Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8+ T cells independently of CD4+ T cell help

Journal of Experimental Medicine

Volumn 189, Issue 7, 1999, Pages 1157-1162

  McCoy, Kathy D ^a,b   Hermans, Ian F ^a   Fraser, J Henry ^a   Le Gros, Graham ^a   Ronchese, Franca ^a  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

CD4+ T cells; CD8+ T cells; CTLA 4 (CD152); Cytotoxicity; Dendritic cells

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CELL MEDIATED CYTOTOXICITY; CELL PROLIFERATION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EFFECTOR CELL; HELPER CELL; IMMUNE RESPONSE; IMMUNOTHERAPY; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; ANTIGENS, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; HUMANS; IMMUNIZATION; IMMUNOCONJUGATES; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0033526111     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.7.1157     Document Type: Article

References (26)

1. Bluestone, J.A. 1995. New perspectives of CD28-B7-mediated T cell costimulation. Immunity. 2:555-559.
2. Thompson, C.B., and J.P. Allison. 1997. The emerging role of CTLA-4 as an immune attenuator. Immunity. 7:445-450.
3. Waterhouse, P., J.M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K.P. Lee, C.B. Thompson, H. Griesser, and T.W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science. 270:985-988.
4. Tivol, E.A., F. Borriello, A.N. Schweitzer, W.P. Lynch, J.A. Bluestone, and A.H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 3:541-547.
5. + T cells. Immunity. 7:885-895.
6. + T cells in vivo is dependent on CD28 costimuladon and inhibited by CTLA-4. J. Immunol. 155:1032-1036.
7. Krummel, M.F., T.J. Sullivan, and J.P. Allison. 1996. Superantigen responses and costimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int. Immunol. 8:519-523.
8. McCoy, K.D., M. Camberis, and G. Le Gros. 1997. Protective immunity to nematode infection is induced by CTLA-4 blockade. J. Exp. Med. 186:183-187.
9. Karandikar, N.J., C.L. Vanderlugt, T.L. Walunas, S.D. Miller, and J.A. Bluestone. 1996. CTLA-4: a negative regulator of autoimmune disease. J. Exp. Med. 184:783-788.
10. Lühder, F., P. Högland, J.P. Allison, C. Benoist, and D. Mathis. 1998. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187:427-432.
11. Perrin, P.J., J.H. Maldonado, T.A. Davis, C.H. June, and M.K. Racke. 1996. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 157:1333-1336.
12. Leach, D.R., M.F. Krummel, and J.P. Allison. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 271:1734-1736.
13. Pircher, H., K. Buerki, R. Lang, H. Hengartner, and R.M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature. 342:559-561.
14. Köntgen, F., G. Süss, C. Stewart, M. Steinmetz, and H. Blüthmann. 1993. Targeted disruption of the MHC class II Aa gene in C57BL/6 mice. Int. Immunol 5:957-964.
15. Hermans, I.F., A. Daish, J. Yang, D.S. Ritchie, and F. Ronchese. 1998. Antigen expressed on tumor cells fails to elicit an immune response, even in the presence of increased numbers of tumor-specific cytotoxic T lymphocyte precursors. Cancer Res. 58:3909-3917.
16. Fraser, J.H., M. Rincon, K.D. McCoy, and G. Le Gros. 1999. CTLA-4 ligation attenuates AP-1, NFAT and NFκB activity in activated T cells. Eur. J. Immunol. In press.
17. Garrigan, K., P. Moroni-Rawson, C. McMurray, I. Hermans, N. Abernethy, J. Watson, and F. Ronchese. 1996. Functional comparison of spleen dendritic cells and dendritic cells cultured in vitro from bone marrow precursors. Blood. 88:3508-3512.
18. Hermans, I.F., A. Daish, P. Moroni-Rawson, and F. Ronchese. 1997. Tumor peptide-pulsed dendritic cells isolated from spleen or cultured in vitro from bone marrow precursors can provide protection against tumor challenge. Cancer Immunol. Immunother. 44:341-347.
19. Walunas, T.L., C.Y. Bakker, and J.A. Bluestone. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541-2550.
20. Lanzavecchia, A. 1998. Immunology. Licence to kill. Nature. 393:413-414.
21. Kurts, C., W.R. Heath, F.R. Carbone, J. Allison, J.F. Miller, and H. Kosaka. 1996. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184: 923-930.
22. Huang, A.Y., P. Golumbek, M. Ahmadzadeh, E. Jaffee, D. Pardoll, and H. Levitsky. 1994. Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science. 264:961-965.
23. Dranoff, G., E. Jaffee, A. Lazenby, P. Golumbek, H. Levitsky, K. Brose, V. Jackson, H. Hamada, D. Pardoll, and R.C. Mulligan. 1993. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. USA. 90:3539-3543.
24. Hurwitz, A.A., T.F. Yu, D.R. Leach, and J.P. Allison. 1998. CTLA-4 blockade synergizes with tumor-derived GM-CSF for treatment of an experimental mammary carcinoma. Proc. Natl. Acad. Sci. USA. 95:10067-10071.
25. Waterhouse, P., M.F. Bachmann, J.M. Penninger, P.S. Ohashi, and T.W. Mak. 1997. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur. J. Immunol. 27:1887-1892.
26. 2+ responses triggered in T cells by dendritic cells compared with B cells. J. Exp. Med. 188:1473-1484.