The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase

Genetics

Volumn 152, Issue 2, 1999, Pages 567-576

  Cornell, M ^a   Evans, D A P ^a   Mann, R ^b   Fostier, M ^a   Flasza, M ^a   Monthatong, M ^a   Artavanis Tsakonas, S ^b,c   Baron, M ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; LIGASE; UBIQUITIN; ZINC FINGER PROTEIN;

ARTICLE; DROSOPHILA MELANOGASTER; GENE CONTROL; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENE REPRESSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; GENES, SUPPRESSOR; GENETIC COMPLEMENTATION TEST; INSECT PROTEINS; LIGASES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PHYLOGENY; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFECTION; UBIQUITIN-PROTEIN LIGASES; WING;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0033051919     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. ABERLE, H., A. BAUER, J. STAPPERT, A. KISPERT and R. KEMLER, 1997 Beta-catenin is a target for the ubiquitin-proteosome pathway. EMBO J. 16: 3797-3804.
2. ARTAVANIS-TSAKONAS, S., K. MATSUNO and M. E. FORTINI, 1995 Notch signaling. Science 268: 225-232.
3. AXELROD, J. D., K. MATSUNO, S. ARTAVANIS-TSAKONAS and N. PERRIMON, 1996 Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science 271: 1826-1832.
4. BEDFORD, M. T., D. C. CHAN and P. LEDER, 1997 FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. EMBO J. 16: 2376-2383.
5. BRAND, A., and N. PERRIMON, 1993 Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
6. BROU, C., F. LOGEAT, M. LECOURTOIS, J. VANDEKERCKHOVE, P. KOUKILSKY et al., 1994 Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homolog, KBF2/ RBP-J kappa, by direct protein-protein interaction with Drosophila Hairless. Genes Dev. 8: 2491-2503.
7. BUSSEAU, I., R. J. DIEDERICH, T. XU and S. ARTAVANIS-TSAKONAS, 1994 A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein. Genetics 136: 585-596.
8. CAPDEVILA, J., and I. GUERRERO, 1994 Targeted expression of the signaling molecule Decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13: 4459-4468.
9. CHEN, H. I., A. EINHOND, S. J. KWAK, H. LINN, E. KOEPE et al., 1997 Characterization of the WW domain of human Yes-associated protein and its polyproline-containing ligands. J. Biol. Chem. 272: 17070-17077.
10. DE CELIS, J. F., 1997 Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing. Development 124: 1007-1018.
11. DE CELIS, J. F., A. GARCIA-BELLIDO and S. J. BRAY, 1996 Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 122: 359-369.
12. DE CELIS, J. F., S. J. BRAY and A. GARCIA-BELLIDO, 1997 Notch signaling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development 124: 1919-1928.
13. DELIDAKIS, C., and S. ARTAVANIS-TSAKONAS, 1992 The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins. Proc. Natl. Acad. Sci. USA 89: 8731-8735.
14. ELLISEN, L. W., J. BIRD, D. C. WEST, A. L. SORENG, T. C. REYNOLDS et al., 1991 TAN-1, The human homologue of the Drosophila Notch gene is broken by chromosomal translocations in T-lymphoblastic neoplasms. Cell 66: 649-661.
15. FABER, P. W., G. T. BARNES, J. SRINIDHI, J. CHEN, J. F. GUSELLA et al., 1998 Huntingtin interacts with a family of WW domain proteins. Hum. Mol. Genet. 7: 1463-1474.
16. FELSENSTEIN, J., 1989 PHYLIP - phylogeny inference package (version 3.2). Cladistics 5: 164-166.
17. FORTINI, M. E., and S. ARTAVANIS-TSAKONAS, 1994 The Suppressor of Hairless protein participates in Notch receptor signaling. Cell 79: 273-282.
18. FOSTIER, M., D. A. P. EVANS, S. ARTAVANIS-TSAKONAS and M. BARON, 1998 Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: a regulator of Notch signaling. Genetics 150: 1477-1485.
19. HING, H., X. SUN and S. ARTAVANIS-TSAKONAS, 1994 Modulation of wingless signaling by Notch in Drosophila. Mech. Dev. 47: 261-268.
20. HUBBARD, E. J. A., G. Y. WU, J. KITAJEWSKI and I. GREENWALD, 1997 Sel-10 a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 11: 3182-3193.
21. HUIBREGTSE, J. M., M. SCHEFFNER, S. BEAUDENON and P. M. HOWLEY, 1995 A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 92: 2563-2567.
22. HUPPERT, S. S., L. J. JACOBSEN and M. A. T. MUSKAVTICH, 1997 Feedback regulation is central to Delta-Notch signaling required for Drosophila wing vein morphogenesis. Development 124: 3283-3291.
23. JHAPPAN, C., D. GALLAHAN, C. STAHLE, E. CHU, G. H. SMITH et al., 1992 Expression of an activated Notch related int3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev. 6: 345-355.
24. JIANG, J., and G. STRUHL, 1998 Regulation of the Hedgehog and wingless signaling pathways by the F-box/WD40-repeat protein Slimb. Nature 391: 493-496.
25. KIM, J., K. D. IRVINE and S. B. CARROLL, 1995 Cell recognition, signal induction and symmetrical gene activation at the dorso ventral boundary of the developing Drosophila wing. Cell 82: 795-802.
26. KUMAR, S., Y. TOMOOKA and M. NODA, 1992 Identification of a set of genes with developmentaly down-regulated expression in the mouse brain. Biochem. Biophys. Res. Commun. 185: 1155-1161.
27. LI, S. H., Y. LI, R. W. CARTHEW and Z. C. LAI, 1997 Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell 90: 469-478.
28. LINDSLEY, D. L., and G. G. ZIMM, 1992 The Genome of Drosophila melanogaster. Academic Press, New York.
29. MACIAS, M. J., M. HYVONEN, E. BARALDI, J. SCHULTZ, M. SUDOL et al., 1996 Structure of the WW domain of a kinase associated protein complexed with a proline-rich peptide. Nature 382: 646-649.
30. MATSUNO, K., R. J. DIEDERICH, M. J. GO, C. M. BLAUMUELLER and S. ARTAVANIS-TSAKONAS, 1995 Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121: 2633-2644.
31. MORGAN, T. H., C. B. BRIDGES and J. SCHULTZ, 1931 Carnegie Inst. Year Book 30: 410.
32. NALEFSKI, E. A., and J. J. FALKE, 1996 The C2 domain calcium-binding motif: structural and functional diversity. Protein Sci. 5: 2375-2390.
33. NEFSKY, B., and D. BEACH, 1996 Publ acts as an E6-AP-like protein ubiquitin ligase in the degradation of cdc25. EMBOJ. 15: 1301-1312.
34. NEUFFELD, T. P., A. F. A. CRUZ, L. A. JOHNSTON and B. EDGAR, 1998 Coordination of growth and cell division in the Drosophila wing. Cell 93: 1183-1193.
35. PALOMBELLA, V. J., O. J. RANDO, A. L. GOLDBERG and T. MANIATIS, 1994 The ubiquitin-proteosome pathway is required for processing the NF-κb precursor protein and the activation of NF-κB. Cell 78: 773-785.
36. 1813 mice. Nat. Genet. 18: 143-146.
37. PIROZZI, G., S. J. MCCONNELL, A. UVEGES, J. M. CARTER, A. B. SPARKS et al., 1997 Identification of novel human WW domain-containing proteins by cloning of ligand targets. J. Biol. Chem. 272: 14611-14616.
38. SCHROETER, E. H., J. A. KISSLINGER and R. KOPAN, 1998 Notch-1 signaling requires ligand induced proteolytic release of intracellular domain. Nature 393: 382-386.
39. + channel deleted in Liddle's syndrome. EMBO J. 15: 2371-2380.
40. STRUHL, G., and A. ADACHI, 1998 Nuclear access and action of Notch in vivo. Cell 93: 649-660.
41. SUDOL, M., 1998 From Src homology domains to other signaling modules: proposal of the "protein recognition code." Oncogene 17: 1469-1474.
42. SUDOL, M., H. I. CHEN, C. BOUGERET, A. EINBOND and P. BORK, 1995 Characterisation of a novel protein-binding-module: the WW domain. FEBS Lett. 369: 67-71.
43. WOOD, J. D., J. YUAN, R. L. MARGOLIS, V. COLOMER, K. DUAN et al., 1998 Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol. Cell. Neurosci. 11: 149-160.
44. ZOLADEK, T., A. TOBIASz, G. VADUVA, M. BOGUTA, N. C. MARTIN et al., 1997 MDP1, a Saccharomyces cerevisiae gene involved in mitochondrial/cytoplasmic protein distribution, is identical to the ubiquitin-protein ligase gene RSP5. Genetics 145: 595-603.