-
1
-
-
0036593175
-
Activation rules: The two-signal theories of immune activation
-
Baxter AG, Hodgkin PD (2002) Activation rules: The two-signal theories of immune activation. Nat Rev Immunol 2:439-446
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 439-446
-
-
Baxter, A.G.1
Hodgkin, P.D.2
-
2
-
-
0023143676
-
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
-
Jenkins MK, Schwartz RH (1987) Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med 165:302-319
-
(1987)
J Exp Med
, vol.165
, pp. 302-319
-
-
Jenkins, M.K.1
Schwartz, R.H.2
-
4
-
-
0014941813
-
A theory of self-nonself discrimination
-
Bretscher P, Cohn M (1970) A theory of self-nonself discrimination. Science 169:1042-1049
-
(1970)
Science
, vol.169
, pp. 1042-1049
-
-
Bretscher, P.1
Cohn, M.2
-
5
-
-
55549110891
-
"It is the antigen(s), stupid" and other lessons from over a decade of vaccitherapy of human cancer
-
Buckwalter MR, Srivastava PK (2008) "It is the antigen(s), stupid" and other lessons from over a decade of vaccitherapy of human cancer. Semin Immunol 20:296-300
-
(2008)
Semin Immunol
, vol.20
, pp. 296-300
-
-
Buckwalter, M.R.1
Srivastava, P.K.2
-
6
-
-
48749093493
-
Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses
-
Hashiguchi M et al (2008) Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses. Proc Natl Acad Sci USA 105:10495-10500
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 10495-10500
-
-
Hashiguchi, M.1
-
7
-
-
0027392843
-
Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells
-
Townsend SE, Allison JP (1993) Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 259:368-370
-
(1993)
Science
, vol.259
, pp. 368-370
-
-
Townsend, S.E.1
Allison, J.P.2
-
8
-
-
0027078670
-
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
-
Chen L et al (1992) Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71:1093-1102
-
(1992)
Cell
, vol.71
, pp. 1093-1102
-
-
Chen, L.1
-
9
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711-723
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
10
-
-
0021175739
-
A 45-kDa human T-cell membrane glycoprotein functions in the regulation of cell proliferative responses
-
Gmunder H, Lesslauer W (1984) A 45-kDa human T-cell membrane glycoprotein functions in the regulation of cell proliferative responses. Eur J Biochem 142:153-160
-
(1984)
Eur J Biochem
, vol.142
, pp. 153-160
-
-
Gmunder, H.1
Lesslauer, W.2
-
11
-
-
84929524612
-
Monoclonal antibodies identifying a novel T-Cell antigen and Ia antigens of human lymphocytes
-
Hansen JA, Martin PJ, Nowinski RC (1980) Monoclonal antibodies identifying a novel T-Cell antigen and Ia antigens of human lymphocytes. Immunogenetics 11:429-439
-
(1980)
Immunogenetics
, vol.11
, pp. 429-439
-
-
Hansen, J.A.1
Martin, P.J.2
Nowinski, R.C.3
-
12
-
-
0020069605
-
B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas
-
Yokochi T, Holly RD, Clark EA (1982) B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas. J Immunol 128:823-827
-
(1982)
J Immunol
, vol.128
, pp. 823-827
-
-
Yokochi, T.1
Holly, R.D.2
Clark, E.A.3
-
13
-
-
0027362823
-
B70 antigen is a second ligand for CTLA-4 and CD28
-
Azuma M et al (1993) B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76-79
-
(1993)
Nature
, vol.366
, pp. 76-79
-
-
Azuma, M.1
-
14
-
-
0027761138
-
Identification of an alternative CTLA-4 ligand co-stimulatory for T cell activation
-
Hathcock KS et al (1993) Identification of an alternative CTLA-4 ligand co-stimulatory for T cell activation. Science 262:905-907
-
(1993)
Science
, vol.262
, pp. 905-907
-
-
Hathcock, K.S.1
-
15
-
-
0027767762
-
Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
-
Freeman GJ et al (1993) Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262:909-911
-
(1993)
Science
, vol.262
, pp. 909-911
-
-
Freeman, G.J.1
-
16
-
-
0028337459
-
Comparative analysis of B7-1 and B7-2 co-stimulatory ligands: Expression and function
-
Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ (1994) Comparative analysis of B7-1 and B7-2 co-stimulatory ligands: expression and function. J Exp Med 180:631-640
-
(1994)
J Exp Med
, vol.180
, pp. 631-640
-
-
Hathcock, K.S.1
Laszlo, G.2
Pucillo, C.3
Linsley, P.4
Hodes, R.J.5
-
18
-
-
0028179886
-
Regulation of immunostimulatory function and co-stimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
-
Larsen CP et al (1994) Regulation of immunostimulatory function and co-stimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J Immunol 152:5208-5219
-
(1994)
J Immunol
, vol.152
, pp. 5208-5219
-
-
Larsen, C.P.1
-
20
-
-
65349119978
-
CD28 and CTLA-4 coreceptor expression and signal transduction
-
Rudd CE, Taylor A, Schneider H (2009) CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 229:12-26
-
(2009)
Immunol Rev
, vol.229
, pp. 12-26
-
-
Rudd, C.E.1
Taylor, A.2
Schneider, H.3
-
21
-
-
0027281691
-
Differential T cell co-stimulatory requirements in CD28-deficient mice
-
Shahinian A et al (1993) Differential T cell co-stimulatory requirements in CD28-deficient mice. Science 261:609-612
-
(1993)
Science
, vol.261
, pp. 609-612
-
-
Shahinian, A.1
-
22
-
-
1842373718
-
Duration of TCR stimulation determines co-stimulatory requirement of T cells
-
Kundig TM et al (1996) Duration of TCR stimulation determines co-stimulatory requirement of T cells. Immunity 5:41-52
-
(1996)
Immunity
, vol.5
, pp. 41-52
-
-
Kundig, T.M.1
-
23
-
-
0030936275
-
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
-
Borriello F et al (1997) B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6:303-313
-
(1997)
Immunity
, vol.6
, pp. 303-313
-
-
Borriello, F.1
-
24
-
-
0023270567
-
A new member of the immunoglobulin superfamily-CTLA-4
-
Brunet JF et al (1987) A new member of the immunoglobulin superfamily-CTLA-4. Nature 328:267-270
-
(1987)
Nature
, vol.328
, pp. 267-270
-
-
Brunet, J.F.1
-
25
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel MF, Allison JP (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 182:459-465
-
(1995)
J Exp Med
, vol.182
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
26
-
-
0030694234
-
The emerging role of CTLA-4 as an immune attenuator
-
Thompson CB, Allison JP (1997) The emerging role of CTLA-4 as an immune attenuator. Immunity 7:445-450
-
(1997)
Immunity
, vol.7
, pp. 445-450
-
-
Thompson, C.B.1
Allison, J.P.2
-
27
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL et al (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405-413
-
(1994)
Immunity
, vol.1
, pp. 405-413
-
-
Walunas, T.L.1
-
28
-
-
0025830902
-
CTLA-4 is a second receptor for the B cell activation antigen B7
-
Linsley PS et al (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174:561-569
-
(1991)
J Exp Med
, vol.174
, pp. 561-569
-
-
Linsley, P.S.1
-
29
-
-
0029899783
-
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
-
Krummel MF, Allison JP (1996) CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 183:2533-2540
-
(1996)
J Exp Med
, vol.183
, pp. 2533-2540
-
-
Krummel, M.F.1
Allison, J.P.2
-
30
-
-
0029953858
-
CTLA-4 ligation blocks CD28-dependent T cell activation
-
Walunas TL, Bakker CY, Bluestone JA (1996) CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 183:2541-2550
-
(1996)
J Exp Med
, vol.183
, pp. 2541-2550
-
-
Walunas, T.L.1
Bakker, C.Y.2
Bluestone, J.A.3
-
31
-
-
0033563271
-
CTLA-4-Mediated inhibition of early events of T cell proliferation
-
Brunner MC et al (1999) CTLA-4-Mediated inhibition of early events of T cell proliferation. J Immunol 162:5813-5820
-
(1999)
J Immunol
, vol.162
, pp. 5813-5820
-
-
Brunner, M.C.1
-
32
-
-
0035102196
-
CTLA-4 regulates induction of anergy in vivo
-
Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH (2001) CTLA-4 regulates induction of anergy in vivo. Immunity 14:145-155
-
(2001)
Immunity
, vol.14
, pp. 145-155
-
-
Greenwald, R.J.1
Boussiotis, V.A.2
Lorsbach, R.B.3
Abbas, A.K.4
Sharpe, A.H.5
-
33
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse P et al (1995) Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270:985-988
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
-
34
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol EA et al (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541-547
-
(1995)
Immunity
, vol.3
, pp. 541-547
-
-
Tivol, E.A.1
-
35
-
-
0031405867
-
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
-
Chambers CA, Sullivan TJ, Allison JP (1997) Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity 7:885-895
-
(1997)
Immunity
, vol.7
, pp. 885-895
-
-
Chambers, C.A.1
Sullivan, T.J.2
Allison, J.P.3
-
36
-
-
0031181647
-
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
-
Chuang E et al (1997) Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. J Immunol 159:144-151
-
(1997)
J Immunol
, vol.159
, pp. 144-151
-
-
Chuang, E.1
-
37
-
-
0030917081
-
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
-
Shiratori T et al (1997) Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 6:583-589
-
(1997)
Immunity
, vol.6
, pp. 583-589
-
-
Shiratori, T.1
-
38
-
-
0036301503
-
CTLA-4: New insights into its biological function and use in tumor immunotherapy
-
Egen JG, Kuhns MS, Allison JP (2002) CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nat Immunol 3:611-618
-
(2002)
Nat Immunol
, vol.3
, pp. 611-618
-
-
Egen, J.G.1
Kuhns, M.S.2
Allison, J.P.3
-
39
-
-
0030611358
-
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
-
Zhang Y, Allison JP (1997) Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc Natl Acad Sci USA 94:9273-9278
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9273-9278
-
-
Zhang, Y.1
Allison, J.P.2
-
40
-
-
4444369694
-
B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse
-
Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP (2004) B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity 21:401-413
-
(2004)
Immunity
, vol.21
, pp. 401-413
-
-
Pentcheva-Hoang, T.1
Egen, J.G.2
Wojnoonski, K.3
Allison, J.P.4
-
41
-
-
0036172220
-
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
-
Egen JG, Allison JP (2002) Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity 16:23-35
-
(2002)
Immunity
, vol.16
, pp. 23-35
-
-
Egen, J.G.1
Allison, J.P.2
-
42
-
-
0035967146
-
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
-
Stamper CC et al (2001) Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature 410:608-611
-
(2001)
Nature
, vol.410
, pp. 608-611
-
-
Stamper, C.C.1
-
43
-
-
45149111788
-
Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy
-
Peggs KS, Quezada SA, Allison JP (2008) Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy. Immunol Rev 224:141-165
-
(2008)
Immunol Rev
, vol.224
, pp. 141-165
-
-
Peggs, K.S.1
Quezada, S.A.2
Allison, J.P.3
-
44
-
-
0037015055
-
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
-
Riley JL et al (2002) Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci USA 99:11790-11795
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11790-11795
-
-
Riley, J.L.1
-
45
-
-
0034658408
-
Structural analysis of CTLA-4 function in vivo
-
Masteller EL, Chuang E, Mullen AC, Reiner SL, Thompson CB (2000) Structural analysis of CTLA-4 function in vivo. J Immunol 164:5319-5327
-
(2000)
J Immunol
, vol.164
, pp. 5319-5327
-
-
Masteller, E.L.1
Chuang, E.2
Mullen, A.C.3
Reiner, S.L.4
Thompson, C.B.5
-
46
-
-
38349074305
-
CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization
-
Schneider H, Smith X, Liu H, Bismuth G, Rudd CE (2008) CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization. Eur J Immunol 38:40-47
-
(2008)
Eur J Immunol
, vol.38
, pp. 40-47
-
-
Schneider, H.1
Smith, X.2
Liu, H.3
Bismuth, G.4
Rudd, C.E.5
-
47
-
-
57349090212
-
CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death
-
Schneider H, Valk E, Leung R, Rudd CE (2008) CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death. PLoS One 3:e3842
-
(2008)
PLoS One
, vol.3
, pp. e3842
-
-
Schneider, H.1
Valk, E.2
Leung, R.3
Rudd, C.E.4
-
48
-
-
0036784567
-
Cutting edge: CTLA-4 (CD152) differentially regulates mitogenactivated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice
-
Schneider H et al (2002) Cutting edge: CTLA-4 (CD152) differentially regulates mitogenactivated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J Immunol 169:3475-3479
-
(2002)
J Immunol
, vol.169
, pp. 3475-3479
-
-
Schneider, H.1
-
49
-
-
0030707866
-
Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70
-
Calvo CR, Amsen D, Kruisbeek AM (1997) Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. J Exp Med 186:1645-1653
-
(1997)
J Exp Med
, vol.186
, pp. 1645-1653
-
-
Calvo, C.R.1
Amsen, D.2
Kruisbeek, A.M.3
-
50
-
-
0033024389
-
Cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibits CD28-induced IkappaBalpha degradation and RelA activation
-
Pioli C, Gatta L, Frasca D, Doria G (1999) Cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibits CD28-induced IkappaBalpha degradation and RelA activation. Eur J Immunol 29:856-863
-
(1999)
Eur J Immunol
, vol.29
, pp. 856-863
-
-
Pioli, C.1
Gatta, L.2
Frasca, D.3
Doria, G.4
-
51
-
-
0033553471
-
CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts
-
Olsson C, Riesbeck K, Dohlsten M, Michaelsson E (1999) CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts. J Biol Chem 274:14400-14405
-
(1999)
J Biol Chem
, vol.274
, pp. 14400-14405
-
-
Olsson, C.1
Riesbeck, K.2
Dohlsten, M.3
Michaelsson, E.4
-
52
-
-
0036852170
-
CTLA-4-Ig regulates tryptophan catabolism in vivo
-
Grohmann U et al (2002) CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 3:1097-1101
-
(2002)
Nat Immunol
, vol.3
, pp. 1097-1101
-
-
Grohmann, U.1
-
53
-
-
1642396607
-
Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells
-
Munn DH, Sharma MD, Mellor AL (2004) Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. J Immunol 172:4100-4110
-
(2004)
J Immunol
, vol.172
, pp. 4100-4110
-
-
Munn, D.H.1
Sharma, M.D.2
Mellor, A.L.3
-
54
-
-
0347994958
-
B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]
-
Taylor PA et al (2004) B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections]. J Immunol 172:34-39
-
(2004)
J Immunol
, vol.172
, pp. 34-39
-
-
Taylor, P.A.1
-
55
-
-
3142708571
-
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
-
Paust S, Lu L, McCarty N, Cantor H (2004) Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci USA 101:10398-10403
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10398-10403
-
-
Paust, S.1
Lu, L.2
McCarty, N.3
Cantor, H.4
-
56
-
-
0033682056
-
B7/CD28 costimulation is essential for the homeostasis of the CD4 + CD25+ immunoregulatory T cells that control autoimmune diabetes
-
Salomon B et al (2000) B7/CD28 costimulation is essential for the homeostasis of the CD4 + CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12:431-440
-
(2000)
Immunity
, vol.12
, pp. 431-440
-
-
Salomon, B.1
-
57
-
-
0344299189
-
Cutting edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
-
Bachmann MF, Kohler G, Ecabert B, Mak TW, Kopf M (1999) Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J Immunol 163:1128-1131
-
(1999)
J Immunol
, vol.163
, pp. 1128-1131
-
-
Bachmann, M.F.1
Kohler, G.2
Ecabert, B.3
Mak, T.W.4
Kopf, M.5
-
58
-
-
0034679567
-
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
-
Read S, Malmstrom V, Powrie F (2000) Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 192:295-302
-
(2000)
J Exp Med
, vol.192
, pp. 295-302
-
-
Read, S.1
Malmstrom, V.2
Powrie, F.3
-
59
-
-
0034679560
-
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
-
Takahashi T et al (2000) Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 192:303-310
-
(2000)
J Exp Med
, vol.192
, pp. 303-310
-
-
Takahashi, T.1
-
60
-
-
0036686399
-
CD4 + CD25+ T cells as immunoregulatory T cells in vitro
-
Chai JG et al (2002) CD4 + CD25+ T cells as immunoregulatory T cells in vitro. Eur J Immunol 32:2365-2375
-
(2002)
Eur J Immunol
, vol.32
, pp. 2365-2375
-
-
Chai, J.G.1
-
61
-
-
17644376164
-
CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4
-
Kataoka H et al (2005) CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4. Int Immunol 17:421-427
-
(2005)
Int Immunol
, vol.17
, pp. 421-427
-
-
Kataoka, H.1
-
62
-
-
9244261022
-
Distinct roles of CTLA-4 and TGF-beta in CD4 + CD25+ regulatory T cell function
-
Tang Q et al (2004) Distinct roles of CTLA-4 and TGF-beta in CD4 + CD25+ regulatory T cell function. Eur J Immunol 34:2996-3005
-
(2004)
Eur J Immunol
, vol.34
, pp. 2996-3005
-
-
Tang, Q.1
-
63
-
-
53749094183
-
CTLA-4 control over Foxp3+ regulatory T cell function
-
Wing K et al (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science 322:271-275
-
(2008)
Science
, vol.322
, pp. 271-275
-
-
Wing, K.1
-
64
-
-
0031678645
-
Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells
-
Chambers CA, Sullivan TJ, Truong T, Allison JP (1998) Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells. Eur J Immunol 28:3137-3143
-
(1998)
Eur J Immunol
, vol.28
, pp. 3137-3143
-
-
Chambers, C.A.1
Sullivan, T.J.2
Truong, T.3
Allison, J.P.4
-
65
-
-
0033587768
-
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses
-
Chambers CA, Kuhns MS, Allison JP (1999) Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses. Proc Natl Acad Sci USA 96:8603-8608
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8603-8608
-
-
Chambers, C.A.1
Kuhns, M.S.2
Allison, J.P.3
-
66
-
-
0036180686
-
CTLA-4 regulates cell cycle progression during a primary immune response
-
Greenwald RJ et al (2002) CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol 32:366-373
-
(2002)
Eur J Immunol
, vol.32
, pp. 366-373
-
-
Greenwald, R.J.1
-
67
-
-
0033526111
-
Cytotoxic T lymphocyteassociated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cells independently of CD4(+) T cell help
-
McCoy KD, Hermans IF, Fraser JH, Le Gros G, Ronchese F (1999) Cytotoxic T lymphocyteassociated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cells independently of CD4(+) T cell help. J Exp Med 189:1157-1162
-
(1999)
J Exp Med
, vol.189
, pp. 1157-1162
-
-
McCoy, K.D.1
Hermans, I.F.2
Fraser, J.H.3
Le Gros, G.4
Ronchese, F.5
-
68
-
-
0037103325
-
Re-establishing peripheral tolerance in the absence of CTLA-4: Complementation by wild-type T cells points to an indirect role for CTLA-4
-
Tivol EA, Gorski J (2002) Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4. J Immunol 169:1852-1858
-
(2002)
J Immunol
, vol.169
, pp. 1852-1858
-
-
Tivol, E.A.1
Gorski, J.2
-
69
-
-
63049090504
-
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
-
Friedline RH et al (2009) CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med 206:421-434
-
(2009)
J Exp Med
, vol.206
, pp. 421-434
-
-
Friedline, R.H.1
-
70
-
-
0028263666
-
Costimulation of tumorreactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma
-
Li Y, McGowan P, Hellstrom I, Hellstrom KE, Chen L (1994) Costimulation of tumorreactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma. J Immunol 153:421-428
-
(1994)
J Immunol
, vol.153
, pp. 421-428
-
-
Li, Y.1
McGowan, P.2
Hellstrom, I.3
Hellstrom, K.E.4
Chen, L.5
-
71
-
-
0028646191
-
Specificity and longevity of antitumor immune responses induced by B7-transfected tumors
-
Townsend SE, Su FW, Atherton JM, Allison JP (1994) Specificity and longevity of antitumor immune responses induced by B7-transfected tumors. Cancer Res 54:6477-6483
-
(1994)
Cancer Res
, vol.54
, pp. 6477-6483
-
-
Townsend, S.E.1
Su, F.W.2
Atherton, J.M.3
Allison, J.P.4
-
72
-
-
0028934350
-
Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 co-stimulatory molecules
-
Yang G, Hellstrom KE, Hellstrom I, Chen L (1995) Antitumor immunity elicited by tumor cells transfected with B7-2, a second ligand for CD28/CTLA-4 co-stimulatory molecules. J Immunol 154:2794-2800
-
(1995)
J Immunol
, vol.154
, pp. 2794-2800
-
-
Yang, G.1
Hellstrom, K.E.2
Hellstrom, I.3
Chen, L.4
-
73
-
-
0033766179
-
Prostate cancer gene therapy: Comparison of adenovirus-mediated expression of interleukin 12 with interleukin 12 plus B7-1 for in situ gene therapy and genemodified, cell-based vaccines
-
Hull GW et al (2000) Prostate cancer gene therapy: comparison of adenovirus-mediated expression of interleukin 12 with interleukin 12 plus B7-1 for in situ gene therapy and genemodified, cell-based vaccines. Clin Cancer Res 6:4101-4109
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4101-4109
-
-
Hull, G.W.1
-
74
-
-
79954442840
-
Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma
-
Li G et al (2011) Triple expression of B7-1, B7-2 and 4-1BBL enhanced antitumor immune response against mouse H22 hepatocellular carcinoma. J Cancer Res Clin Oncol 137:695-703
-
(2011)
J Cancer Res Clin Oncol
, vol.137
, pp. 695-703
-
-
Li, G.1
-
75
-
-
0036223749
-
Phase i trial of a B7-1 (CD80) gene modified autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic renal cell carcinoma
-
Antonia SJ et al (2002) Phase I trial of a B7-1 (CD80) gene modified autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic renal cell carcinoma. J Urol 167:1995-2000
-
(2002)
J Urol
, vol.167
, pp. 1995-2000
-
-
Antonia, S.J.1
-
76
-
-
4344559720
-
Allogeneic vaccination with a B7. 1 HLA-A gene-modified adenocarcinoma cell line in patients with advanced non-small-cell lung cancer
-
Raez LE et al (2004) Allogeneic vaccination with a B7.1 HLA-A gene-modified adenocarcinoma cell line in patients with advanced non-small-cell lung cancer. J Clin Oncol 22:2800-2807
-
(2004)
J Clin Oncol
, vol.22
, pp. 2800-2807
-
-
Raez, L.E.1
-
77
-
-
0038826485
-
Vaccination of women with metastatic breast cancer, using a co-stimulatory gene (CD80)-modified, HLA-A2-matched, allogeneic, breast cancer cell line: Clinical and immunological results
-
Dols A et al (2003) Vaccination of women with metastatic breast cancer, using a co-stimulatory gene (CD80)-modified, HLA-A2-matched, allogeneic, breast cancer cell line: clinical and immunological results. Hum Gene Ther 14:1117-1123
-
(2003)
Hum Gene Ther
, vol.14
, pp. 1117-1123
-
-
Dols, A.1
-
78
-
-
0037334794
-
Identification of tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells
-
Dols A et al (2003) Identification of tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells. J Immunother 26:163-170
-
(2003)
J Immunother
, vol.26
, pp. 163-170
-
-
Dols, A.1
-
79
-
-
22144457398
-
Targeting the local tumor microenvironment with vaccinia virus expressing B7. 1 for the treatment of melanoma
-
Kaufman HL et al (2005) Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. J Clin Invest 115:1903-1912
-
(2005)
J Clin Invest
, vol.115
, pp. 1903-1912
-
-
Kaufman, H.L.1
-
80
-
-
40749088132
-
Phase II trial of B7-1 (CD-86) transduced, cultured autologous tumor cell vaccine plus subcutaneous interleukin-2 for treatment of stage IV renal cell carcinoma
-
Fishman M et al (2008) Phase II trial of B7-1 (CD-86) transduced, cultured autologous tumor cell vaccine plus subcutaneous interleukin-2 for treatment of stage IV renal cell carcinoma. J Immunother 31:72-80
-
(2008)
J Immunother
, vol.31
, pp. 72-80
-
-
Fishman, M.1
-
81
-
-
0033766694
-
Phase i clinical trial of a recombinant canarypoxvirus (ALVAC) vaccine expressing human carcinoembryonic antigen and the B7. 1 co-stimulatory molecule
-
Horig H et al (2000) Phase I clinical trial of a recombinant canarypoxvirus (ALVAC) vaccine expressing human carcinoembryonic antigen and the B7.1 co-stimulatory molecule. Cancer Immunol Immunother 49:504-514
-
(2000)
Cancer Immunol Immunother
, vol.49
, pp. 504-514
-
-
Horig, H.1
-
82
-
-
0034122338
-
Pilot study of a dual gene recombinant avipox vaccine containing both carcinoembryonic antigen (CEA) and B7. 1 transgenes in patients with recurrent CEAexpressing adenocarcinomas
-
von Mehren M et al (2000) Pilot study of a dual gene recombinant avipox vaccine containing both carcinoembryonic antigen (CEA) and B7.1 transgenes in patients with recurrent CEAexpressing adenocarcinomas. Clin Cancer Res 6:2219-2228
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2219-2228
-
-
Von Mehren, M.1
-
83
-
-
0034890429
-
Technology evaluation: CEA-TRICOM, Therion Biologics Corp
-
Morse MA (2001) Technology evaluation: CEA-TRICOM, Therion Biologics Corp. Curr Opin Mol Ther 3:407-412
-
(2001)
Curr Opin Mol Ther
, vol.3
, pp. 407-412
-
-
Morse, M.A.1
-
85
-
-
49649090374
-
Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma
-
Gulley JL et al (2008) Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma. Clin Cancer Res 14:3060-3069
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3060-3069
-
-
Gulley, J.L.1
-
86
-
-
77955980318
-
Comparative analysis of MVA-CD40L and MVA-TRICOM vectors for enhancing the immunogenicity of chronic lymphocytic leukemia (CLL) cells
-
Litzinger MT, Foon KA, Tsang KY, Schlom J, Palena C (2010) Comparative analysis of MVA-CD40L and MVA-TRICOM vectors for enhancing the immunogenicity of chronic lymphocytic leukemia (CLL) cells. Leuk Res 34:1351-1357
-
(2010)
Leuk Res
, vol.34
, pp. 1351-1357
-
-
Litzinger, M.T.1
Foon, K.A.2
Tsang, K.Y.3
Schlom, J.4
Palena, C.5
-
87
-
-
34247246801
-
Drug evaluation: Therion's rV-PSA-TRICOM + rF-PSA-TRICOM prime-boost prostate cancer vaccine
-
Doehn C, Kausch I, Bohmer T, Sommerauer M, Jocham D (2007) Drug evaluation: Therion's rV-PSA-TRICOM + rF-PSA-TRICOM prime-boost prostate cancer vaccine. Curr Opin Mol Ther 9:183-189
-
(2007)
Curr Opin Mol Ther
, vol.9
, pp. 183-189
-
-
Doehn, C.1
Kausch, I.2
Bohmer, T.3
Sommerauer, M.4
Jocham, D.5
-
88
-
-
33745920149
-
A pilot trial of a carcinoembryonic antigen/ TRICOM-based vaccine and radiation to liver metastases in patients with carcinoembryonic antigen-positive solid tumors
-
Ahlers CM, Camphausen K, Citrin D, Arlen PM, Gulley JL (2006) A pilot trial of a carcinoembryonic antigen/ TRICOM-based vaccine and radiation to liver metastases in patients with carcinoembryonic antigen-positive solid tumors. Clin Colorectal Cancer 6:72-75
-
(2006)
Clin Colorectal Cancer
, vol.6
, pp. 72-75
-
-
Ahlers, C.M.1
Camphausen, K.2
Citrin, D.3
Arlen, P.M.4
Gulley, J.L.5
-
89
-
-
33644872328
-
TRICOM vector based cancer vaccines
-
Garnett CT et al (2006) TRICOM vector based cancer vaccines. Curr Pharm Des 12:351-361
-
(2006)
Curr Pharm des
, vol.12
, pp. 351-361
-
-
Garnett, C.T.1
-
90
-
-
30544449854
-
A phase i trial of pox PSA vaccines (PROSTVAC-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM) in patients with prostate cancer
-
DiPaola RS et al (2006) A phase I trial of pox PSA vaccines (PROSTVAC-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM) in patients with prostate cancer. J Transl Med 4:1
-
(2006)
J Transl Med
, vol.4
, pp. 1
-
-
Dipaola, R.S.1
-
91
-
-
20044364936
-
Phase i study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas
-
Marshall JL et al (2005) Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. J Clin Oncol 23:720-731
-
(2005)
J Clin Oncol
, vol.23
, pp. 720-731
-
-
Marshall, J.L.1
-
92
-
-
38849160991
-
Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer
-
Kaufman HL et al (2007) Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer. J Transl Med 5:60
-
(2007)
J Transl Med
, vol.5
, pp. 60
-
-
Kaufman, H.L.1
-
93
-
-
0038359163
-
Clinical protocol. Intra-Lesional rF-B7.1 versus rF-TRICOM vaccine in the treatment of metastatic cancer
-
Kaufman HL et al (2003) Clinical protocol. Intra-Lesional rF-B7.1 versus rF-TRICOM vaccine in the treatment of metastatic cancer. Hum Gene Ther 14:803-827
-
(2003)
Hum Gene Ther
, vol.14
, pp. 803-827
-
-
Kaufman, H.L.1
-
94
-
-
0034824727
-
A phase i trial of intralesional rV-Tricom vaccine in the treatment of malignant melanoma
-
Kaufman HL et al (2001) A phase I trial of intralesional rV-Tricom vaccine in the treatment of malignant melanoma. Hum Gene Ther 12:1459-1480
-
(2001)
Hum Gene Ther
, vol.12
, pp. 1459-1480
-
-
Kaufman, H.L.1
-
95
-
-
33144480152
-
Local delivery of vaccinia virus expressing multiple co-stimulatory molecules for the treatment of established tumors
-
Kaufman HL et al (2006) Local delivery of vaccinia virus expressing multiple co-stimulatory molecules for the treatment of established tumors. Hum Gene Ther 17:239-244
-
(2006)
Hum Gene Ther
, vol.17
, pp. 239-244
-
-
Kaufman, H.L.1
-
96
-
-
0028867835
-
Manipulation of co-stimulatory signals to enhance antitumor T-cell responses
-
Allison JP, Hurwitz AA, Leach DR (1995) Manipulation of co-stimulatory signals to enhance antitumor T-cell responses. Curr Opin Immunol 7:682-686
-
(1995)
Curr Opin Immunol
, vol.7
, pp. 682-686
-
-
Allison, J.P.1
Hurwitz, A.A.2
Leach, D.R.3
-
97
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP (1996) Enhancement of antitumor immunity by CTLA-4 blockade. Science 271:1734-1736
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
98
-
-
0030743846
-
Manipulation of T cell co-stimulatory and inhibitory signals for immunotherapy of prostate cancer
-
Kwon ED et al (1997) Manipulation of T cell co-stimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc Natl Acad Sci USA 94:8099-8103
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8099-8103
-
-
Kwon, E.D.1
-
99
-
-
0030853610
-
Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: The effect is manifested only at the restricted tumor-bearing stages
-
Yang YF et al (1997) Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: The effect is manifested only at the restricted tumor-bearing stages. Cancer Res 57:4036-4041
-
(1997)
Cancer Res
, vol.57
, pp. 4036-4041
-
-
Yang, Y.F.1
-
100
-
-
0033213599
-
CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell-and IL-2-dependent mechanism
-
Shrikant P, Khoruts A, Mescher MF (1999) CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell-and IL-2-dependent mechanism. Immunity 11:483-493
-
(1999)
Immunity
, vol.11
, pp. 483-493
-
-
Shrikant, P.1
Khoruts, A.2
Mescher, M.F.3
-
101
-
-
0033613173
-
In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
-
Sotomayor EM, Borrello I, Tubb E, Allison JP, Levitsky HI (1999) In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance. Proc Natl Acad Sci USA 96:11476-11481
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11476-11481
-
-
Sotomayor, E.M.1
Borrello, I.2
Tubb, E.3
Allison, J.P.4
Levitsky, H.I.5
-
102
-
-
0032404099
-
Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice
-
Mokyr MB, Kalinichenko T, Gorelik L, Bluestone JA (1998) Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res 58:5301-5304
-
(1998)
Cancer Res
, vol.58
, pp. 5301-5304
-
-
Mokyr, M.B.1
Kalinichenko, T.2
Gorelik, L.3
Bluestone, J.A.4
-
103
-
-
0038745486
-
Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade
-
Davila E, Kennedy R, Celis E (2003) Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res 63:3281-3288
-
(2003)
Cancer Res
, vol.63
, pp. 3281-3288
-
-
Davila, E.1
Kennedy, R.2
Celis, E.3
-
104
-
-
11144353596
-
CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems
-
Gregor PD et al (2004) CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems. Vaccine 22:1700-1708
-
(2004)
Vaccine
, vol.22
, pp. 1700-1708
-
-
Gregor, P.D.1
-
105
-
-
3442883353
-
Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors
-
Daftarian P et al (2004) Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors. Cancer Res 64:5407-5414
-
(2004)
Cancer Res
, vol.64
, pp. 5407-5414
-
-
Daftarian, P.1
-
106
-
-
12244252335
-
Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
-
Demaria S et al (2005) Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res 11:728-734
-
(2005)
Clin Cancer Res
, vol.11
, pp. 728-734
-
-
Demaria, S.1
-
107
-
-
29844436043
-
The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling
-
Met O et al (2006) The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling. Cancer Lett 231:247-256
-
(2006)
Cancer Lett
, vol.231
, pp. 247-256
-
-
Met, O.1
-
108
-
-
57649123650
-
Recombinant vesicular stomatitis virus targeted to Her2/neu combined with anti-CTLA4 antibody eliminates implanted mammary tumors
-
Gao Y, Whitaker-Dowling P, Griffin JA, Barmada MA, Bergman I (2009) Recombinant vesicular stomatitis virus targeted to Her2/neu combined with anti-CTLA4 antibody eliminates implanted mammary tumors. Cancer Gene Ther 16:44-52
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 44-52
-
-
Gao, Y.1
Whitaker-Dowling, P.2
Griffin, J.A.3
Barmada, M.A.4
Bergman, I.5
-
109
-
-
0033517152
-
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
-
van Elsas A, Hurwitz AA, Allison JP (1999) Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 190:355-366
-
(1999)
J Exp Med
, vol.190
, pp. 355-366
-
-
Van Elsas, A.1
Hurwitz, A.A.2
Allison, J.P.3
-
110
-
-
0033592924
-
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
-
Kwon ED et al (1999) Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy. Proc Natl Acad Sci USA 96:15074-15079
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 15074-15079
-
-
Kwon, E.D.1
-
111
-
-
69949085196
-
Fractionated but not single-dose radiotherapy induces an immunemediated abscopal effect when combined with anti-CTLA-4 antibody
-
Dewan MZ et al (2009) Fractionated but not single-dose radiotherapy induces an immunemediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 15:5379-5388
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5379-5388
-
-
Dewan, M.Z.1
-
112
-
-
33749353175
-
Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity
-
den Brok MH et al (2006) Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity. Br J Cancer 95:896-905
-
(2006)
Br J Cancer
, vol.95
, pp. 896-905
-
-
Den Brok, M.H.1
-
113
-
-
0032544067
-
CTLA-4 blockade synergizes with tumorderived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
-
Hurwitz AA, Yu TF, Leach DR, Allison JP (1998) CTLA-4 blockade synergizes with tumorderived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci USA 95:10067-10071
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10067-10071
-
-
Hurwitz, A.A.1
Yu, T.F.2
Leach, D.R.3
Allison, J.P.4
-
114
-
-
17944364189
-
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
-
van Elsas A et al (2001) Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J Exp Med 194:481-489
-
(2001)
J Exp Med
, vol.194
, pp. 481-489
-
-
Van Elsas, A.1
-
115
-
-
0034194329
-
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
-
Hurwitz AA et al (2000) Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 60:2444-2448
-
(2000)
Cancer Res
, vol.60
, pp. 2444-2448
-
-
Hurwitz, A.A.1
-
116
-
-
77954938867
-
Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy
-
Mangsbo SM et al (2010) Enhanced tumor eradication by combining CTLA-4 or PD-1 blockade with CpG therapy. J Immunother 33:225-235
-
(2010)
J Immunother
, vol.33
, pp. 225-235
-
-
Mangsbo, S.M.1
-
117
-
-
70350234739
-
Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors
-
Curran MA, Allison JP (2009) Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors. Cancer Res 69:7747-7755
-
(2009)
Cancer Res
, vol.69
, pp. 7747-7755
-
-
Curran, M.A.1
Allison, J.P.2
-
118
-
-
33745851479
-
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
-
Quezada SA, Peggs KS, Curran MA, Allison JP (2006) CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest 116:1935-1945
-
(2006)
J Clin Invest
, vol.116
, pp. 1935-1945
-
-
Quezada, S.A.1
Peggs, K.S.2
Curran, M.A.3
Allison, J.P.4
-
119
-
-
68149155982
-
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
-
Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP (2009) Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 206:1717-1725
-
(2009)
J Exp Med
, vol.206
, pp. 1717-1725
-
-
Peggs, K.S.1
Quezada, S.A.2
Chambers, C.A.3
Korman, A.J.4
Allison, J.P.5
-
120
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic Tlymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
Phan GQ et al (2003) Cancer regression and autoimmunity induced by cytotoxic Tlymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA 100:8372-8377
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8372-8377
-
-
Phan, G.Q.1
-
121
-
-
32644467549
-
Antitumor activity in melanoma and anti-self responses in a phase i trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
-
Ribas A et al (2005) Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol 23:8968-8977
-
(2005)
J Clin Oncol
, vol.23
, pp. 8968-8977
-
-
Ribas, A.1
-
122
-
-
58049202334
-
Phase I/II study of ipilimumab for patients with metastatic melanoma
-
Weber JS et al (2008) Phase I/II study of ipilimumab for patients with metastatic melanoma. J Clin Oncol 26:5950-5956
-
(2008)
J Clin Oncol
, vol.26
, pp. 5950-5956
-
-
Weber, J.S.1
-
123
-
-
0003311698
-
MDX-010 (human anti-CTLA4): A phase i trial in malignant melanoma
-
abstr 56
-
Tchekmedyian S et al (2002) MDX-010 (human anti-CTLA4): A phase I trial in malignant melanoma. Proc Am Soc Clin Oncol 21:223 (abstr 56)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 223
-
-
Tchekmedyian, S.1
-
124
-
-
0344341626
-
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
-
Hodi FS et al (2003) Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci USA 100:4712-4717
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4712-4717
-
-
Hodi, F.S.1
-
125
-
-
24944459890
-
Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
-
Attia P et al (2005) Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 23:6043-6053
-
(2005)
J Clin Oncol
, vol.23
, pp. 6043-6053
-
-
Attia, P.1
-
126
-
-
20044395957
-
Autoimmunity in a phase i trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma
-
Sanderson K et al (2005) Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma. J Clin Oncol 23:741-750
-
(2005)
J Clin Oncol
, vol.23
, pp. 741-750
-
-
Sanderson, K.1
-
127
-
-
27844458057
-
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: A phase I/II study
-
Maker AV et al (2005) Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: A phase I/II study. Ann Surg Oncol 12:1005-1016
-
(2005)
Ann Surg Oncol
, vol.12
, pp. 1005-1016
-
-
Maker, A.V.1
-
128
-
-
36748999428
-
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
-
Downey SG et al (2007) Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res 13:6681-6688
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6681-6688
-
-
Downey, S.G.1
-
129
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
-
Wolchok JD et al (2010) Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 11:155-164
-
(2010)
Lancet Oncol
, vol.11
, pp. 155-164
-
-
Wolchok, J.D.1
-
130
-
-
79955581263
-
A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naive patients with advanced melanoma
-
Hersh EM et al (2011) A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naive patients with advanced melanoma. Invest New Drugs 29:489-498
-
(2011)
Invest New Drugs
, vol.29
, pp. 489-498
-
-
Hersh, E.M.1
-
131
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C et al (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364:2517-2526
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
-
132
-
-
34250223096
-
A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer
-
Small EJ et al (2007) A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. Clin Cancer Res 13:1810-1815
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1810-1815
-
-
Small, E.J.1
-
133
-
-
37049036074
-
Randomized phase II study comparing 4 monthly doses of ipilimumab (MDX-010) as a single agent or in combination with a single dose of docetaxel in patients with hormone-refractory prostate cancer
-
ASCO Annual Meeting Proceedings Part I. (June 20 Supplement)
-
Small E et al (2006) Randomized phase II study comparing 4 monthly doses of ipilimumab (MDX-010) as a single agent or in combination with a single dose of docetaxel in patients with hormone-refractory prostate cancer. J Clin Oncol 24(18s):4609, ASCO Annual Meeting Proceedings Part I. (June 20 Supplement)
-
(2006)
J Clin Oncol
, vol.24
, Issue.18
, pp. 4609
-
-
Small, E.1
-
134
-
-
58349090027
-
Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF
-
Fong L et al (2009) Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. Cancer Res 69:609-615
-
(2009)
Cancer Res
, vol.69
, pp. 609-615
-
-
Fong, L.1
-
135
-
-
77951443592
-
Initial phase II experience of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration-resistant prostate cancer (mCRPC)
-
abstr 5138
-
Slovin SF et al (2009) Initial phase II experience of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol 27:15s (suppl; abstr 5138)
-
(2009)
J Clin Oncol
, vol.27
, pp. 15s
-
-
Slovin, S.F.1
-
136
-
-
76749133945
-
Phase i trial of targeted therapy with PSA-TRICOM vaccine (V) and ipilimumab (ipi) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)
-
abstr 5144
-
Mohebtash M et al (2009) Phase I trial of targeted therapy with PSA-TRICOM vaccine (V) and ipilimumab (ipi) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol 27:15s (suppl; abstr 5144)
-
(2009)
J Clin Oncol
, vol.27
, pp. 15s
-
-
Mohebtash, M.1
-
137
-
-
78449264515
-
Phase II trial of ipilimumab (IPI) and paclitaxel/carboplatin (P/C) in first-line stage IIIb/IV non-small cell lung cancer (NON-SMALL CELL LUNG CANCER)
-
abstr 7531
-
Lynch TJ et al (2010) Phase II trial of ipilimumab (IPI) and paclitaxel/carboplatin (P/C) in first-line stage IIIb/IV non-small cell lung cancer (NON-SMALL CELL LUNG CANCER). J Clin Oncol 28:15s (suppl; abstr 7531)
-
(2010)
J Clin Oncol
, vol.28
, pp. 15s
-
-
Lynch, T.J.1
-
138
-
-
70350244852
-
Phase i study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma
-
Ansell SM et al (2009) Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma. Clin Cancer Res 15:6446-6453
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6446-6453
-
-
Ansell, S.M.1
-
139
-
-
61849165013
-
CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation
-
Bashey A et al (2009) CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation. Blood 113:1581-1588
-
(2009)
Blood
, vol.113
, pp. 1581-1588
-
-
Bashey, A.1
-
140
-
-
37349072460
-
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
Yang JC et al (2007) Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother 30:825-830
-
(2007)
J Immunother
, vol.30
, pp. 825-830
-
-
Yang, J.C.1
-
141
-
-
77958050577
-
Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
-
Royal RE et al (2010) Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J Immunother 33:828-833
-
(2010)
J Immunother
, vol.33
, pp. 828-833
-
-
Royal, R.E.1
-
142
-
-
54449091476
-
CTLA-4 blockade increases IFNgamma-producing CD4 + ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
-
Liakou CI et al (2008) CTLA-4 blockade increases IFNgamma-producing CD4 + ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci USA 105:14987-14992
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14987-14992
-
-
Liakou, C.I.1
-
143
-
-
62449309334
-
Anti-CTLA-4 therapy results in higher CD4 + ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues
-
Chen H et al (2009) Anti-CTLA-4 therapy results in higher CD4 + ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues. Proc Natl Acad Sci USA 106:2729-2734
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2729-2734
-
-
Chen, H.1
-
144
-
-
77952337834
-
Preoperative CTLA-4 blockade: Tolerability and immune monitoring in the setting of a presurgical clinical trial
-
Carthon BC et al (2010) Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res 16:2861-2871
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2861-2871
-
-
Carthon, B.C.1
-
145
-
-
33646886997
-
Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma
-
Reuben JM et al (2006) Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma. Cancer 106:2437-2444
-
(2006)
Cancer
, vol.106
, pp. 2437-2444
-
-
Reuben, J.M.1
-
146
-
-
61449090474
-
Phase I/II trial of tremelimumab in patients with metastatic melanoma
-
Camacho LH et al (2009) Phase I/II trial of tremelimumab in patients with metastatic melanoma. J Clin Oncol 27:1075-1081
-
(2009)
J Clin Oncol
, vol.27
, pp. 1075-1081
-
-
Camacho, L.H.1
-
147
-
-
76049092889
-
Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma
-
Kirkwood JM et al (2010) Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. Clin Cancer Res 16:1042-1048
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1042-1048
-
-
Kirkwood, J.M.1
-
148
-
-
84929561517
-
Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide or dacar-bazine) in patients with advanced melanoma [abstract LBA9011]
-
Ribas, A., et al. (2009) Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide or dacar-bazine) in patients with advanced melanoma [abstract LBA9011]. J Clin Oncol 26 (Suppl.)
-
(2009)
J Clin Oncol
, vol.26
-
-
Ribas, A.1
-
149
-
-
78649237899
-
Evaluation of baseline serum C-reactive protein (CRP) and benefit from tremelimumab compared to chemotherapy in first-line melanoma
-
abstr 2609
-
Marshall MA, Ribas A, Huang B (2010) Evaluation of baseline serum C-reactive protein (CRP) and benefit from tremelimumab compared to chemotherapy in first-line melanoma. J Clin Oncol 28:15s (suppl; abstr 2609)
-
(2010)
J Clin Oncol
, vol.28
, pp. 15s
-
-
Marshall, M.A.1
Ribas, A.2
Huang, B.3
-
150
-
-
77954230122
-
Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells
-
Vonderheide RH et al (2010) Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells. Clin Cancer Res 16:3485-3494
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3485-3494
-
-
Vonderheide, R.H.1
-
151
-
-
76749084659
-
Randomized phase II clinical trial comparing tremelimumab (CP-675,206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NON-SMALL CELL LUNG CANCER)
-
abstr 8071
-
Zatloukal P et al (2009) Randomized phase II clinical trial comparing tremelimumab (CP-675,206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NON-SMALL CELL LUNG CANCER). J Clin Oncol 27:15s (suppl; abstr 8071)
-
(2009)
J Clin Oncol
, vol.27
, pp. 15s
-
-
Zatloukal, P.1
-
152
-
-
79551717184
-
Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
-
Rini BI et al (2011) Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer 117:758-767
-
(2011)
Cancer
, vol.117
, pp. 758-767
-
-
Rini, B.I.1
-
153
-
-
49249127442
-
Alpha-CTLA-4 mAb-associated panenteritis: A histologic and immunohistochemical analysis
-
Oble DA et al (2008) Alpha-CTLA-4 mAb-associated panenteritis: A histologic and immunohistochemical analysis. Am J Surg Pathol 32:1130-1137
-
(2008)
Am J Surg Pathol
, vol.32
, pp. 1130-1137
-
-
Oble, D.A.1
-
154
-
-
78449244037
-
The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications
-
Di Giacomo AM, Biagioli M, Maio M (2010) The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications. Semin Oncol 37:499-507
-
(2010)
Semin Oncol
, vol.37
, pp. 499-507
-
-
Di Giacomo, A.M.1
Biagioli, M.2
Maio, M.3
-
155
-
-
33744792341
-
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
-
Beck KE et al (2006) Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol 24:2283-2289
-
(2006)
J Clin Oncol
, vol.24
, pp. 2283-2289
-
-
Beck, K.E.1
-
156
-
-
61349114199
-
Ipilimumab: Controversies in its development, utility and autoimmune adverse events
-
Weber J (2009) Ipilimumab: controversies in its development, utility and autoimmune adverse events. Cancer Immunol Immunother 58:823-830
-
(2009)
Cancer Immunol Immunother
, vol.58
, pp. 823-830
-
-
Weber, J.1
-
157
-
-
27444440093
-
Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
-
Blansfield JA et al (2005) Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother 28:593-598
-
(2005)
J Immunother
, vol.28
, pp. 593-598
-
-
Blansfield, J.A.1
-
158
-
-
77949274549
-
Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: Serious immune related adverse events across a spectrum of cancer subtypes
-
Dillard T, Yedinak CG, Alumkal J, Fleseriu M (2010) Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes. Pituitary 13:29-38
-
(2010)
Pituitary
, vol.13
, pp. 29-38
-
-
Dillard, T.1
Yedinak, C.G.2
Alumkal, J.3
Fleseriu, M.4
-
159
-
-
10744222813
-
Immunization of patients with metastatic melanoma using both class Iand class II-restricted peptides from melanoma-associated antigens
-
Phan GQ et al (2003) Immunization of patients with metastatic melanoma using both class Iand class II-restricted peptides from melanoma-associated antigens. J Immunother 26:349-356
-
(2003)
J Immunother
, vol.26
, pp. 349-356
-
-
Phan, G.Q.1
-
160
-
-
77950258677
-
Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: Lymphocyte count after 2 doses correlates with survival
-
Ku GY et al (2010) Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival. Cancer 116:1767-1775
-
(2010)
Cancer
, vol.116
, pp. 1767-1775
-
-
Ku, G.Y.1
-
161
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
Wolchok JD et al (2009) Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 15:7412-7420
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
-
162
-
-
77950285080
-
Association of peripheral blood absolute lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab [abstract]
-
Berman D et al (2009) Association of peripheral blood absolute lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab [abstract]. J Clin Oncol 27:3020
-
(2009)
J Clin Oncol
, vol.27
, pp. 3020
-
-
Berman, D.1
-
163
-
-
78449244712
-
CTLA-4 blockade with ipilimumab increases peripheral CD8+ T cells: Correlation with clinical outcomes [abstract]
-
Yang A et al (2010) CTLA-4 blockade with ipilimumab increases peripheral CD8+ T cells: correlation with clinical outcomes [abstract]. J Clin Oncol 28:2555
-
(2010)
J Clin Oncol
, vol.28
, pp. 2555
-
-
Yang, A.1
-
164
-
-
58149483422
-
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
-
Yuan J et al (2008) CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. Proc Natl Acad Sci USA 105:20410-20415
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 20410-20415
-
-
Yuan, J.1
-
165
-
-
0026700235
-
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
-
Ishida Y, Agata Y, Shibahara K, Honjo T (1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 11:3887-3895
-
(1992)
EMBO J
, vol.11
, pp. 3887-3895
-
-
Ishida, Y.1
Agata, Y.2
Shibahara, K.3
Honjo, T.4
-
166
-
-
0030005099
-
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
-
Agata Y et al (1996) Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol 8:765-772
-
(1996)
Int Immunol
, vol.8
, pp. 765-772
-
-
Agata, Y.1
-
167
-
-
33749338938
-
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
-
Petrovas C et al (2006) PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 203:2281-2292
-
(2006)
J Exp Med
, vol.203
, pp. 2281-2292
-
-
Petrovas, C.1
-
168
-
-
12144290320
-
Structural and functional analysis of the co-stimulatory receptor programmed death-1
-
Zhang X et al (2004) Structural and functional analysis of the co-stimulatory receptor programmed death-1. Immunity 20:337-347
-
(2004)
Immunity
, vol.20
, pp. 337-347
-
-
Zhang, X.1
-
169
-
-
0030845707
-
The human PD-1 gene: Complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors
-
Finger LR et al (1997) The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors. Gene 197:177-187
-
(1997)
Gene
, vol.197
, pp. 177-187
-
-
Finger, L.R.1
-
170
-
-
0028081358
-
Structure and chromosomal localization of the human PD-1 gene (PDCD1)
-
Shinohara T, Taniwaki M, Ishida Y, Kawaichi M, Honjo T (1994) Structure and chromosomal localization of the human PD-1 gene (PDCD1). Genomics 23:704-706
-
(1994)
Genomics
, vol.23
, pp. 704-706
-
-
Shinohara, T.1
Taniwaki, M.2
Ishida, Y.3
Kawaichi, M.4
Honjo, T.5
-
171
-
-
0032736029
-
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
-
Dong H, Zhu G, Tamada K, Chen L (1999) B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 5:1365-1369
-
(1999)
Nat Med
, vol.5
, pp. 1365-1369
-
-
Dong, H.1
Zhu, G.2
Tamada, K.3
Chen, L.4
-
172
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman GJ et al (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192:1027-1034
-
(2000)
J Exp Med
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
-
173
-
-
0037111483
-
Expression of programmed death 1 ligands by murine T cells and APC
-
Yamazaki T et al (2002) Expression of programmed death 1 ligands by murine T cells and APC. J Immunol 169:5538-5545
-
(2002)
J Immunol
, vol.169
, pp. 5538-5545
-
-
Yamazaki, T.1
-
174
-
-
4444355857
-
Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: Relevance for the immune modulatory effect in multiple sclerosis
-
Schreiner B et al (2004) Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. J Neuroimmunol 155:172-182
-
(2004)
J Neuroimmunol
, vol.155
, pp. 172-182
-
-
Schreiner, B.1
-
175
-
-
0037152153
-
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
-
Ishida M et al (2002) Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol Lett 84:57-62
-
(2002)
Immunol Lett
, vol.84
, pp. 57-62
-
-
Ishida, M.1
-
176
-
-
0242442492
-
Expression of the B7-related molecule B7-H1 by glioma cells: A potential mechanism of immune paralysis
-
Wintterle S et al (2003) Expression of the B7-related molecule B7-H1 by glioma cells: A potential mechanism of immune paralysis. Cancer Res 63:7462-7467
-
(2003)
Cancer Res
, vol.63
, pp. 7462-7467
-
-
Wintterle, S.1
-
177
-
-
20244384862
-
Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
-
Ohigashi Y et al (2005) Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res 11:2947-2953
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2947-2953
-
-
Ohigashi, Y.1
-
178
-
-
10344220548
-
Co-stimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
-
Thompson RH et al (2004) Co-stimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci USA 101:17174-17179
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 17174-17179
-
-
Thompson, R.H.1
-
179
-
-
34347400169
-
Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway
-
Liu J et al (2007) Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood 110:296-304
-
(2007)
Blood
, vol.110
, pp. 296-304
-
-
Liu, J.1
-
180
-
-
33846118474
-
Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
-
Parsa AT et al (2007) Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med 13:84-88
-
(2007)
Nat Med
, vol.13
, pp. 84-88
-
-
Parsa, A.T.1
-
181
-
-
33847611968
-
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
-
Hamanishi J et al (2007) Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci USA 104:3360-3365
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 3360-3365
-
-
Hamanishi, J.1
-
182
-
-
34247113727
-
PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: Associations with localized stage progression
-
Inman BA et al (2007) PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression. Cancer 109:1499-1505
-
(2007)
Cancer
, vol.109
, pp. 1499-1505
-
-
Inman, B.A.1
-
183
-
-
4243096258
-
B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
-
Konishi J et al (2004) B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res 10:5094-5100
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5094-5100
-
-
Konishi, J.1
-
184
-
-
34248586083
-
Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers
-
Nakanishi J et al (2007) Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers. Cancer Immunol Immunother 56:1173-1182
-
(2007)
Cancer Immunol Immunother
, vol.56
, pp. 1173-1182
-
-
Nakanishi, J.1
-
185
-
-
34247532726
-
Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
-
Nomi T et al (2007) Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 13:2151-2157
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2151-2157
-
-
Nomi, T.1
-
186
-
-
33745491116
-
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
-
Wu C et al (2006) Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem 108:19-24
-
(2006)
Acta Histochem
, vol.108
, pp. 19-24
-
-
Wu, C.1
-
188
-
-
0036549835
-
Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells
-
Eppihimer MJ et al (2002) Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells. Microcirculation 9:133-145
-
(2002)
Microcirculation
, vol.9
, pp. 133-145
-
-
Eppihimer, M.J.1
-
189
-
-
31444451661
-
Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274)
-
Lee SJ et al (2006) Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274). FEBS Lett 580:755-762
-
(2006)
FEBS Lett
, vol.580
, pp. 755-762
-
-
Lee, S.J.1
-
190
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
Latchman Y et al (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2:261-268
-
(2001)
Nat Immunol
, vol.2
, pp. 261-268
-
-
Latchman, Y.1
-
191
-
-
0035794314
-
B7-DC, a new dendritic cell molecule with potent co-stimulatory properties for T cells
-
Tseng SY et al (2001) B7-DC, a new dendritic cell molecule with potent co-stimulatory properties for T cells. J Exp Med 193:839-846
-
(2001)
J Exp Med
, vol.193
, pp. 839-846
-
-
Tseng, S.Y.1
-
192
-
-
32044471903
-
Mast cells enhance T cell activation: Importance of mast cell co-stimulatory molecules and secreted TNF
-
Nakae S et al (2006) Mast cells enhance T cell activation: importance of mast cell co-stimulatory molecules and secreted TNF. J Immunol 176:2238-2248
-
(2006)
J Immunol
, vol.176
, pp. 2238-2248
-
-
Nakae, S.1
-
193
-
-
34548810934
-
PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding
-
Zhong X, Tumang JR, Gao W, Bai C, Rothstein TL (2007) PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding. Eur J Immunol 37:2405-2410
-
(2007)
Eur J Immunol
, vol.37
, pp. 2405-2410
-
-
Zhong, X.1
Tumang, J.R.2
Gao, W.3
Bai, C.4
Rothstein, T.L.5
-
194
-
-
0038302927
-
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
-
Loke P, Allison JP (2003) PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci USA 100:5336-5341
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5336-5341
-
-
Loke, P.1
Allison, J.P.2
-
195
-
-
0036207926
-
PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2
-
Carter L et al (2002) PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur J Immunol 32:634-643
-
(2002)
Eur J Immunol
, vol.32
, pp. 634-643
-
-
Carter, L.1
-
196
-
-
0037438490
-
Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: Attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses
-
Bennett F et al (2003) Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. J Immunol 170:711-718
-
(2003)
J Immunol
, vol.170
, pp. 711-718
-
-
Bennett, F.1
-
197
-
-
29744462591
-
PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion
-
Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML (2005) PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion. Eur J Immunol 35:3561-3569
-
(2005)
Eur J Immunol
, vol.35
, pp. 3561-3569
-
-
Saunders, P.A.1
Hendrycks, V.R.2
Lidinsky, W.A.3
Woods, M.L.4
-
198
-
-
49249089425
-
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
-
Fife BT, Bluestone JA (2008) Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev 224:166-182
-
(2008)
Immunol Rev
, vol.224
, pp. 166-182
-
-
Fife, B.T.1
Bluestone, J.A.2
-
199
-
-
33745736420
-
T-cell tolerance or function is determined by combinatorial co-stimulatory signals
-
Nurieva R et al (2006) T-cell tolerance or function is determined by combinatorial co-stimulatory signals. EMBO J 25:2623-2633
-
(2006)
EMBO J
, vol.25
, pp. 2623-2633
-
-
Nurieva, R.1
-
200
-
-
0035923535
-
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
-
Okazaki T, Maeda A, Nishimura H, Kurosaki T, Honjo T (2001) PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl Acad Sci USA 98:13866-13871
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13866-13871
-
-
Okazaki, T.1
Maeda, A.2
Nishimura, H.3
Kurosaki, T.4
Honjo, T.5
-
201
-
-
3142688997
-
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
-
Chemnitz JM, Parry RV, Nichols KE, June CH, Riley JL (2004) SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol 173:945-954
-
(2004)
J Immunol
, vol.173
, pp. 945-954
-
-
Chemnitz, J.M.1
Parry, R.V.2
Nichols, K.E.3
June, C.H.4
Riley, J.L.5
-
202
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
Parry RV et al (2005) CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol 25:9543-9553
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9543-9553
-
-
Parry, R.V.1
-
203
-
-
4444317516
-
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
-
Sheppard KA et al (2004) PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett 574:37-41
-
(2004)
FEBS Lett
, vol.574
, pp. 37-41
-
-
Sheppard, K.A.1
-
204
-
-
36749010774
-
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
-
Pentcheva-Hoang T, Chen L, Pardoll DM, Allison JP (2007) Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability. Proc Natl Acad Sci USA 104:17765-17770
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 17765-17770
-
-
Pentcheva-Hoang, T.1
Chen, L.2
Pardoll, D.M.3
Allison, J.P.4
-
205
-
-
0037131988
-
Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells
-
Nguyen LT et al (2002) Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells. J Exp Med 196:1393-1398
-
(2002)
J Exp Med
, vol.196
, pp. 1393-1398
-
-
Nguyen, L.T.1
-
206
-
-
0037442244
-
Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells
-
Radhakrishnan S et al (2003) Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells. J Immunol 170:1830-1838
-
(2003)
J Immunol
, vol.170
, pp. 1830-1838
-
-
Radhakrishnan, S.1
-
207
-
-
33748881940
-
Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation
-
Kuipers H et al (2006) Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation. Eur J Immunol 36:2472-2482
-
(2006)
Eur J Immunol
, vol.36
, pp. 2472-2482
-
-
Kuipers, H.1
-
208
-
-
33644853625
-
Immunomodulation using the recombinant monoclonal human B7-DC cross-linking antibody rHIgM12
-
Van Keulen VP et al (2006) Immunomodulation using the recombinant monoclonal human B7-DC cross-linking antibody rHIgM12. Clin Exp Immunol 143:314-321
-
(2006)
Clin Exp Immunol
, vol.143
, pp. 314-321
-
-
Van Keulen, V.P.1
-
209
-
-
85168571519
-
Induction of a gene expression program in dendritic cells with a crosslinking IgM antibody to the co-stimulatory molecule B7-DC
-
Blocki FA et al (2006) Induction of a gene expression program in dendritic cells with a crosslinking IgM antibody to the co-stimulatory molecule B7-DC. FASEB J 20:2408-2410
-
(2006)
FASEB J
, vol.20
, pp. 2408-2410
-
-
Blocki, F.A.1
-
210
-
-
34447646310
-
Programmed death-1 ligand 1 interacts specifically with the B7-1 co-stimulatory molecule to inhibit T cell responses
-
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ (2007) Programmed death-1 ligand 1 interacts specifically with the B7-1 co-stimulatory molecule to inhibit T cell responses. Immunity 27:111-122
-
(2007)
Immunity
, vol.27
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
211
-
-
0035846991
-
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
-
Nishimura H et al (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291:319-322
-
(2001)
Science
, vol.291
, pp. 319-322
-
-
Nishimura, H.1
-
212
-
-
0033180181
-
Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
-
Nishimura H, Nose M, Hiai H, Minato N, Honjo T (1999) Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11:141-151
-
(1999)
Immunity
, vol.11
, pp. 141-151
-
-
Nishimura, H.1
Nose, M.2
Hiai, H.3
Minato, N.4
Honjo, T.5
-
213
-
-
3242677686
-
PD-L1-deficient mice show that PD-L1 on T cells, antigenpresenting cells, and host tissues negatively regulates T cells
-
Latchman YE et al (2004) PD-L1-deficient mice show that PD-L1 on T cells, antigenpresenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci USA 101:10691-10696
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10691-10696
-
-
Latchman, Y.E.1
-
214
-
-
1642306942
-
B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes
-
Dong H et al (2004) B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity 20:327-336
-
(2004)
Immunity
, vol.20
, pp. 327-336
-
-
Dong, H.1
-
215
-
-
0037477605
-
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
-
Ansari MJ et al (2003) The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med 198:63-69
-
(2003)
J Exp Med
, vol.198
, pp. 63-69
-
-
Ansari, M.J.1
-
216
-
-
0037477604
-
Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis
-
Salama AD et al (2003) Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J Exp Med 198:71-78
-
(2003)
J Exp Med
, vol.198
, pp. 71-78
-
-
Salama, A.D.1
-
217
-
-
23844529169
-
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type i diabetes
-
Wang J et al (2005) Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes. Proc Natl Acad Sci USA 102:11823-11828
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 11823-11828
-
-
Wang, J.1
-
218
-
-
27644562256
-
Co-stimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma
-
Thompson RH et al (2005) Co-stimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma. Cancer 104:2084-2091
-
(2005)
Cancer
, vol.104
, pp. 2084-2091
-
-
Thompson, R.H.1
-
219
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong H et al (2002) Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat Med 8:793-800
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
-
220
-
-
0037307930
-
Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production
-
Brown JA et al (2003) Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 170:1257-1266
-
(2003)
J Immunol
, vol.170
, pp. 1257-1266
-
-
Brown, J.A.1
-
221
-
-
33645736792
-
Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
-
Thompson RH et al (2006) Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 66:3381-3385
-
(2006)
Cancer Res
, vol.66
, pp. 3381-3385
-
-
Thompson, R.H.1
-
222
-
-
45049087313
-
Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia
-
Xerri L et al (2008) Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Hum Pathol 39:1050-1058
-
(2008)
Hum Pathol
, vol.39
, pp. 1050-1058
-
-
Xerri, L.1
-
223
-
-
33746877544
-
Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma
-
Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ (2006) Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 30:802-810
-
(2006)
Am J Surg Pathol
, vol.30
, pp. 802-810
-
-
Dorfman, D.M.1
Brown, J.A.2
Shahsafaei, A.3
Freeman, G.J.4
-
224
-
-
0141672946
-
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma
-
Rosenwald A et al (2003) Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma. J Exp Med 198:851-862
-
(2003)
J Exp Med
, vol.198
, pp. 851-862
-
-
Rosenwald, A.1
-
225
-
-
23844439584
-
Expression of functional B7-H2 and B7. 2 co-stimulatory molecules and their prognostic implications in de novo acute myeloid leukemia
-
Tamura H et al (2005) Expression of functional B7-H2 and B7.2 co-stimulatory molecules and their prognostic implications in de novo acute myeloid leukemia. Clin Cancer Res 11:5708-5717
-
(2005)
Clin Cancer Res
, vol.11
, pp. 5708-5717
-
-
Tamura, H.1
-
226
-
-
0037126021
-
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
-
Iwai Y et al (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 99:12293-12297
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12293-12297
-
-
Iwai, Y.1
-
227
-
-
25144522150
-
B7-H1 glycoprotein blockade: A novel strategy to enhance immunotherapy in patients with renal cell carcinoma
-
Thompson RH et al (2005) B7-H1 glycoprotein blockade: A novel strategy to enhance immunotherapy in patients with renal cell carcinoma. Urology 66:10-14
-
(2005)
Urology
, vol.66
, pp. 10-14
-
-
Thompson, R.H.1
-
228
-
-
34848900497
-
Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs
-
Wong RM et al (2007) Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs. Int Immunol 19:1223-1234
-
(2007)
Int Immunol
, vol.19
, pp. 1223-1234
-
-
Wong, R.M.1
-
229
-
-
66949111877
-
PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients
-
Fourcade J et al (2009) PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients. J Immunol 182:5240-5249
-
(2009)
J Immunol
, vol.182
, pp. 5240-5249
-
-
Fourcade, J.1
-
230
-
-
77952343328
-
Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
-
Matsuzaki J et al (2010) Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc Natl Acad Sci USA 107:7875-7880
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 7875-7880
-
-
Matsuzaki, J.1
-
231
-
-
70349569569
-
Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
-
Ahmadzadeh M et al (2009) Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 114:1537-1544
-
(2009)
Blood
, vol.114
, pp. 1537-1544
-
-
Ahmadzadeh, M.1
-
232
-
-
0141953992
-
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma
-
Strome SE et al (2003) B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Res 63:6501-6505
-
(2003)
Cancer Res
, vol.63
, pp. 6501-6505
-
-
Strome, S.E.1
-
233
-
-
0842325739
-
PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells
-
Blank C et al (2004) PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res 64:1140-1145
-
(2004)
Cancer Res
, vol.64
, pp. 1140-1145
-
-
Blank, C.1
-
234
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano F et al (2005) Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 65:1089-1096
-
(2005)
Cancer Res
, vol.65
, pp. 1089-1096
-
-
Hirano, F.1
-
235
-
-
0038273853
-
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
-
Curiel TJ et al (2003) Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 9:562-567
-
(2003)
Nat Med
, vol.9
, pp. 562-567
-
-
Curiel, T.J.1
-
236
-
-
13844294372
-
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
-
Iwai Y, Terawaki S, Honjo T (2005) PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int Immunol 17:133-144
-
(2005)
Int Immunol
, vol.17
, pp. 133-144
-
-
Iwai, Y.1
Terawaki, S.2
Honjo, T.3
-
237
-
-
3142721882
-
Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity
-
Radhakrishnan S et al (2004) Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity. Cancer Res 64:4965-4972
-
(2004)
Cancer Res
, vol.64
, pp. 4965-4972
-
-
Radhakrishnan, S.1
-
238
-
-
27644461382
-
Investigation on the effects of soluble programmed death-1 (sPD-1) enhancing anti-tumor immune response
-
Yuan Y et al (2004) Investigation on the effects of soluble programmed death-1 (sPD-1) enhancing anti-tumor immune response. J Huazhong Univ Sci Technolog Med Sci 24:531-534
-
(2004)
J Huazhong Univ Sci Technolog Med Sci
, vol.24
, pp. 531-534
-
-
Yuan, Y.1
-
239
-
-
6344240464
-
Blocking programmed death-1 ligand-PD-1 interactions by local gene therapy results in enhancement of antitumor effect of secondary lymphoid tissue chemokine
-
He YF et al (2004) Blocking programmed death-1 ligand-PD-1 interactions by local gene therapy results in enhancement of antitumor effect of secondary lymphoid tissue chemokine. J Immunol 173:4919-4928
-
(2004)
J Immunol
, vol.173
, pp. 4919-4928
-
-
He, Y.F.1
-
240
-
-
77957747417
-
Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia
-
Zhou Q et al (2010) Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood 116:2484-2493
-
(2010)
Blood
, vol.116
, pp. 2484-2493
-
-
Zhou, Q.1
-
241
-
-
77749279776
-
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
-
Curran MA, Montalvo W, Yagita H, Allison JP (2010) PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci USA 107:4275-4280
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 4275-4280
-
-
Curran, M.A.1
Montalvo, W.2
Yagita, H.3
Allison, J.P.4
-
242
-
-
38449107219
-
Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine
-
Webster WS et al (2007) Targeting molecular and cellular inhibitory mechanisms for improvement of antitumor memory responses reactivated by tumor cell vaccine. J Immunol 179:2860-2869
-
(2007)
J Immunol
, vol.179
, pp. 2860-2869
-
-
Webster, W.S.1
-
243
-
-
63449124514
-
Anti-programmed death-1 synergizes with granulocyte macrophage colonystimulating factor-secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors
-
Li B et al (2009) Anti-programmed death-1 synergizes with granulocyte macrophage colonystimulating factor-secreting tumor cell immunotherapy providing therapeutic benefit to mice with established tumors. Clin Cancer Res 15:1623-1634
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1623-1634
-
-
Li, B.1
-
244
-
-
77951637543
-
Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma
-
Pilon-Thomas S, Mackay A, Vohra N, Mule JJ (2010) Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma. J Immunol 184:3442-3449
-
(2010)
J Immunol
, vol.184
, pp. 3442-3449
-
-
Pilon-Thomas, S.1
Mackay, A.2
Vohra, N.3
Mule, J.J.4
-
245
-
-
49649114804
-
Phase i safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger R et al (2008) Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 14:3044-3051
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3044-3051
-
-
Berger, R.1
-
246
-
-
0029072123
-
Activation of human lymphocytes by a monoclonal antibody to B lymphoblastoid cells; Molecular mass and distribution of binding protein
-
Hardy B, Galli M, Rivlin E, Goren L, Novogrodsky A (1995) Activation of human lymphocytes by a monoclonal antibody to B lymphoblastoid cells; molecular mass and distribution of binding protein. Cancer Immunol Immunother 40:376-382
-
(1995)
Cancer Immunol Immunother
, vol.40
, pp. 376-382
-
-
Hardy, B.1
Galli, M.2
Rivlin, E.3
Goren, L.4
Novogrodsky, A.5
-
247
-
-
0030903694
-
A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice
-
Hardy B, Kovjazin R, Raiter A, Ganor N, Novogrodsky A (1997) A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice. Proc Natl Acad Sci USA 94:5756-5760
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5756-5760
-
-
Hardy, B.1
Kovjazin, R.2
Raiter, A.3
Ganor, N.4
Novogrodsky, A.5
-
248
-
-
0028073505
-
A monoclonal antibody against a human B lymphoblastoid cell line induces tumor regression in mice
-
Hardy B, Yampolski I, Kovjazin R, Galli M, Novogrodsky A (1994) A monoclonal antibody against a human B lymphoblastoid cell line induces tumor regression in mice. Cancer Res 54:5793-5796
-
(1994)
Cancer Res
, vol.54
, pp. 5793-5796
-
-
Hardy, B.1
Yampolski, I.2
Kovjazin, R.3
Galli, M.4
Novogrodsky, A.5
-
249
-
-
77954899030
-
Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR et al (2010) Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28:3167-3175
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
-
250
-
-
78449243489
-
Immune checkpoint proteins: A new therapeutic paradigm for cancerpreclinical background: CTLA-4 and PD-1 blockade
-
Weber J (2010) Immune checkpoint proteins: A new therapeutic paradigm for cancerpreclinical background: CTLA-4 and PD-1 blockade. Semin Oncol 37:430-439
-
(2010)
Semin Oncol
, vol.37
, pp. 430-439
-
-
Weber, J.1
-
251
-
-
0037810670
-
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
-
Watanabe N et al (2003) BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 4:670-679
-
(2003)
Nat Immunol
, vol.4
, pp. 670-679
-
-
Watanabe, N.1
-
252
-
-
2442477456
-
An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection
-
Han P, Goularte OD, Rufner K, Wilkinson B, Kaye J (2004) An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection. J Immunol 172:5931-5939
-
(2004)
J Immunol
, vol.172
, pp. 5931-5939
-
-
Han, P.1
Goularte, O.D.2
Rufner, K.3
Wilkinson, B.4
Kaye, J.5
-
253
-
-
14844357247
-
B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells
-
Hurchla MA et al (2005) B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells. J Immunol 174:3377-3385
-
(2005)
J Immunol
, vol.174
, pp. 3377-3385
-
-
Hurchla, M.A.1
-
255
-
-
33646171259
-
Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells
-
Otsuki N, Kamimura Y, Hashiguchi M, Azuma M (2006) Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. Biochem Biophys Res Commun 344:1121-1127
-
(2006)
Biochem Biophys Res Commun
, vol.344
, pp. 1121-1127
-
-
Otsuki, N.1
Kamimura, Y.2
Hashiguchi, M.3
Azuma, M.4
-
256
-
-
0344495270
-
Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2
-
Gavrieli M, Watanabe N, Loftin SK, Murphy TL, Murphy KM (2003) Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. Biochem Biophys Res Commun 312:1236-1243
-
(2003)
Biochem Biophys Res Commun
, vol.312
, pp. 1236-1243
-
-
Gavrieli, M.1
Watanabe, N.2
Loftin, S.K.3
Murphy, T.L.4
Murphy, K.M.5
-
257
-
-
19944433635
-
B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator
-
Sedy JR et al (2005) B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol 6:90-98
-
(2005)
Nat Immunol
, vol.6
, pp. 90-98
-
-
Sedy, J.R.1
-
258
-
-
0031907988
-
LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator
-
Mauri DN et al (1998) LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 8:21-30
-
(1998)
Immunity
, vol.8
, pp. 21-30
-
-
Mauri, D.N.1
-
259
-
-
0030298375
-
Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
-
Montgomery RI, Warner MS, Lum BJ, Spear PG (1996) Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87:427-436
-
(1996)
Cell
, vol.87
, pp. 427-436
-
-
Montgomery, R.I.1
Warner, M.S.2
Lum, B.J.3
Spear, P.G.4
-
260
-
-
0030920262
-
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5
-
Hsu H et al (1997) ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. J Biol Chem 272:13471-13474
-
(1997)
J Biol Chem
, vol.272
, pp. 13471-13474
-
-
Hsu, H.1
-
261
-
-
0030920913
-
Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1
-
Marsters SA et al (1997) Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. J Biol Chem 272:14029-14032
-
(1997)
J Biol Chem
, vol.272
, pp. 14029-14032
-
-
Marsters, S.A.1
-
262
-
-
0030984895
-
A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation
-
Kwon BS et al (1997) A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation. J Biol Chem 272:14272-14276
-
(1997)
J Biol Chem
, vol.272
, pp. 14272-14276
-
-
Kwon, B.S.1
-
263
-
-
0034667773
-
Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor
-
Morel Y et al (2000) Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. J Immunol 165:4397-4404
-
(2000)
J Immunol
, vol.165
, pp. 4397-4404
-
-
Morel, Y.1
-
264
-
-
10944229172
-
LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; A novel key partner in T cell-dependent B cell terminal differentiation
-
Duhen T et al (2004) LIGHT costimulates CD40 triggering and induces immunoglobulin secretion; a novel key partner in T cell-dependent B cell terminal differentiation. Eur J Immunol 34:3534-3541
-
(2004)
Eur J Immunol
, vol.34
, pp. 3534-3541
-
-
Duhen, T.1
-
265
-
-
15144341298
-
Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth
-
Harrop JA et al (1998) Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth. J Biol Chem 273:27548-27556
-
(1998)
J Biol Chem
, vol.273
, pp. 27548-27556
-
-
Harrop, J.A.1
-
266
-
-
17744403172
-
Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines
-
Harrop JA et al (1998) Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines. J Immunol 161:1786-1794
-
(1998)
J Immunol
, vol.161
, pp. 1786-1794
-
-
Harrop, J.A.1
-
267
-
-
0037124334
-
Targeted disruption of LIGHT causes defects in co-stimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis
-
Scheu S et al (2002) Targeted disruption of LIGHT causes defects in co-stimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis. J Exp Med 195:1613-1624
-
(2002)
J Exp Med
, vol.195
, pp. 1613-1624
-
-
Scheu, S.1
-
268
-
-
0035500289
-
The critical role of LIGHT, a TNF family member, in T cell development
-
Wang J et al (2001) The critical role of LIGHT, a TNF family member, in T cell development. J Immunol 167:5099-5105
-
(2001)
J Immunol
, vol.167
, pp. 5099-5105
-
-
Wang, J.1
-
269
-
-
0034117337
-
Modulation of T-cell-mediated immunity in tumor and graft-versushost disease models through the LIGHT co-stimulatory pathway
-
Tamada K et al (2000) Modulation of T-cell-mediated immunity in tumor and graft-versushost disease models through the LIGHT co-stimulatory pathway. Nat Med 6:283-289
-
(2000)
Nat Med
, vol.6
, pp. 283-289
-
-
Tamada, K.1
-
270
-
-
0034655166
-
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response
-
Tamada K et al (2000) LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response. J Immunol 164:4105-4110
-
(2000)
J Immunol
, vol.164
, pp. 4105-4110
-
-
Tamada, K.1
-
271
-
-
0033553489
-
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
-
Yu KY et al (1999) A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem 274:13733-13736
-
(1999)
J Biol Chem
, vol.274
, pp. 13733-13736
-
-
Yu, K.Y.1
-
272
-
-
0038658878
-
LIGHT-HVEM signaling and the regulation of T cellmediated immunity
-
Granger SW, Rickert S (2003) LIGHT-HVEM signaling and the regulation of T cellmediated immunity. Cytokine Growth Factor Rev 14:289-296
-
(2003)
Cytokine Growth Factor Rev
, vol.14
, pp. 289-296
-
-
Granger, S.W.1
Rickert, S.2
-
273
-
-
0035451607
-
The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity
-
Morel Y, Truneh A, Sweet RW, Olive D, Costello RT (2001) The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity. J Immunol 167:2479-2486
-
(2001)
J Immunol
, vol.167
, pp. 2479-2486
-
-
Morel, Y.1
Truneh, A.2
Sweet, R.W.3
Olive, D.4
Costello, R.T.5
-
274
-
-
0032530695
-
Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes
-
Anumanthan A et al (1998) Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol 161:2780-2790
-
(1998)
J Immunol
, vol.161
, pp. 2780-2790
-
-
Anumanthan, A.1
-
275
-
-
0027295531
-
A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity
-
Maiza H et al (1993) A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity. J Exp Med 178:1121-1126
-
(1993)
J Exp Med
, vol.178
, pp. 1121-1126
-
-
Maiza, H.1
-
276
-
-
25444496156
-
Murine CD160, Ig-like receptor on NK cells and NKT cells, recognizes classical and nonclassical MHC class i and regulates NK cell activation
-
MaedaMet al (2005) Murine CD160, Ig-like receptor on NK cells and NKT cells, recognizes classical and nonclassical MHC class I and regulates NK cell activation. J Immunol 175:4426-4432
-
(2005)
J Immunol
, vol.175
, pp. 4426-4432
-
-
Al, M.1
-
277
-
-
0033083193
-
Cutting edge: MHC class i triggering by a novel cell surface ligand costimulates proliferation of activated human T cells
-
Agrawal S et al (1999) Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J Immunol 162:1223-1226
-
(1999)
J Immunol
, vol.162
, pp. 1223-1226
-
-
Agrawal, S.1
-
278
-
-
0037168611
-
Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity
-
Le Bouteiller P et al (2002) Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity. Proc Natl Acad Sci USA 99:16963-16968
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16963-16968
-
-
Le Bouteiller, P.1
-
279
-
-
6344269330
-
Cutting edge: Engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset
-
Barakonyi A et al (2004) Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset. J Immunol 173:5349-5354
-
(2004)
J Immunol
, vol.173
, pp. 5349-5354
-
-
Barakonyi, A.1
-
280
-
-
77954674575
-
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
-
Bengsch B et al (2010) Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation. PLoS Pathog 6:e1000947
-
(2010)
PLoS Pathog
, vol.6
, pp. e1000947
-
-
Bengsch, B.1
-
281
-
-
38349149016
-
CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator
-
Cai G et al (2008) CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator. Nat Immunol 9:176-185
-
(2008)
Nat Immunol
, vol.9
, pp. 176-185
-
-
Cai, G.1
-
282
-
-
65349084376
-
The CD160, BTLA, LIGHT/HVEM pathway: A bidirectional switch regulating T-cell activation
-
Cai G, Freeman GJ (2009) The CD160, BTLA, LIGHT/HVEM pathway: A bidirectional switch regulating T-cell activation. Immunol Rev 229:244-258
-
(2009)
Immunol Rev
, vol.229
, pp. 244-258
-
-
Cai, G.1
Freeman, G.J.2
-
283
-
-
0036461018
-
The role of TNF receptor and TNF superfamily molecules in organ transplantation
-
Adams AB, Larsen CP, Pearson TC, Newell KA (2002) The role of TNF receptor and TNF superfamily molecules in organ transplantation. Am J Transplant 2:12-18
-
(2002)
Am J Transplant
, vol.2
, pp. 12-18
-
-
Adams, A.B.1
Larsen, C.P.2
Pearson, T.C.3
Newell, K.A.4
-
284
-
-
34047122672
-
CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment
-
Rabot M et al (2007) CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment. Int Immunol 19:401-409
-
(2007)
Int Immunol
, vol.19
, pp. 401-409
-
-
Rabot, M.1
-
285
-
-
27744512543
-
Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells
-
Krieg C, Han P, Stone R, Goularte OD, Kaye J (2005) Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells. J Immunol 175:6420-6427
-
(2005)
J Immunol
, vol.175
, pp. 6420-6427
-
-
Krieg, C.1
Han, P.2
Stone, R.3
Goularte, O.D.4
Kaye, J.5
-
286
-
-
59849096134
-
Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation
-
Giustiniani J, Bensussan A, Marie-Cardine A (2009) Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation. J Immunol 182:63-71
-
(2009)
J Immunol
, vol.182
, pp. 63-71
-
-
Giustiniani, J.1
Bensussan, A.2
Marie-Cardine, A.3
-
287
-
-
49449113696
-
Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator
-
Oya Y et al (2008) Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator. Arthritis Rheum 58:2498-2510
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2498-2510
-
-
Oya, Y.1
-
288
-
-
33646050660
-
Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation
-
Deppong C et al (2006) Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation. J Immunol 176:3909-3913
-
(2006)
J Immunol
, vol.176
, pp. 3909-3913
-
-
Deppong, C.1
-
289
-
-
33846479499
-
B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation
-
Krieg C, Boyman O, Fu YX, Kaye J (2007) B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation. Nat Immunol 8:162-171
-
(2007)
Nat Immunol
, vol.8
, pp. 162-171
-
-
Krieg, C.1
Boyman, O.2
Fu, Y.X.3
Kaye, J.4
-
290
-
-
65249168307
-
Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction
-
Liu X et al (2009) Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. J Immunol 182:4516-4520
-
(2009)
J Immunol
, vol.182
, pp. 4516-4520
-
-
Liu, X.1
-
291
-
-
0037128641
-
Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival
-
Ye Q et al (2002) Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J Exp Med 195:795-800
-
(2002)
J Exp Med
, vol.195
, pp. 795-800
-
-
Ye, Q.1
-
292
-
-
0037094087
-
Cutting edge: Selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT
-
Tamada K et al (2002) Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. J Immunol 168:4832-4835
-
(2002)
J Immunol
, vol.168
, pp. 4832-4835
-
-
Tamada, K.1
-
293
-
-
10744226848
-
LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function
-
Liu J et al (2003) LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function. Int Immunol 15:861-870
-
(2003)
Int Immunol
, vol.15
, pp. 861-870
-
-
Liu, J.1
-
294
-
-
0035660806
-
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT
-
Wang J et al (2001) The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest 108:1771-1780
-
(2001)
J Clin Invest
, vol.108
, pp. 1771-1780
-
-
Wang, J.1
-
295
-
-
11144357862
-
Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy
-
Wang J et al (2004) Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest 113:826-835
-
(2004)
J Clin Invest
, vol.113
, pp. 826-835
-
-
Wang, J.1
-
296
-
-
20044389839
-
The role of herpesvirus entry mediator as a negative regulator of T cellmediated responses
-
Wang Y et al (2005) The role of herpesvirus entry mediator as a negative regulator of T cellmediated responses. J Clin Invest 115:711-717
-
(2005)
J Clin Invest
, vol.115
, pp. 711-717
-
-
Wang, Y.1
-
297
-
-
0032530318
-
LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer
-
Zhai Y et al (1998) LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J Clin Invest 102:1142-1151
-
(1998)
J Clin Invest
, vol.102
, pp. 1142-1151
-
-
Zhai, Y.1
-
298
-
-
0346025546
-
Stimulation of non-Hodgkin's lymphoma via HVEM: An alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity
-
Costello RT et al (2003) Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity. Leukemia 17:2500-2507
-
(2003)
Leukemia
, vol.17
, pp. 2500-2507
-
-
Costello, R.T.1
-
299
-
-
78549281806
-
Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis
-
Cheung KJ et al (2010) Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis. Cancer Res 70:9166-9174
-
(2010)
Cancer Res
, vol.70
, pp. 9166-9174
-
-
Cheung, K.J.1
-
300
-
-
77951031861
-
CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia
-
Liu FT et al (2010) CD160 signaling mediates PI3K-dependent survival and growth signals in chronic lymphocytic leukemia. Blood 115:3079-3088
-
(2010)
Blood
, vol.115
, pp. 3079-3088
-
-
Liu, F.T.1
-
301
-
-
74949125667
-
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
-
Derre L et al (2010) BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J Clin Invest 120:157-167
-
(2010)
J Clin Invest
, vol.120
, pp. 157-167
-
-
Derre, L.1
-
302
-
-
74949088573
-
Putting the brakes on BTLA in T cell-mediated cancer immunotherapy
-
Paulos CM, June CH (2010) Putting the brakes on BTLA in T cell-mediated cancer immunotherapy. J Clin Invest 120:76-80
-
(2010)
J Clin Invest
, vol.120
, pp. 76-80
-
-
Paulos, C.M.1
June, C.H.2
-
303
-
-
49949152063
-
Targeting tumors with LIGHT to generate metastasis-clearing immunity
-
Yu P, Fu YX (2008) Targeting tumors with LIGHT to generate metastasis-clearing immunity. Cytokine Growth Factor Rev 19:285-294
-
(2008)
Cytokine Growth Factor Rev
, vol.19
, pp. 285-294
-
-
Yu, P.1
Fu, Y.X.2
-
304
-
-
10744227434
-
Priming of naive T cells inside tumors leads to eradication of established tumors
-
Yu P et al (2004) Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol 5:141-149
-
(2004)
Nat Immunol
, vol.5
, pp. 141-149
-
-
Yu, P.1
-
305
-
-
0034640539
-
The lymphotoxin-beta receptor is necessary and sufficient for LIGHTmediated apoptosis of tumor cells
-
Rooney IA et al (2000) The lymphotoxin-beta receptor is necessary and sufficient for LIGHTmediated apoptosis of tumor cells. J Biol Chem 275:14307-14315
-
(2000)
J Biol Chem
, vol.275
, pp. 14307-14315
-
-
Rooney, I.A.1
-
306
-
-
77952833756
-
Expression of LIGHT/TNFSF14 combined with vaccination against human papillomavirus Type 16 E7 induces significant tumor regression
-
Kanodia S et al (2010) Expression of LIGHT/TNFSF14 combined with vaccination against human papillomavirus Type 16 E7 induces significant tumor regression. Cancer Res 70:3955-3964
-
(2010)
Cancer Res
, vol.70
, pp. 3955-3964
-
-
Kanodia, S.1
-
307
-
-
34548646455
-
Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases
-
Yu P et al (2007) Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases. J Immunol 179:1960-1968
-
(2007)
J Immunol
, vol.179
, pp. 1960-1968
-
-
Yu, P.1
-
308
-
-
76249106207
-
Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo
-
Han L et al (2009) Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo. J Immunol 183:7842-7850
-
(2009)
J Immunol
, vol.183
, pp. 7842-7850
-
-
Han, L.1
-
309
-
-
0025338920
-
LAG-3, a novel lymphocyte activation gene closely related to CD4
-
Triebel F et al (1990) LAG-3, a novel lymphocyte activation gene closely related to CD4. J Exp Med 171:1393-1405
-
(1990)
J Exp Med
, vol.171
, pp. 1393-1405
-
-
Triebel, F.1
-
310
-
-
22544445249
-
Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells
-
Kisielow M, Kisielow J, Capoferri-Sollami G, Karjalainen K (2005) Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells. Eur J Immunol 35:2081-2088
-
(2005)
Eur J Immunol
, vol.35
, pp. 2081-2088
-
-
Kisielow, M.1
Kisielow, J.2
Capoferri-Sollami, G.3
Karjalainen, K.4
-
311
-
-
0027979962
-
Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand
-
Huard B, Gaulard P, Faure F, Hercend T, Triebel F (1994) Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand. Immunogenetics 39:213-217
-
(1994)
Immunogenetics
, vol.39
, pp. 213-217
-
-
Huard, B.1
Gaulard, P.2
Faure, F.3
Hercend, T.4
Triebel, F.5
-
312
-
-
0026681864
-
Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens
-
Baixeras E et al (1992) Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J Exp Med 176:327-337
-
(1992)
J Exp Med
, vol.176
, pp. 327-337
-
-
Baixeras, E.1
-
313
-
-
0029129218
-
CD4/major histocompatibility complex class II interaction analyzed with CD4-and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins
-
Huard B, Prigent P, Tournier M, Bruniquel D, Triebel F (1995) CD4/major histocompatibility complex class II interaction analyzed with CD4-and lymphocyte activation gene-3 (LAG-3)-Ig fusion proteins. Eur J Immunol 25:2718-2721
-
(1995)
Eur J Immunol
, vol.25
, pp. 2718-2721
-
-
Huard, B.1
Prigent, P.2
Tournier, M.3
Bruniquel, D.4
Triebel, F.5
-
314
-
-
0030902983
-
Characterization of the major histocompatibility complex class II binding site on LAG-3 protein
-
Huard B et al (1997) Characterization of the major histocompatibility complex class II binding site on LAG-3 protein. Proc Natl Acad Sci USA 94:5744-5749
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 5744-5749
-
-
Huard, B.1
-
315
-
-
0038068048
-
The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells
-
Workman CJ, Vignali DA (2003) The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 33:970-979
-
(2003)
Eur J Immunol
, vol.33
, pp. 970-979
-
-
Workman, C.J.1
Vignali, D.A.2
-
316
-
-
19544374904
-
The negative regulatory function of the lymphocyteactivation gene-3 co-receptor (CD223) on human T cells
-
Macon-Lemaitre L, Triebel F (2005) The negative regulatory function of the lymphocyteactivation gene-3 co-receptor (CD223) on human T cells. Immunology 115:170-178
-
(2005)
Immunology
, vol.115
, pp. 170-178
-
-
Macon-Lemaitre, L.1
Triebel, F.2
-
317
-
-
0032532284
-
CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling
-
Hannier S, Tournier M, Bismuth G, Triebel F (1998) CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling. J Immunol 161:4058-4065
-
(1998)
J Immunol
, vol.161
, pp. 4058-4065
-
-
Hannier, S.1
Tournier, M.2
Bismuth, G.3
Triebel, F.4
-
318
-
-
0030009494
-
Independent modes of natural killing distinguished in mice lacking Lag3
-
Miyazaki T, Dierich A, Benoist C, Mathis D (1996) Independent modes of natural killing distinguished in mice lacking Lag3. Science 272:405-408
-
(1996)
Science
, vol.272
, pp. 405-408
-
-
Miyazaki, T.1
Dierich, A.2
Benoist, C.3
Mathis, D.4
-
319
-
-
11844269957
-
Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223)
-
Workman CJ, Vignali DA (2005) Negative regulation of T cell homeostasis by lymphocyte activation gene-3 (CD223). J Immunol 174:688-695
-
(2005)
J Immunol
, vol.174
, pp. 688-695
-
-
Workman, C.J.1
Vignali, D.A.2
-
320
-
-
5644263642
-
Role of LAG-3 in regulatory T cells
-
Huang CT et al (2004) Role of LAG-3 in regulatory T cells. Immunity 21:503-513
-
(2004)
Immunity
, vol.21
, pp. 503-513
-
-
Huang, C.T.1
-
321
-
-
77953395286
-
LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites
-
Camisaschi C et al (2010) LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites. J Immunol 184:6545-6551
-
(2010)
J Immunol
, vol.184
, pp. 6545-6551
-
-
Camisaschi, C.1
-
322
-
-
34249944837
-
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4
-
Joosten SA et al (2007) Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4. Proc Natl Acad Sci USA 104:8029-8034
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8029-8034
-
-
Joosten, S.A.1
-
323
-
-
0037090060
-
Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223)
-
Andreae S, Piras F, Burdin N, Triebel F (2002) Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223). J Immunol 168:3874-3880
-
(2002)
J Immunol
, vol.168
, pp. 3874-3880
-
-
Andreae, S.1
Piras, F.2
Burdin, N.3
Triebel, F.4
-
324
-
-
0141790894
-
MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223)
-
Andreae S, Buisson S, Triebel F (2003) MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223). Blood 102:2130-2137
-
(2003)
Blood
, vol.102
, pp. 2130-2137
-
-
Andreae, S.1
Buisson, S.2
Triebel, F.3
-
325
-
-
44449110691
-
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II
-
Liang B et al (2008) Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol 180:5916-5926
-
(2008)
J Immunol
, vol.180
, pp. 5916-5926
-
-
Liang, B.1
-
326
-
-
33947655511
-
Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4 + CD25+ regulatory T cells
-
Bayry J, Triebel F, Kaveri SV, Tough DF (2007) Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4 + CD25+ regulatory T cells. J Immunol 178:4184-4193
-
(2007)
J Immunol
, vol.178
, pp. 4184-4193
-
-
Bayry, J.1
Triebel, F.2
Kaveri, S.V.3
Tough, D.F.4
-
327
-
-
36048963838
-
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems
-
Grosso JF et al (2007) LAG-3 regulates CD8+ T cell accumulation and effector function in murine self-and tumor-tolerance systems. J Clin Invest 117:3383-3392
-
(2007)
J Clin Invest
, vol.117
, pp. 3383-3392
-
-
Grosso, J.F.1
-
328
-
-
0034114926
-
A soluble lymphocyte activation gene-3 molecule used as a vaccine adjuvant elicits greater humoral and cellular immune responses to both particulate and soluble antigens
-
El Mir S, Triebel F (2000) A soluble lymphocyte activation gene-3 molecule used as a vaccine adjuvant elicits greater humoral and cellular immune responses to both particulate and soluble antigens. J Immunol 164:5583-5589
-
(2000)
J Immunol
, vol.164
, pp. 5583-5589
-
-
El Mir, S.1
Triebel, F.2
-
329
-
-
0032711858
-
Lymphocyte activation gene-3 induces tumor regression and antitumor immune responses
-
Prigent P, El Mir S, Dreano M, Triebel F (1999) Lymphocyte activation gene-3 induces tumor regression and antitumor immune responses. Eur J Immunol 29:3867-3876
-
(1999)
Eur J Immunol
, vol.29
, pp. 3867-3876
-
-
Prigent, P.1
El Mir, S.2
Dreano, M.3
Triebel, F.4
-
330
-
-
0038181120
-
LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice
-
Cappello P et al (2003) LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice. Cancer Res 63:2518-2525
-
(2003)
Cancer Res
, vol.63
, pp. 2518-2525
-
-
Cappello, P.1
-
332
-
-
35748957791
-
A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells
-
Brignone C, Grygar C, Marcu M, Schakel K, Triebel F (2007) A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells. J Immunol 179:4202-4211
-
(2007)
J Immunol
, vol.179
, pp. 4202-4211
-
-
Brignone, C.1
Grygar, C.2
Marcu, M.3
Schakel, K.4
Triebel, F.5
-
333
-
-
34248531949
-
IMP321 (sLAG-3) safety and T cell response potentiation using an influenza vaccine as a model antigen: A single-blind phase i study
-
Brignone C, Grygar C, Marcu M, Perrin G, Triebel F (2007) IMP321 (sLAG-3) safety and T cell response potentiation using an influenza vaccine as a model antigen: A single-blind phase I study. Vaccine 25:4641-4650
-
(2007)
Vaccine
, vol.25
, pp. 4641-4650
-
-
Brignone, C.1
Grygar, C.2
Marcu, M.3
Perrin, G.4
Triebel, F.5
-
334
-
-
34247266009
-
IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: A single blind randomised controlled phase i study
-
Brignone C, Grygar C, Marcu M, Perrin G, Triebel F (2007) IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: A single blind randomised controlled phase I study. J Immune Based Ther Vaccines 5:5
-
(2007)
J Immune Based Ther Vaccines
, vol.5
, pp. 5
-
-
Brignone, C.1
Grygar, C.2
Marcu, M.3
Perrin, G.4
Triebel, F.5
-
335
-
-
70349669259
-
A phase i pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma
-
Brignone C, Escudier B, Grygar C, Marcu M, Triebel F (2009) A phase I pharmacokinetic and biological correlative study of IMP321, a novel MHC class II agonist, in patients with advanced renal cell carcinoma. Clin Cancer Res 15:6225-6231
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6225-6231
-
-
Brignone, C.1
Escudier, B.2
Grygar, C.3
Marcu, M.4
Triebel, F.5
-
336
-
-
77955487541
-
First-line chemoimmunotherapy in metastatic breast carcinoma: Combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity
-
Brignone C et al (2010) First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity. J Transl Med 8:71
-
(2010)
J Transl Med
, vol.8
, pp. 71
-
-
Brignone, C.1
-
337
-
-
5844252552
-
B7-H3: A co-stimulatory molecule for T cell activation and IFNgamma production
-
Chapoval AI et al (2001) B7-H3: A co-stimulatory molecule for T cell activation and IFNgamma production. Nat Immunol 2:269-274
-
(2001)
Nat Immunol
, vol.2
, pp. 269-274
-
-
Chapoval, A.I.1
-
338
-
-
0037097801
-
Characterization of mouse and human B7-H3 genes
-
Sun M et al (2002) Characterization of mouse and human B7-H3 genes. J Immunol 168:6294-6297
-
(2002)
J Immunol
, vol.168
, pp. 6294-6297
-
-
Sun, M.1
-
339
-
-
0041381300
-
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses
-
Suh WK et al (2003) The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol 4:899-906
-
(2003)
Nat Immunol
, vol.4
, pp. 899-906
-
-
Suh, W.K.1
-
340
-
-
10744232878
-
Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains
-
Steinberger P et al (2004) Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J Immunol 172:2352-2359
-
(2004)
J Immunol
, vol.172
, pp. 2352-2359
-
-
Steinberger, P.1
-
341
-
-
33646485691
-
Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation
-
King RG, Herrin BR, Justement LB (2006) Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation. J Immunol 176:6012-6021
-
(2006)
J Immunol
, vol.176
, pp. 6012-6021
-
-
King, R.G.1
Herrin, B.R.2
Justement, L.B.3
-
342
-
-
0037331539
-
The human TREM gene cluster at 6p21. 1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44
-
Allcock RJ, Barrow AD, Forbes S, Beck S, Trowsdale J (2003) The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol 33:567-577
-
(2003)
Eur J Immunol
, vol.33
, pp. 567-577
-
-
Allcock, R.J.1
Barrow, A.D.2
Forbes, S.3
Beck, S.4
Trowsdale, J.5
-
343
-
-
33644520242
-
Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma
-
Tirapu I et al (2006) Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma. Cancer Res 66:2442-2450
-
(2006)
Cancer Res
, vol.66
, pp. 2442-2450
-
-
Tirapu, I.1
-
344
-
-
0038433329
-
B7S1, a novel B7 family member that negatively regulates T cell activation
-
Prasad DV, Richards S, Mai XM, Dong C (2003) B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18:863-873
-
(2003)
Immunity
, vol.18
, pp. 863-873
-
-
Prasad, D.V.1
Richards, S.2
Mai, X.M.3
Dong, C.4
-
345
-
-
14744305769
-
B7-H3 promotes acute and chronic allograft rejection
-
Wang L et al (2005) B7-H3 promotes acute and chronic allograft rejection. Eur J Immunol 35:428-438
-
(2005)
Eur J Immunol
, vol.35
, pp. 428-438
-
-
Wang, L.1
-
346
-
-
0038094524
-
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
-
Sica GL et al (2003) B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18:849-861
-
(2003)
Immunity
, vol.18
, pp. 849-861
-
-
Sica, G.L.1
-
347
-
-
0042337394
-
B7x: A widely expressed B7 family member that inhibits T cell activation
-
Zang X et al (2003) B7x: A widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci USA 100:10388-10392
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10388-10392
-
-
Zang, X.1
-
348
-
-
10744220428
-
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family
-
Choi IH et al (2003) Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. J Immunol 171:4650-4654
-
(2003)
J Immunol
, vol.171
, pp. 4650-4654
-
-
Choi, I.H.1
-
349
-
-
34548798737
-
Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma
-
Kryczek I et al (2007) Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Res 67:8900-8905
-
(2007)
Cancer Res
, vol.67
, pp. 8900-8905
-
-
Kryczek, I.1
-
350
-
-
33745317769
-
Cutting edge: Induction of B7-H4 on APCs through IL-10: Novel suppressive mode for regulatory T cells
-
Kryczek I et al (2006) Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. J Immunol 177:40-44
-
(2006)
J Immunol
, vol.177
, pp. 40-44
-
-
Kryczek, I.1
-
351
-
-
33645853780
-
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
-
Kryczek I et al (2006) B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. J Exp Med 203:871-881
-
(2006)
J Exp Med
, vol.203
, pp. 871-881
-
-
Kryczek, I.1
-
352
-
-
33747786345
-
Generation and characterization of B7-H4/B7S1/B7x-deficient mice
-
Suh WK et al (2006) Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol 26:6403-6411
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6403-6411
-
-
Suh, W.K.1
-
353
-
-
33745605153
-
B7-H3 and B7-H4 expression in non-small-cell lung cancer
-
Sun Y et al (2006) B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 53:143-151
-
(2006)
Lung Cancer
, vol.53
, pp. 143-151
-
-
Sun, Y.1
-
354
-
-
33745886516
-
B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival
-
Krambeck AE et al (2006) B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. Proc Natl Acad Sci USA 103:10391-10396
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10391-10396
-
-
Krambeck, A.E.1
-
355
-
-
52649160243
-
Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma
-
Crispen PL et al (2008) Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma. Clin Cancer Res 14:5150-5157
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5150-5157
-
-
Crispen, P.L.1
-
356
-
-
51049113616
-
Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage
-
Thompson RH et al (2008) Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage. Cancer Res 68:6054-6058
-
(2008)
Cancer Res
, vol.68
, pp. 6054-6058
-
-
Thompson, R.H.1
-
357
-
-
34548046956
-
B7-H3 ligand expression by prostate cancer: A novel marker of prognosis and potential target for therapy
-
Roth TJ et al (2007) B7-H3 ligand expression by prostate cancer: A novel marker of prognosis and potential target for therapy. Cancer Res 67:7893-7900
-
(2007)
Cancer Res
, vol.67
, pp. 7893-7900
-
-
Roth, T.J.1
-
358
-
-
37649013179
-
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
-
Zang X et al (2007) B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci USA 104:19458-19463
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19458-19463
-
-
Zang, X.1
-
359
-
-
77953229339
-
Clinical significance and regulation of the co-stimulatory molecule B7-H3 in human colorectal carcinoma
-
Sun J et al (2010) Clinical significance and regulation of the co-stimulatory molecule B7-H3 in human colorectal carcinoma. Cancer Immunol Immunother 59:1163-1171
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 1163-1171
-
-
Sun, J.1
-
360
-
-
34250183451
-
B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration
-
Miyatake T et al (2007) B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. Gynecol Oncol 106:119-127
-
(2007)
Gynecol Oncol
, vol.106
, pp. 119-127
-
-
Miyatake, T.1
-
361
-
-
29144453266
-
B7-H4 overexpression in ovarian tumors
-
Tringler B et al (2006) B7-H4 overexpression in ovarian tumors. Gynecol Oncol 100:44-52
-
(2006)
Gynecol Oncol
, vol.100
, pp. 44-52
-
-
Tringler, B.1
-
362
-
-
45549085243
-
Detection of B7-H4 and p53 in pancreatic cancer: Potential role as a cytological diagnostic adjunct
-
Awadallah NS et al (2008) Detection of B7-H4 and p53 in pancreatic cancer: potential role as a cytological diagnostic adjunct. Pancreas 36:200-206
-
(2008)
Pancreas
, vol.36
, pp. 200-206
-
-
Awadallah, N.S.1
-
363
-
-
16344391363
-
B7-h4 is highly expressed in ductal and lobular breast cancer
-
Tringler B et al (2005) B7-h4 is highly expressed in ductal and lobular breast cancer. Clin Cancer Res 11:1842-1848
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1842-1848
-
-
Tringler, B.1
-
364
-
-
33644689145
-
Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis
-
Wu CP et al (2006) Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis. World J Gastroenterol 12:457-459
-
(2006)
World J Gastroenterol
, vol.12
, pp. 457-459
-
-
Wu, C.P.1
-
365
-
-
6344241440
-
B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells
-
Luo L et al (2004) B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells. J Immunol 173:5445-5450
-
(2004)
J Immunol
, vol.173
, pp. 5445-5450
-
-
Luo, L.1
-
366
-
-
33644855144
-
Arsenic trioxide synergizes with B7H3-mediated immunotherapy to eradicate hepatocellular carcinomas
-
Luo L et al (2006) Arsenic trioxide synergizes with B7H3-mediated immunotherapy to eradicate hepatocellular carcinomas. Int J Cancer 118:1823-1830
-
(2006)
Int J Cancer
, vol.118
, pp. 1823-1830
-
-
Luo, L.1
-
367
-
-
33646525441
-
An orthotopic colon cancer model for studying the B7-H3 antitumor effect in vivo
-
Lupu CM et al (2006) An orthotopic colon cancer model for studying the B7-H3 antitumor effect in vivo. J Gastrointest Surg 10:635-645
-
(2006)
J Gastrointest Surg
, vol.10
, pp. 635-645
-
-
Lupu, C.M.1
-
368
-
-
0141851079
-
Mouse B7-H3 induces antitumor immunity
-
Sun X et al (2003) Mouse B7-H3 induces antitumor immunity. Gene Ther 10:1728-1734
-
(2003)
Gene Ther
, vol.10
, pp. 1728-1734
-
-
Sun, X.1
-
369
-
-
0021234164
-
Monoclonal antibodies to antigens associated with transitional cell carcinoma of the human urinary bladder. I. Determination of the selectivity of six antibodies by cell ELISA and immunofluorescence
-
Koho H et al (1984) Monoclonal antibodies to antigens associated with transitional cell carcinoma of the human urinary bladder. I. Determination of the selectivity of six antibodies by cell ELISA and immunofluorescence. Cancer Immunol Immunother 17:165-172
-
(1984)
Cancer Immunol Immunother
, vol.17
, pp. 165-172
-
-
Koho, H.1
-
370
-
-
0002857279
-
Immune regulation by CD40-CD40-L interactions
-
van Kooten C, Banchereau J (1997) Immune regulation by CD40-CD40-L interactions. Front Biosci 2:d1-d11
-
(1997)
Front Biosci
, vol.2
, pp. d1-d11
-
-
Van Kooten, C.1
Banchereau, J.2
-
371
-
-
0030744132
-
Functions of CD40 on B cells, dendritic cells and other cells
-
van Kooten C, Banchereau J (1997) Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Immunol 9:330-337
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 330-337
-
-
Van Kooten, C.1
Banchereau, J.2
-
372
-
-
0037144612
-
A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
-
Bourgeois C, Rocha B, Tanchot C (2002) A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297:2060-2063
-
(2002)
Science
, vol.297
, pp. 2060-2063
-
-
Bourgeois, C.1
Rocha, B.2
Tanchot, C.3
-
373
-
-
0034546367
-
Role for CD40-CD40 ligand interactions in the immune response to solid tumours
-
Alexandroff AB et al (2000) Role for CD40-CD40 ligand interactions in the immune response to solid tumours. Mol Immunol 37:515-526
-
(2000)
Mol Immunol
, vol.37
, pp. 515-526
-
-
Alexandroff, A.B.1
-
374
-
-
33947223664
-
Prospect of targeting the CD40 pathway for cancer therapy
-
Vonderheide RH (2007) Prospect of targeting the CD40 pathway for cancer therapy. Clin Cancer Res 13:1083-1088
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1083-1088
-
-
Vonderheide, R.H.1
-
375
-
-
0028783879
-
Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma. Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells
-
Agathanggelou A et al (1995) Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma. Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells. Am J Pathol 147:1152-1160
-
(1995)
Am J Pathol
, vol.147
, pp. 1152-1160
-
-
Agathanggelou, A.1
-
376
-
-
0033120913
-
CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-gamma
-
Altenburg A, Baldus SE, Smola H, Pfister H, Hess S (1999) CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-gamma. J Immunol 162:4140-4147
-
(1999)
J Immunol
, vol.162
, pp. 4140-4147
-
-
Altenburg, A.1
Baldus, S.E.2
Smola, H.3
Pfister, H.4
Hess, S.5
-
377
-
-
16644389621
-
CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule
-
Palmer DH et al (2004) CD40 expression in prostate cancer: A potential diagnostic and therapeutic molecule. Oncol Rep 12:679-682
-
(2004)
Oncol Rep
, vol.12
, pp. 679-682
-
-
Palmer, D.H.1
-
378
-
-
34548084865
-
CD40-mediated death and cytokine secretion in colorectal cancer: A potential target for inflammatory tumour cell killing
-
Georgopoulos NT et al (2007) CD40-mediated death and cytokine secretion in colorectal cancer: A potential target for inflammatory tumour cell killing. Int J Cancer 121:1373-1381
-
(2007)
Int J Cancer
, vol.121
, pp. 1373-1381
-
-
Georgopoulos, N.T.1
-
379
-
-
49049096326
-
Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis
-
Ishikawa K et al (2008) Up-regulation of CD40 with juxtacrine activity in human nonsmall lung cancer cells correlates with poor prognosis. Cancer 113:530-541
-
(2008)
Cancer
, vol.113
, pp. 530-541
-
-
Ishikawa, K.1
-
380
-
-
0030986884
-
CD40: A pivotal receptor in the determination of life/death decisions in B lymphocytes
-
Klaus GG, Choi MS, Lam EW, Johnson-Leger C, Cliff J (1997) CD40: A pivotal receptor in the determination of life/death decisions in B lymphocytes. Int Rev Immunol 15:5-31
-
(1997)
Int Rev Immunol
, vol.15
, pp. 5-31
-
-
Klaus, G.G.1
Choi, M.S.2
Lam, E.W.3
Johnson-Leger, C.4
Cliff, J.5
-
381
-
-
0036134879
-
Cutting Edge: Ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease
-
Higuchi T et al (2002) Cutting Edge: ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol 168:9-12
-
(2002)
J Immunol
, vol.168
, pp. 9-12
-
-
Higuchi, T.1
-
382
-
-
0032484987
-
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
-
Henn V et al (1998) CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391:591-594
-
(1998)
Nature
, vol.391
, pp. 591-594
-
-
Henn, V.1
-
383
-
-
0038297520
-
Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients
-
Danese S et al (2003) Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology 124:1249-1264
-
(2003)
Gastroenterology
, vol.124
, pp. 1249-1264
-
-
Danese, S.1
-
384
-
-
0345700237
-
Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis
-
Filion LG, Matusevicius D, Graziani-Bowering GM, Kumar A, Freedman MS (2003) Monocyte-derived IL12, CD86 (B7-2) and CD40L expression in relapsing and progressive multiple sclerosis. Clin Immunol 106:127-138
-
(2003)
Clin Immunol
, vol.106
, pp. 127-138
-
-
Filion, L.G.1
Matusevicius, D.2
Graziani-Bowering, G.M.3
Kumar, A.4
Freedman, M.S.5
-
385
-
-
0036314023
-
CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition
-
Katsiari CG et al (2002) CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition. Lupus 11:370-378
-
(2002)
Lupus
, vol.11
, pp. 370-378
-
-
Katsiari, C.G.1
-
386
-
-
0037016008
-
Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells
-
Schonbeck U et al (2002) Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells. Circulation 106:2888-2893
-
(2002)
Circulation
, vol.106
, pp. 2888-2893
-
-
Schonbeck, U.1
-
387
-
-
77958045597
-
CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893
-
Kalbasi A et al (2010) CD40 expression by human melanocytic lesions and melanoma cell lines and direct CD40 targeting with the therapeutic anti-CD40 antibody CP-870,893. J Immunother 33:810-816
-
(2010)
J Immunother
, vol.33
, pp. 810-816
-
-
Kalbasi, A.1
-
388
-
-
0037352072
-
Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion
-
Mackey MF, Wang Z, Eichelberg K, Germain RN (2003) Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion. Eur J Immunol 33:779-789
-
(2003)
Eur J Immunol
, vol.33
, pp. 779-789
-
-
Mackey, M.F.1
Wang, Z.2
Eichelberg, K.3
Germain, R.N.4
-
390
-
-
0027414691
-
CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
-
Allen RC et al (1993) CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259:990-993
-
(1993)
Science
, vol.259
, pp. 990-993
-
-
Allen, R.C.1
-
391
-
-
0035940417
-
Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM
-
Ferrari S et al (2001) Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci USA 98:12614-12619
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12614-12619
-
-
Ferrari, S.1
-
392
-
-
4644292965
-
The hyper IgM syndrome-an evolving story
-
Etzioni A, Ochs HD (2004) The hyper IgM syndrome-an evolving story. Pediatr Res 56:519-525
-
(2004)
Pediatr Res
, vol.56
, pp. 519-525
-
-
Etzioni, A.1
Ochs, H.D.2
-
393
-
-
0025630628
-
Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells
-
Uckun FM et al (1990) Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells. Blood 76:2449-2456
-
(1990)
Blood
, vol.76
, pp. 2449-2456
-
-
Uckun, F.M.1
-
394
-
-
0028063044
-
Expression of CD28 and CD40 in human myeloma cells: A comparative study with normal plasma cells
-
Pellat-Deceunynck C et al (1994) Expression of CD28 and CD40 in human myeloma cells: A comparative study with normal plasma cells. Blood 84:2597-2603
-
(1994)
Blood
, vol.84
, pp. 2597-2603
-
-
Pellat-Deceunynck, C.1
-
395
-
-
0037332242
-
Heterogeneous expression and regulation of CD40 in human hepatocellular carcinoma
-
Holub M et al (2003) Heterogeneous expression and regulation of CD40 in human hepatocellular carcinoma. Eur J Gastroenterol Hepatol 15:119-126
-
(2003)
Eur J Gastroenterol Hepatol
, vol.15
, pp. 119-126
-
-
Holub, M.1
-
396
-
-
48249155420
-
Expression of CD40 in ovarian cancer and adenovirus-mediated CD40 ligand therapy on ovarian cancer in vitro
-
Jiang E et al (2008) Expression of CD40 in ovarian cancer and adenovirus-mediated CD40 ligand therapy on ovarian cancer in vitro. Tumori 94:356-361
-
(2008)
Tumori
, vol.94
, pp. 356-361
-
-
Jiang, E.1
-
397
-
-
0033912082
-
CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
-
Eliopoulos AG et al (2000) CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily. Mol Cell Biol 20:5503-5515
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5503-5515
-
-
Eliopoulos, A.G.1
-
398
-
-
0035886792
-
Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin
-
Ghamande S et al (2001) Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin. Cancer Res 61:7556-7562
-
(2001)
Cancer Res
, vol.61
, pp. 7556-7562
-
-
Ghamande, S.1
-
399
-
-
0034900413
-
Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer
-
Tong AW et al (2001) Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer. Clin Cancer Res 7:691-703
-
(2001)
Clin Cancer Res
, vol.7
, pp. 691-703
-
-
Tong, A.W.1
-
400
-
-
0033135236
-
Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand
-
Hirano A et al (1999) Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand. Blood 93:2999-3007
-
(1999)
Blood
, vol.93
, pp. 2999-3007
-
-
Hirano, A.1
-
401
-
-
0030685703
-
Antitumor responses induced by transgenic expression of CD40 ligand
-
Grossmann ME, Brown MP, Brenner MK (1997) Antitumor responses induced by transgenic expression of CD40 ligand. Hum Gene Ther 8:1935-1943
-
(1997)
Hum Gene Ther
, vol.8
, pp. 1935-1943
-
-
Grossmann, M.E.1
Brown, M.P.2
Brenner, M.K.3
-
402
-
-
17944366839
-
Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer
-
Noguchi M et al (2001) Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-gamma gene into lung cancer. Cancer Gene Ther 8:421-429
-
(2001)
Cancer Gene Ther
, vol.8
, pp. 421-429
-
-
Noguchi, M.1
-
403
-
-
0036195217
-
In vivo induction of antitumor immunity and protection against tumor growth by injection of CD154-expressing tumor cells
-
Grangeon C et al (2002) In vivo induction of antitumor immunity and protection against tumor growth by injection of CD154-expressing tumor cells. Cancer Gene Ther 9:282-288
-
(2002)
Cancer Gene Ther
, vol.9
, pp. 282-288
-
-
Grangeon, C.1
-
404
-
-
0036192133
-
Antitumor immune responses derived from transgenic expression of CD40 ligand in myeloma cells
-
Liu Y, Qureshi M, Xiang J (2002) Antitumor immune responses derived from transgenic expression of CD40 ligand in myeloma cells. Cancer Biother Radiopharm 17:11-18
-
(2002)
Cancer Biother Radiopharm
, vol.17
, pp. 11-18
-
-
Liu, Y.1
Qureshi, M.2
Xiang, J.3
-
405
-
-
0033804952
-
In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity
-
Sun Y et al (2000) In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity. Gene Ther 7:1467-1476
-
(2000)
Gene Ther
, vol.7
, pp. 1467-1476
-
-
Sun, Y.1
-
406
-
-
0037371149
-
Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: Coordination of dendritic and CD8+ cell responses
-
Murphy WJ et al (2003) Synergistic anti-tumor responses after administration of agonistic antibodies to CD40 and IL-2: coordination of dendritic and CD8+ cell responses. J Immunol 170:2727-2733
-
(2003)
J Immunol
, vol.170
, pp. 2727-2733
-
-
Murphy, W.J.1
-
407
-
-
0042591416
-
Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors
-
Nowak AK, Robinson BW, Lake RA (2003) Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors. Cancer Res 63:4490-4496
-
(2003)
Cancer Res
, vol.63
, pp. 4490-4496
-
-
Nowak, A.K.1
Robinson, B.W.2
Lake, R.A.3
-
408
-
-
0032984347
-
Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40
-
Sotomayor EM et al (1999) Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40. Nat Med 5:780-787
-
(1999)
Nat Med
, vol.5
, pp. 780-787
-
-
Sotomayor, E.M.1
-
409
-
-
0032896709
-
CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help
-
French RR, Chan HT, Tutt AL, Glennie MJ (1999) CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nat Med 5:548-553
-
(1999)
Nat Med
, vol.5
, pp. 548-553
-
-
French, R.R.1
Chan, H.T.2
Tutt, A.L.3
Glennie, M.J.4
-
410
-
-
0032984496
-
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy
-
Diehl L et al (1999) CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy. Nat Med 5:774-779
-
(1999)
Nat Med
, vol.5
, pp. 774-779
-
-
Diehl, L.1
-
411
-
-
0041737455
-
Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell-dependent immunity to B-cell lymphoma
-
Honeychurch J, Glennie MJ, Johnson PW, Illidge TM (2003) Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell-dependent immunity to B-cell lymphoma. Blood 102:1449-1457
-
(2003)
Blood
, vol.102
, pp. 1449-1457
-
-
Honeychurch, J.1
Glennie, M.J.2
Johnson, P.W.3
Illidge, T.M.4
-
412
-
-
0034141468
-
Induction of CTL responses by simultaneous administration of liposomal peptide vaccine with anti-CD40 and anti-CTLA-4 mAb
-
Ito D, Ogasawara K, Iwabuchi K, Inuyama Y, Onoe K (2000) Induction of CTL responses by simultaneous administration of liposomal peptide vaccine with anti-CD40 and anti-CTLA-4 mAb. J Immunol 164:1230-1235
-
(2000)
J Immunol
, vol.164
, pp. 1230-1235
-
-
Ito, D.1
Ogasawara, K.2
Iwabuchi, K.3
Inuyama, Y.4
Onoe, K.5
-
413
-
-
33744987907
-
Eradication of established tumors in mice by a combination antibodybased therapy
-
Uno T et al (2006) Eradication of established tumors in mice by a combination antibodybased therapy. Nat Med 12:693-698
-
(2006)
Nat Med
, vol.12
, pp. 693-698
-
-
Uno, T.1
-
414
-
-
1642362512
-
Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type i IFN
-
Ahonen CL et al (2004) Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN. J Exp Med 199:775-784
-
(2004)
J Exp Med
, vol.199
, pp. 775-784
-
-
Ahonen, C.L.1
-
415
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
Beatty GL et al (2011) CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331:1612-1616
-
(2011)
Science
, vol.331
, pp. 1612-1616
-
-
Beatty, G.L.1
-
416
-
-
34548580969
-
Anti-CD40 agonist antibodies: Preclinical and clinical experience
-
Khalil M, Vonderheide RH (2007) Anti-CD40 agonist antibodies: preclinical and clinical experience. Update Cancer Ther 2:61-65
-
(2007)
Update Cancer Ther
, vol.2
, pp. 61-65
-
-
Khalil, M.1
Vonderheide, R.H.2
-
417
-
-
78449262545
-
Biology and clinical applications of CD40 in cancer treatment
-
Fonsatti E, Maio M, Altomonte M, Hersey P (2010) Biology and clinical applications of CD40 in cancer treatment. Semin Oncol 37:517-523
-
(2010)
Semin Oncol
, vol.37
, pp. 517-523
-
-
Fonsatti, E.1
Maio, M.2
Altomonte, M.3
Hersey, P.4
-
418
-
-
0035397985
-
Phase i study of recombinant human CD40 ligand in cancer patients
-
Vonderheide RH et al (2001) Phase I study of recombinant human CD40 ligand in cancer patients. J Clin Oncol 19:3280-3287
-
(2001)
J Clin Oncol
, vol.19
, pp. 3280-3287
-
-
Vonderheide, R.H.1
-
419
-
-
33947506186
-
Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
-
Vonderheide RH et al (2007) Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol 25:876-883
-
(2007)
J Clin Oncol
, vol.25
, pp. 876-883
-
-
Vonderheide, R.H.1
-
420
-
-
78549256115
-
Immune modulation with weekly dosing of an agonist CD40 antibody in a phase i study of patients with advanced solid tumors
-
Ruter J, Antonia SJ, Burris HA 3rd, Huhn RD, Vonderheide RH (2010) Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors. Cancer Biol Ther 10:983-993
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 983-993
-
-
Ruter, J.1
Antonia, S.J.2
Burris Iii, H.A.3
Huhn, R.D.4
Vonderheide, R.H.5
-
421
-
-
70349334508
-
Phase i study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
-
Advani R et al (2009) Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J Clin Oncol 27:4371-4377
-
(2009)
J Clin Oncol
, vol.27
, pp. 4371-4377
-
-
Advani, R.1
-
422
-
-
76349120845
-
A phase i study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia
-
Furman RR, Forero-Torres A, Shustov A, Drachman JG (2010) A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia. Leuk Lymphoma 51:228-235
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 228-235
-
-
Furman, R.R.1
Forero-Torres, A.2
Shustov, A.3
Drachman, J.G.4
-
423
-
-
77952315198
-
A phase i multidose study of dacetuzumab (SGN-40; Humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma
-
Hussein M et al (2010) A phase I multidose study of dacetuzumab (SGN-40; humanized anti-CD40 monoclonal antibody) in patients with multiple myeloma. Haematologica 95:845-848
-
(2010)
Haematologica
, vol.95
, pp. 845-848
-
-
Hussein, M.1
-
424
-
-
0030962132
-
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis
-
Nocentini G et al (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 94:6216-6221
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 6216-6221
-
-
Nocentini, G.1
-
425
-
-
0033602151
-
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR
-
Gurney AL et al (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr Biol 9:215-218
-
(1999)
Curr Biol
, vol.9
, pp. 215-218
-
-
Gurney, A.L.1
-
426
-
-
1642379813
-
GITR, a member of the TNF receptor superfamily, is co-stimulatory to mouse T lymphocyte subpopulations
-
Ronchetti S et al (2004) GITR, a member of the TNF receptor superfamily, is co-stimulatory to mouse T lymphocyte subpopulations. Eur J Immunol 34:613-622
-
(2004)
Eur J Immunol
, vol.34
, pp. 613-622
-
-
Ronchetti, S.1
-
427
-
-
0345598872
-
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is co-stimulatory for T cells
-
Tone M et al (2003) Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is co-stimulatory for T cells. Proc Natl Acad Sci USA 100:15059-15064
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15059-15064
-
-
Tone, M.1
-
428
-
-
0036170938
-
Stimulation of CD25(+) CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
-
Shimizu J, Yamazaki S, Takahashi T, Ishida Y, Sakaguchi S (2002) Stimulation of CD25(+) CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 3:135-142
-
(2002)
Nat Immunol
, vol.3
, pp. 135-142
-
-
Shimizu, J.1
Yamazaki, S.2
Takahashi, T.3
Ishida, Y.4
Sakaguchi, S.5
-
429
-
-
0036195161
-
CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
-
McHugh RS et al (2002) CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311-323
-
(2002)
Immunity
, vol.16
, pp. 311-323
-
-
McHugh, R.S.1
-
430
-
-
1642338649
-
Cloning and characterization of GITR ligand
-
Kim JD et al (2003) Cloning and characterization of GITR ligand. Genes Immun 4:564-569
-
(2003)
Genes Immun
, vol.4
, pp. 564-569
-
-
Kim, J.D.1
-
431
-
-
24644515759
-
In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology
-
Suvas S et al (2005) In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. J Virol 79:11935-11942
-
(2005)
J Virol
, vol.79
, pp. 11935-11942
-
-
Suvas, S.1
-
432
-
-
0141570624
-
Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells
-
Yu KY et al (2003) Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells. Biochem Biophys Res Commun 310:433-438
-
(2003)
Biochem Biophys Res Commun
, vol.310
, pp. 433-438
-
-
Yu, K.Y.1
-
433
-
-
17444414236
-
GITR: A multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily
-
Nocentini G, Riccardi C (2005) GITR: A multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily. Eur J Immunol 35:1016-1022
-
(2005)
Eur J Immunol
, vol.35
, pp. 1016-1022
-
-
Nocentini, G.1
Riccardi, C.2
-
434
-
-
79953792856
-
Modulation of CTLA-4 and GITR for Cancer Immunotherapy
-
Avogadri F, Yuan J, Yang A, Schaer D, Wolchok JD (2011) Modulation of CTLA-4 and GITR for Cancer Immunotherapy. Curr Top Microbiol Immunol 344:211-244
-
(2011)
Curr Top Microbiol Immunol
, vol.344
, pp. 211-244
-
-
Avogadri, F.1
Yuan, J.2
Yang, A.3
Schaer, D.4
Wolchok, J.D.5
-
435
-
-
20444398182
-
Glucocorticoid-induced TNF receptor, a co-stimulatory receptor on naive and activated T cells, uses TNF receptor-associated factor 2 in a novel fashion as an inhibitor of NF-kappa B activation
-
Esparza EM, Arch RH (2005) Glucocorticoid-induced TNF receptor, a co-stimulatory receptor on naive and activated T cells, uses TNF receptor-associated factor 2 in a novel fashion as an inhibitor of NF-kappa B activation. J Immunol 174:7875-7882
-
(2005)
J Immunol
, vol.174
, pp. 7875-7882
-
-
Esparza, E.M.1
Arch, R.H.2
-
436
-
-
0036947870
-
GITR interacts with the pro-apoptotic protein Siva and induces apoptosis
-
Spinicelli S et al (2002) GITR interacts with the pro-apoptotic protein Siva and induces apoptosis. Cell Death Differ 9:1382-1384
-
(2002)
Cell Death Differ
, vol.9
, pp. 1382-1384
-
-
Spinicelli, S.1
-
437
-
-
1842424807
-
Cutting edge: Ligation of the glucocorticoidinduced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis
-
Kohm AP, Williams JS, Miller SD (2004) Cutting edge: ligation of the glucocorticoidinduced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis. J Immunol 172:4686-4690
-
(2004)
J Immunol
, vol.172
, pp. 4686-4690
-
-
Kohm, A.P.1
Williams, J.S.2
Miller, S.D.3
-
438
-
-
2942532501
-
Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells
-
Kanamaru F et al (2004) Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol 172:7306-7314
-
(2004)
J Immunol
, vol.172
, pp. 7306-7314
-
-
Kanamaru, F.1
-
439
-
-
6344279933
-
Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+ CD25+ T cells
-
Stephens GL et al (2004) Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+ CD25+ T cells. J Immunol 173:5008-5020
-
(2004)
J Immunol
, vol.173
, pp. 5008-5020
-
-
Stephens, G.L.1
-
441
-
-
1642332369
-
Regulation of autoimmune diabetes by non-islet-specific T cells-A role for the glucocorticoid-induced TNF receptor
-
Suri A et al (2004) Regulation of autoimmune diabetes by non-islet-specific T cells-A role for the glucocorticoid-induced TNF receptor. Eur J Immunol 34:447-454
-
(2004)
Eur J Immunol
, vol.34
, pp. 447-454
-
-
Suri, A.1
-
442
-
-
3242800449
-
GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease
-
Muriglan SJ et al (2004) GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease. J Exp Med 200:149-157
-
(2004)
J Exp Med
, vol.200
, pp. 149-157
-
-
Muriglan, S.J.1
-
443
-
-
0038106763
-
Regulation of murine inflammatory bowel disease by CD25+ and CD25-CD4+ glucocorticoid-induced TNF receptor family-related gene + regulatory T cells
-
Uraushihara K et al (2003) Regulation of murine inflammatory bowel disease by CD25+ and CD25-CD4+ glucocorticoid-induced TNF receptor family-related gene + regulatory T cells. J Immunol 171:708-716
-
(2003)
J Immunol
, vol.171
, pp. 708-716
-
-
Uraushihara, K.1
-
444
-
-
25844517914
-
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4+ regulatory T cells
-
Ko K et al (2005) Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4+ regulatory T cells. J Exp Med 202:885-891
-
(2005)
J Exp Med
, vol.202
, pp. 885-891
-
-
Ko, K.1
-
445
-
-
4644342928
-
Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
-
Turk MJ et al (2004) Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med 200:771-782
-
(2004)
J Exp Med
, vol.200
, pp. 771-782
-
-
Turk, M.J.1
-
446
-
-
33646876477
-
Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity
-
Ramirez-Montagut T et al (2006) Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. J Immunol 176:6434-6442
-
(2006)
J Immunol
, vol.176
, pp. 6434-6442
-
-
Ramirez-Montagut, T.1
-
447
-
-
77955279163
-
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation
-
Cohen AD et al (2010) Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation. PLoS One 5:e10436
-
(2010)
PLoS One
, vol.5
, pp. e10436
-
-
Cohen, A.D.1
-
448
-
-
77955515915
-
Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy
-
Coe D et al (2010) Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy. Cancer Immunol Immunother 59:1367-1377
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 1367-1377
-
-
Coe, D.1
-
449
-
-
33646419260
-
Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity
-
Cohen AD et al (2006) Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity. Cancer Res 66:4904-4912
-
(2006)
Cancer Res
, vol.66
, pp. 4904-4912
-
-
Cohen, A.D.1
-
450
-
-
77649093452
-
Combining T-cell vaccination and application of agonistic anti-GITR mAb (DTA-1) induces complete eradication of HPV oncogene expressing tumors in mice
-
Hoffmann C et al (2010) Combining T-cell vaccination and application of agonistic anti-GITR mAb (DTA-1) induces complete eradication of HPV oncogene expressing tumors in mice. J Immunother 33:136-145
-
(2010)
J Immunother
, vol.33
, pp. 136-145
-
-
Hoffmann, C.1
-
451
-
-
79952770456
-
Anti-GITR antibodies-Potential clinical applications for tumor immunotherapy
-
Schaer DA, Cohen AD, Wolchok JD (2010) Anti-GITR antibodies-Potential clinical applications for tumor immunotherapy. Curr Opin Investig Drugs 11:1378-1386
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 1378-1386
-
-
Schaer, D.A.1
Cohen, A.D.2
Wolchok, J.D.3
-
452
-
-
0344247505
-
CDNA sequences of two inducible T-cell genes
-
Kwon BS, Weissman SM (1989) cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci USA 86:1963-1967
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 1963-1967
-
-
Kwon, B.S.1
Weissman, S.M.2
-
454
-
-
0036199305
-
Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells
-
Futagawa T et al (2002) Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol 14:275-286
-
(2002)
Int Immunol
, vol.14
, pp. 275-286
-
-
Futagawa, T.1
-
455
-
-
0035057630
-
CD137 expression in tumor vessel walls. High correlation with malignant tumors
-
Broll K, Richter G, Pauly S, Hofstaedter F, Schwarz H (2001) CD137 expression in tumor vessel walls. High correlation with malignant tumors. Am J Clin Pathol 115:543-549
-
(2001)
Am J Clin Pathol
, vol.115
, pp. 543-549
-
-
Broll, K.1
Richter, G.2
Pauly, S.3
Hofstaedter, F.4
Schwarz, H.5
-
456
-
-
0032535119
-
NK1. 1 cells express 4-1BB (CDw137) co-stimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies
-
Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L (1998) NK1.1 cells express 4-1BB (CDw137) co-stimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol 190:167-172
-
(1998)
Cell Immunol
, vol.190
, pp. 167-172
-
-
Melero, I.1
Johnston, J.V.2
Shufford, W.W.3
Mittler, R.S.4
Chen, L.5
-
457
-
-
0037094139
-
4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function
-
Wen T, Bukczynski J, Watts TH (2002) 4-1BB ligand-mediated costimulation of human T cells induces CD4 and CD8 T cell expansion, cytokine production, and the development of cytolytic effector function. J Immunol 168:4897-4906
-
(2002)
J Immunol
, vol.168
, pp. 4897-4906
-
-
Wen, T.1
Bukczynski, J.2
Watts, T.H.3
-
458
-
-
0028899550
-
ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages
-
Schwarz H, Valbracht J, Tuckwell J, von Kempis J, Lotz M (1995) ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood 85:1043-1052
-
(1995)
Blood
, vol.85
, pp. 1043-1052
-
-
Schwarz, H.1
Valbracht, J.2
Tuckwell, J.3
Von Kempis, J.4
Lotz, M.5
-
459
-
-
0033137063
-
Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal
-
Takahashi C, Mittler RS, Vella AT (1999) Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J Immunol 162:5037-5040
-
(1999)
J Immunol
, vol.162
, pp. 5037-5040
-
-
Takahashi, C.1
Mittler, R.S.2
Vella, A.T.3
-
460
-
-
20244386539
-
Molecular and biological characterization of human 4-1BB and its ligand
-
Alderson MR et al (1994) Molecular and biological characterization of human 4-1BB and its ligand. Eur J Immunol 24:2219-2227
-
(1994)
Eur J Immunol
, vol.24
, pp. 2219-2227
-
-
Alderson, M.R.1
-
461
-
-
0031569279
-
Signals through 4-1BB are co-stimulatory to previously activated splenic T cells and inhibit activation-induced cell death
-
Hurtado JC, Kim YJ, Kwon BS (1997) Signals through 4-1BB are co-stimulatory to previously activated splenic T cells and inhibit activation-induced cell death. J Immunol 158:2600-2609
-
(1997)
J Immunol
, vol.158
, pp. 2600-2609
-
-
Hurtado, J.C.1
Kim, Y.J.2
Kwon, B.S.3
-
462
-
-
0030845586
-
4-1BB co-stimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
-
Shuford WW et al (1997) 4-1BB co-stimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186:47-55
-
(1997)
J Exp Med
, vol.186
, pp. 47-55
-
-
Shuford, W.W.1
-
463
-
-
56149122030
-
CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages
-
Jiang D, Chen Y, Schwarz H (2008) CD137 induces proliferation of murine hematopoietic progenitor cells and differentiation to macrophages. J Immunol 181:3923-3932
-
(2008)
J Immunol
, vol.181
, pp. 3923-3932
-
-
Jiang, D.1
Chen, Y.2
Schwarz, H.3
-
464
-
-
0028009709
-
4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells
-
Pollok KE et al (1994) 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells. Eur J Immunol 24:367-374
-
(1994)
Eur J Immunol
, vol.24
, pp. 367-374
-
-
Pollok, K.E.1
-
465
-
-
47849100724
-
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells
-
Lee SW et al (2008) Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol 9:917-926
-
(2008)
Nat Immunol
, vol.9
, pp. 917-926
-
-
Lee, S.W.1
-
466
-
-
60549117865
-
Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease
-
Lin GH et al (2009) Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease. J Immunol 182:934-947
-
(2009)
J Immunol
, vol.182
, pp. 934-947
-
-
Lin, G.H.1
-
467
-
-
56149102016
-
4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease
-
Mack DG et al (2008) 4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease. J Immunol 181:4381-4388
-
(2008)
J Immunol
, vol.181
, pp. 4381-4388
-
-
Mack, D.G.1
-
468
-
-
0034662209
-
Analysis of expression and function of the co-stimulatory molecule 4-1BB in alloimmune responses
-
Tan JT et al (2000) Analysis of expression and function of the co-stimulatory molecule 4-1BB in alloimmune responses. Transplantation 70:175-183
-
(2000)
Transplantation
, vol.70
, pp. 175-183
-
-
Tan, J.T.1
-
469
-
-
65349153714
-
Immune regulation by 4-1BB and 4-1BBL: Complexities and challenges
-
Wang C, Lin GH, McPherson AJ, Watts TH (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev 229:192-215
-
(2009)
Immunol Rev
, vol.229
, pp. 192-215
-
-
Wang, C.1
Lin, G.H.2
McPherson, A.J.3
Watts, T.H.4
-
470
-
-
0036838689
-
4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1
-
Lee HW et al (2002) 4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1. J Immunol 169:4882-4888
-
(2002)
J Immunol
, vol.169
, pp. 4882-4888
-
-
Lee, H.W.1
-
471
-
-
50949121437
-
ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo
-
Sabbagh L, Pulle G, Liu Y, Tsitsikov EN, Watts TH (2008) ERK-dependent Bim modulation downstream of the 4-1BB-TRAF1 signaling axis is a critical mediator of CD8 T cell survival in vivo. J Immunol 180:8093-8101
-
(2008)
J Immunol
, vol.180
, pp. 8093-8101
-
-
Sabbagh, L.1
Pulle, G.2
Liu, Y.3
Tsitsikov, E.N.4
Watts, T.H.5
-
472
-
-
0032101119
-
CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand
-
Saoulli K et al (1998) CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J Exp Med 187:1849-1862
-
(1998)
J Exp Med
, vol.187
, pp. 1849-1862
-
-
Saoulli, K.1
-
473
-
-
0031962348
-
4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB
-
Arch RH, Thompson CB (1998) 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol Cell Biol 18:558-565
-
(1998)
Mol Cell Biol
, vol.18
, pp. 558-565
-
-
Arch, R.H.1
Thompson, C.B.2
-
474
-
-
0034541168
-
Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response
-
Cannons JL, Choi Y, Watts TH (2000) Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response. J Immunol 165:6193-6204
-
(2000)
J Immunol
, vol.165
, pp. 6193-6204
-
-
Cannons, J.L.1
Choi, Y.2
Watts, T.H.3
-
475
-
-
0032567645
-
Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B
-
Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS (1998) Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B. Biochem Biophys Res Commun 242:613-620
-
(1998)
Biochem Biophys Res Commun
, vol.242
, pp. 613-620
-
-
Jang, I.K.1
Zh, L.2
Kim, Y.J.3
Kim, S.H.4
Kwon, B.S.5
-
476
-
-
40049091217
-
4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulation-dependent rescue of functionally impaired HIV-specific CD8 T cells
-
Wang C et al (2007) 4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulation-dependent rescue of functionally impaired HIV-specific CD8 T cells. J Immunol 179:8252-8263
-
(2007)
J Immunol
, vol.179
, pp. 8252-8263
-
-
Wang, C.1
-
477
-
-
0033982793
-
Co-stimulation of antigenspecific CD4 T cells by 4-1BB ligand
-
Gramaglia I, Cooper D, Miner KT, Kwon BS, Croft M (2000) Co-stimulation of antigenspecific CD4 T cells by 4-1BB ligand. Eur J Immunol 30:392-402
-
(2000)
Eur J Immunol
, vol.30
, pp. 392-402
-
-
Gramaglia, I.1
Cooper, D.2
Miner, K.T.3
Kwon, B.S.4
Croft, M.5
-
478
-
-
0029916309
-
ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival
-
Schwarz H, Blanco FJ, von Kempis J, Valbracht J, Lotz M (1996) ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. Blood 87:2839-2845
-
(1996)
Blood
, vol.87
, pp. 2839-2845
-
-
Schwarz, H.1
Blanco, F.J.2
Von Kempis, J.3
Valbracht, J.4
Lotz, M.5
-
479
-
-
0032754036
-
Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
-
DeBenedette MA et al (1999) Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol 163:4833-4841
-
(1999)
J Immunol
, vol.163
, pp. 4833-4841
-
-
Debenedette, M.A.1
-
480
-
-
0036075444
-
In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses
-
Halstead ES, Mueller YM, Altman JD, Katsikis PD (2002) In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses. Nat Immunol 3:536-541
-
(2002)
Nat Immunol
, vol.3
, pp. 536-541
-
-
Halstead, E.S.1
Mueller, Y.M.2
Altman, J.D.3
Katsikis, P.D.4
-
481
-
-
0036467421
-
Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis
-
Sun Y et al (2002) Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 168:1457-1465
-
(2002)
J Immunol
, vol.168
, pp. 1457-1465
-
-
Sun, Y.1
-
482
-
-
7044261952
-
4-1BB-mediated immunotherapy of rheumatoid arthritis
-
Seo SK et al (2004) 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 10:1088-1094
-
(2004)
Nat Med
, vol.10
, pp. 1088-1094
-
-
Seo, S.K.1
-
483
-
-
31644447822
-
Immunotherapy targeting 4-1BB and its ligand
-
Vinay DS, Kwon BS (2006) Immunotherapy targeting 4-1BB and its ligand. Int J Hematol 83:23-28
-
(2006)
Int J Hematol
, vol.83
, pp. 23-28
-
-
Vinay, D.S.1
Kwon, B.S.2
-
484
-
-
0033571176
-
Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy
-
Mittler RS, Bailey TS, Klussman K, Trailsmith MD, Hoffmann MK (1999) Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy. J Exp Med 190:1535-1540
-
(1999)
J Exp Med
, vol.190
, pp. 1535-1540
-
-
Mittler, R.S.1
Bailey, T.S.2
Klussman, K.3
Trailsmith, M.D.4
Hoffmann, M.K.5
-
485
-
-
0031007143
-
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
-
Melero I et al (1997) Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 3:682-685
-
(1997)
Nat Med
, vol.3
, pp. 682-685
-
-
Melero, I.1
-
486
-
-
0031906785
-
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway
-
Melero I et al (1998) Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway. Eur J Immunol 28:1116-1121
-
(1998)
Eur J Immunol
, vol.28
, pp. 1116-1121
-
-
Melero, I.1
-
487
-
-
0033560179
-
4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine
-
Guinn BA, DeBenedette MA, Watts TH, Berinstein NL (1999) 4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine. J Immunol 162:5003-5010
-
(1999)
J Immunol
, vol.162
, pp. 5003-5010
-
-
Guinn, B.A.1
Debenedette, M.A.2
Watts, T.H.3
Berinstein, N.L.4
-
488
-
-
0037103147
-
4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner
-
Miller RE et al (2002) 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner. J Immunol 169:1792-1800
-
(2002)
J Immunol
, vol.169
, pp. 1792-1800
-
-
Miller, R.E.1
-
489
-
-
27144497304
-
The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma
-
Xu DP et al (2005) The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma. Gene Ther 12:1526-1533
-
(2005)
Gene Ther
, vol.12
, pp. 1526-1533
-
-
Xu, D.P.1
-
490
-
-
0033253965
-
Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy
-
Sica G, Chen L (1999) Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. Arch Immunol Ther Exp (Warsz) 47:275-279
-
(1999)
Arch Immunol Ther Exp (Warsz)
, vol.47
, pp. 275-279
-
-
Sica, G.1
Chen, L.2
-
491
-
-
0036195860
-
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
-
Wilcox RA et al (2002) Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest 109:651-659
-
(2002)
J Clin Invest
, vol.109
, pp. 651-659
-
-
Wilcox, R.A.1
-
492
-
-
77956214554
-
Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice
-
Lin GH et al (2010) Evaluating the cellular targets of anti-4-1BB agonist antibody during immunotherapy of a pre-established tumor in mice. PLoS One 5:e11003
-
(2010)
PLoS One
, vol.5
, pp. e11003
-
-
Lin, G.H.1
-
493
-
-
70349243743
-
In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb
-
Murillo O et al (2009) In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb. Eur J Immunol 39:2424-2436
-
(2009)
Eur J Immunol
, vol.39
, pp. 2424-2436
-
-
Murillo, O.1
-
494
-
-
70350713055
-
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion
-
Houot R et al (2009) Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Blood 114:3431-3438
-
(2009)
Blood
, vol.114
, pp. 3431-3438
-
-
Houot, R.1
-
495
-
-
77950403194
-
CD137 agonist antibody prevents cancer recurrence: Contribution of CD137 on both hematopoietic and nonhematopoietic cells
-
Narazaki H, Zhu Y, Luo L, Zhu G, Chen L (2010) CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells. Blood 115:1941-1948
-
(2010)
Blood
, vol.115
, pp. 1941-1948
-
-
Narazaki, H.1
Zhu, Y.2
Luo, L.3
Zhu, G.4
Chen, L.5
-
496
-
-
8544249166
-
Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines
-
Ito F et al (2004) Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res 64:8411-8419
-
(2004)
Cancer Res
, vol.64
, pp. 8411-8419
-
-
Ito, F.1
-
497
-
-
0037096878
-
Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumorspecific CD8+ T cells
-
May KF Jr, Chen L, Zheng P, Liu Y (2002) Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumorspecific CD8+ T cells. Cancer Res 62:3459-3465
-
(2002)
Cancer Res
, vol.62
, pp. 3459-3465
-
-
May, K.F.1
Chen, L.2
Zheng, P.3
Liu, Y.4
-
498
-
-
54749092889
-
Combination therapy with cisplatin and anti-4-1BB: Synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity
-
Kim YH, Choi BK, Kim KH, Kang SW, Kwon BS (2008) Combination therapy with cisplatin and anti-4-1BB: synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity. Cancer Res 68:7264-7269
-
(2008)
Cancer Res
, vol.68
, pp. 7264-7269
-
-
Kim, Y.H.1
Choi, B.K.2
Kim, K.H.3
Kang, S.W.4
Kwon, B.S.5
-
499
-
-
33746924449
-
Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity
-
Kocak E et al (2006) Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. Cancer Res 66:7276-7284
-
(2006)
Cancer Res
, vol.66
, pp. 7276-7284
-
-
Kocak, E.1
-
500
-
-
34250156711
-
Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo
-
Xiao H et al (2007) Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunity against murine H22 hepatocarcinoma in vivo. Clin Cancer Res 13:1823-1830
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1823-1830
-
-
Xiao, H.1
-
501
-
-
33947696816
-
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice
-
Niu L et al (2007) Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. J Immunol 178:4194-4213
-
(2007)
J Immunol
, vol.178
, pp. 4194-4213
-
-
Niu, L.1
-
502
-
-
78449237499
-
Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
-
Ascierto PA, Simeone E, Sznol M, Fu YX, Melero I (2010) Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 37:508-516
-
(2010)
Semin Oncol
, vol.37
, pp. 508-516
-
-
Ascierto, P.A.1
Simeone, E.2
Sznol, M.3
Fu, Y.X.4
Melero, I.5
-
503
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L (2007) Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer 7:95-106
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
504
-
-
55949113750
-
Phase i study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
-
May 20 suppl; abstr 3007
-
Sznol M et al (2008) Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). J Clin Oncol 26:133s (May 20 suppl; abstr 3007)
-
(2008)
J Clin Oncol
, vol.26
, pp. 133s
-
-
Sznol, M.1
-
505
-
-
84977163299
-
Targeted therapy for metastatic melanoma: From bench to bedside
-
Hwu, W.J. Targeted therapy for metastatic melanoma: from bench to bedside. HemeOnc today (http://www.hemonctoday.com/article.aspx?rid=65856)
-
HemeOnc Today
-
-
Hwu, W.J.1
-
506
-
-
0023503073
-
Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts
-
Paterson DJ et al (1987) Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol 24:1281-1290
-
(1987)
Mol Immunol
, vol.24
, pp. 1281-1290
-
-
Paterson, D.J.1
-
507
-
-
0028853808
-
Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues
-
Durkop H, Latza U, Himmelreich P, Stein H (1995) Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues. Br J Haematol 91:927-931
-
(1995)
Br J Haematol
, vol.91
, pp. 927-931
-
-
Durkop, H.1
Latza, U.2
Himmelreich, P.3
Stein, H.4
-
508
-
-
0029812623
-
OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand
-
al-Shamkhani A et al (1996) OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur J Immunol 26:1695-1699
-
(1996)
Eur J Immunol
, vol.26
, pp. 1695-1699
-
-
Al-Shamkhani, A.1
-
509
-
-
38449090407
-
Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells
-
Soroosh P, Ine S, Sugamura K, Ishii N (2007) Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells. J Immunol 179:5014-5023
-
(2007)
J Immunol
, vol.179
, pp. 5014-5023
-
-
Soroosh, P.1
Ine, S.2
Sugamura, K.3
Ishii, N.4
-
511
-
-
0032534582
-
Ox-40 ligand: A potent co-stimulatory molecule for sustaining primary CD4 T cell responses
-
Gramaglia I, Weinberg AD, Lemon M, Croft M(1998) Ox-40 ligand: A potent co-stimulatory molecule for sustaining primary CD4 T cell responses. J Immunol 161:6510-6517
-
(1998)
J Immunol
, vol.161
, pp. 6510-6517
-
-
Gramaglia, I.1
Weinberg, A.D.2
Lemon, M.3
Croft, M.4
-
512
-
-
1542514775
-
Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells
-
Takeda I et al (2004) Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J Immunol 172:3580-3589
-
(2004)
J Immunol
, vol.172
, pp. 3580-3589
-
-
Takeda, I.1
-
513
-
-
11144246359
-
Expanding role of T-cell costimulators in regulatory T-cell function: Recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells
-
Ndhlovu LC, Takeda I, Sugamura K, Ishii N (2004) Expanding role of T-cell costimulators in regulatory T-cell function: recent advances in accessory molecules expressed on both regulatory and nonregulatory T cells. Crit Rev Immunol 24:251-266
-
(2004)
Crit Rev Immunol
, vol.24
, pp. 251-266
-
-
Ndhlovu, L.C.1
Takeda, I.2
Sugamura, K.3
Ishii, N.4
-
514
-
-
4444381480
-
Functional expression of CD134 by neutrophils
-
Baumann R et al (2004) Functional expression of CD134 by neutrophils. Eur J Immunol 34:2268-2275
-
(2004)
Eur J Immunol
, vol.34
, pp. 2268-2275
-
-
Baumann, R.1
-
515
-
-
36048956341
-
OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice
-
Zaini J et al (2007) OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice. J Clin Invest 117:3330-3338
-
(2007)
J Clin Invest
, vol.117
, pp. 3330-3338
-
-
Zaini, J.1
-
516
-
-
0022379617
-
A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I)
-
Tanaka Y, Inoi T, Tozawa H, Yamamoto N, Hinuma Y (1985) A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I). Int J Cancer 36:549-555
-
(1985)
Int J Cancer
, vol.36
, pp. 549-555
-
-
Tanaka, Y.1
Inoi, T.2
Tozawa, H.3
Yamamoto, N.4
Hinuma, Y.5
-
517
-
-
0026030090
-
Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type i transactivator p40tax
-
Miura S et al (1991) Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax. Mol Cell Biol 11:1313-1325
-
(1991)
Mol Cell Biol
, vol.11
, pp. 1313-1325
-
-
Miura, S.1
-
518
-
-
0030468789
-
Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
-
Gruss HJ (1996) Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily. Int J Clin Lab Res 26:143-159
-
(1996)
Int J Clin Lab Res
, vol.26
, pp. 143-159
-
-
Gruss, H.J.1
-
519
-
-
0028227874
-
Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor
-
Godfrey WR, Fagnoni FF, Harara MA, Buck D, Engleman EG (1994) Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. J Exp Med 180:757-762
-
(1994)
J Exp Med
, vol.180
, pp. 757-762
-
-
Godfrey, W.R.1
Fagnoni, F.F.2
Harara, M.A.3
Buck, D.4
Engleman, E.G.5
-
520
-
-
0028023305
-
Molecular characterization of murine and human OX40/OX40 ligand systems: Identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
-
Baum PR et al (1994) Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J 13:3992-4001
-
(1994)
EMBO J
, vol.13
, pp. 3992-4001
-
-
Baum, P.R.1
-
521
-
-
0031872028
-
CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
-
Flynn S, Toellner KM, Raykundalia C, Goodall M, Lane P (1998) CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J Exp Med 188:297-304
-
(1998)
J Exp Med
, vol.188
, pp. 297-304
-
-
Flynn, S.1
Toellner, K.M.2
Raykundalia, C.3
Goodall, M.4
Lane, P.5
-
522
-
-
0031572569
-
Expression and function of OX40 ligand on human dendritic cells
-
Ohshima Y et al (1997) Expression and function of OX40 ligand on human dendritic cells. J Immunol 159:3838-3848
-
(1997)
J Immunol
, vol.159
, pp. 3838-3848
-
-
Ohshima, Y.1
-
523
-
-
33645074150
-
Activated T cells express the OX40 ligand: Requirements for induction and co-stimulatory function
-
Mendel I, Shevach EM (2006) Activated T cells express the OX40 ligand: requirements for induction and co-stimulatory function. Immunology 117:196-204
-
(2006)
Immunology
, vol.117
, pp. 196-204
-
-
Mendel, I.1
Shevach, E.M.2
-
524
-
-
0029895222
-
The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells
-
Imura A et al (1996) The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J Exp Med 183:2185-2195
-
(1996)
J Exp Med
, vol.183
, pp. 2185-2195
-
-
Imura, A.1
-
525
-
-
1942500171
-
Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: A possible role in asthma?
-
Burgess JK et al (2004) Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: A possible role in asthma? J Allergy Clin Immunol 113:683-689
-
(2004)
J Allergy Clin Immunol
, vol.113
, pp. 683-689
-
-
Burgess, J.K.1
-
526
-
-
0033427047
-
OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection
-
Kopf M et al (1999) OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Immunity 11:699-708
-
(1999)
Immunity
, vol.11
, pp. 699-708
-
-
Kopf, M.1
-
527
-
-
0344286707
-
Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)
-
Pippig SD et al (1999) Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol 163:6520-6529
-
(1999)
J Immunol
, vol.163
, pp. 6520-6529
-
-
Pippig, S.D.1
-
528
-
-
0034665502
-
The OX40 co-stimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
-
Gramaglia I et al (2000) The OX40 co-stimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J Immunol 165:3043-3050
-
(2000)
J Immunol
, vol.165
, pp. 3043-3050
-
-
Gramaglia, I.1
-
529
-
-
0034677176
-
Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand
-
Murata K et al (2000) Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J Exp Med 191:365-374
-
(2000)
J Exp Med
, vol.191
, pp. 365-374
-
-
Murata, K.1
-
530
-
-
34948883517
-
OX40 costimulation turns off Foxp3+ Tregs
-
Vu MD et al (2007) OX40 costimulation turns off Foxp3+ Tregs. Blood 110:2501-2510
-
(2007)
Blood
, vol.110
, pp. 2501-2510
-
-
Vu, M.D.1
-
531
-
-
14744285671
-
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: A novel regulatory role for OX40 and its comparison with GITR
-
Valzasina B et al (2005) Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: A novel regulatory role for OX40 and its comparison with GITR. Blood 105:2845-2851
-
(2005)
Blood
, vol.105
, pp. 2845-2851
-
-
Valzasina, B.1
-
532
-
-
34548646019
-
Cutting edge: OX40 inhibits TGF-beta-and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3+ T cells
-
So T, Croft M (2007) Cutting edge: OX40 inhibits TGF-beta-and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3+ T cells. J Immunol 179:1427-1430
-
(2007)
J Immunol
, vol.179
, pp. 1427-1430
-
-
So, T.1
Croft, M.2
-
533
-
-
65349112520
-
The significance of OX40 and OX40L to T-cell biology and immune disease
-
Croft M, So T, Duan W, Soroosh P (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev 229:173-191
-
(2009)
Immunol Rev
, vol.229
, pp. 173-191
-
-
Croft, M.1
So, T.2
Duan, W.3
Soroosh, P.4
-
534
-
-
77951060733
-
OX40 is required for regulatory T cellmediated control of colitis
-
Griseri T, Asquith M, Thompson C, Powrie F (2010) OX40 is required for regulatory T cellmediated control of colitis. J Exp Med 207:699-709
-
(2010)
J Exp Med
, vol.207
, pp. 699-709
-
-
Griseri, T.1
Asquith, M.2
Thompson, C.3
Powrie, F.4
-
535
-
-
77949654340
-
Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right
-
Ruby CE et al (2009) Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. J Immunol 183:4853-4857
-
(2009)
J Immunol
, vol.183
, pp. 4853-4857
-
-
Ruby, C.E.1
-
536
-
-
0034651736
-
Engagement of the OX-40 receptor in vivo enhances antitumor immunity
-
Weinberg AD et al (2000) Engagement of the OX-40 receptor in vivo enhances antitumor immunity. J Immunol 164:2160-2169
-
(2000)
J Immunol
, vol.164
, pp. 2160-2169
-
-
Weinberg, A.D.1
-
537
-
-
0034306979
-
Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth
-
Kjaergaard J et al (2000) Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth. Cancer Res 60:5514-5521
-
(2000)
Cancer Res
, vol.60
, pp. 5514-5521
-
-
Kjaergaard, J.1
-
538
-
-
0035576267
-
Augmentation versus inhibition: Effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor
-
Kjaergaard J et al (2001) Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J Immunol 167:6669-6677
-
(2001)
J Immunol
, vol.167
, pp. 6669-6677
-
-
Kjaergaard, J.1
-
539
-
-
0036799040
-
OX40 ligation enhances primary and memory cytotoxic T lymphocyte responses in an immunotherapy for hepatic colon metastases
-
Pan PY, Zang Y, Weber K, Meseck ML, Chen SH (2002) OX40 ligation enhances primary and memory cytotoxic T lymphocyte responses in an immunotherapy for hepatic colon metastases. Mol Ther 6:528-536
-
(2002)
Mol Ther
, vol.6
, pp. 528-536
-
-
Pan, P.Y.1
Zang, Y.2
Weber, K.3
Meseck, M.L.4
Chen, S.H.5
-
540
-
-
0034904266
-
Induction of anti-mammary cancer immunity by engaging the OX-40 receptor in vivo
-
Morris A et al (2001) Induction of anti-mammary cancer immunity by engaging the OX-40 receptor in vivo. Breast Cancer Res Treat 67:71-80
-
(2001)
Breast Cancer Res Treat
, vol.67
, pp. 71-80
-
-
Morris, A.1
-
541
-
-
4143106890
-
Anti-tumour therapeutic efficacy of OX40L in murine tumour model
-
Ali SA et al (2004) Anti-tumour therapeutic efficacy of OX40L in murine tumour model. Vaccine 22:3585-3594
-
(2004)
Vaccine
, vol.22
, pp. 3585-3594
-
-
Ali, S.A.1
-
542
-
-
41149174875
-
Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models
-
Sadun RE et al (2008) Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models. J Immunother 31:235-245
-
(2008)
J Immunother
, vol.31
, pp. 235-245
-
-
Sadun, R.E.1
-
543
-
-
70249141660
-
Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo
-
Redmond WL, Gough MJ, Weinberg AD (2009) Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo. Eur J Immunol 39:2184-2194
-
(2009)
Eur J Immunol
, vol.39
, pp. 2184-2194
-
-
Redmond, W.L.1
Gough, M.J.2
Weinberg, A.D.3
-
544
-
-
34250358993
-
Cooperation between CD4 and CD8 T cells for antitumor activity is enhanced by OX40 signals
-
Song A, Song J, Tang X, Croft M(2007) Cooperation between CD4 and CD8 T cells for antitumor activity is enhanced by OX40 signals. Eur J Immunol 37:1224-1232
-
(2007)
Eur J Immunol
, vol.37
, pp. 1224-1232
-
-
Song, A.1
Song, J.2
Tang, X.3
Croft, M.4
-
545
-
-
42249097689
-
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
-
Piconese S, Valzasina B, Colombo MP (2008) OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med 205:825-839
-
(2008)
J Exp Med
, vol.205
, pp. 825-839
-
-
Piconese, S.1
Valzasina, B.2
Colombo, M.P.3
-
546
-
-
0037218624
-
OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-Apc signaling to boost the host T cell antitumor response
-
Gri G, Gallo E, Di Carlo E, Musiani P, Colombo MP (2003) OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-Apc signaling to boost the host T cell antitumor response. J Immunol 170:99-106
-
(2003)
J Immunol
, vol.170
, pp. 99-106
-
-
Gri, G.1
Gallo, E.2
Di Carlo, E.3
Musiani, P.4
Colombo, M.P.5
-
547
-
-
66049113612
-
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis
-
Hirschhorn-Cymerman D et al (2009) OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis. J Exp Med 206:1103-1116
-
(2009)
J Exp Med
, vol.206
, pp. 1103-1116
-
-
Hirschhorn-Cymerman, D.1
-
548
-
-
77958047687
-
Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice
-
Gough MJ et al (2010) Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice. J Immunother 33:798-809
-
(2010)
J Immunother
, vol.33
, pp. 798-809
-
-
Gough, M.J.1
-
549
-
-
38949156782
-
Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer
-
Yokouchi H et al (2008) Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer. Cancer Sci 99:361-367
-
(2008)
Cancer Sci
, vol.99
, pp. 361-367
-
-
Yokouchi, H.1
-
550
-
-
33750546487
-
Anti-OX40 (CD134) administration to nonhuman primates: Immunostimulatory effects and toxicokinetic study
-
Weinberg AD et al (2006) Anti-OX40 (CD134) administration to nonhuman primates: immunostimulatory effects and toxicokinetic study. J Immunother 29:575-585
-
(2006)
J Immunother
, vol.29
, pp. 575-585
-
-
Weinberg, A.D.1
-
551
-
-
78449237498
-
Signaling through OX40 enhances antitumor immunity
-
Jensen SM et al (2010) Signaling through OX40 enhances antitumor immunity. Semin Oncol 37:524-532
-
(2010)
Semin Oncol
, vol.37
, pp. 524-532
-
-
Jensen, S.M.1
-
552
-
-
34247183575
-
Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain
-
Morris NP et al (2007) Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain. Mol Immunol 44:3112-3121
-
(2007)
Mol Immunol
, vol.44
, pp. 3112-3121
-
-
Morris, N.P.1
-
553
-
-
0033590502
-
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
-
Hutloff A et al (1999) ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397:263-266
-
(1999)
Nature
, vol.397
, pp. 263-266
-
-
Hutloff, A.1
-
554
-
-
0034327808
-
Mouse inducible co-stimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells
-
McAdam AJ et al (2000) Mouse inducible co-stimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol 165:5035-5040
-
(2000)
J Immunol
, vol.165
, pp. 5035-5040
-
-
McAdam, A.J.1
-
555
-
-
40449116396
-
ICOS controls the pool size of effector-memory and regulatory T cells
-
Burmeister Y et al (2008) ICOS controls the pool size of effector-memory and regulatory T cells. J Immunol 180:774-782
-
(2008)
J Immunol
, vol.180
, pp. 774-782
-
-
Burmeister, Y.1
-
556
-
-
0033576707
-
T-cell co-stimulation through B7RP-1 and ICOS
-
Yoshinaga SK et al (1999) T-cell co-stimulation through B7RP-1 and ICOS. Nature 402:827-832
-
(1999)
Nature
, vol.402
, pp. 827-832
-
-
Yoshinaga, S.K.1
-
557
-
-
0033212778
-
B7h, a novel co-stimulatory homolog of B7. 1 and B7.2, is induced by TNFalpha
-
Swallow MM, Wallin JJ, Sha WC (1999) B7h, a novel co-stimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity 11:423-432
-
(1999)
Immunity
, vol.11
, pp. 423-432
-
-
Swallow, M.M.1
Wallin, J.J.2
Sha, W.C.3
-
558
-
-
0345492422
-
B7h is required for T cell activation, differentiation, and effector function
-
Nurieva RI, Mai XM, Forbush K, Bevan MJ, Dong C (2003) B7h is required for T cell activation, differentiation, and effector function. Proc Natl Acad Sci USA 100:14163-14168
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 14163-14168
-
-
Nurieva, R.I.1
Mai, X.M.2
Forbush, K.3
Bevan, M.J.4
Dong, C.5
-
559
-
-
0035988233
-
A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses
-
Arimura Y et al (2002) A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses. Int Immunol 14:555-566
-
(2002)
Int Immunol
, vol.14
, pp. 555-566
-
-
Arimura, Y.1
-
560
-
-
0242586146
-
Mechanisms of H4/ICOS costimulation: Effects on proximal TCR signals and MAP kinase pathways
-
Feito MJ et al (2003) Mechanisms of H4/ICOS costimulation: effects on proximal TCR signals and MAP kinase pathways. Eur J Immunol 33:204-214
-
(2003)
Eur J Immunol
, vol.33
, pp. 204-214
-
-
Feito, M.J.1
-
561
-
-
0038545370
-
CD28 and inducible co-stimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes
-
Parry RV, Rumbley CA, Vandenberghe LH, June CH, Riley JL (2003) CD28 and inducible co-stimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes. J Immunol 171:166-174
-
(2003)
J Immunol
, vol.171
, pp. 166-174
-
-
Parry, R.V.1
Rumbley, C.A.2
Vandenberghe, L.H.3
June, C.H.4
Riley, J.L.5
-
562
-
-
73949090666
-
Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
-
Gigoux M et al (2009) Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci USA 106:20371-20376
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20371-20376
-
-
Gigoux, M.1
-
563
-
-
49649098826
-
ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse
-
Fos C et al (2008) ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse. J Immunol 181:1969-1977
-
(2008)
J Immunol
, vol.181
, pp. 1969-1977
-
-
Fos, C.1
-
564
-
-
77952348017
-
Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS)
-
Simpson TR, Quezada SA, Allison JP (2010) Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS). Curr Opin Immunol 22:326-332
-
(2010)
Curr Opin Immunol
, vol.22
, pp. 326-332
-
-
Simpson, T.R.1
Quezada, S.A.2
Allison, J.P.3
-
565
-
-
0035804254
-
ICOS co-stimulatory receptor is essential for T-cell activation and function
-
Dong C et al (2001) ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409:97-101
-
(2001)
Nature
, vol.409
, pp. 97-101
-
-
Dong, C.1
-
566
-
-
0035804269
-
ICOS is essential for effective T-helper-cell responses
-
Tafuri A et al (2001) ICOS is essential for effective T-helper-cell responses. Nature 409:105-109
-
(2001)
Nature
, vol.409
, pp. 105-109
-
-
Tafuri, A.1
-
567
-
-
23444434705
-
The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
-
Akiba H et al (2005) The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 175:2340-2348
-
(2005)
J Immunol
, vol.175
, pp. 2340-2348
-
-
Akiba, H.1
-
568
-
-
65449156015
-
The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells
-
Tuettenberg A et al (2009) The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells. J Immunol 182:3349-3356
-
(2009)
J Immunol
, vol.182
, pp. 3349-3356
-
-
Tuettenberg, A.1
-
569
-
-
0037340349
-
Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
-
Grimbacher B et al (2003) Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol 4:261-268
-
(2003)
Nat Immunol
, vol.4
, pp. 261-268
-
-
Grimbacher, B.1
-
570
-
-
0042195831
-
Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses
-
Mak TW et al (2003) Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat Immunol 4:765-772
-
(2003)
Nat Immunol
, vol.4
, pp. 765-772
-
-
Mak, T.W.1
-
571
-
-
33749151018
-
ICOS deficiency is associated with a severe reduction of CXCR5 + CD4 germinal center Th cells
-
Bossaller L et al (2006) ICOS deficiency is associated with a severe reduction of CXCR5 + CD4 germinal center Th cells. J Immunol 177:4927-4932
-
(2006)
J Immunol
, vol.177
, pp. 4927-4932
-
-
Bossaller, L.1
-
572
-
-
58449124804
-
The co-stimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
-
Bauquet AT et al (2009) The co-stimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 10:167-175
-
(2009)
Nat Immunol
, vol.10
, pp. 167-175
-
-
Bauquet, A.T.1
-
573
-
-
0034600567
-
Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection
-
Kopf M et al (2000) Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection. J Exp Med 192:53-61
-
(2000)
J Exp Med
, vol.192
, pp. 53-61
-
-
Kopf, M.1
-
574
-
-
70449566838
-
Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells
-
Clay BS et al (2009) Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells. PLoS One 4: e7525
-
(2009)
PLoS One
, vol.4
, pp. e7525
-
-
Clay, B.S.1
-
575
-
-
70349102877
-
CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo
-
Shilling RA et al (2009) CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo. Cell Immunol 259:177-184
-
(2009)
Cell Immunol
, vol.259
, pp. 177-184
-
-
Shilling, R.A.1
-
576
-
-
0038433326
-
Transcriptional regulation of th2 differentiation by inducible costimulator
-
Nurieva RI et al (2003) Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity 18:801-811
-
(2003)
Immunity
, vol.18
, pp. 801-811
-
-
Nurieva, R.I.1
-
577
-
-
66949171812
-
Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients
-
Takahashi N et al (2009) Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol 182:5515-5527
-
(2009)
J Immunol
, vol.182
, pp. 5515-5527
-
-
Takahashi, N.1
-
578
-
-
44649189089
-
Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
-
Ito T et al (2008) Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity 28:870-880
-
(2008)
Immunity
, vol.28
, pp. 870-880
-
-
Ito, T.1
-
579
-
-
0037455003
-
Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10
-
Lohning M et al (2003) Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J Exp Med 197:181-193
-
(2003)
J Exp Med
, vol.197
, pp. 181-193
-
-
Lohning, M.1
-
580
-
-
0036732461
-
Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
-
Akbari O et al (2002) Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 8:1024-1032
-
(2002)
Nat Med
, vol.8
, pp. 1024-1032
-
-
Akbari, O.1
-
581
-
-
49149125958
-
Expression of ICOS on human melanoma-infiltrating CD4 + CD25highFoxp3+ T regulatory cells: Implications and impact on tumor-mediated immune suppression
-
Strauss L et al (2008) Expression of ICOS on human melanoma-infiltrating CD4 + CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression. J Immunol 180:2967-2980
-
(2008)
J Immunol
, vol.180
, pp. 2967-2980
-
-
Strauss, L.1
-
582
-
-
73949140415
-
Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival
-
Bogunovic D et al (2009) Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival. Proc Natl Acad Sci USA 106:20429-20434
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20429-20434
-
-
Bogunovic, D.1
-
583
-
-
78049518331
-
The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells
-
Paulos CM et al (2010) The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells. Sci Transl Med 2:55ra78
-
(2010)
Sci Transl Med
, vol.2
, pp. 55ra78
-
-
Paulos, C.M.1
-
584
-
-
33745031054
-
Treatment of transplanted CT26 tumour with dendritic cell vaccine in combination with blockade of vascular endothelial growth factor receptor 2 and CTLA-4
-
Pedersen AE, Buus S, Claesson MH (2006) Treatment of transplanted CT26 tumour with dendritic cell vaccine in combination with blockade of vascular endothelial growth factor receptor 2 and CTLA-4. Cancer Lett 235:229-238
-
(2006)
Cancer Lett
, vol.235
, pp. 229-238
-
-
Pedersen, A.E.1
Buus, S.2
Claesson, M.H.3
-
585
-
-
0035903324
-
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreative cytotxic T lymphocyte responses
-
Sutmuller RP, van Duivenvoorde LM, van Elsas A et al (2001) Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreative cytotxic T lymphocyte responses. J Exp Med 194:823-832
-
(2001)
J Exp Med
, vol.194
, pp. 823-832
-
-
Sutmuller, R.P.1
Van Duivenvoorde, L.M.2
Van Elsas, A.3
-
586
-
-
0037443573
-
CTLA-4 blockadeenhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model
-
Espenshied J, Lamont J, Longmate J et al (2003) CTLA-4 blockadeenhances the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model. J Immunol 170:3401-3401
-
(2003)
J Immunol
, vol.170
, pp. 3401-3401
-
-
Espenshied, J.1
Lamont, J.2
Longmate, J.3
-
587
-
-
69949095926
-
A randomized, double-blide, placebo controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
-
Weber et al (2009) A randomized, double-blide, placebo controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma. Clin Cancer Res 15:5591-5598
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5591-5598
-
-
Weber1
-
588
-
-
52649088779
-
CTLA4 bloackade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: Surrogate marker of efficacy of tremelimumba?
-
Menard C et al (2008) CTLA4 bloackade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumba? Clinical Cancer Res. 14:5242-9
-
(2008)
Clinical Cancer Res.
, vol.14
, pp. 5242-5249
-
-
Menard, C.1
-
589
-
-
82155168544
-
A prospective phase II trial expoloring the association between tumor microenvironment biomakers and clinical activity of ipilimumab in advanced melanoma
-
Hamid et al (2011) A prospective phase II trial expoloring the association between tumor microenvironment biomakers and clinical activity of ipilimumab in advanced melanoma. J of Translational Medicine 9:204
-
(2011)
J of Translational Medicine
, vol.9
, pp. 204
-
-
Hamid1
-
590
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian S et al (2012) Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer. NEJM 366(26):2443-2454
-
(2012)
NEJM
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.1
-
591
-
-
84867572490
-
Targeting of 4-1BB by monoclonal antibody PD-05082566 enhances T cell function and promotes anti-tumor activity
-
Fisher T et al (2012) Targeting of 4-1BB by monoclonal antibody PD-05082566 enhances T cell function and promotes anti-tumor activity Cancer Immunol Immunother 280 M.K. Callahan et al.
-
(2012)
Cancer Immunol Immunother 280 M.K. Callahan et al
-
-
Fisher, T.1
|