Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 21, 1999, Pages 11872-11877

  Herreman, An ^a   Hartmann, Dieter ^c   Annaert, Wim ^a   Saftig, Paul ^d   Craessaerts, Katleen ^a   Serneels, Lutgarde ^a   Umans, Lieve ^a   Schrijvers, Vincent ^a   Checler, Frédéric ^e   Vanderstichele, Hugo ^f   Baekelandt, Veerle ^a   Dressel, Ralf ^g   Cupers, Philippe ^a   Huylebroeck, Danny ^b   Zwijsen, An ^b   Van Leuven, Fred ^a   De Strooper, Bart ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c Kiel and Lungen Clinic Grosshansdorf   (Germany)

^d Zentrum Biochem Molec Zellbiologie   (Germany)

^e CNRS   (France)

^f INNOGENETICS   (Belgium)

^g Institut für Humangenetik   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; EMBRYO DEVELOPMENT; GENE ACTIVITY; GENE MUTATION; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; GENOTYPE; HIPPOCAMPUS; HOMOZYGOTE; LUNG; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MODELS, GENETIC; MUTAGENESIS; PHENOTYPE; PRESENILIN-1; PRESENILIN-2; RECEPTORS, NOTCH; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 13044278313     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.21.11872     Document Type: Article

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