Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy

Journal of Experimental Medicine

Volumn 190, Issue 10, 1999, Pages 1535-1540

  Mittler, Robert S ^a,c   Bailey, Tina S ^a   Klussman, Kerry ^a   Trailsmith, Mark D ^a   Hoffmann, Michael K ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4 1BB receptor; Anergy; Costimulation; Humoral immunity

Indexed keywords

CD8 ANTIGEN; FICOLL; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; B LYMPHOCYTE; CLONAL ANERGY; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; HELPER CELL; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHEEP;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; ANTIGENS, CD; ANTIGENS, CD137; ERYTHROCYTES; FEMALE; FICOLL; IMMUNE TOLERANCE; IMMUNIZATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RATS; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES; T-LYMPHOCYTES, HELPER-INDUCER; TRINITROBENZENES;

EID: 0033571176     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.10.1535     Document Type: Article

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