The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH -17 cells

Nature Immunology

Volumn 10, Issue 2, 2009, Pages 167-175

  Bauquet, Aurelie T ^a   Jin, Hulin ^a   Paterson, Alison M ^b   Mitsdoerffer, Meike ^a   Ho, I Cheng ^b   Sharpe, Arlene H ^b   Kuchroo, Vijay K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; INDUCIBLE T CELL COSTIMULATOR PROTEIN; INTERLEUKIN 21; INTERLEUKIN 23; TRANSCRIPTION FACTOR C MAF; UNCLASSIFIED DRUG;

ARTICLE; CELL MATURATION; CYTOKINE PRODUCTION; FOLLICULAR T HELPER CELL; GENE LOSS; HELPER CELL; IMMUNOREGULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH17 CELL;

ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; INTERLEUKIN-17; INTERLEUKINS; MICE; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS C-MAF; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 58449124804     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1690     Document Type: Article

References (49)

1. Lock, C. et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 8, 500-508 (2002).
2. Matusevicius, D. et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 5, 101-104 (1999).
3. Aarvak, T., Chabaud, M., Miossec, P. & Natvig, J.B. IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells. J. Immunol. 162, 1246-1251 (1999).
4. Teunissen, M.B., Koomen, C.W., de Waal Malefyt, R., Wierenga, E.A. & Bos, J.D. Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J. Invest. Dermatol. 111, 645-649 (1998).
5. Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240 (2005).
6. Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 179-189 (2006).
7. H17 lineage. Nature 441, 231-234 (2006).
8. Cua, D.J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003).
9. Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133-1141 (2005).
10. Aggarwal, S., Ghilardi, N., Xie, M.H., de Sauvage, F.J. & Gurney, A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278, 1910-1914 (2003).
11. H17 cells. Nature 448, 484-487 (2007).
12. H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8, 967-974 (2007).
13. Chtanova, T. et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/ Th2 effector cells that provide help for B cells. J. Immunol. 173, 68-78 (2004).
14. hi CD4 T cells and is independent of CD57 expression. Eur. J. Immunol. 36, 1892-1903 (2006).
15. MacLennan, I.C. Germinal centers. Annu. Rev. Immunol. 12, 117-139 (1994).
16. Liu, Y.J. et al. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation. Immunity 4, 241-250 (1996).
17. Schaerli, P. et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192, 1553-1562 (2000).
18. + T cells. J. Exp. Med. 193, 1373-1381 (2001).
19. Hutloff, A. et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397, 263-266 (1999).
20. Dong, C. et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409, 97-101 (2001).
21. Mak, T.W. et al. Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat. Immunol. 4, 765-772 (2003).
22. Grimbacher, B. et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat. Immunol. 4 261-268 (2003).
23. Warnatz, K. et al. Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency. Blood 107, 3045-3052 (2006).
24. + follicular B helper T cell maintenance in vivo. J. Immunol. 175, 2340-2348 (2005).
25. +CD4 germinal center Th cells. J. Immunol. 177, 4927-4932 (2006).
26. + Th cells produce distinct cytokines in different mucosal immune responses. Eur. J. Immunol. 33, 392-401 (2003).
27. H2 cells anymore. Nat. Immunol. 2, 573-574 (2001).
28. H17 and regulatory T cells. Nature 441, 235-238 (2006).
29. Komiyama, Y. et al. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177, 566-573 (2006).
30. + T helper cells. Cell 126, 1121-1133 (2006).
31. + T follicular helper cells. J. Immunol. 179 8180-8190 (2007).
32. Ansel, K.M., McHeyzer-Williams, L.J., Ngo, V.N., McHeyzer-Williams, M.G. & Cyster, J.G. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190, 1123-1134 (1999).
33. Coyle, A.J. et al. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13, 95-105 (2000).
34. Ozkaynak, E. et al. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat. Immunol. 2, 591-596 (2001).
35. Nurieva, R.I. et al. Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity 18, 801-811 (2003).
36. Usui, Y. et al. The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis. Eur. J. Immunol. 36, 3071-3081 (2006).
37. + effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J. Exp. Med. 197, 181-193 (2003).
38. Ito, T. et al. Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J. Exp. Med. 204, 105-115 (2007).
39. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997).
40. H1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 7, 425-428 (2007).
41. Sonderegger, I. et al. Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. Eur. J. Immunol. 36, 2849-2856 (2006).
42. Hsu, H.C. et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat. Immunol. 9, 166-175 (2008).
43. Dong, C., Temann, U.A. & Flavell, R.A. Cutting edge: Critical role of inducible costimulator in germinal center reactions. J. Immunol. 166, 3659-3662 (2001).
44. Wong, S.C., Oh, E., Ng, C.H. & Lam, K.P. Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7-H2. Blood 102, 1381-1388 (2003).
45. Vinuesa, C.G. et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435, 452-458 (2005).
46. Yu, D. et al. Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature 450, 299-303 (2007).
47. Nakae, S., Nambu, A., Sudo, K. & Iwakura, Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171, 6173-6177 (2003).
48. Greenwald, R.J., McAdam, A.J., Van der Woude, D., Satoskar, A.R. & Sharpe, A.H. Cutting edge: Inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis. J. Immunol. 168, 991-995 (2002).
49. McAdam, A.J. et al. ICOS is critical for CD40-mediated antibody class switching. Nature 409, 102-105 (2001).