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Volumn 28, Issue 6, 2008, Pages 870-880

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

Author keywords

CELLIMMUNO

Indexed keywords

CD28 ANTIGEN; CELL PROTEIN; INTERLEUKIN 10; PROTEIN ICOS; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 44649189089     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.03.018     Document Type: Article
Times cited : (454)

References (54)
  • 3
    • 0034235746 scopus 로고    scopus 로고
    • Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: Possible implications for negative selection
    • Annunziato F., Romagnani P., Cosmi L., Beltrame C., Steiner B.H., Lazzeri E., Raport C.J., Galli G., Manetti R., Mavilia C., et al. Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: Possible implications for negative selection. J. Immunol. 165 (2000) 238-246
    • (2000) J. Immunol. , vol.165 , pp. 238-246
    • Annunziato, F.1    Romagnani, P.2    Cosmi, L.3    Beltrame, C.4    Steiner, B.H.5    Lazzeri, E.6    Raport, C.J.7    Galli, G.8    Manetti, R.9    Mavilia, C.10
  • 4
    • 34248598295 scopus 로고    scopus 로고
    • Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells
    • Aschenbrenner K., D'Cruz L.M., Vollmann E.H., Hinterberger M., Emmerich J., Swee L.K., Rolink A., and Klein L. Selection of Foxp3(+) regulatory T cells specific for self antigen expressed and presented by Aire(+) medullary thymic epithelial cells. Nat. Immunol. 8 (2007) 351-358
    • (2007) Nat. Immunol. , vol.8 , pp. 351-358
    • Aschenbrenner, K.1    D'Cruz, L.M.2    Vollmann, E.H.3    Hinterberger, M.4    Emmerich, J.5    Swee, L.K.6    Rolink, A.7    Klein, L.8
  • 5
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman C., Mauze S., Leach M.W., Coffman R.L., and Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190 (1999) 995-1004
    • (1999) J. Exp. Med. , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 6
    • 0031993130 scopus 로고    scopus 로고
    • Interleukin 10 is a growth factor for a population of regulatory T cells
    • Asseman C., and Powrie F. Interleukin 10 is a growth factor for a population of regulatory T cells. Gut 42 (1998) 157-158
    • (1998) Gut , vol.42 , pp. 157-158
    • Asseman, C.1    Powrie, F.2
  • 7
    • 0028158319 scopus 로고
    • High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells
    • Bacchetta R., Bigler M., Touraine J.L., Parkman R., Tovo P.A., Abrams J., de Waal Malefyt R., de Vries J.E., and Roncarolo M.G. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J. Exp. Med. 179 (1994) 493-502
    • (1994) J. Exp. Med. , vol.179 , pp. 493-502
    • Bacchetta, R.1    Bigler, M.2    Touraine, J.L.3    Parkman, R.4    Tovo, P.A.5    Abrams, J.6    de Waal Malefyt, R.7    de Vries, J.E.8    Roncarolo, M.G.9
  • 8
    • 33645778289 scopus 로고    scopus 로고
    • MHC class II expression identifies functionally distinct human regulatory T cells
    • Baecher-Allan C., Wolf E., and Hafler D.A. MHC class II expression identifies functionally distinct human regulatory T cells. J. Immunol. 176 (2006) 4622-4631
    • (2006) J. Immunol. , vol.176 , pp. 4622-4631
    • Baecher-Allan, C.1    Wolf, E.2    Hafler, D.A.3
  • 9
    • 2242423605 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    • Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., and Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420 (2002) 502-507
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 10
    • 0035920510 scopus 로고    scopus 로고
    • Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells
    • Bensinger S.J., Bandeira A., Jordan M.S., Caton A.J., and Laufer T.M. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J. Exp. Med. 194 (2001) 427-438
    • (2001) J. Exp. Med. , vol.194 , pp. 427-438
    • Bensinger, S.J.1    Bandeira, A.2    Jordan, M.S.3    Caton, A.J.4    Laufer, T.M.5
  • 11
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y., Kuchroo V.K., Inobe J., Hafler D.A., and Weiner H.L. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis. Science 265 (1994) 1237-1240
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 12
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., and Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 204 (2007) 1757-1764
    • (2007) J. Exp. Med. , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3    Hall, J.4    Sun, C.M.5    Belkaid, Y.6    Powrie, F.7
  • 13
  • 14
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4 (2003) 330-336
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 15
    • 0037301566 scopus 로고    scopus 로고
    • A central role for peripheral dendritic cells in the induction of acquired thymic tolerance
    • Goldschneider I., and Cone R.E. A central role for peripheral dendritic cells in the induction of acquired thymic tolerance. Trends Immunol. 24 (2003) 77-81
    • (2003) Trends Immunol. , vol.24 , pp. 77-81
    • Goldschneider, I.1    Cone, R.E.2
  • 16
    • 0141703239 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes
    • Green E.A., Gorelik L., McGregor C.M., Tran E.H., and Flavell R.A. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. USA 100 (2003) 10878-10883
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10878-10883
    • Green, E.A.1    Gorelik, L.2    McGregor, C.M.3    Tran, E.H.4    Flavell, R.A.5
  • 18
    • 34548721641 scopus 로고    scopus 로고
    • Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis
    • Haas J., Fritzsching B., Trubswetter P., Korporal M., Milkova L., Fritz B., Vobis D., Krammer P.H., Suri-Payer E., and Wildemann B. Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis. J. Immunol. 179 (2007) 1322-1330
    • (2007) J. Immunol. , vol.179 , pp. 1322-1330
    • Haas, J.1    Fritzsching, B.2    Trubswetter, P.3    Korporal, M.4    Milkova, L.5    Fritz, B.6    Vobis, D.7    Krammer, P.H.8    Suri-Payer, E.9    Wildemann, B.10
  • 19
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 21
  • 22
    • 33745201828 scopus 로고    scopus 로고
    • Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells
    • Janke M., Witsch E.J., Mages H.W., Hutloff A., and Kroczek R.A. Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells. Immunology 118 (2006) 353-360
    • (2006) Immunology , vol.118 , pp. 353-360
    • Janke, M.1    Witsch, E.J.2    Mages, H.W.3    Hutloff, A.4    Kroczek, R.A.5
  • 23
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., and Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med. 193 (2001) 1285-1294
    • (2001) J. Exp. Med. , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 24
    • 0036926154 scopus 로고    scopus 로고
    • Natural type I interferon-producing cells as a link between innate and adaptive immunity
    • Kadowaki N., and Liu Y.J. Natural type I interferon-producing cells as a link between innate and adaptive immunity. Hum. Immunol. 63 (2002) 1126-1132
    • (2002) Hum. Immunol. , vol.63 , pp. 1126-1132
    • Kadowaki, N.1    Liu, Y.J.2
  • 25
    • 33845453812 scopus 로고    scopus 로고
    • Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    • Kamanaka M., Kim S.T., Wan Y.Y., Sutterwala F.S., Lara-Tejero M., Galan J.E., Harhaj E., and Flavell R.A. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 25 (2006) 941-952
    • (2006) Immunity , vol.25 , pp. 941-952
    • Kamanaka, M.1    Kim, S.T.2    Wan, Y.Y.3    Sutterwala, F.S.4    Lara-Tejero, M.5    Galan, J.E.6    Harhaj, E.7    Flavell, R.A.8
  • 26
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R., Cox T., Yasayko S.A., and Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4 (2003) 337-342
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 27
    • 0037128660 scopus 로고    scopus 로고
    • Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood
    • Kimmig S., Przybylski G.K., Schmidt C.A., Laurisch K., Mowes B., Radbruch A., and Thiel A. Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood. J. Exp. Med. 195 (2002) 789-794
    • (2002) J. Exp. Med. , vol.195 , pp. 789-794
    • Kimmig, S.1    Przybylski, G.K.2    Schmidt, C.A.3    Laurisch, K.4    Mowes, B.5    Radbruch, A.6    Thiel, A.7
  • 29
    • 0037131969 scopus 로고    scopus 로고
    • Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells
    • Levings M.K., Sangregorio R., Sartirana C., Moschin A.L., Battaglia M., Orban P.C., and Roncarolo M.G. Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196 (2002) 1335-1346
    • (2002) J. Exp. Med. , vol.196 , pp. 1335-1346
    • Levings, M.K.1    Sangregorio, R.2    Sartirana, C.3    Moschin, A.L.4    Battaglia, M.5    Orban, P.C.6    Roncarolo, M.G.7
  • 31
    • 33646162855 scopus 로고    scopus 로고
    • A unified theory of central tolerance in the thymus
    • Liu Y.J. A unified theory of central tolerance in the thymus. Trends Immunol. 27 (2006) 215-221
    • (2006) Trends Immunol. , vol.27 , pp. 215-221
    • Liu, Y.J.1
  • 32
    • 0037455003 scopus 로고    scopus 로고
    • Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10
    • Lohning M., Hutloff A., Kallinich T., Mages H.W., Bonhagen K., Radbruch A., Hamelmann E., and Kroczek R.A. Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J. Exp. Med. 197 (2003) 181-193
    • (2003) J. Exp. Med. , vol.197 , pp. 181-193
    • Lohning, M.1    Hutloff, A.2    Kallinich, T.3    Mages, H.W.4    Bonhagen, K.5    Radbruch, A.6    Hamelmann, E.7    Kroczek, R.A.8
  • 33
    • 0037148511 scopus 로고    scopus 로고
    • Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: A novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    • McGuirk P., McCann C., and Mills K.H. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: A novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195 (2002) 221-231
    • (2002) J. Exp. Med. , vol.195 , pp. 221-231
    • McGuirk, P.1    McCann, C.2    Mills, K.H.3
  • 34
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    • Nakamura K., Kitani A., and Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194 (2001) 629-644
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 35
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • O'Garra A., and Vieira P. Regulatory T cells and mechanisms of immune system control. Nat. Med. 10 (2004) 801-805
    • (2004) Nat. Med. , vol.10 , pp. 801-805
    • O'Garra, A.1    Vieira, P.2
  • 36
    • 0037099613 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    • Piccirillo C.A., Letterio J.J., Thornton A.M., McHugh R.S., Mamura M., Mizuhara H., and Shevach E.M. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J. Exp. Med. 196 (2002) 237-246
    • (2002) J. Exp. Med. , vol.196 , pp. 237-246
    • Piccirillo, C.A.1    Letterio, J.J.2    Thornton, A.M.3    McHugh, R.S.4    Mamura, M.5    Mizuhara, H.6    Shevach, E.M.7
  • 37
    • 33746256850 scopus 로고    scopus 로고
    • Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression
    • Rasheed A.U., Rahn H.P., Sallusto F., Lipp M., and Muller G. Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur. J. Immunol. 36 (2006) 1892-1903
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1892-1903
    • Rasheed, A.U.1    Rahn, H.P.2    Sallusto, F.3    Lipp, M.4    Muller, G.5
  • 39
    • 0033738329 scopus 로고    scopus 로고
    • The role of different subsets of T regulatory cells in controlling autoimmunity
    • Roncarolo M.G., and Levings M.K. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr. Opin. Immunol. 12 (2000) 676-683
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 676-683
    • Roncarolo, M.G.1    Levings, M.K.2
  • 42
    • 0035054606 scopus 로고    scopus 로고
    • Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro
    • Stephens L.A., Mottet C., Mason D., and Powrie F. Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur. J. Immunol. 31 (2001) 1247-1254
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1247-1254
    • Stephens, L.A.1    Mottet, C.2    Mason, D.3    Powrie, F.4
  • 43
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., and Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204 (2007) 1775-1785
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6    Belkaid, Y.7
  • 44
    • 0035062581 scopus 로고    scopus 로고
    • Human anergic/suppressive CD4(+)CD25(+) T cells: A highly differentiated and apoptosis-prone population
    • Taams L.S., Smith J., Rustin M.H., Salmon M., Poulter L.W., and Akbar A.N. Human anergic/suppressive CD4(+)CD25(+) T cells: A highly differentiated and apoptosis-prone population. Eur. J. Immunol. 31 (2001) 1122-1131
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1122-1131
    • Taams, L.S.1    Smith, J.2    Rustin, M.H.3    Salmon, M.4    Poulter, L.W.5    Akbar, A.N.6
  • 45
    • 3042792942 scopus 로고    scopus 로고
    • CD25+CD4+ T cells in human cord blood: An immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene
    • Takahata Y., Nomura A., Takada H., Ohga S., Furuno K., Hikino S., Nakayama H., Sakaguchi S., and Hara T. CD25+CD4+ T cells in human cord blood: An immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene. Exp. Hematol. 32 (2004) 622-629
    • (2004) Exp. Hematol. , vol.32 , pp. 622-629
    • Takahata, Y.1    Nomura, A.2    Takada, H.3    Ohga, S.4    Furuno, K.5    Hikino, S.6    Nakayama, H.7    Sakaguchi, S.8    Hara, T.9
  • 46
    • 32644461389 scopus 로고    scopus 로고
    • The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity
    • Tarbell K.V., Yamazaki S., and Steinman R.M. The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity. Semin. Immunol. 18 (2006) 93-102
    • (2006) Semin. Immunol. , vol.18 , pp. 93-102
    • Tarbell, K.V.1    Yamazaki, S.2    Steinman, R.M.3
  • 48
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton A.M., and Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188 (1998) 287-296
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 53
    • 24144480562 scopus 로고    scopus 로고
    • Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
    • Watanabe N., Wang Y.H., Lee H.K., Ito T., Cao W., and Liu Y.J. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature 436 (2005) 1181-1185
    • (2005) Nature , vol.436 , pp. 1181-1185
    • Watanabe, N.1    Wang, Y.H.2    Lee, H.K.3    Ito, T.4    Cao, W.5    Liu, Y.J.6
  • 54
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • Weiner H.L. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 182 (2001) 207-214
    • (2001) Immunol. Rev. , vol.182 , pp. 207-214
    • Weiner, H.L.1


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