Nicastrin is required for γ-secretase cleavage of the Drosophila Notch receptor

Developmental Cell

Volumn 2, Issue 1, 2002, Pages 69-78

  Hu, Yue ^a   Ye, Yihong ^a,b   Fortini, Mark E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Harvard Medical of Nicastrin might affect formation and or function of School   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; MEMBRANE PROTEIN; NICASTRIN; NICASTRIN PROTEIN; PRESENILIN 1; PROTEIN NOTCH; PROTEIN SUBUNIT; PROTEINASE; S182 PROTEIN; SECRETASE; DROSOPHILA PROTEIN; NOTCH PROTEIN, DROSOPHILA; NOTCH RECEPTOR;

ANIMAL; ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA; EMBRYO; ENZYME SUBSTRATE; FEMALE; GENE ACTIVATION; GENE FUNCTION; GENETIC LINKAGE; GENETICS; MALE; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MUTANT; MUTATION; NONHUMAN; PHENOTYPE; PHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PROCESSING; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; ENDOPEPTIDASES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MUTATION; PRESENILIN-1; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 0036007117     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(01)00105-8     Document Type: Article

References (51)

1. Notch signaling: Cell fate control and signal integration in development
2. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
3. A novel proteolytic cleavage involved in Notch signaling: The role of the disintegrin-metalloprotease TACE
4. Nicastrin binds to membrane-tethered Notch
5. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
6. Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc
7. Presenilins and the intramembrane proteolysis of proteins: Facts and fiction
8. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
9. The expression of neurogenic loci in imaginal epidermal cells of Drosophila melanogaster
10. Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
11. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
12. Notch and Presenilin: A proteolytic mechanism emerges
13. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye
14. Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
15. Drosophila presenilin is required for neuronal differentiation and affects Notch subcellular localization and signaling
16. Sequence of the Notch locus of Drosophila melanogaster: Relationship of the encoded protein to mammalian clotting and growth factors
17. A common enzyme connects Notch signaling and Alzheimer's disease
18. The neurogenic Suppressor of Hairless DNA-binding protein mediates I've transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling
19. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo
20. Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state
21. Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
22. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
23. The Notch1 receptor is cleaved constitutively by a furin-like convertase
24. Isolation and expression of scabrous, a gene regulating neurogenesis in Drosophila
25. A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1
26. γ-secretase, evidence for multiple proteolytic activities and influence of membrane position of substrate on generation of amyloid β peptides of varying length
27. Effects of PS1 deficiency on membrane protein trafficking in neurons
28. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
29. 2+-ATPase function is required for proper Notch receptor synthesis
30. Calcium depletion dissociates and activates heterodimeric Notch receptors
31. Endoproteolytic processing and stabilization of wild-type and mutant Presenilin
32. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor
33. Presenilin-1 and -2 are molecular targets for γ-secretase inhibitors
34. Translating cell biology into therapeutic advances in Alzheimer's disease
35. Intramembrane proteolysis by presenilins
36. A loss of function mutation of Presenilin-2 interferes with amyloid β-peptide production and Notch signaling
37. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
38. Requirements for Presenilin-dependent cleavage of Notch and other transmembrane domain proteins
39. Presenilin is required for activity and nuclear access of Notch in Drosophila
40. Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila
41. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
42. Endoproteolysis of Presenilin 1 and accumulation of processed derivatives in vivo
43. The ins and outs of Notch signaling
44. Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats
45. A substrate-based difluoro ketone selectively inhibits Alzheimer's γ-secretase activity
46. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
47. Mosaic analysis using FLP recombinase
48. Characterization of Drosophila Presenilin and its colocalization with Notch during development
49. Proteolysis and developmental signal transduction
50. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
51. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing