Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

Nature

Volumn 387, Issue 6630, 1997, Pages 288-292

  Wong, Philip C ^a   Zheng, Hui ^b   Chen, Hua ^a   Becher, Mark W ^a   Sirinathsinghji, Dalip J S ^c   Trumbauer, Myrna E ^b   Chen, Howard Y ^b   Price, Donald L ^a   Van Der Ploeg, Lex H T ^b   Sisodia, Sangram S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Biostatist and Res Data Systems   (United States)

^c NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN;

ALZHEIMER DISEASE; ARTICLE; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE MUTATION; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; SOMITE;

ANIMALS; BODY PATTERNING; CENTRAL NERVOUS SYSTEM; EMBRYONIC AND FETAL DEVELOPMENT; GENE TARGETING; MEMBRANE PROTEINS; MESODERM; MICE; PRESENILIN-1; PROTEIN PRECURSORS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS; MAMMALIA; VERTEBRATA;

EID: 17744401440     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/387288a0     Document Type: Article

References (30)

1. Busfield, F. & Goate, A. M. in Pathology of Alzheimer's Disease, 59-75 (Academic, San Diego, 1995).
2. Sherrington, R. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760 (1995).
3. Levy-Lahad, E. et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977 (1995).
4. Rogaev, E. I. et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778 (1995).
5. Cruts, M., Hendriks, L. & Van Broeckhoven, C. The presenilin genes: a new gene family involved in Alzheimer's disease pathology. Hum. Mol. Genet. 5, 1449-1455 (1996).
6. Thinakaran, G. et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190 (1996).
7. Levitan, D. et al. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 93, 14940-14944 (1996).
8. Artavanis-Tsakonas, S., Matsuno, K. & Fortini, M. E. Notch Signaling. Science 268, 225-232 (1995).
9. Levitan, D. & Greenwald, I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351-354 (1995).
10. Bettenhausen, B. et al. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121, 2407-2418 (1995).
11. Conlon, R. A. et al. Notch1 is required for the coordinate segmentation of somites. Development 121, 1533-1545 (1995).
12. Swiatek, P. J. et al. Notch1 is essential for postimplantation development in mice. Genes Dev. 8, 707-719 (1994).
13. Hrabe de Angelis, M., McyIntyre II, J. & Gossler, A. Maintenance of somite borders in mice requires the Delta homologue Dll1. Nature 386, 717-721 (1997).
14. Verbout, A. J. The development of the vertebral column. Adv. Anal. Embryol. Cell Biol. 90, 1-122 (1985).
15. Christ, B. & Wilting, J. From somites to vertebral column. Ann. Anat. 174, 23-32 (1992).
16. Burgess, R., Cserjesi, P., Ligon, K. L. & Olson, E. N. Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites. Dev. Biol. 168, 296-306 (1995).
17. Deutsch, U., Dressler, G. R. & Gruss, P. Pax-1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development Cell 53, 617-625 (1988).
18. Koseki, H. et al. A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae. Development 119, 649-660 (1993).
19. Montarras, D. et al. Developmental patterns in the expression of Myf5, MyoD, myogenin, and MRF4 during myogenesis. New Biol. 3, 592-600 (1991).
20. Stern, C. D. & Keynes, R. J. Interactions between somite cells: the formation and maintenance of segment boundaries in the chick embryo. Development 99, 261-272 (1987).
21. Kalcheim, C. & Teillet, M.-A. Consequences of somite manipulation on the pattern of dorsal root ganglion development. Development 106, 85-93 (1989).
22. Lee, M. K. et al. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J. Neurosci. 16, 7513-7525 (1996).
23. Kovacs, D. M. et al. Alzheimer-associated presenilin 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Med. 2, 224-229 (1996).
24. Scheuner, D. et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864-870 (1996).
25. Duff, K. et al. Increased amyloid-β42(43) in brain of mice expressing mutant presenilin 1. Nature 383, 710-713 (1996).
26. Borchelt, D. R. et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013 (1996).
27. Joutel, A. et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 383, 707-710 (1996).
28. Mansour, S. L. et al. Disruption of the protooncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348-352 (1988).
29. Zheng, H. et al. β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81, 571-480 (1995).
30. Hogan, B., Beddington, R., Costantini, F. & Lacy, E. Manipulating the Mouse Embryo: A Laboratory Manual 2nd edn (Cold Spring Harbor Laboratory Press, NY, 1994).