Notch signaling: From the outside in

Developmental Biology

Volumn 228, Issue 2, 2000, Pages 151-165

  Mumm, Jeffrey S ^a   Kopan, Raphael ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; PROTEINASE;

DNA PROTEIN COMPLEX; DROSOPHILA; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC ORGANIZATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0034671686     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.9960     Document Type: Review

References (178)

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7. Functional analysis of the TAN-1 gene, a human homolog of Drosophila Notch
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9. Interaction between Wingless and Notch signaling pathways mediated by dishevelled
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11. Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription
12. Notch and neurogenesis
13. Microenvironmentai influences on human B-cell development
14. A Notch affair
15. Notch signalling in Drosophila: Three ways to use a pathway
16. Repression by Notch is required before Wingless signalling during muscle progenitor cell development in Drosophila
17. Wingless modulates the effects of dominant negative Notch moiecules in the developing wing of Drosophila
18. A functional analysis of Notch mutations in Drosophila
19. The Abruptex mutations of Notch disrupt the establishment of proneural ciusters in Drosophila
20. A novel proteolytic cleavage involved in Notch signaling: The role of the distinigrin-metailoprotease TACE
21. The SREBP pathway -Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
22. Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
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26. Presenilins, processing of beta-amyloid precursor protein, and Notch signaling
27. Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos
28. Notch1 is required for the coordinate segmentation of somites
29. The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase
30. The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42
31. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
32. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
33. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
34. Notch signaling in T cell development
35. ebi regulates epidermal growth factor receptor signaling pathways in Drosophila
36. Mice lacking both presenilin genes exhibit early embryonic patterning defects
37. The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor
38. SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans
39. TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
40. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1
41. The suppressor of hairless protein participates in Notch receptor signaling
42. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye
43. Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of Notch signaling
44. rax, hes1, and Notch1 promote the formation of Muller glia by postnatal retinal progenitor cells
45. Radial glial identity is promoted by Notch1 signaling in the murine forebrain
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50. Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells
51. Notch signaling in vertebrate development and disease
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53. Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb
54. A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells
55. Alzheimer's disease - In search of gamma-secretase
56. Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function
57. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
58. Effects of mutant rat dynamin on endocytosis
59. T-cell regulation of peripheral tolerance and immunity: The potential role for Notch signalling
60. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
61. Masking of the CBF1/RBPjκ transcriptional repression domain by Epstein-Barr virus EBNA2
62. Sel-10 a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the cdc4 family of proteins
63. Beaded of goldschmidt, an antimorphic allele of serrate, encodes a protein lacking transmembrane and intracellular domains
64. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
65. Signalling downstream of activated mammalian Notch
66. Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands
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68. Fringe forms a complex with Notch
69. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
70. Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives
71. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
72. Notch/Lin-12 signaling - Transduction by regulated protein slicing
73. The Lin-12/Notch signaling pathway and its regulation
74. Good things must come to an end: How is Notch signaling turned off?
75. A common enzyme connects Notch signaling with Alzheimer disease
76. The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
77. Signal transduction by activated mNotch: Importance of proteolyric processing and its regulation by the extracellular domain
78. The Notch pathway: Democracy and aristocracy in the seiection of cell fate
79. Reversible blockage of membrane retrieval and endocytosis in the garland cell of the temperaturesensitive mutant of Drosophila melanogaster, shibiretsl
80. Notch signaling and the determination of appendage identity
81. Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis
82. Functional interaction between the mouse Notch1 intracellular region and histone acetyltransferases PCAF and GCN5
83. Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region
84. The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling
85. Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos
86. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans s182 Alzheimers disease gene
87. Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans
88. Notch signalling and the control of cell fate choices in vertebrates
89. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32d cells through interaction with Notch1
90. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
91. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
92. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state
93. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
94. A subset of Notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex
95. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
96. Arbiter of differentiation and death: Notch signaling meets apoptosis
97. Fringe is a glycosyltransferase that modifies Notch
98. Repression by Suppressor of Hairless and activation by Notch are required to define a single row of single-minde expressing cells in the Drosophila embryo
99. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
100. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
101. Delta-Notch signaling and Drosophila cell fate choice
102. Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators
103. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
104. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
105. The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription
106. Notch inhibition of E47 supports the existence of a novel signaling pathway
107. Modulators of Notch signaling
108. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
109. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
110. Determination of vertebrate retinal progenitor cell fate by the Notch pathway and basic helix-loop-helix transcription factors
111. LAG-3 a putative transcriptional activator in the C. elegans Notch pathway
112. Mastermind is a putative activator for Notch
113. Shibire, a neurogenic mutant of Drosophila
114. Chromosomal deficiencies and embryonic development of Drosophila melanogaster
115. Processing of the Notch ligand Delta by the metalloprotease Kuzbanian
116. Recognition and ubiquitination of Notch by Itch, a Hect-Type E3 Ubiquitin Ligase
117. Calcium depletion dissociates and activates heterodimeric Notch receptors
118. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
119. Evidence for a physical interaction between presenilin and Notch
120. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor
121. Nuclear Notch1 signaling and the regulation of dendritic development
122. Mouse mammary tumor gene int-3: A member of the Notch gene family transforms mammary epithelial cells
123. Regulation of T cell fate by Notch
124. Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats
125. Kuz, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
126. Positive and negative signals between interacting cells for establishing neural fate
127. A widespread and early requirement for a novel Notch function during Drosophila embryogenesis
128. Positive and negative thymocyte selection
129. Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2
130. Cell-cell interactions during neural development - Multiple types of lateral inhibitions involved in Drosophila eye development
131. Development of neurogenic placodes in Xenopus laevis
132. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
133. Mastermind acts downstream of Notch to specify neuronal cell fates in the Drosophila central nervous system
134. Dominant-negative mutation in the beta 2 and beta 6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage
135. Presenilin-1 and 2 are molecular targets for gamma secretase inhibitors
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137. Contact-dependent inhibition of cortical neurite growth mediated by Notch signaling
138. Requirement For dynamin during Notch signaling In Drosophila neurogenesis
139. Notch signaling inhibits muscle cell differentiation through a CBF 1-independent pathway
140. Temperature-sensitive mutations of the Notch locus in Drosophila melanogaster
141. Temperaturesensitive periods and autonomy of pleiotropic effects of 1(1)Nts1, a conditional Notch lethal in Drosophila
142. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant
143. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
144. Mouse Jagged1 physically interacts with Notch2 and other Notch receptors - Assessment by quantitative methods
145. Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila
146. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs
147. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins
148. Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2
149. Nuclear access and action of Notch in vivo
150. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
151. Presenilin is required for activity and nuclear access of Notch in Drosophila
152. Fundamentally different logic of gene regulation in eukaryotes and prokaryotes
153. Secreted forms of Delta and Serrate define antagonists of Notch signaling in Drosophila
154. Notch1 is essential for postimplantation development in mice
155. The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators
156. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-j-kappa/Su(H)
157. LIM protein Kyot2 negatively regulates transcription by association with the RBP-j DNA-binding protein
158. Neural induction in embryos
159. Decoding vectorial information from a gradient: Sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye
160. Distinct human Numb isoforms regulate differentiation vs. proliferation in the neuronal lineage
161. Numb localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to Notch-1
162. Notch receptor activation inhibits oligodendrocyte differentiation
163. Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless
164. The ins and outs of Notch signaling
165. Notch signal transduction: A real Rip and more [Review]
166. Sup-17, a Caenorhabditis elegans adam protein related to Drosophila Kuzbanian, and its role in Lin-12/Notch signalling
167. Notch and wingless regulate expression of cuticle patterning genes
168. Notch responds differently to Delta and Wingless in cultured Drosophila cells
169. Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling
170. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease
171. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
172. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
173. Fringe: Defining borders by regulating the Notch pathway
174. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
175. A novel protein (Nicastrin) modulates presenilin-mediated Notch/Glp1 and APP processing
176. An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila
177. A role for SKIP in EBNA2 activation of CBF1·repressed promoters
178. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC to facilitate NotchIC function