Notch1 and Amyloid Precursor Protein Are Competitive Substrates for Presenilin1-dependent γ-Secretase Cleavage

Journal of Biological Chemistry

Volumn 276, Issue 32, 2001, Pages 30018-30023

  Berezovska, Oksana ^b   Jack, Christine ^b   Deng, Amy ^b   Gastineau, Nicole ^b   Rebeck, G William ^b   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELL MEMBRANES; DISEASES; ENZYME KINETICS; NEUROPHYSIOLOGY; PROTEINS;

PROTEOLYSIS;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; DELTA LIGAND; GAMMA SECRETASE; LIGAND; MEMBRANE PROTEIN; NOTCH LIGAND; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PRESENILIN 1; PROTEINASE; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; CELL SURFACE RECEPTOR; LUCIFERASE; NOTCH1 PROTEIN, HUMAN; NOTCH1 PROTEIN, MOUSE; PSEN1 PROTEIN, HUMAN; SECRETASE; TRANSCRIPTION FACTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SUBSTRATE; HUMAN; MOUSE; NERVE CELL; NONHUMAN; NOTCH C TERMINAL DOMAIN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; ANIMAL; BINDING COMPETITION; BIOLOGICAL MODEL; BIOTINYLATION; CELL NUCLEUS; CULTURE MEDIUM; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; IMMUNOBLOTTING; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TIME; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALIA;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING, COMPETITIVE; BIOTINYLATION; BLOTTING, WESTERN; CELL NUCLEUS; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOBLOTTING; LIGANDS; LUCIFERASES; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NEURONS; PRESENILIN-1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0035839591     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008268200     Document Type: Article

References (54)

1. De Strooper, B., and Annaert, W. (2000) J. Cell Sci. 113, 1857-1870
2. Selkoe, D. (1998) Trends Cell Biol. 8, 447-453
3. Wilson, C., Doms, R., and Lee, V. (1999) J Neuropathol. Exp. Neurol. 58, 787-794
4. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Thekla, S. D., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
5. Wolfe, M., De Los Angeles, J., Miller, D., Xia, W., and Selkoe, D. (1999) Biochemistry 38, 11223-11230
6. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
7. Li, Y., Xu, M., Lai, M., Huang, Q., Castro, J., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., Register, R., Sardana, M., Shearman, M., Smith, A., Shi, X., Yin, K., Shafer, J., and Gardell, S. (2000) Nature 405, 689-694
8. Esler, W., Kimberly, W., Ostaszewski, B., Diehl, T., Moore, C., Tsai, J., Rahmati, T., Xia, W., Selkoe, D., and Wolfe, M. (2000) Nature Cell Biol. 2, 428-434
9. Kopan, R., Schroeter, E., Weibtraub, H., and Nye, J. (1996) Proc. Natl. Acad. Sci. (U. S. A.) 93, 1683-1688
10. Schroeter, E., Kisslinger, J., and Kopan, R. (1998) Nature 393, 382-386
11. Berezovska, O., Jack, C., McLean, P., Aster, J. C., Hicks, C., Xia, W., Wolfe, M. S., Kimberly, W. T., Weinmaster, G., Selkoe, D. J., and Hyman, B. T. (2000) J. Neurochem. 75, 583-593
12. Artavanis-Tsakonas, S., Matsuno, K., and Fortini, M. E. (1995) Science 268, 225-232
13. Kopan, R., and Turner, D. (1996) Curr. Opin. Neurobiol. 6, 594-601
14. Weinmaster, G. (1997) Mol. Cell Neurosci. 9, 91-102
15. Struhl, G., and Adachi, A. (1998) Cell 93, 649-660
16. Artavanis-Tsakonas, S., Rand, M. D., and Lake, R. J. (1999) Science 284, 770-776
17. Muskavitch, M. A. (1994) Dev. Biol. 166, 415-430
18. de la Pompa, J., Wakeham, A., Correia, K., Samper, E., Brown, S., Aguilera, R., Nakano, T., Honjo, T., Mak, T., Rossant, J., and Conlon, R. (1997) Development 126, 1139-1148
19. Chitnis, A. (1999) Curr. Opin. Neurobiol. 9, 18-25
20. Berezovska, O., McLean, P., Knowles, R., Frosh, M., Lu, F. M., Lux, S. E., and Hyman, B. T. (1999) Neuroscience 93, 433-439
21. Sestan, N., Artavanis-Tsakonas, S., and Rakis, P. (1999) Science 286, 741-746
22. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1999) Nature 398, 518-521
23. Ray, W., Yao, M., Mumm, J., Schroeter, E., Saftig, P., Wolfe, M., Selkoe, D., Kopan, R., and Goate, A. (1999) J. Biol. Chem. 274, 36801-36807
24. Song, W., Nadeau, P., Yang, X., Shen, J., and Yankner, B. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6959-6063
25. Steiner, H., Duff, K., Capell, A., Romig, H., Grim, M., Lincoln, S., Hardy, J., Yu, X., Picciano, M., Fechteler, K., Citron, M., Kopan, R., Pesold, B., Keck, S., Baader, M., Tomita, T., Iwatsubo, T., Baumeister, R., and Haass, C. (1999) J. Biol. Chem. 274, 28669-28673
26. Herreman, A., Serneels, L., Annaert, W., Collen, D., Schoonjans, L., and DeStrooper, B. (2000) Nat. Cell Biol. 2, 461-462
27. Zhang, Z., Nadeau, P., Song, W., Donoviel, D., Yuan, M., Bernstein, A., and Yankner, B. (2000) Nat. Cell Biol. 2, 463-465
28. Wolfe, M., Xia, W., Moore, C., Leatherwood, D., Ostaszewski, B., Rahmati, T., Donkor, I., and Selkoe, D. (1999) Biochemistry 38, 4720-4727
29. Wolfe, M., Citron, M., Diehl, T., Xia, W., Donkor, I., and Selkoe, D. (1998) J. Med. Chem. 41, 6-9
30. Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., and Cole, G. (1996) Science 274, 99-102
31. Berezovska, O., Frosch, M., McLean, P., Knowles, R., Koo, E., Kang, D., Shen, J., Lu, F. M., Lux, S. E., Tonegawa, S., and Hyman, B. T. (1999) Mol. Brain Res. 69, 273-280
32. Qiu, Z., Strickland, D., Hyman, B., and Rebeck, G. (1999) J. Neurochem. 73, 1393-1398
33. Hsieh, J. J., Henkel, T., Salmon, P., Robey, E., Peterson, M. G., and Hayward, S. D. (1996) Mol. Cell Biol. 16, 952-959
34. Wang, S., Sdrulla, A., diSibio, G., Bush, G., Nofziger, D., Hicks, C., Weinmaster, G., and Barres, B. (1998) Neuron 21, 63-75
35. Nitsch, R. M., Deng, A., Tennis, M., Schoenfeld, D., and Growdon, J. (2000) Ann. Neurol. 48, 913-918
36. Citron, M., Diehl, T. S., Gordon, G., Biere, A., Seubert, P., and Selkoe, D. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 13170-13175
37. Knops, J., Suomensaari, S., Lee, M., McConlogue, L., Seubert, P., and Sinha, S. (1995) J. Biol. Chem. 270, 2419-2422
38. Selkoe, D., Podlisny, M., Joachim, C., Vickers, E., Lee, G., Fritz, L., and Oltersdor, T. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7341-7345
39. Aster, J., Robertson, E., Hasserjian, R., Turner, J., Kieff, E., and Sklar, J. (1997) J. Biol. Chem. 272, 11336-11343
40. Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y. Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D. S., Holmes, E., Milman, P., Liang, Y., Zhang, D. M., Xu, D. H., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L. S., Sorbi, S., Bruni, A., Fraser, P., and St George-Hyslop, P. (2000) Nature 407, 48-54
41. Leem, J., Saura, C., Tomita, T., Iwatsubo, T., and Thinakaran, G. (2000) Society for Neuroscience Meeting, New Orleans, Abstr. 474.11.
42. Gridley, T. (1997) Mol. Cell Neurosci. 9, 103-108
43. Berezovska, O., Xia, M., and Hyman, B. (1998) J. Neuropath. Exp. Neurol. 57, 738-745
44. Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C. M., Kim, G., Seekins, S., Yager, D., Slunt, H. H., Wang, R., Seeger, M., Levey, A. I., Gandy, S. E., Copeland, N. G., Jenkins, N. A., Price, D. L., Younkin, S. G., and Sisodia, S. S. (1996) Neuron 17, 1005-1013
45. Qian, S., Jiang, P., Guan, X., Singh, G., Trumbauer, M., Yu, H., Chen, H., Van der Ploeg, L., and Zheng, H. (1998) Neuron 20, 611-617
46. Sudoh, S., Kawamura, Y., Sato, S., Wang, R., Saido, T., Oyama, F., Sakaki, Y., Komano, H., and Yanagisawa, K. (1998) J. Neurochem. 71, 1535-1543
47. Kulic, L., Walter, J., Multhaup, G., Teplow, D., Baumeister, R., Romig, H., A., C., Steiner, H., and Haass, C. (2000) Proc. Natl. Acad. Sci., U. S. A. 97, 5913-5918
48. Jack, C., Berezovska, O., Wolfe, M., and Hyman, B. (2001) Mol. Brain Res. 87, 166-174
49. Levitan, D., Doyle, T., Brousseau, D., Lee, M., Thinakaran, G., Slunt, H., Sisodia, S., and Greenwald, I. (1996) Proc Natl Acad Sci (U. S. A.). 93, 14940-14944
50. Baumeister, R., Leimer, U., Zweckbronner, I., Jakubek, C., Grunberg, J., and Haass, C. (1997) Genes Funct. 1, 149-159
51. Wittenburg, N., Eimer, S., Lakowski, B., Rohrig, S., Rudolph, C., and Baumeister, R. (2000) Nature 406, 306-309
52. Capell, A., Steiner, H., Romig, H., Keck, S., Baader, M., Grim, M., Baumeister, R., and Haass, C. (2000) Nat. Cell Biol. 2, 205-211
53. Petit, A., Bihel, F., da Costa, C. A., Pourquie, O., Checler, F., and Kraus, J. L. (2001) Nat. Cell Biol. 3, 507-511
54. Berezovska, O., Xia, M. Q., Page, K., Wasco, W., Tanzi, R. E., and Hyman, B. T. (1997) J. Neuropath. Exp. Neurol. 56, 40-44