A substrate-based difluoro ketone selectively inhibits Alzheimer's γ-secretase activity

Journal of Medicinal Chemistry

Volumn 41, Issue 1, 1998, Pages 6-9

  Wolfe, Michael S ^a   Citron, Martin ^b   Diehl, Thekla S ^c   Xia, Weiming ^c   Donkor, Isaac O ^a   Selkoe, Dennis J ^d  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; CALPAIN; CALPASTATIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; KETONE DERIVATIVE; SERINE PROTEINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL STRAIN; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG SELECTIVITY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PROCESSING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CHO CELLS; CRICETINAE; ENDOPEPTIDASES; HUMANS; KETONES; OLIGOPEPTIDES; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0031915681     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970621b     Document Type: Article

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