CTLA-4 regulates induction of anergy in vivo

Immunity

Volumn 14, Issue 2, 2001, Pages 145-155

  Greenwald, Rebecca J ^a   Boussiotis, Vassiliki A ^b   Lorsbach, Robert B ^c   Abbas, Abul K ^d   Sharpe, Arlene H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; PROTEIN KINASE; PROTEIN P27;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CLONAL ANERGY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0035102196     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00097-8     Document Type: Article

References (46)

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3. B70 antigen is a second ligand for CTLA-4 and CD28
4. Cutting edge: Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
5. CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction
6. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes
7. CTLA-4-mediated inhibition of early events of T cell proliferation
8. Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro
9. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
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12. Induction of T cell anergy in the absence of CTLA-4/B7 interaction
13. Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
14. Th1 cell anergy and blockade in G1a phase of the cell cycle
15. Effects of tolerance induction on early cell cycle progression by Th1 clones
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18. Polarization of naive CD4+ T cells toward the Th1 subset by CTLA-4 costimulation
19. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
20. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses
21. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
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24. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1
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26. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
27. D-type cyclin-dependent kinase activity in mammalian cells
28. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo Thymocytes in vivo
29. The role of CTLA-4 in regulating Th2 differentiation
30. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
31. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis
32. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
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36. CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism
37. In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
38. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan destruction, revealing a critical negative regulatory role of CTLA-4
39. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
40. Role of interleukin 12 and costimulators in T cell anergy in vivo
41. Specific T-cell tolerance may reflect selective activation of lymphokine synthesis
42. Specific T-cell tolerance may be preceded by a primary response
43. CTLA-4 regulates tolerance induction and T cell differentiation in vivo
44. CTLA-4 ligation blocks CD28-dependent T cell activation
45. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
46. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein