Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality

Development

Volumn 126, Issue 15, 1999, Pages 3415-3424

  Hamada, Yoshio ^a   Kadokawa, Yuzo ^b   Okabe, Masaru ^c   Ikawa, Masahito ^c   Coleman, John R ^e   Tsujimoto, Yoshihide ^d  

^a NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^e BROWN UNIVERSITY   (United States)

Author keywords

galactosidase; Cell death; Gene expression; Mouse; Notch2; Targeting

Indexed keywords

ANKYRIN; BETA GALACTOSIDASE; HYBRID PROTEIN; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYO DEATH; FEMALE; GENE EXPRESSION; GENE MUTATION; HEART; HISTOLOGY; IN SITU HYBRIDIZATION; MOUSE; MOUSE MUTANT; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; SOMITE; TISSUE DISTRIBUTION;

ANIMALS; ANKYRINS; APOPTOSIS; BASE SEQUENCE; CELL DIVISION; DNA PRIMERS; DROSOPHILA; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL DEATH; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; IN SITU HYBRIDIZATION; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUTATION; NERVOUS SYSTEM; PREGNANCY; RECEPTOR, NOTCH2; RECEPTORS, CELL SURFACE; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 0032868937     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Artavanis-Tsakonas, S., Matsuno, K. and Fortini M. E. (1995). Notch signaling. Science 268, 225-232.
2. Bigas, A., Martin, D. I. and Milner, L. A. (1998). Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol. Cell. Biol. 18, 2324-2333.
3. Coffman, C. R., Skoglund, P., Harris, W. A. and Kintner, C. R. (1993). Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell 73, 659-671.
4. Conlon, R. A., Reaume, A. G. and Rossant, J. (1995). Notch1 is required for the coordinate segmentation of somites. Development 121, 1533-1545.
5. de la Pompa, J. L., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J. and Conlon, R. A. (1997). Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124, 1139-1148.
6. Dorsky, R. I., Rapaport, D. H., and Harris, W. A. (1995). Xotch inhibits cell differentiation in the Xenopus retina. Neuron 14, 487-496.
7. Doyle, A., Griffiths, J. B. and Newell, D. G. (1996) Cell & Tissue Culture: Laboratory procedures. Wiley & Sons, Chichester, UK.
8. Ebensperger, C., Wilting, J., Brand-Saberi, B., Mizutani, Y., Christ, B., Balling, R. and Koseki, H. (1995). Pax-1. a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos. Anat. Embryol. 191, 297-310.
9. Ellisen, L. W., Bird, J., West, D. C., Soreng, A. L., Reynolds, T. C., Smith, S. D. and Sklar, J. (1991). TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649-661.
10. Franco del Amo, F., Smith, D. E., Swiatek, P. J., Gendron-Maguire, M., Greenspan, R. J., McMahon, A, P. and Gridley, T. (1992). Expression of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development 115, 737-745.
11. Franco del Amo, F., Gendron-Maguire, M., Swiatek, P. J., Jenkins, N. A., Copeland, N. G. and Gridley, T. (1993). Cloning, analysis and chromosomal localization of Notch-1, a mouse homolog of Drosophila Notch. Genomics 15, 259-264.
12. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S. A. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
13. Glücksmann, A. (1951). Cell death in normal vertebrate ontology. Biol. Rev. 26, 59-86.
14. Higuchi, M., Kiyama, H., Hayakawa, T., Hamada, Y. and Tsujimoto, Y. (1995). Differential expression of Notch1 and Notch2 in developing and adult mouse Brain. Mol. Brain Res. 29, 263-272.
15. Honjo, T. (1996). The shortest path from the surface to the nucleus: RBP-Jκ/Su(H) transcription factor. Genes to Cells. 1, 1-9.
16. Jarriault, S., Brou, C., Logeat, F., Schroeter, E. S., Kopan, R. and Isreal, A. (1995). Signalling downstream of activated mammalian Notch. Nature 377, 355-358.
17. Kato, H., Sakai, T., Tamura, K., Minoguchi, S., Shirayoshi, Y., Hamada, Y., Tsujimoto, Y. and Honjo, T. (1996). Functional conservation of mouse Notch receptor family members. FEBS Lett. 395, 221-224.
18. Kopan, R. and Weintraub, H. (1993). Mouse Notch: Expression in hair follicles correlate with cell fate determination. J. Cell Biol. 121, 631-641.
19. Kopan, R., Nye, J. S. and Weintraub, H. (1994). The intracellular domain of mouse Notch; a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of myoD. Development 120, 2385-2396.
20. Lardelli, M. and Lendahl, U. (1993). MoichA and MotchB-Two mouse Notch homologues coexpressed in a wide variety of tissues. Exp. Cell Res. 204, 364-372.
21. Lardelli, M., Dahlstrand, J. and Lendahl, U. (1994). The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech. Dev. 46, 123-136.
22. Lendahl, U. (1998) A growing family of Notch ligands. BioEssays 20, 103-107.
23. Lindsell, C. E., Shawber, C. J., Boulter, J. and Weinmaster, G. (1995). Jagged: A mammalian ligand that activates Notch1. Cell 80, 909-917.
24. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. and Roder, J. C. (1993). Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sdci. USA 90, 8424-8428.
25. Nye, J. S., Kopan, R. and Axel, R. (1994). An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 120, 2421-2432.
26. Oka, C., Nakano, T., Wakeham, A., de la Pompa, J. L., Mori, C., Sakai, T., Okazaki, S., Kawaichi, M., Shiota, K., Mak, T. W. and Honjo, T. (1995). Disruption of the mouse RBP-Jκ gene results in early embryonic death. Development 121, 3291-3301.
27. Oppenheim, R. W. (1991). Cell death during development of the nervous system. Ann. Rev. Neurosci. 14, 453-501.
28. Reaume, A. G., Conlon, R. A., Zirngibl, R., Yamaguchi, T. P., and Rossant, J. (1992). Expression analysis of a Notch homologue in the mouse embryo. Dev. Biol. 154, 377-387.
29. Rebay, I., Fehon, R. G. and Artavanis-Tsakonas, S. (1993). Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74, 319-329.
30. Robey, E. (1997). Notch in vertebrates. Curr. Op. Gen. Dev. 7, 551-557.
31. Robbins, J., Blondel, B. J., Gallahan, D. and Callahan, R. (1992). Mouse mammary tumor gene int-3: A member of the notch gene family transforms mammary epithelial cells. J. Virol. 66, 2594-2599.
32. Swiatek, P. J., Lindsell, C. E., Franco del Amo, F., Weinmaster, G. and Gridley, T. (1994), Notch1 is essential for postimplantation development in mice. Genes Dev. 8, 707-719.
33. Tamura, K., Taniguchi, Y., Minoguchi, S., Sakai, T., Tin Tum, Furukawa, T. and Honjo, T. (1995). Physical interaction of a novel domain of the notch receptor with the RBP-Jκ transcription factor. Curr. Biol. 5, 1416-1423.
34. Tanaka, M., Sawada, M., Yoshida, S., Hanaoka, F. and Marunouchi, T. (1995). Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures. Neurosci. Lett. 199, 37-40.
35. Uyttendaele, H., Marazzi, G., Wu, G., Yan, Q., Sassoon, D. and Kitajewski, J. (1996). Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122, 2251-2259.
36. Weinmaster, G. (1998). Notch signaling: direct or what? Curr. Op. Gen. Dev. 8, 436-442.
37. Weinmaster, G., Roberts, V. J. and Lemke, G. (1991). A homolog of Drosophila Notch expressed during mammalian development. Development 113, 199-205.
38. Weinmaster, G., Roberts, V. J. and Lemke, G. (1992). Notch2: A second mammalian Notch gene. Development 116, 931-941.
39. Wilkinson, D. G. and Nieto, M. A. (1993). Detection of messenger RNA by in situ hybridization of tissue sections and whole mounts. In Guide to Techniques in Mouse Development Methods in Enzymology vol. 225, (ed. Wassarman, P. M. and DePamphilis, M. L.), pp. 361-373. Academic Press, Inc.
40. Williams, R., Lendahl, U. and Lardelli, M. (1995). Complementary and combinatorial patterns of Notch gene family expression during early mouse development. Mech. Dev. 53, 357-368.
41. Wurst, W. and Joyner, A. L. (1991). Production of targeted embryonic stem cell clones In Gene Targeting: A Practical approach, (ed. A. L. Joyner), pp. 33-61. Oxford University Press, Oxford.
42. Yagi, T., Nada, S., Watanabe, N., Takemoto, H., Kohmura, N., Ikawa, Y. and Aizawa, S. (1993). A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene. Analyt. Biochem. 214, 77-86.
43. Zhang, N. and Gridley, T. (1998). Defects in somite formation in lunatic fringe-deficient mice. Nature 394, 374-377.