Aspartate mutations in presenilin and γ-secretase inhibitors both impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch1 signaling

Journal of Neurochemistry

Volumn 75, Issue 2, 2000, Pages 583-593

  Berezovska, Oksana ^e   Jack, Christine ^e   McLean, Pamela ^e   Aster, Jon C ^a   Hicks, Carol ^c   Xia, Weiming ^b   Wolfe, Michael S ^b   Kimberly, W Taylor ^b   Weinmaster, Gerry ^c   Selkoe, Dennis J ^b   Hyman, Bradley T ^d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Brigham and Women's Hospital Center for Neurologic Diseases   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e NONE

Author keywords

Delta; Notch; Nuclear translocation; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; GAMMA SECRETASE; NOTCH RECEPTOR; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; GENETIC TRANSFECTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

AMINO ACID SUBSTITUTION; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID; ASPARTIC ENDOPEPTIDASES; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; ENDOPEPTIDASES; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; LUCIFERASES; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; NUCLEAR PROTEINS; POINT MUTATION; PRESENILIN-1; PRESENILIN-2; PROTEASE INHIBITORS; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0033944273     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0750583.x     Document Type: Article

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