B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

Immunity

Volumn 12, Issue 4, 2000, Pages 431-440

  Salomon, Benoît ^a   Lenschow, Deborah J ^a   Rhee, Lesley ^a   Ashourian, Neda ^a   Singh, Bhagarith ^b   Sharpe, Arlene ^c   Bluestone, Jeffrey A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL STIMULATION; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HOMEOSTASIS; IMMUNOREGULATION; IMMUNOSTIMULATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0033682056     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80195-8     Document Type: Article

References (39)

1. Regulation of surface and intracellular expression of CTLA4 on mouse T cells
2. Checkpoints in the progression of autoimmune disease: Lesson from diabetes models
3. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
4. Induction of autoimmunity in the absence of CD28 costimulation
5. Cutting edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
6. Accessory molecules
7. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice
8. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
9. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis
10. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
11. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
12. Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability
13. Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate 'active tolerance' in the nonobese diabetic mouse
14. Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
15. CTLA-4: A negative regulator of autoimmune disease
16. Organ-specific autoimmunity
17. TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype
18. Duration of TCR stimulation determines costimulatory requirement of T cells
19. CD28/B7 system of T cell costimulation
20. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
21. Identification of a monoclonal antibody specific for a murine T3 polypeptide
22. Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28
23. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
24. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
25. Regulatory CD4 T cells: Expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
26. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
27. Role of B7:CD24/CTLA-4 in the induction of chronic relapsing experimental allerg c encephalomyelitis
28. B7.2 has opposing roles during the activation versus effector stages of experimental autoimmune thyroiditis
29. CD28 costimulation promotes the production of TH2 cytokines
30. Differential T cell costimulatory requirements in CD28-deficient mice
31. Differential requirements for CD28 and CD40 ligand in the induction of experimental autoimmune myasthenia gravis
32. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
33. Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival
34. CD28-deficient mice are highly resistant to collagen-induced arthritis
35. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
36. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CLTA-4
37. Genetics of type 1 diabetes
38. CTLA-4 regulates tolerance induction and T cell differentiation in vivo
39. CTLA-4 can function as a negative regulator of T cell activation