Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 17, 2010, Pages 7875-7880

  Matsuzaki, Junko ^a   Gnjatic, Sacha ^b   Mhawech Fauceglia, Paulette ^a   Beck, Amy ^a   Miller, Austin ^a   Tsuji, Takemasa ^b   Eppolito, Cheryl ^a   Qian, Feng ^a   Lele, Shashikant ^a   Shrikant, Protul ^a   Old, Lloyd J ^b   Odunsi, Kunle ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

IL 10; IL 6; T cell receptor; Tumor infiltrating lymphocytes

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; NY ESO 1 ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ASCITES; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMORAL IMMUNITY; OVARY CANCER; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; TUMOR ASSOCIATED LEUKOCYTE; UPREGULATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, NEOPLASM; APOPTOSIS REGULATORY PROTEINS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MEMBRANE PROTEINS; OVARIAN NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 77952343328     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003345107     Document Type: Article

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