Presenilin is required for proper morphology and function of neurons in C. elegans

Nature

Volumn 406, Issue 6793, 2000, Pages 306-309

  Wittenburg, Nicole ^a   Elmer, Stefan ^a   Lakowski, Bernard ^a   Röhrig, Sascha ^a   Rudolph, Claudla ^b   Baumelster, Ralf ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b EleGene AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PRESENILIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CELL STRUCTURE; CHOLINERGIC NERVE CELL; GENE MUTATION; INTERNEURON; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE SENSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; HELMINTH PROTEINS; HUMANS; MEMBRANE PROTEINS; MUTATION; NEURONS; PRESENILIN-1; TEMPERATURE;

ANIMALIA; CAENORHABDITIS ELEGANS; HUMULUS; INVERTEBRATA;

EID: 0034691513     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35018575     Document Type: Article

References (30)

1. Haass, C. & De Strooper, B. The presenilins in Alzheimer's disease - proteolysis holds the key. Science 286, 916-919 (1999).
2. Levitan, D. & Greenwald, I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351-354 (1995).
3. Levitan, D. et al. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 93, 14940-14944 (1996).
4. Baumeister, R. et al. Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes Funct. 1, 149-159 (1997).
5. Hedgecock, E. M. & Russell, R. L. Normal and mutant thermotaxis in the nematode Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 72, 4061-4065 (1975).
6. Mori, I. & Ohshima, Y. Neural regulation of thermotaxis in Caenorhabditis elegans. Nature 376, 344-348 (1995).
7. White, J. G., Southgate, E., Thomson, J. N. & Brenner, S. The structure of the nervous system of the nematode Caenorhabditis elegans. Phil. Trans. R. Soc. Lond. 314, 1-340 (1986).
8. Hedgecock, E. M., Culotti, I. G., Thomson, J. N. & Perkins, L. A. Axonal guidance mutants of Caenorhabditis elegans identified by filling sensory neurons with fluorescein dyes. Dev. Biol. 111, 158-170 (1985).
9. Hobert, O. et al. Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron 19, 345-357 (1997).
10. Westlund, B., Parry, D., Clover, R., Basson, M. & Johnson, C. D. Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. Proc. Natl Acad. Sci. USA 96, 2497-2502 (1999).
11. Kovacs, D. M. et al. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Med. 2, 224-229 (1996).
12. Cook, D. G. et al. Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites. Proc. Natl Acad. Sci. USA 93, 9223-9228 (1996).
13. Lee, M. K. et al. Expression of Presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J. Neurosci. 16, 7513-7525 (1996).
14. Peckol, E., Zallen, J., Yarrow, J. & Bargmann, C. Sensory activity affects sensory axon development in C. elegans. Development 126, 1891-1902 (1999).
15. 2+ channel cause myotonia in Caenorhabditis elegans. EMBO J. 16, 6066-6076 (1997).
16. Katayama, T. et al. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nature Cell Biol. 1, 479-485 (1999).
17. Struhl, G, & Greenwald, I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398, 522-525 (1999).
18. Wolfe, M. S. et al. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517 (1999).
19. Ye, Y., Lukinova, N. & Fortini, M. E. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants. Nature 398, 525-529 (1999).
20. Giniger, E., Jan, L. & Jan, Y. Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch. Development 117, 431-440 (1993).
21. Berezovska, O. et al. Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience 93, 433-439 (1999).
22. Sestan, N., Artavanis-Tsakonas, S. & Rakic, P. Contact-dependent inhibition of cortical neurite growth mediated by Notch signaling. Science 286, 741-746 (1999).
23. Berezovska, O. et al. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res. Mol. Brain Res. 69, 273-280 (1999).
24. Franklin, J. L. et al. Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1. Curr. Biol. 9, 1448-1457 (1999).
25. Pedersen, W. A., Guo, Q., Hartman, B. K. & Mattson, M. P. Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1. J. Biol. Chem. 272, 22397-22400 (1997).
26. Mayford, M. & Kandel, E. R. Genetic approaches to memory storage. Trends Genet. 15, 463-470 (1999).
27. Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94 (1974).
28. Maduro, M. & Pilgrim, D. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141, 977-988 (1995).
29. Yu, S., Avery, L., Baude, E. & Garbers, D. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Proc. Natl Acad. Sci. USA 94, 3384-3387 (1997).
30. Hobert, O., D'Alberti, T., Liu, X. & Ruvkun, G. Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11. J. Neurosci. 18, 2084-2096 (1998).