The transmembrane aspartates in presenilin 1 and 2 are obligatory for γ-secretase activity and amyloid β-protein generation

Journal of Biological Chemistry

Volumn 275, Issue 5, 2000, Pages 3173-3178

  Kimberly, W Taylor ^a   Xia, Weiming ^a   Rahmati, Talat ^a   Wolfe, Michael S ^a   Selkoe, Dennis J ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMYLOID BETA PROTEIN; ASPARAGINE; GAMMA SECRETASE; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHO CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; GENE OVEREXPRESSION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID; CHO CELLS; CRICETINAE; ENDOPEPTIDASES; MEMBRANE PROTEINS; PRESENILIN-1; PRESENILIN-2;

ANIMALIA;

EID: 0000792598     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.5.3173     Document Type: Article

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