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Kimble, J.1
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of special interest. A good recent review, which includes a detailed discussion of the molecular components of the Notch signaling pathway and the consequences of their loss in vertebrates after being `knocked out'.
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of special interest Lewis J. Neurogenic genes and vertebrate neurogenesis. Curr Opin Neurobiol. 6:1996;3-10 A good recent review, which includes a detailed discussion of the molecular components of the Notch signaling pathway and the consequences of their loss in vertebrates after being `knocked out'.
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Curr Opin Neurobiol
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, pp. 3-10
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Lewis, J.1
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0028943243
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Notch signaling
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of special interest. Another recent review (see [3]) that provides excellent coverage of genes that are not mentioned in the current review but that are potentially involved in Notch signaling.
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of special interest Artavanis-Tsakonas S, Matsuno K, Fortini ME. Notch signaling. Science. 268:1995;225-232 Another recent review (see [3]) that provides excellent coverage of genes that are not mentioned in the current review but that are potentially involved in Notch signaling.
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Science
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Artavanis-Tsakonas, S.1
Matsuno, K.2
Fortini, M.E.3
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Campos OJ. Genetic mechanisms of early neurogenesis in Drosophila melanogaster. J Physiol (Paris). 88:1994;111-122.
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Campos, O.J.1
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Simpson P. Developmental genetics. The Notch connection. Nature. 375:1995;736-737.
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Nature
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Simpson, P.1
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Greenwald I. Structure/function studies of lin-12/Notch proteins. Curr Opin Genet Dev. 4:1994;556-562.
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Nye JS, Kopan R. Developmental signaling: vertebrate ligands for Notch. Curr Biol. 5:1995;966-969.
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Nye, J.S.1
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9
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0027300294
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Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos
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Coffman CR, Skoglund P, Harris WA, Kintner CR. Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell. 73:1993;659-671.
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Coffman, C.R.1
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Kintner, C.R.4
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10
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0030003538
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Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain
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of special interest. Provides evidence that a truncated version of Notch, lacking most of the extracellular domain, is constitutively active. It appears that the truncated version is processed and the intracellular portion is localized to the nucleus This raises the possibility that Notch is processed in response to ligand binding. See also [12].
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of special interest Kopan R, Schroeter EH, Weintraub H, Nye JS. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA. 93:1996;1683-1687 Provides evidence that a truncated version of Notch, lacking most of the extracellular domain, is constitutively active. It appears that the truncated version is processed and the intracellular portion is localized to the nucleus This raises the possibility that Notch is processed in response to ligand binding. See also [12].
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(1996)
Proc Natl Acad Sci USA
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Kopan, R.1
Schroeter, E.H.2
Weintraub, H.3
Nye, J.S.4
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11
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0027991383
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The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
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Kopan R, Nye SJ, Weintraub H. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development. 120:1994;2385-2396.
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Development
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Kopan, R.1
Nye, S.J.2
Weintraub, H.3
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12
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0027386233
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Antineurogenic phenotypes induces by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
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Lieber T, Kidd S, Alcamo E, Corbin V, Young MW. Antineurogenic phenotypes induces by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev. 7:1993;1949-1965.
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Lieber, T.1
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Struhl G, Fitzgerald K, Greenwald I. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell. 74:1993;331-345.
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The Notch signaling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo
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Jennings B, Preiss A, Delidakis C, Bray S. The Notch signaling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo. Development. 120:1994;3537-3548.
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Development
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Jennings, B.1
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Bray, S.4
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15
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Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins
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Jennings B, De Celis J, Delidakis C, Preiss A, Bray S. Role of Notch and achaete-scute complex in the expression of Enhancer of split bHLH proteins. Development. 121:1995;3745-3752.
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Jennings, B.1
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Knust E. Cell fate choice during early neurogenesis in Drosophila melanogaster. Perspect Dev Neurobiol. 2:1994;141-149.
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Technau, G.M.1
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0030044345
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Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signaling in Drosophila
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Heitzler P, Bourouis M, Ruel L, Carteret C, Simpson P. Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signaling in Drosophila. Development. 122:1996;161-171.
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Heitzler, P.1
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Simpson, P.5
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19
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-
0028973381
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The neurogenic Suppressor of Hairless DNA binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling
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of outstanding interest. Together with [20], this paper establishes the role of Su(H) as a link between E(spl) transcription and Notch. Of particular interest is evidence provided in support for Notch activity that is independent of Su(H).
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of outstanding interest Lecourtois M, Schweisguth F. The neurogenic Suppressor of Hairless DNA binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling. Genes Dev. 9:1995;2598-2608 Together with [20], this paper establishes the role of Su(H) as a link between E(spl) transcription and Notch. Of particular interest is evidence provided in support for Notch activity that is independent of Su(H).
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(1995)
Genes Dev
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Lecourtois, M.1
Schweisguth, F.2
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20
-
-
0028973380
-
Suppressor of Hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity
-
of outstanding interest. Provides a detailed study of the roles of Su(H), achaete and Notch in E(spl) transcription. It also provides evidence for Notch activity that is independent of Su(H). See also annotation [19].
-
of outstanding interest Bailey AM, Posakony JW. Suppressor of Hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 9:1995;2609-2622 Provides a detailed study of the roles of Su(H), achaete and Notch in E(spl) transcription. It also provides evidence for Notch activity that is independent of Su(H). See also annotation [19].
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(1995)
Genes Dev
, vol.9
, pp. 2609-2622
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-
Bailey, A.M.1
Posakony, J.W.2
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21
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0029028707
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Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum
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Schweisguth F. Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum. Development. 121:1995;1875-1884.
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(1995)
Development
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Schweisguth, F.1
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22
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-
0030014642
-
Lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)
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of special interest. Provides evidence supporting regulation of Notch genes by Su(H)/lag-1, which is a necessary step in the feedback loop.
-
of special interest Christensen S, Kodoyianni V, Bosenberg M, Friedman L, Kimble J. lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development. 122:1996;1373-1383 Provides evidence supporting regulation of Notch genes by Su(H)/lag-1, which is a necessary step in the feedback loop.
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(1996)
Development
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Christensen, S.1
Kodoyianni, V.2
Bosenberg, M.3
Friedman, L.4
Kimble, J.5
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23
-
-
0029897171
-
Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signaling development
-
of special interest. In vivo demonstration that during fate selection in the sensory organ precursor, Su(H) is nuclear, which further supports the model that proposes that Notch acts in the nucleus [10, 12] rather than the one suggesting that Su(H) is retained or modified by Notch in the cytoplasm (see [4]).
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of special interest Gho M, Lecourtois M, Geraud G, Posakony J, Schweisguth F. Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signaling development. Development. 122:1996;1673-1682 In vivo demonstration that during fate selection in the sensory organ precursor, Su(H) is nuclear, which further supports the model that proposes that Notch acts in the nucleus [10, 12] rather than the one suggesting that Su(H) is retained or modified by Notch in the cytoplasm (see [4]).
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(1996)
Development
, vol.122
, pp. 1673-1682
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Gho, M.1
Lecourtois, M.2
Geraud, G.3
Posakony, J.4
Schweisguth, F.5
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24
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0029678250
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The shortest path from the surface to the nucleus: RBPjk/Su(H) transcription factor
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Honjo T. The shortest path from the surface to the nucleus: RBPjk/Su(H) transcription factor. Genes Cells. 1:1996;1-9.
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(1996)
Genes Cells
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Honjo, T.1
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25
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0028988990
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Masking of the CBF1/RBPjk transcriptional repression domain by Epstein-Barr virus EBNA2
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Hsieh JJ, Hayward SD. Masking of the CBF1/RBPjk transcriptional repression domain by Epstein-Barr virus EBNA2. Science. 268:1995;560-563.
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Science
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Hsieh, J.J.1
Hayward, S.D.2
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26
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0028232358
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Recognition sequence of a highly conserved DNA binding protein RBP-J kappa
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Tun T, Hamaguchi Y, Matsunami N, Furukawa T, Honjo T, Kawaichi M. Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res. 22:1994;965-971.
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Tun, T.1
Hamaguchi, Y.2
Matsunami, N.3
Furukawa, T.4
Honjo, T.5
Kawaichi, M.6
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27
-
-
0029085935
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An activated form of murine Notch stimulates transcription of the HES-1 gene through the DNA-binding protein KBF2/RBP-Jk
-
of special interest. Provides evidence for direct Notch - Su(H) interactions.
-
of special interest Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israël A. An activated form of murine Notch stimulates transcription of the HES-1 gene through the DNA-binding protein KBF2/RBP-Jk. Nature. 377:1995;355-358 Provides evidence for direct Notch - Su(H) interactions.
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(1995)
Nature
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-
Jarriault, S.1
Brou, C.2
Logeat, F.3
Schroeter, E.H.4
Kopan, R.5
Israël, A.6
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28
-
-
0030063909
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Truncated mammalian Notch 1 activates CBF1/RBPjk repressed genes by a mechanism resembling that of the Epstein-Barr virus EBNA2
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of special interest. Extends and lends further support to [27], providing a mechanistic basis for activation of Su(H) by Notch binding. See also [24].
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of special interest Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward D. Truncated mammalian Notch 1 activates CBF1/RBPjk repressed genes by a mechanism resembling that of the Epstein-Barr virus EBNA2. Mol Cell Biol. 16:1996;952-959 Extends and lends further support to [27], providing a mechanistic basis for activation of Su(H) by Notch binding. See also [24].
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Mol Cell Biol
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Hsieh, J.J.1
Henkel, T.2
Salmon, P.3
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29
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Henderson ST, Gao D, Lambie EJ, Kimble J. Lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development. 120:1994;2913-2924.
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Henderson, S.T.1
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31
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Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila
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Tax FE, Yeargers JJ, Thomas JH. Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila. Nature. 368:1994;150-154.
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Tax, F.E.1
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The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo
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Mello CC, Draper BW, Priess JR. The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo. Cell. 77:1994;95-106.
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Mello, C.C.1
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Wilkinson HA, Fitzgerald K, Greenwald I. Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision. Cell. 79:1994;1187-1198.
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Wilkinson, H.A.1
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Cubas P, De Celis J, Campuzano S, Modolell J. Proneural clusters of achaeta-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev. 5:1991;996-1008.
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Cubas, P.1
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Muskavitch MA. Delta-notch signaling and Drosophila cell fate choice. Dev Biol. 166:1994;415-430.
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Muskavitch, M.A.1
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of outstanding interest
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of outstanding interest Goriely A, Dumont N, Dambly CC, Ghysen A. The determination of sense organs in Drosophila: effect of the neurogenic mutations in the embryo. Development. 113:1991;1395-1404.
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Goriely, A.1
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37
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This excellent review discusses models for interactions between the Notch and Wg pathways that are based on recent molecular and genetic data.
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Blair SS. Notch and Wingless signals collide. Nature. 271:1996;1822-1823 This excellent review discusses models for interactions between the Notch and Wg pathways that are based on recent molecular and genetic data.
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Blair, S.S.1
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38
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Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila
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of special interest. An elegant study that explains some of the previously contradictory observations on Notch and Wg interactions at the margin of the Drosophila wing.
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of special interest Rulifson EJ, Blair SS. Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila. Development. 121:1995;2813-2824 An elegant study that explains some of the previously contradictory observations on Notch and Wg interactions at the margin of the Drosophila wing.
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(1995)
Development
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Rulifson, E.J.1
Blair, S.S.2
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39
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Wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development
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Philips RG, Whittle JR. Wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development. Development. 118:1993;427-438.
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Development
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Philips, R.G.1
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Couso JP, Bishop SA, Martinez Arias A. The wingless signalling pathway and the patterning of the wing marin in Drosophila. Development. 120:1994;621-636.
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Couso, J.P.1
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41
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0029670476
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Interaction between wingless and notch signaling pathways mediated by dishevelled
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of outstanding interest. Two-hybrid interaction and co-localization studies of proteins from transfected genes indicate the association of Notch and dsh. The authors propose a novel mechanism to explain genetic and other data (presented both in this paper and reviewed in [37]) that indicate an antagonistic interaction between Wg/dsh signals and Notch function in the Drosophila wing.
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of outstanding interest Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N. Interaction between wingless and notch signaling pathways mediated by dishevelled. Science. 271:1996;1826-1832 Two-hybrid interaction and co-localization studies of proteins from transfected genes indicate the association of Notch and dsh. The authors propose a novel mechanism to explain genetic and other data (presented both in this paper and reviewed in [37]) that indicate an antagonistic interaction between Wg/dsh signals and Notch function in the Drosophila wing.
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(1996)
Science
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Axelrod, J.D.1
Matsuno, K.2
Artavanis-Tsakonas, S.3
Perrimon, N.4
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A dual role for the protein kinase shaggy in the repression of achaete-scute
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Simpson P, Ruel L, Heitzler P, Bourouis M. A dual role for the protein kinase shaggy in the repression of achaete-scute. Development. 1993;29-39. (suppl).
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Simpson, P.1
Ruel, L.2
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Bourouis, M.4
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43
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0029076109
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Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless
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Gonzalez-Gaitan M, Jackle H. Invagination centers within the Drosophila stomatogastric nervous system anlage are positioned by Notch-mediated signaling which is spatially controlled through wingless. Development. 121:1995;2313-2325.
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Chu-LaGraff Q, Doe CQ. Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Science. 261:1993;1594-1597.
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Hill RJ, Sternberg PW. Cell fate patterning during C. elegans vulval development. Development. 1993;9-18. (suppl).
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(1993)
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