Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

Nature

Volumn 414, Issue 6864, 2001, Pages 643-648

  Kamal, Adeela ^a,b   Almenar Queralt, Angels ^a   LeBlanc, James F ^c   Roberts, Elizabeth A ^a   Goldstein, Lawrence S B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BIOGEN   (United States)

^c CIPHERGEN BIOSYSTEMS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; DISEASES; PROTEINS;

PROTEOLYTIC PROCESSING;

BIOMEDICAL ENGINEERING;

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; IMMUNOGLOBULIN LIGHT CHAIN; KINESIN; MEMBRANE RECEPTOR; PRESENILIN 1;

PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE FIBER TRANSPORT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXONAL TRANSPORT; AXONS; CELL COMPARTMENTATION; CELL MEMBRANE; CORPUS CALLOSUM; GANGLIA, SPINAL; KINESIN; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL; SCIATIC NERVE;

EID: 0035818998     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/414643a     Document Type: Article

References (30)

1. Translating cell biology into therapeutic advances in Alzheimer's disease
2. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
3. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
4. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
5. In search of γ-secretase: Presenilin at the cutting edge
6. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
7. Cell surface presenilin-1 participates in the γ-secretase-like proteolysis of Notch
8. Presenilin 1 controls γ-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons
9. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum
10. Evidence that production and release of amyloid β-protein involves the endocytic pathway
11. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "β-secretase" site occurs in the Golgi apparatus
12. Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
13. Novel β-secretase cleavage of β-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells
14. Detection of a novel intraneuronal pool of insoluble amyloid β protein that accumulates with time in culture
15. Retention of the Aizheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid β-peptide
16. The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
17. β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
18. Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein
19. Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein
20. Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the β-amyloid-precursor protein
21. Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides
22. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors
23. The C. elegans uric-104 gene encodes a putative kinesin heavy chain-like protein
24. Purification and tissue level of the β-amyloid peptide precursor of rat brain
25. The distribution, abundance and subcellular localization of kinesin
26. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
27. Kinesin-dependent axonal transport is mediated by the Sunday driver (SYD) protein
28. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
29. Subcellular localization of presenilins: Association with a unique membrane pool in cultured cells
30. A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60