Induction of antitumor immunity by transduction of CD40 ligand gene and interferon-γ gene into lung cancer

Cancer Gene Therapy

Volumn 8, Issue 6, 2001, Pages 421-429

  Noguchi, Masahiro ^a   Imaizumi, Kazuyoshi ^a   Kawabe, Tsutomu ^a   Wakayama, Hisashi ^a   Horio, Yoshitsugu ^a   Sekido, Yoshitaka ^a   Hara, Toru ^a   Hashimoto, Naozumi ^a   Takahashi, Masahide ^a   Shimokata, Kaoru ^a   Hasegawa, Yoshinori ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antitumor immunity; CD40 ligand; Cytotoxic T lymphocyte; Interferon ; Lung cancer

Indexed keywords

CD40 ANTIGEN; GAMMA INTERFERON; LIGAND;

ANIMAL CELL; ARTICLE; CANCER IMMUNOTHERAPY; CELL INFILTRATION; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE; GENETIC TRANSDUCTION; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LIGAND BINDING; LUNG CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR IMMUNITY;

ANIMALS; CANCER VACCINES; CD40 LIGAND; DNA, COMPLEMENTARY; GENE THERAPY; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; LUNG NEOPLASMS; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; TRANSDUCTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 17944366839     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700320     Document Type: Article

References (37)

1. Gene therapy for lung cancer
2. A new era for cancer immunotherapy based on the genes that encode cancer antigens
3. Human tumor antigens for cancer vaccine development
4. The great escape: Is immune evasion required for tumor progression?
5. Induction of antigen-specific T cell anergy: An early event in the course of tumor progression
6. Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40
7. The CD40 antigen and its ligand
8. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
9. Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154
10. Licence to kill
11. Enhancement of tumoficidal activity of alveolar macrophages via CD40-CD40 ligand interaction
12. Enzymatic determination of transmissible replicating factors associated with mouse tumors
13. Control of pigment production in mouse melanoma cells in vitro. Evocation and maintenance
14. Calcium-independent pathway of tumor necrosis factor-mediated lysis of target cells
15. Effects of TGF-β on the immune system: Implications for cancer immunotherapy
16. Interleukin-10: A cytokine used by tumors to escape immunosurveillance
17. Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: Up-regulation of interleukin 10 and down-regulation of interleukin 12 production
18. Tumor expression of Fas ligand (CD95L) and the consequences
19. Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells
20. Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1
21. Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses
22. Depletion of IL-10-TGF-β-producing regulatory γδ T cells by administering a daunomycin-conjugated specific monoclonal antibody in early tumor lesions augments the activity of CTLs and NK cells
23. The immune system in the elderly: III. Innate immunity
24. Functions of CD40 on B cells, dendritic cells and other cells
25. Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation
26. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
27. CD40 expression by human monocytes: Regulation by cytokines and activation of monocytes by the ligand for CD40
28. CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth
29. What is the real role of CD40 in cancer immunotherapy?
30. Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand
31. Activation of CD40 favors the growth and vascularization of Kaposi's sarcoma
32. Antitumor effect of CD40 ligand: Elicitation of local and systemic antitumor responses by IL-12 and B7
33. Antitumor responses induced by transgenic expression of CD40 ligand
34. Antimetastatic vaccination of tumor-bearing mice with two types of IFN-γ gene-inserted tumor cells
35. High-level IL-12 production by human dendritic cells requires two signals
36. Synergistic action of fms-like tyrosine kinase 3 ligand and CD40 ligand in the induction of dendritic cells and generation of antitumor immunity in vivo
37. Dendritic cells infiltrating tumors cotransduced with granulocyte/macrophage colony-stimulating factor (GM-CSF) and CD40 ligand genes take up and present endogenous tumor-associated antigens, and prime naive mice for a cytotoxic T lymphocyte response