Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Genes and Development

Volumn 16, Issue 7, 2002, Pages 846-858

  Hitoshi, Seiji ^a,e   Alexson, Tania ^a   Tropepe, Vincent ^a,f   Donoviel, Dorit ^b,g   Elia, Andrew J ^a   Nye, Jeffrey S ^c   Conlon, Ronald A ^d   Mak, Tak W ^a   Bernstein, Alan ^b   Van Der Kooy, Derek ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c NORTHWESTERN UNIVERSITY   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF TOKYO   (Japan)

^f WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^g LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

Cell cycle time; Embryonic stem cell; Multipotentiality; Presenilin; RBP J ; Self renewal

Indexed keywords

NOTCH RECEPTOR; PRESENILIN 1; PROTEIN; PROTEIN RBP JKAPPA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOASSAY; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CELL COUNT; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE; GLIA CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; BRAIN; BROMODEOXYURIDINE; CELL CYCLE; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MUTATION; NEURONS; PRESENILIN-1; PROSENCEPHALON; PROTEIN BINDING; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0036205049     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.975202     Document Type: Article

References (51)

1. Notch signaling
2. Notch signaling: Cell fate control and signal integration in development
3. The expression and function of Notch pathway genes in the developing rat eye
4. Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex
5. Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors
6. Generalized potential of adult neural stem cells
7. Methods for determining numbers of cells and synapses: A case for more uniform standards of review
8. Notch1 is required for the coordinate segmentation of somites
9. Conservation of the Notch signalling pathway in mammalian neurogenesis
10. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
11. Mice lacking both presenilin genes exhibit early embryonic patterning defects
12. Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells
13. rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells
14. Mammalian neural stem cells
15. Radial glial identity is promoted by Notch1 signaling in the murine forebrain
16. Presenilin-1 regulates neuronal differentiation during neurogcnesis
17. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
18. Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system
19. Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
20. The LIN-12/Notch signaling pathway and its regulation
21. Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development
22. Long-distance neuronal migration in the adult mammalian brain
23. Separate proliferation kinetics of fibroblast growth factor-responsive and epidermal growth factor-responsive neural stem cells within the embryonic forebrain germinal zone
24. Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements
25. Isolation of lineage-restricted neuronal precursors from multipotent neuroepithclial stem cells
26. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
27. Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells
28. In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain
29. The bHLH gene Hes1 as a repressor of the neuronal commitment of CNS stem cells
30. A role of presenilin-1 in nuclear accumulation of Irel fragments and induction of the mammalian unfolded protein response
31. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
32. Applications of retrovirus-mediated expression cloning
33. Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
34. Disruption of the mouse RBP-Jκ gene results in early embryonic death
35. Processing of the Notch ligand Delta by the metalloprotease Kuzbanian
36. Timing of CNS cell generation: A programmed sequence of neuron and glia cell production from isolated murine cortical stem cells
37. Clonal population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell
38. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
39. ic
40. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
41. Notch and presenilins in vertebrates and invertebrates: Implications for neuronal development and degeneration
42. Notch signaling inhibits muscle cell differentiation through a CBFl-independent pathway
43. Skeletal and CNS defects in presenilin-1-deficient mice
44. Neurogenesis in the adult is involved in the formation of trace memories
45. Presenilin 1 negatively regulates β-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of β-amyloid precursor protein and Notch processing
46. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate
47. Tansforming growth factor-α null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
48. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
49. Direct neural fate specification from embryonic stem cells: A primitive mammalian neural stem cell stage acquired through a default mechanism
50. Is there a neural stem cell in the mammalian forebrain?
51. Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm