CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Schneider, Helga ^a,b   Valk, Elke ^a,b   Leung, Rufina ^b   Rudd, Christopher E ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL XL; PROTEIN KINASE B; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; LEUKOCYTE ANTIGEN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CLONAL ANERGY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; UPREGULATION; BIOSYNTHESIS; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD; APOPTOSIS; CELL DEATH; CELL PROLIFERATION; CELLS, CULTURED; CLONAL ANERGY; INTERLEUKIN-2; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 57349090212     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003842     Document Type: Article

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