Notch signaling in the nervous system. Pieces still missing from the puzzle

BioEssays

Volumn 22, Issue 3, 2000, Pages 264-273

  Baker, Nicholas E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; MEMBRANE PROTEIN; NOTCH PROTEIN, DROSOPHILA; NOTCH RECEPTOR; TRANSACTIVATOR PROTEIN;

ANIMAL; DROSOPHILA; METABOLISM; NERVE CELL; NERVOUS SYSTEM; NERVOUS SYSTEM FUNCTION; PHYSIOLOGY; PRENATAL DEVELOPMENT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; MEMBRANE PROTEINS; NERVOUS SYSTEM; NERVOUS SYSTEM PHYSIOLOGY; NEURONS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0034111618     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-1878(200003)22:3<264::AID-BIES8>3.0.CO;2-M     Document Type: Review

References (91)

1. Chitnis AB. Control of neurogenesis - lessons from frogs, fish and flies. Curr Opin Neurobiol 1999;9:18-25.
2. Brand M, Jarman AP, Jan LY, Jan YN. asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation. Development 1993;119:1-17.
3. Lee JE. Basic helix-loop-helix genes in neural development. Curr Opin Neurobiol 1997;7:13-20.
4. Cubas P. de Celis J-F, Campuzano S, Modolell J. Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev 1991;5:996-1008.
5. Heitzler P, Simpson P. The choice of cell fate in the epidermis of Drosophila. Cell 1991;64:1083-1092.
6. Chitnis A, Kintner C. Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons in Xenopus embryos. Development 1996;122:2295-2301.
7. Klueg KM, Parody TR. Muskavitch MAT. Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development. Mol Biol Cell 1998;9:1709-1723.
8. Qi H, et al. Processing of the Notch ligand Delta by the metalloprotease Kuzbanian. Science 1999;283:91-94.
9. Weinmaster G. The ins and outs of Notch signaling. Mol Cell Neuroscience 1997;9:91-102.
10. Chan Y-M, Jan YN. Roles for proteolysis and trafficking in notch maturation and signal transduction. Cell 1998;94:423-426.
11. Hardy J, Israel A. In search of γ-secretase. Nature 1999;398:466-467.
12. Jarriault S, et al. Signalling downstream of activated mammalian Notch. Nature 1995;377:355-358.
13. Lieber T, Kidd S, Alcamo E, Corbin V, Young MW. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function of Notch in nuclei. Genes Dev 1993;7:1949-1965.
14. Jennings B, Preiss A, Delidakis C, Bray S. The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development 1994;120:3537-3548.
15. de Celis JF, et al. Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development. Development 1996;122:2719-2728.
16. Eastman DS, et al. Activated Notch regulation of Enhancer of split mγ and mδ expression is mediated by Suppressor of Hairless. Mol Cell Biol 1997;17:5620-5628.
17. Fisher A, Caudy M. The function of hairy-related bHLH repressor proteins in cell fate decisions. Bioessays 1998;20:298-306.
18. Hinz U, Giebel B, Campos-Ortega JA. The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 1994;76:77-87.
19. Giebel B, Campos-Ortega JA. Functional dissection of the Drosophila enhancer-of-split protein, a suppressor of neurogenesis. Proc Natl Acad Sci USA 1997;94:6250-6254.
20. Lai EC, Posakony JW. Regulation of Drosophila neurogenesis by RNA:RNA dupexes? Cell 1998;93:1103-1104.
21. Wilkinson HA, Fitzgerald K, Greenwald I. Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell 1994;79:1187-1198.
22. Greenwald I, Rubin GM. Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 1992;68:271-281.
23. Myat A, Henrique D, Ish-Horowicz D, Lewis J. A chick homologue of Serrate and its relationship with Notch and Delta homologues during central neurogenesis. Dev Biol 1996;174:233-247.
24. Rooke JE, Xu T. Positive and negative signals between interacting cells for establishing neural fate Bioessays 1998;20:209-214.
25. Kidd S, Baylies MK, Gasic GP, Young MW. Structure and function of the Notch protein in developing Drosophila. Genes Dev 1989;3: 1113-1129.
26. Johansen KM, Fehon RG, Artavanis-Tsakonas S. The Notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuoronal precursor cells during Drosophila development. J Cell Biol 1989;109:2427-2440.
27. Kooh PJ, Fehon RG, Muskavitch MAT. Implicalions of dynamic patterns of Delta and Notch expression for cellular interactions during Drosophila development. Development 1993;117:
28. Parks AL, Huppert SS, Musovitch MAT. The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster. Mech Dev 1997;63:61-74.
29. Baker NE, Yu SY. The R8-photoreceptor equivalence group in Drosophila: fate choice preceeds regulated Delta transcription and is independent of Notch gene dose. Mech Dev 1998;74:3-14.
30. Seugnet L, Simpson P, Haenlin M. Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila. Development 1997;124:2015-2025.
31. Struhl G, Fitzgerald K, Greenwald I. Intrinsic activity of the lin-12 and Notch intracellular domains in vivo. Cell 1993;74:331-345.
32. Baker NE, Yu S, Han D. Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr Biol 1996;6:1290-1301.
33. Nakao K, Campos-Ortega JA. Persistent expression of genes of the Enhancer of split complex suppresses neural development in Drosophila, Neuron 1996;16:275-286.
34. Ligoxygakis P, Yu S-Y, Delidakis C, Baker NE. A subset of N functions during Drosophila eye development require Su(H) and the E(spl) gene complex. Development 1998;125:2893-2900.
35. Dokucu ME, Zipursky SL, Cagan RL. Atonal, Rough and the resolution of proneural clusters in the developing Drosophila retina. Development 1996;1224139-4147.
36. Couso J, Bishop S, MArtinez-Arias A. The wingless signaling pathway and the patterning of the wing margin in Drosophila. Development 1994;120:621-636.
37. Couso JP, Knust E, Martinez Arias A. Serrate and wingless cooperate to induce vestigial gene expression and wing formation in Drosophila. Curr Biol 1995;5:1437-1448.
38. Kim J, Irvine KD, Carroll SB. Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing Drosophila wing. Cell 1995;82:795-802.
39. Doherty D, Feger G, Younger-Sheperd S, Jan LY, Jan YN. Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation. Genes Dev 1996;10:421-434.
40. de Celis JF, Garcia-Bellido A, Bray SJ. Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 1996;122:359-369.
41. Panin VM, Papayannopoulos V, Wilson R, Irvine KD. Fringe modulates Notch-ligand interactions. Nature 1997;387:908-912.
42. Fleming RJ, Gu Y, Hukreide NA. Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 1997;124:2973-2981.
43. Yuan YP, Schultz J, Mlodzik M, Bork P. Secreted Fringe-like signaling molecules may be glycosyltransferases. Cell 1997;88:9-11.
44. Cho KO, Choi KW. Fringe is essential for mirror symmetry and morphogenesis in the Drosophila eye. Nature 1998;396:272-276.
45. Dominguez M, de Celis JF. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature 1999;396:276-278.
46. Papayannopoulos V, Tomlinson A, Panin VM, Rauskolb C, Irvine KD. Dorsal-ventral signaling in the Drosophila eye. Science 1998;281: 2031-2034.
47. Baker NE, Mlodzik M, Rubin GM. Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous. Science 1990;250:1370-1377.
48. Mlodzik M, Baker NE, Rubin GM. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila. Genes Dev 1990;4: 1848-1861.
49. Ellis MC, Weber U, Wiersdorff V, Mlodzik M. Confrontation of scabrous expressing and non-expressing cells is essential for normal ommatidial spacing in the Drosophila eye. 1994;120:1959-1969.
50. Lee E-C, Baker, unpublished results.
51. Lee E, Baker NE. GP300sca is not a high affinity ligand for Notch. Biochem Biophy Res Comm 1996;225:720-725.
52. Klein T, Brennan K, Martinez-Arias A. An intrinsic dominant negative activity of serrate that is regulated during wing development in Drosophila. Dev Biol 1997;189:123-134.
53. Micchelli CA, Rulifson EJ, Blair SS. The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 1997;124: 1485-1495.
54. Freeman M. Cell determination strategies in the Drosophila eye. Development 1997;124:261-270.
55. Perrimon N, Perkins LA. There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor Cell 1997;89:13-16.
56. Schweitzer R, Shilo BZ. A thousand and one roles for the Drosophila EGF receptor. Trends Genet 1997;13:191-196.
57. Brunner D. et al. The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 1994;370: 386-389.
58. O'Neill EM, Rebay I, Tjian R, Rubin GM. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway Cell 1994;78:137-147.
59. Rebay I, Rubin GM. Van functions as a general innibitor of differentiation and is negatively regulated by activation of the Ras/MAPK pathway. Cell 1995;81:857-866.
60. Dominguez M, Wassarman JD. Freeman M. Multiple functions of the EGF receptor in Drosophila eye development. Curr Biol 1998;8:1039-1048.
61. Lesokhin A, Yu S-Y, Katz J, Baker NE. Several levels of EGF Receptor signalling during photoreceptor specification in Ellipse, wild type, and null mutant Drosophila. Dev Biol 1999;205:129-144.
62. Spencer SA, Powell PA, Miller DT, Cagan RL. Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development 1998;125:4777-4790.
63. Kumar JP et al. Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 1998;125: 3875-3885.
64. Chen C-K, Chien C-T. Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors Proc Natl Acad Sci USA 1999;96:5055-5060.
65. Strom A, Castella P, Rockwood J, Wagner J, Caudy M. Mediation of NGF signaling by post-translational inhibition of HES-1 a basic helix-loop-helix represser of neuronal differentiation. Genes Dev 1997;11: 3168-3181.
66. Skeath JB, Panganiban G, Selegue J, Carroll SB. Gene regulation in two dimensions: the proneural achaete and scute genes are controlled by combinations of axis-patterning genes through a common intergenic control region. Genes Dev 1992;6:2606-2619.
67. Heberlein U, Singh CM, Luk AY, Donohoe TJ. Growth and differentiation in the Drosophila eye coordinated by hedgehog. Nature 1995;373: 709-711.
68. Simpson P. A prepattern for sensory organs. Drosophila development. Curr Biol 1996;6:948-950.
69. Gomez-Skarmeta JL, et al. Cis-regulation of achaete and scute shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs. Genes Dev 1995;9:1869-1882.
70. Jarman AP, Sur Y, Jan LY, Jan YN. Role of the proneural gene atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 1995;121:2019-2030.
71. Culi J, Modolell J. Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that s regulated by Notch signaling. Genes Dev 1998;12:2036-2047.
72. Sun Y, Jan LY, Jan YN. Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system Development 1998;125:3731-3740.
73. Skeath JB, Panganiban GF, Carroll SB. The ventral nervous system detective gene controls proneural gene expression at two distinct steps curing neuroblast formation in Drosophila. Development 1994;120: 1517-1524.
74. Leviten MW, Lai EC, Posakony JW. The Drosophila gene Bearded encodes a novel small protein and shares 3′ UTR sequence motifs with multiple Enahancer of split complex genes. Development 1997;124: 4039-4051.
75. Wurmbach E, Wech I, Preiss A. The Enhancer of split complex of Drosophila melanogaster harbors three classes of Notch responsive genes. Mech Dev 1999;80:171-180.
76. Blaumueller CM, Oui H, Zagouras P, Artavanis-Tsakonas, S. Intracellular cleavage of Notch leads to a heteredimeric receptor on the plasma membrane. Cell 1997;90:281-291.
77. Logeat F, et al. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA 1998;95:8108-8112.
78. Wesley CS. Notch and Wingless regulate expression of cuticle patterning genes. Mol Cell Biol 1999;19:5743-5758.
79. Greenwald I, Seydoux G. Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans. Nature 1990;346:197-199.
80. Aster J, et al. Functional analysis of the TAN-1 gene, a human homolog of Drosophila Notch. CSH Symposium Quant Biol 1994;59: 125-136.
81. Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats Development 1995;121: 2633-2644.
82. Axelrod JD. Matsuno K, Artavanis-Tsakonas S, Perrmon N. Interaction between wingless and Notch signaling pathways mediated by dishevelled. Science 1996;271:1826-1832.
83. Hubbard EJA, Dong Q, Greenwald I. Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans. Science 1996;273:112-115.
84. Royet J, Bouwmeester T, Cohen SM. Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity. EMBO J 1998;15:7351-7360.
85. Artavanis-Tsakonas S, Matsuno K, Fortini ME. Notch signalling. Science 1995;268:225-232.
86. Greenwald I. LIN-12/Notch signaling: lessons from worms and flies. Genes Dev 1998;12:1751-1762.
87. Hing HK, Sun X, Artavanis-Tsakonas S. Modulation of wingless signaling by Notch in Drosophila. Mech Dev 1994;47:261-268.
88. Couso JP, Martinez Arias A. Notch is required for wingless signaling in the epidermis of Drosophila. Cell 1994;79:259-272.
89. Blair SS. Shaggy (zeste-white 3) and the formation of supernumerary bristle precursors in the developing wing blade of Drosophila. Dev Biol 1992;152:263-278.
90. Phillips RG, Whittle JR. wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development. Development 1993;118:427-438.
91. Schweitzer R, Shaharabany M, Seger R, Shilo B-Z. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ectoderm determination. Genes Dev 1995;9: 1518-1529.