The amyloid precursor protein (APP)-cytoplasmic fragment generated by γ-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

Journal of Neurochemistry

Volumn 78, Issue 5, 2001, Pages 1168-1178

  Cupers, Philippe ^a   Orlans, Isabelle ^a   Craessaerts, Katleen ^a   Annaert, Wim ^a,b   De Strooper, Bart ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b Neuronal Cell Biology Group   (Belgium)

Author keywords

secretase; Amyloid precursor protein; APP C59

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DETERGENT; DNA BINDING PROTEIN; GAMMA SECRETASE; MEMBRANE PROTEIN; NOTCH RECEPTOR; PROTEASOME INHIBITOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR SP1;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL NUCLEUS; CELL STRAIN BHK; CONTROLLED STUDY; CYTOPLASM; EMBRYO; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SENILE PLAQUE; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL FRACTIONATION; CELL NUCLEUS; CELLS, CULTURED; CRICETINAE; CYTOPLASM; ENDOPEPTIDASES; GENETIC VECTORS; KIDNEY; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEURONS; PRESENILIN-1; RECEPTORS, NOTCH; SEMLIKI FOREST VIRUS; SP1 TRANSCRIPTION FACTOR; SUBCELLULAR FRACTIONS; TRANSFECTION;

ANIMALIA; CRICETINAE;

EID: 0034839287     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00516.x     Document Type: Article

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