Fringe: Defining borders by regulating the Notch pathway

Current Opinion in Neurobiology

Volumn 9, Issue 5, 1999, Pages 537-543

  Wu, Jane Y ^a   Rao, Yi ^b  

^a Molec Biol Pharmacol W   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE RECEPTOR; PROTEIN;

CELL INTERACTION; DROSOPHILA; EMBRYO DEVELOPMENT; EYE DEVELOPMENT; LIGAND BINDING; LIMB BUD; NEURAL TUBE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

EID: 0032873837     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(99)00020-3     Document Type: Review

References (49)

1. •].
2. •].
3. •].
4. •] provide excellent reviews on the biology and the signaling mechanisms of the Notch pathway.
5. •].
6. •].
7. •] lists several concerns for this model.
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17. Panin VM, Papayannopoulos V, Wilson R, Irvine KD Fringe modulates Notch-ligand interactions. Nature. 387:1997;908-912. Genetic analysis in the wing disc elegantly shows that fng inhibits Ser and enhances Dl. These effects were found to be cell-autonomous, and the site of fng action was therefore suggested to be in the signal receiving cell. Fng protein expressed in the Drosophila S2 cell line was found to be associated with the cell membrane.
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26. Moran JL, Levorse JM, Vogt TF Limbs move beyond the radical fringe. Nature. 399:1999;741-742.
27. Zhang N, Gridley T Reply to limbs move beyond the radical fringe. Nature. 399:1999;741-742.
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33. •].
34. •] report that, similar to hairy-1, lFng is expressed in a rhythmic pattern in the presomitic mesoderm. However, unlike hairy-1, lFng expression is dependent on protein synthesis, and may thus be downstream of hairy-1 or other earlier acting components in the molecular clock involved in somite segmentation.
35. •].
36. •] report the phenotype of lFng knockout mice. This paper provides an interesting model on the functional mechanism of Fng action.
37. Bishop SA, Klein T, Martinez Arias A, Couso JP Composite signalling from Serrate and Delta establishes leg segments in Drosophila through Notch. Development. 126:1999;2993-3003. Fly legs develop from concentric segments along the proximal-distal axis. The authors found that Ser, Dl and Notch have roles in leg segmentation. fng inhibits both Ser and Dl. There is a twist to the relationship of Ser and Dl: Ser is expressed in concentric rings proximal to the presumptive joints, whereas Dl is expressed throughout the leg; however, a high level of Dl is expressed in the same region as Ser. fng seems to inhibit Ser and Dl both in cells expressing Ser and in those neighboring them.
38. ••], the authors report a role for Notch in leg segmentation.
39. ••].
40. ••].
41. ••] demonstrate a role for fng in defining the equator in the Drosophila eye. They also show that Ser, Dl, and Notch are involved in reciprocal signaling across the D/V border to define the equator. The reader is recommended to look at the color figures in these papers to see how the signaling would work.
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