메뉴 건너뛰기




Volumn 109, Issue 5, 2002, Pages 651-659

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CD137 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD 137; UNCLASSIFIED DRUG;

EID: 0036195860     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0214184     Document Type: Article
Times cited : (249)

References (45)
  • 3
    • 0027285735 scopus 로고
    • Inducible T cell antigen 4-1BB. Analysis of expression and function
    • (1993) J. Immunol. , vol.150 , pp. 771-781
    • Pollok, K.E.1
  • 5
    • 0032101119 scopus 로고    scopus 로고
    • CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand
    • (1998) J. Exp. Med. , vol.187 , pp. 1849-1862
    • Saouili, K.1
  • 6
    • 0034541168 scopus 로고    scopus 로고
    • Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response
    • (2000) J. Immunol. , vol.165 , pp. 6193-6204
    • Cannons, J.L.1    Choi, Y.2    Watts, T.H.3
  • 9
    • 0033954331 scopus 로고    scopus 로고
    • CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes
    • (2000) Int. Immunol. , vol.12 , pp. 73-82
    • Kienzle, G.1    Kempis, J.2
  • 13
    • 0032754036 scopus 로고    scopus 로고
    • Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
    • (1999) J. Immunol. , vol.163 , pp. 4833-4841
    • DeBenedette, M.A.1
  • 14
    • 0034162569 scopus 로고    scopus 로고
    • 4-1BB costimulatinn is required for protective antiviral immunity after peptide vaccination
    • (2000) J. Immunol. , vol.164 , pp. 2320-2325
    • Tan, J.T.1
  • 15
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • (1997) Nat. Med. , vol.3 , pp. 682-685
    • Melero, I.1
  • 17
    • 0031906785 scopus 로고    scopus 로고
    • Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy, with the CD28 co-stimulatory pathway
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1116-1121
    • Melero, I.1
  • 18
    • 0034616629 scopus 로고    scopus 로고
    • Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: Long-term remission of liver metastases in a mouse model
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 931-936
    • Martinet, O.1
  • 19
    • 0034218442 scopus 로고    scopus 로고
    • Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation
    • (2000) Mol. Ther. , vol.2 , pp. 39-46
    • Chen, S.H.1
  • 20
    • 0027320440 scopus 로고
    • Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells
    • (1993) Eur. J. Immunol. , vol.23 , pp. 2242-2249
    • Feltkamp, M.C.1
  • 21
    • 0029083121 scopus 로고
    • A vaccine conjugate of 'ISCAR' immunocarrier and pepride epitopes of the E7 cervical cancer-associated protein of human papillomavirus type 16 elicits specific Th1- and Th2-type responses in immunized mice in the absence of oil-based adjuvants
    • (1995) Clin. Exp. Immunol. , vol.101 , pp. 265-271
    • Tindle, R.W.1
  • 22
    • 0030068375 scopus 로고    scopus 로고
    • Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
    • (1996) Cancer Res. , vol.56 , pp. 21-26
    • Lin, K.Y.1
  • 23
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1
  • 24
    • 0031041233 scopus 로고    scopus 로고
    • Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma
    • (1997) J. Exp. Med. , vol.185 , pp. 453-459
    • Bloom, M.B.1
  • 25
    • 0034671292 scopus 로고    scopus 로고
    • Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model
    • (2000) Cancer Res. , vol.60 , pp. 6995-7001
    • Schreurs, M.W.J.1
  • 26
    • 0032899121 scopus 로고    scopus 로고
    • b:Vp2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28
    • (1999) J. Virol. , vol.73 , pp. 3702-3708
    • Johnson, A.J.1
  • 28
    • 0023821578 scopus 로고
    • Introduction of soluble protein into the class I pathway of antigen processing and presentation
    • (1988) Cell , vol.54 , pp. 777-785
    • Moore, M.1    Carbone, F.2    Bevan, M.3
  • 29
    • 0034117337 scopus 로고    scopus 로고
    • Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
    • (2000) Nat. Med. , vol.6 , pp. 283-289
    • Tamada, K.1
  • 31
    • 0030845586 scopus 로고    scopus 로고
    • - T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • (1997) J. Exp. Med. , vol.186 , pp. 47-55
    • Shuford, W.F.1
  • 32
    • 0034662262 scopus 로고    scopus 로고
    • Identification of a novel tumor-specific CTL epitope presented by RMA, EL-4, and MBL-2 lymphomas reveals their common origin
    • (2000) J. Immunol. , vol.165 , pp. 869-877
    • Van Hall, T.1
  • 33
    • 0031888608 scopus 로고    scopus 로고
    • Immunological ignorance of silent antigens as an explanation of tumor evasion
    • (1998) Immunol. Today , vol.19 , pp. 338-341
    • Chen, L.1
  • 35
    • 0030807565 scopus 로고    scopus 로고
    • Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy
    • (1997) J. Exp. Med. , vol.186 , pp. 229-238
    • Wick, M.1
  • 38
    • 0030899873 scopus 로고    scopus 로고
    • Immunological ignorance of an E7-induced cyrolytie T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16
    • (1997) J. Virol. , vol.71 , pp. 3998-4004
    • Melero, I.1
  • 39
    • 0035266427 scopus 로고    scopus 로고
    • Divergent effects of 4-1BB antibodies on antitumor immunity and on rumor-reactive T-cell generation
    • (2001) Cancer Res. , vol.61 , pp. 2031-2037
    • Kim, J.1
  • 40
    • 0033497345 scopus 로고    scopus 로고
    • Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes
    • (1999) Semin. Cancer Biol. , vol.9 , pp. 405-411
    • Zur Hausen, H.1
  • 44
    • 0034234934 scopus 로고    scopus 로고
    • HER-2/neu is a tumor rejection target in tolerized HER-2/neu transgenic mice
    • (2000) Cancer Res. , vol.60 , pp. 3569-3576
    • Reilly, K.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.