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Science

Volumn 286, Issue 5441, 1999, Pages 916-919

The presenilins in Alzheimer's disease - Proteolysis holds the key

(2) Haass, Christian a De Strooper, Bart b

a UNIVERSITY OF MUNICH (Germany)

b DEPARTMENT OF PLANT SYSTEMS BIOLOGY (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; CELLULAR DISTRIBUTION; GENE MUTATION; HUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; PROTEASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 0033615580 PISSN: 00368075 EISSN: None Source Type: Journal
DOI: 10.1126/science.286.5441.916 Document Type: Review

Times cited : (375)

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- note
- The authors wish to thank the members of their laboratories for critical discussion. This work was supported by grants from the Deutsche Forschungsgemeinschaft, the Verum Foundation, the Fritz Thyssen Foundation, the Hirnliga, and the Boehringer ingelheim KG (to C.H.). B.D.S. is a research leader of the FWO-Vlaanderen and supported by the Human Frontier of Science Program (HFSP), the Interuniversitaire Attractiepolen, Belgium, tne International Alzheimer's Disease Research Foundation (IARF), the Bayer Alzheimer research network (BARN), and the Vlaams Instituut voor Biotechnologie.

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