Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

Biochemistry

Volumn 38, Issue 35, 1999, Pages 11223-11230

  Wolfe, Michael S ^a,b,c   De Los Angeles, Joseph ^b,d   Miller, Duane D ^b   Xia, Weiming ^c   Selkoe, Dennis J ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTATE AMMONIA LYASE; ASPARTIC ACID; GAMMA SECRETASE; MEMBRANE PROTEIN; PRESENILIN 1; PRESENILIN 2; PROTEINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; CHO CELL; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME SUBSTRATE; GENE MUTATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; REVIEW;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL MEMBRANE; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; MEMBRANE PROTEINS; PRESENILIN-1;

ANIMALIA;

EID: 0033621152     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991080q     Document Type: Review

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