Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1786-1794

  Harrop, Jeremy A ^a   Reddy, Manjula ^a   Dede, Kimberly ^a   Brigham Burke, Michael ^a   Lyn, Sally ^a   Tan, Kong B ^a   Silverman, Carol ^a   Eichman, Christopher ^a   DiPrinzio, Rocco ^a   Spampanato, Jay ^a   Porter, Terence ^a   Holmes, Stephen ^a,b   Young, Peter R ^a   Truneh, Alemseged ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; HERPES VIRUS; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CYTOKINES; EPITOPES, T-LYMPHOCYTE; GROWTH INHIBITORS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 14; RECEPTORS, VIRUS; SIMPLEXVIRUS; SOLUBILITY; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 17744403172     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Loetscher, H., Y. C. Pan, H. W. Lahm, R. Gentz, M. Brockhaus, H. Tabuchi, and W. Lesslauer. 1990. Molecular cloning and expression of the human 55kDa TNF receptor. Cell 61:351.
2. Schall, T. J., M. Lewis, K. J. Koller, A. Lee, G. C. Rice, G. H. W. Wong, T. Gatanaga, G. A. Granger, R. Lentz, H. Raab, W. J. Hohr, and D. V. Goeddel. 1990. Molecular cloning and expression of a receptor for human TNF. Cell 61:361.
3. Smith, C. A., T. Davis, D. Anderson, L. Solam, M. P. Beckmann, R. Jerzy, S. K. Dower, D. Cosman, and R. G. Goodwin. 1990. A receptor for TNF defines an unusual family of cellular and viral proteins. Science 248:1019.
4. Van Lier, R. A., J. Borst, T. M. Vroom, H. Klein, P. Van Mourik, W. P. Zeijemaker, and C. J. Melief. 1987. Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. J. Immunol. 139:1589.
5. Durkorp, H., U. Latza, M. Hummel, F. Eitelbach, B. Seed, and H. Stein. 1992. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. Cell 68:421.
6. Banchereau, J., F. Bazan, D. Blanchard, F. Briere, J. P. Galizzi, C. van Kooten, Y. P. Lui, F. Rousset, and S. Saeland. 1994. The CD40 antigen and its ligand. Cell 68:421.
7. Stamenkovic, I., E. A. Clark, and B. Seed. 1989. A B lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 8:1403.
8. Kwon, B. S., and S. M. Weissman. 1989. cDNA sequences of two inducible T-cell genes. Proc. Natl. Acad. Sci. USA 86:1963.
9. Mallett, S., S. Fossum, and A. N. Barclay. 1990. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes: a molecule related to nerve growth factor receptor. EMBO J. 9:1063.
10. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233.
11. Johnson, D., A. Lanahan, C. R. Buck, A. Sehgal, C. Morgan, E. Mercer, M. Bothwell, and M. Chao. 1986. Expression and structure of the human NGF receptor. Cell 47:545.
12. Baens, M., M. Chaffanet, J. J. Cassiman, H. van den Berghe, and P. Marymen. 1993. Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid. Genomics 16:214.
13. Marsters, S. A., J. P. Sheridan, C. J. Donahue, R. M. Pitti, C. L. Gray, A. D. Goddard, K. D. Bauer, and A. Ashkenazi. 1996. APO-3, a new member of the TNF receptor family, contains a death domain and activates apoptosis and NF-κB. Curr. Biol. 6:1669.
14. Kitson, J., T. Raven, Y.-P. Jiang, D. V. Goeddel, K. M. Giles, K.-T. Pun, C. J. Grinhma, R. Brown, and S. N. Farrow. 1996. A death-domain-containing receptor that mediates apoptosis. Nature 384:372.
15. Chinnaiyan, A. M., K. O'Rourke, G.-L. Yu, R. H. Lyons, M. Garg, G. D. Duan, L. Xing, R. Gentz, J. Ni, and V. M. Dixit. 1996. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 274:990.
16. Screaton, G. R., X.-N. Xu, A. L. Olsen, A. E. Cowper, R. Tan, A. J. McMichael, and J. I. Bell. 1997. LARD: a new lymphoid-specinc death domain containing receptor regulated by alternative pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 94:4615.
17. Bodmer, J.-L., K. Burns, P. Schneider, K. Hofmann, V. Steiner, M. Thome, T. Bornand, M. Hahne, M. Schroter, K. Becker, A. Wilson, L. E. French, J. L. Browning, H. R. MacDonald, and J. Tschopp. 1997. TRAMP, a novel apoptosis-mediating receptor with sequence homology to TNF receptor 1 and Fas (Apo-1/CD95). Immunity 6:79.
18. Pan, G., K. O'Rourke, A. M. Chinnaiyan, R. Gentz, R. Ebner, J. Ni, and V. M. Dixit. 1996. The receptor for the cytotoxic ligand TRAIL. Science 276:111.
19. Pan, G., J. Ni, Y. F. Wei, G. Yu, R. Gentz, and V. M. Dixit. 1997. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277:815.
20. Walczak, H., M. A. Degliesposti, R. S. Johnson, P. J. Smolak, J. P. Waugh, N. Boiani, M. S. Timour, M. J. Gerhart, K. A. Schooley, R. G. Goodwin, and C. T. Rauch. 1997. TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL. EMBO J. 17:5386.
21. Degliesposti, M. A., P. J. Smolak, H. Walczak, J. P. Waugh, C. P. Huang, R. F. Dubrose, R. G. Goodwin, and C. A. Smith. 1997. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J. Exp. Med. 186:1165.
22. Sheridan, J. P., S. A. Marsters, R. M. Pitti, A. Gurney, M. Skubatch, D. Baldwin, L. Ramakrishnan, C. L. Gray, K. Baker, W. I. Wood, A. D. Goddard, P. Godowski, and A. Ashkenazi. 1997. Control of TRAIL-induced apoptosis by a family of signalling and decoy receptors. Science 277:818.
23. Simonet, W. S., D. L. Lacey, C. R. Dunstan, M. Kelley, M. S. Chang, R. Luthy, H. Q. Nguyen, S. Wooden, L. Bennett, T. Boone, G. Shimamoto, M. DeRose, R. Elliott, A. Colombero, H. L. Tan, G. Trail, J. Sullivan, E. Davy, N. Bucay, L. Renshaw-Gegg, T. M. Hugues, D. Hill, W. Pattison, P. Campbell, W. J. Boyle, et al. 1997. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309.
24. Howard, S. T., Y. S. Chan, and G. L. Smith. 1991. Vaccinia virus homologues of the Shope fibroma virus inverted terminal repeat proteins and a discontinuous ORF related to the TNF receptor family. Virology 180:633.
25. Hu, F. Q., C. A. Smith, and D. J. Pickup. 1994. Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor. Virology 204:343.
26. Gruss, H.-J., and S. K. Dower. 1995. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood 85:3378.
27. Smith, C. A., T. Farrah, and R. G. Goodwin. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76:959.
28. Armitage, R. 1994. Tumor necrosis factor receptor superfamily members and their ligands. Curr. Opin. Immunol. 6:407.
29. Kwon, B. S., K. B. Tan, J. Ni, K. O. Oh, Z. H. Lee, K. K. Kim, M. H. Kim, R. Gentz, G. Laing, J. A. Harrop, S. D. Lyn, C. Silverman, T. G. Porter, A. Truneh, and P. R. Young. 1997. A newly identified member of the TNF superfamily with a wide tissue distribution and involvement in lymphocyte activation. J. Biol. Chem. 272:14272.
30. Montgomery, R. I., M. S. Warner, B. J. Lum, and P. G. Spear. 1996. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87:427.
31. Marsters, S. A., T. M. Ayres, M. Skubatch, C. L. Gray, M. Rothe, and A. Ashkenazi. 1997. Herpesvirus entry mediator, a member of the TNF receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activated transcription factors NF-KB and AP-1. J. Biol. Chem. 272:14029.
32. Hsu, H., I. Solovyev, A. Colombero, R. Elliott, M. Kelley, and W. J. Boyle. 1997 ATAR, a novel TNF receptor family member, signals through TRAF2 and TRAF5. J. Biol. Chem. 272:13471.
33. Kumar, S., M. D. Minnich, and P. R. Young. 1995. ST2/T1 protein functionally binds to two secreted proteins from BALB/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1. J. Biol. Chem. 270:27905.
34. Jonsson, U., and M. Malmqvist. 1992. Real time biospecific interaction analysis. Advances in Biosensors. JAI Press, London, pp. 291-336.
35. L on activated T cells and can be prevented by CD28 costimulation. J. Immunol. 158:598.
36. Alzona, M., H. M. Jack, R. I. Fisher, and T. M. Ellis. 1994. CD30 defines a subset of activated human T cells that produce IFN-γ and IL-5 and exhibit enhanced B cell helper activity. J. Immunol. 153:2861.
37. Harrop, J. A., J. Spampanato, M. Reddy, C. Eichman, R. Cook, and A. Truneh. 1997. Kinetics of expression of TNF receptor superfamily molecules and other cytokine receptors on activated CD-positive T cells. In Leukocyte VI. T. Kishimoto, H. Kikutani, A. von dem Borne, S. Goyert, D. Mason, M. Miyasaka, L. Moretta, K. Okumura, S. Shaw, T. Springer, K. Sugamura and H. Zola, eds. Garland Publishing, Inc., New York, p. 871-873.
38. Pollok, K. E., S. H. Kim, and B. S. Kwon. 1995. Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4. Eur. J. Immunol. 25:488.
39. Calderhead, D. M., J. E. Buhlmann, A. J. van den Eertwegh, E. Claassen, R. J. Noelle, and H. P. Fell. 1993. Cloning of mouse OX40: a T cell activation marker that may mediate T-B cell interactions. J. Immunol. 151:5261.
40. + naive T cell stimulation. J. Immunol. 153:5422.
41. Hintzen, R. Q., R. A. van Lier, K. C. Kuijpers, P. A. Baars, W. Schaasberg, C. J. Lucas, and C. H. Polman. 1991. Elevated levels of a soluble form of the T cell activation antigen CD27 in cerebrospinal fluid of multiple sclerosis patients. J. Neuroimmunol. 35:211.
42. Loenen, W. A., E. De Vries, L. A. Gravestein, R. Q. Hintzen, R. A. Van Lier, and J. Borst. 1992. The CD27 membrane receptor, a lymphocyte-specific member of the nerve growth factor receptor family, gives rise to a soluble form by protein processing that does not involve receptor endocytosis. Eur. J. Immunol. 22:447.
43. Hintzen, R. Q., S. M. Lens, M. P. Beckmann, D. Lynch, R. G. Goodwin, and R. A. van Lier. 1994. Characterization of the human CD27 ligand, a novel member of the TNF gene family. J. Immunol. 152:1762.
44. r detected only on CD4 positive T blasts. Mol. Immunol. 24:1281.
45. Bowen, M. A., R. K. Lee, G. Miragliotta, S. Y. Nam, and E. R. Podack. 1996. Structure and expression of murine CD30 and its role in cytokine production. J. Immunol. 156:442.
46. Struber, E., M. Neurath, D. Calderhead, H. P. Fell, and W. Strober. 1995. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2:507.
47. Vermot-Desroches, C., J. Wijdenes, L. Valmu, C. Roy, R. Pigott, P. Nortamo, and C. G. Gahmberg. 1995. A CD44 mAb differentially regulates CD11a/CD18 binding to intracellular adhesion molecules CD54, CD102 and CD50. Eur. J. Immunol. 25:2460.
48. Spertini, F., A. V. Wang, T. Chatila, and R. S. Geha. 1994. Engagement of the common leukocyte antigen CD45 induces homotypic aggregation of activated human T cells. J. Immunol. 153:1593.
49. Wingren, A. G., E. Parra, M. Varga, T. Kalland, H. O. Sjogren, G. Hedlundand, and M. Dohlsten. 1995. T cell activation pathways: B7, LFA-3, and ICAM-1 shape unique T cell profiles. Crit. Rev. Immunol. 15:235.
50. Hurtaldo, J. C., S. H. Kim, K. E. Pollok, Z. H. Lee, and B. S. Kwon. 1995. Potential role of 4-1BB in T cell activation: comparison with co-stimulatory molecule CD28. J. Immunol. 155:3360.
51. Alderson, M. R., C. A. Smith, T. W. Tough, T. Davis-Smith, R. J. Armitage, B. Falk, E. Roux, E. Baker, G. R. Sutherland, W. S. Din, and R. G. Goodwin. 1994. Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol 24:2219.
52. Zhou, Z., K. E. Pollok, K. K. Kim, Y. T. Kim, and B. S. Kwon. 1994. Functional analysis of T-cell antigen 4-1BB I activated intestinal intra-epithelial T lymphocytes. Immunol. Lett. 41:177.
53. + T cells with homology to TNF. J. Exp. Med. 180:757.
54. Falini, B., S. Pileri, G. Pizzolo, H. Durkop, L. Flenghi, F. Stirpe, M. F. Martelli, and H. Stein. 1995. CD30 (Ki-1) molecule: a new cytokine receptor of the TNF receptor superfamily as a tool for diagnosis and immunotherapy. Blood 85:1.
55. Baker, S. J., and E. P. Reddy. 1996. Transducers of life and death: TNF receptor superfamily and associated proteins. Oncogene 12:1.
56. Hsu, H., J. Xiong, and D. V. Goeddel. 1995. The TNF receptor 1-associated protein TRADD signals cell death and NF-KB activation. Cell 81:495.
57. Sugita, K., Y. Torimoto, Y. Nojima, J. F. Daley, S. F. Schlossman, and C. Morimoto. 1991. The IA4 molecule (CD27) is involved in T cell activation. J. Immunol. 147:1477.
58. Agematsu, K., T. Kobata, F.-C. Yang, T. Nakazawa, K. Fukushima, M. Kitahara, T. Mori, K. Sugita, C. Morimoto, and A. Komiyama. 1995. CD27/CD70 interaction directly drives B cell IgG and IgM synthesis. Eur. J. Immunol. 25:2825.
59. Howard, L. M., and D. J. Reen. 1997. CD72 ligation regulates defective naive newborn B cell responses. Cell. Immunol. 175:179.
60. Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years after. Cell 87:13.
61. Mauri, D. N., R. Ebner, R. I. Montgomery, K. D. Kochel, T. C. Cheung, G.-L. Yu, S. Ruberi, M. Murphy, R. J. Eisenberg, G. H. Cohen, P. G. Spear, and C. F. Ware. 1998. LIGHT, a new member of the TNF superfamily and lymphotoxin α are ligands for Herpesvirus entry mediator. Immunity 8:21.