris, W.A., Jan, L.Y., Jan, Y.N., and Vetter, M.L. (1997). Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron 79, 981-994.
58. Landis, S.C. (1990). Target regulation of neurotransmitter phenotype. Trends. Neurosci. 13, 344-350.
59. Lane, M.E., Sauer, K., Wallace, K., Jan, Y.N., Lehner, C.F., and Vaessin, H. (1996). Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87, 1225-1235.
60. Lassar, A.B., Skapek, S.X., and Novitch, B. (1994). Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Curr. Opin. Cell Biol. 6, 788-794.
61. Lawrence, P.A., and Struhl, G. (1996). Morphogens, compartments, and pattern: lessons from Drosophila? Cell 85, 951-961.
62. Le Douarin, N.M. (1986). Cell line segregation during peripheral nervous system ontogeny. Science 237, 1515-1522.
63. Lecuit, T., and Cohen, S.M. (1997). Proximal-distal axis formation in the Drosophila leg. Nature 388, 139-145.
64. Lee, J.E. (1997) Basic helix-loop-helix genes in neural development. Gurr. Opin. Neurobiol. 7, 13-20.
65. Lee, J.E., Hollenberg, S.M., Snider, L., Turner, D.L., Lipnick, N., and Weintraub, H. (1995). Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268, 836-844.
66. Lehner, C.F., and Lane, M.E. (1997). Cell cycle regulators in Drosophila: downstream and part of developmental decisions. J. Cell Sci. 770, 523-528.
67. Liem, K.F., Jr., Tremml, G., and Jessell, T.M. (1997). A role forthe roof plate and its resident TGFβ-related proteins in neuronal patterning in the dorsal spinal cord. Cell 97, 127-138.
68. Lillien, L. (1995). Changes in retinal cell fate induced by overexpression of EGF receptor. Nature 377, 158-162.
69. Lillien, L. (1998). Neural progenitors and stem cells: mechanisms of progenitor heterogeneity. Curr. Opin. Neurobiol. 8, 37-44.
70. Lillien, L., and Cepko, C. (1992). Control of proliferation in the retina: temporal changes in responsiveness to FGF and TGF alpha. Development 775, 253-266.
71. Lillien, L., and Wancio, D. (1998). Changes in epidermal growth factor receptor expression and competence to generate glia regulate timing and choice of differentiation in the retina. Mol. Cell. Neurosci. 70, 296-308.
72. Lin, J.H., Saito, T., Anderson, D.J., Lance-Jones, C., Jessell, T.M., and Arber, S. (1998). Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression. Cell 95, 393-407.
73. Lisman, J. (1994). The CaM kinase II hypothesis for the storage of synaptic memory. Trends Neurosci. 77, 406-412.
74. Lo, L., and Anderson, D.J. (1995). Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities. Neuron 75, 527-539.
75. Lo, L., Sommer, L, and Anderson, D.J. (1997). MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells. Curr. Biol. 7, 440-450.
76. Lo, L., Tiveron, M.C., and Anderson, D.J. (1998). MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity. Development 725, 609-620.
77. Lu, B., Jan, L.Y., and Jan, Y.N. (1998). Asymmetric cell division: lessons from flies and worms. Curr. Opin. Genet. Dev. 8, 393-399.
78. Ma, Q., Kintner, C., and Anderson, D.J. (1996). Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87, 43-52.
79. Massague, J., and Polyak, K. (1995). Mammalian antiproliferative signals and their targets. Curr. Opin. Genet. Dev. 5, 91-96.
80. McConnell, S.K., and Kaznowski, C.E. (1991 ). Cell cycle dependence of laminar determination in developing neocortex. Science 254, 282-285.
81. McConnell, S.K. (1995). Constructing the cerebral cortex: neurogenesis and fate determination. Neuron 75, 761-768.
82. Michelsohn, A.M., and Anderson, D.J. (1992). Changes in competence determine the timing of two sequential glucocorticoid effects on sympathoadrenal progenitors. Neuron 8, 589-604.
83. Molkentin, J.D., and Olson, E.N. (1996). Defining the regulatory networks for muscle development. Curr. Opin. Genet. Dev. 6, 445-453.
84. Morin, X., Cremer, H., Hirsch, M.R., Kapur, R.P., Goridis, C., and Brunet, J.F. (1997). Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient forthe homeobox gene Phox2a. Neuron 78, 411-423.
85. Morrison, S.J., Shah, N.M., and Anderson, D.J. (1997). Regulatory mechanisms in stem cell biology. Cell 88, 287-298.
86. Morrow, E.M., Belliveau, M.J., and Cepko, C.L (1998). Two phases of rod photoreceptor differentiation during rat retinal development. J. Neurosci. 78, 3738-3748.
87. Mulligan, G., and Jacks, T. (1998). The retinoblastoma gene family: cousins with overlapping interests. Trends Genet. 14, 223-229.
88. Neophytou, C., Vernallis, A.B., Smith, A., and Raff, M.C. (1997). Müller-cell-derived leukaemia inhibitory factor arrests rod photoreceptor differentitaion at a postmitotic pre-rod stage of development. Development 724, 2345-2354.
89. Nonchev, S., Maconochie, M., Gould, A., Morrison, A., and Krumlauf, R. (1997). Cross-regulatory interactions between Hox genes and the control for segmental expression in the vertebrate central nervous system. Cold Spring Harbor Symp. Quant. Biol. 62, 313-323.
90. Olson, E.C., Schinder, A.F., Dantzker, J.L., Marcus, E.A., Spitzer, N.C., and Harris, W. A. (1998). Properties of ectopic neurons induced by Xenopus neurogeninl misexpression. Mol. Cell. Neurosci. 12, 281-299.
91. Panchision, D., Hazel, T., and McKay, R. (1998). Plasticity and stem cells in the vertebrate nervous system. Curr. Opin. Cell Biol. 10, 727-733.
92. Panin, V.M., Papayannopoulos, V., Wilson, R., and Irvine, K.D. (1997). Fringe modulates Notch-ligand interactions. Nature 387, 908-912.
93. Paro, R., Strutt, H., and Cavalli, G. (1998). Heritable chromatin states induced by the Polycomb and trithorax group genes. Novartis. Found. Symp. 274, 51-61.
94. Pattyn, A., Morin, X., Cremer, H., Goridis, C., and Brunet, J.F. (1997). Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis. Development 124, 4065-4075.
95. Pettemann, B., and Henderson, C.E. (1998). Neuronal cell death. Neuron 20, 633-647.
96. Piette, J. (1997). The transition from proliferation to differentiation in nerve cells: what can we learn from muscle? Exp. Cell Res. 234, 193-204.
97. Raff, M.C., Durand, B., and Gao, F.B. (1998). Cell number control and timing in animal development: the oligodendrocyte cell lineage. Int. J. Dev. Biol. 42, 263-267.
98. Ruiz i Altaba, A., Jessell, T.M., and Roelink, H. (1995). Restrictions to floor plate induction by hedgehog and winged-helix genes in the neural tube of frog embryos. Mol. Cell. Neurosci. 6, 106-121.
99. Sasaki, H., and Hogan, B.L.M. (1994). HNF-3 β as a regulator of floor plate development. Cell 76, 103-115.
100. Sassone-Corsi, P. (1995). Transcription factors responsive to cAMP. Annu. Rev. Cell Dev. Biol. 11, 355-377.
101. Saucedo-Cardenas, O., Quintana-Hau, J.D., Le, W.D., Smidt, M.P., Cox, J.J., De Mayo, F., Burbach, J.P., and Conneely, O.M. (1998). Nurrl is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc. Natl. Acad. Sci. USA 95, 4013-4018.
102. Schier, A.F., and Gehring, W.J. (1992). Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature 356, 804-807.
103. Schoenherr, C.J., and Anderson, D.U. (1995a). Silencing is golden: negative regulation in the control of neuronal gene transcription. Curr. Opin. Neurobiol. 5, 566-571.
104. Schoenherr, C. J., and Anderson, D.U. (1995b). The neuron-restrictive silencer factor (NRSF): a coordinate represser of multiple neuron-specific genes. Science 267, 1360-1363.
105. Schoenherr, C.J., Raquette, A.J., and Anderson, D.U. (1996). Identification of potential target genes for the neuron-restrictive silencer factor. Proc. Natl. Acad. Sci. USA 93, 9881-9886.
106. Schroeter, E.H., Kisslinger, U.A., and Kopan, R. (1998). Notch-1 signaling requires ligand-induced proteolytic release of intracellular domain. Nature 393, 382-386.
107. Schumacher, A., and Magnuson, T. (1997). Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet. 13, 167-170.
108. Schwarte, J.H. (1993). Cognitive kinases. Proc. Natl. Acad. Sci. USA 90, 8310-8313.
109. Schweitzer, R., Howes, R., Smith, R., Shilo, B.Z., and Freeman, M. (1995). Inhibition of Drosophila EGF receptor activation by the secreted protein Argos. Nature 376, 699-702.
110. Sherr, C.J., and Roberts, J.M. (1995). Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9, 1149-1163.
111. Sidow, A. (1996). Gen(om)e duplications in the evolution of early vertebrates. Curr. Opin. Genet. Dev. 6, 715-722.
112. Simpson, P. (1997). Notch signaling in development: on equivalence groups and asymmetric development potential. Curr. Opin. Genet. Dev. 7, 537-542.
113. Skapek, S.X., Rhee, J., Spicer, D.B., and Lassai, A.B. (1995). Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science 267, 1022-1024.
114. Slack, F., and Ruvkun, G. (1997). Temporal pattern formation by heterochronic genes. Annu. Rev. Genet. 31, 611-634.
115. Sockanathan, S., and Jessell, T.M. (1998). Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 94, 503-514.
116. Sommer, L., Ma, Q., and Anderson, D.U. (1996). Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CMS and PNS. Mol. Cell. Neurosci. 8, 221-241.
117. Stevens, C.F. (1998). Neuronal diversity: too many cell types for comfort? Curr. Biol. 8, 708-710.
118. Struhl, G., and Adachi, A. (1998). Nuclear access and action of Notch in vivo. Cell 93, 649-660.
119. Swanson, D.U., Zellmer, E., and Lewis, E.J. (1997). The homeodomain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes. J. Biol. Chem. 272, 27382-27392.
120. Tanabe, Y., William, C., and Jessell, T.M. (1998). Specification of motor neuron identity by the MNR2 homeodomain protein. Cell 95, 67-80.
121. Temple, S., and Raff, M.C. (1986). Clonal analysis of oligodendrocyte development in culture: evidence for a developmental clock that counts cell divisions. Cell 44, 773-779.
122. Thomsen, G.H. (1997). Antagonism within and around the organizer: BMP inhibitors in vertebrate body patterning. Trends Genet. 13, 209-211.
123. Thor, S., and Thomas, J.B. (1997). The Drosophila islet gene governs axon pathfinding and neurotransmitter identity. Neuron 18, 397-409.
124. Tikoo, R., Casaccia-Bonnefil, P., Chao, M.V., and Koff, A. (1997). Changes in cyclin-deptendent kinase 2 and p27kip1 accompany glial cell differentiation of central glia-4 cells. J. Biol. Chem. 272, 442-447.
125. Kip1 in oligodendrocyte progenitor cells results in cell-cycle growth arrest. J. Neurobiol. 36, 431-440.
126. Tsukiyama, T., and Wu, C. (1997). Chromatin remodeling and transcription. Curr. Opin. Genet. Dev. 7, 182-191.
127. Valarche, I., Tissier-Seta, J.P., Hirsch, M.R., Martinez, S., Goridis, C., and Brunet, J.F. (1993). The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter pehnotype. Development 779, 881-896.
128. Van Lockeren, Campagne, M., and Gill R. (1998). Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene Bax. J. Comp. Neurol. 397, 181-198.
129. Walsh, K., and Perlman, H. (1997). Cell cycle exit upon myogenic differentiation. Curr. Opin. Genet. Dev. 7, 597-602.
130. Wasserman, J.D., and Freeman, M. (1998). An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95, 355-364.
131. Watanabe, G., Pena, P., Shambaugh, G.E., Haines, G.K., and Pestell, R.G. (1998). Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development. Brain Res. Dev. Brain Res. 708, 77-87.
132. Wenner, P., and Frank, E. (1995). Peripheral target specification of synaptic connectivity of muscle spindle sensory neurons with spinal motorneurons. J. Neurosci. 75, 8191-8198.
133. Wilson, P.A., and Hemmati-Brivanlou, A. (1997). Vertebrate neural induction: inducers, inhibitors, and a new synthesis. Neuron 78, 699-710.
134. Xue, D., Tu, Y., and Chalfie, M. (1993). Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3. Science 267, 1324-1328.
135. Yang, C.Y., Kim, H.S., See, H., Kim, C.H., Brunet, J.F., and Kim, K.S. (1998). Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the do pamine β-hydroxylase gene. J. Neurochem. 71, 1813-1826.
136. Zabludoff, S.D., Csete, M., Wagner, R., Yu, X., and Wold, B.J. (1998). P27Kip 1 is expressed transiently in developing myotomes and enhances myogenesis. Cell Growth Differ. 9, 1-11.
137. Zellmer, E., Zhang, Z., Greco, D., Rhodes, J., Cassel, S., and Lewis, E.J. (1995). A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes. J. Neurosci. 15, 8109-8120.
138. Zetterberg, A., Larsson, O., and Winman, K.G. (1995). What is the restriction point? Curr. Opin. Cell Biol. 7, 835-842.
139. Zettelstrom, R.H., Solomin, L, Jansson, L, Hoffer, B.J., Olson, L., and Perlmann, T. (1997). Dopamine neuron agenesis in Nurrl -deficient mice. Science 276, 248-250.
140. Zhong, H., Voll, R.E., and Ghosh, S. (1998). Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP p300. Mol. Cell 1, 661-671.
141. Zorn, A.M. (1997). Cell-cell signaling: frog frizbees. Curr. Biol. 7, 501-504.