Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)

Journal of Immunology

Volumn 163, Issue 12, 1999, Pages 6520-6529

  Pippig, Susanne ^a,e   Peña Rossi, Claudia ^a,f   Long, James ^a   Godfrey, Wayne R ^a   Fowell, Deborah J ^a   Reiner, Steven L ^c   Birkeland, Marian L ^d   Locksley, Richard M ^a,b   Barclay, A Neil ^d   Killeen, Nigel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e NOVARTIS PHARMA AG   (Switzerland)

^f Serono International SA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; HUMORAL IMMUNITY; IMMUNOREACTIVITY; LEISHMANIA MAJOR; LYMPHOCYTE PROLIFERATION; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIBODIES, HELMINTH; ANTIBODIES, PROTOZOAN; ANTIGENS, CD27; B-LYMPHOCYTES; FEMALE; GENE TARGETING; IMMUNITY, CELLULAR; LEISHMANIA MAJOR; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, MUTANT STRAINS; NIPPOSTRONGYLUS; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES;

EID: 0344286707     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Smith, C. A., T. Farrah, and R. G. Goodwin. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76:959.
2. Matsumoto, M., Y. X. Fu, H. Molina, and D. D. Chaplin. 1997. Lymphotoxin-α-deficient and TNF receptor-1-deficient mice define developmental and functional characteristics of germinal centers. Immunol. Rev. 156:137.
3. Korner, H., M. Cook, D. S. Riminton, F. A. Lemckert, R. M. Hoek, B. Ledermann, F. Kontgen, B. Fazekas de St Groth, and J. D. Sedgwick. 1997. Distinct roles for lymphotoxin-α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur. J. Immunol. 27:2600.
4. Bazzoni, F., and B. Beutler. 1996. The tumor necrosis factor ligand and receptor families. N. Engl. J. Med. 334:1717.
5. Kong, Y. Y., H. Yoshida, I. Sarosi, H. L. Tan, E. Timms, C. Capparelli, S. Morony, A. J. Oliveira-dos-Santos, G. Van, A. Itie, et al. 1999. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315.
6. Chaplin, D. D., and Y. Fu. 1998. Cytokine regulation of secondary lymphoid organ development. Curr. Opin. Immunol. 10:289.
7. Gravestein, L. A., and J. Borst. 1998. Tumor necrosis factor receptor family members in the immune system. Semin. Immunol. 10:423.
8. Al-Shamkhani, A., S. Mallett, M. H. Brown, W. James, and A. N. Barclay. 1997. Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells. J. Biol. Chem. 272:5275.
9. Armitage, R. J. 1994. Tumor necrosis factor receptor superfamily members and their ligands. Curr. Opin. Immunol. 6:407.
10. Gruss, H. J., and S. K. Dower. 1995. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood 85:3378.
11. Cao, Z., J. Xiong, M. Takeuchi, T. Kurama, and D. V. Goeddel. 1996. TRAF6 is a signal transducer for interleukin-1. Nature 383:443.
12. Arch, R. H., R. W. Gedrich, and C. B. Thompson. 1998. Tumor necrosis factor receptor-associated factors (TRAFs): a family of adapter proteins that regulates life and death. Genes Dev. 12:2821.
13. Yeh, W. C., A. Shahinian, D. Speiser, J. Kraunus, F. Billia, A. Wakeham, J. L. de la Pompa, D. Ferrick, B. Hum, N. Iscove, et al. 1997. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 7:715.
14. Lomaga, M. A., W. C. Yeh, I. Sarosi, G. S. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, et al. 1999. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13:1015.
15. Matsumoto, M., S. Mariathasan, M. H. Nahm, F. Baranyay, J. J. Peschon, and D. D. Chaplin. 1996. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271:1289.
16. Koni, P. A., R. Sacca, P. Lawton, J. L. Browning, N. H. Ruddle, and R. A. Flavell. 1997. Distinct roles in lymphoid organogenesis for lymphotoxins α and beta revealed in lymphotoxin β-deficient mice. Immunity 6:491.
17. r detected only on CD4 positive T blasts. Mol. Immunol. 24:1281.
18. al-Shamkhani, A., M. L. Birkeland, M. Puklavec, M. H. Brown, W. James, and A. N. Barclay. 1996. OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur. J. Immunol. 26:1695.
19. Baum, P. R., R. B. Gayle, 3rd, F. Ramsdell, S. Srinivasan, R. A. Sorensen, M. L. Watson, M. F. Seldin, E. Baker, G. R. Sutherland, K. N. Clifford, et al. 1994. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 13:3992.
20. + T cells with homology to tumor necrosis factor. J. Exp. Med. 180:757.
21. + T cells. Int. Immunol. 10:453.
22. Akiba, H., M. Atsuta, H. Yagita, and K. Okumura. 1998. Identification of rat OX40 ligand by molecular cloning. Biochem. Biophys. Res. Commun. 251:131.
23. Gramaglia, I., A. D. Weinberg, M. Lemon, and M. Croft. 1998. Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 161:6510.
24. Saoulli, K., S. Y. Lee, J. L. Cannons, W. C. Yeh, A. Santana, M. D. Goldstein, N. Bangia, M. A. DeBenedette, T. W. Mak, Y. Choi, and T. H. Watts. 1998. CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand. J. Exp. Med. 187:1849.
25. + T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp Med. 186:47.
26. Vinay, D. S., and B. S. Kwon. 1998. Role of 4-1BB in immune responses. Semin. Immunol. 10:481.
27. + T cells into high IL-4-producing effectors. Blood 92:3338.
28. + T cells into high IL-4-producing effectors. Int. Arch. Allergy Immunol. 118:384.
29. Flynn, S., K. M. Toellner, C. Raykundalia, M. Goodall, and P. Lane. 1998. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 188:297.
30. Weinberg, A. D., K. W. Wegmann, C. Funatake, and R. H. Whitham. 1999. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J. Immunol. 162:1818.
31. + T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis. J. Neurosci. Res. 43:42.
32. Kawamata, S., T. Hori, A. Imura, A. Takaori-Kondo, and T. Uchiyama. 1998. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2-and TRAF5-mediated NF-κB activation. J. Biol. Chem. 273:5808.
33. Arch, R. H., and C. B. Thompson. 1998. 4-1BB and OX40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor-κB. Mol. Cell. Biol. 18:558.
34. Takahashi, C., R. S. Mittler, and A. T. Vella. 1999. Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal. J. Immunol. 162:5037.
35. Weinberg, A. D., A. T. Vella, and M. Croft. 1998. OX-40: life beyond the effector T cell stage. Semin. Immunol. 10:471.
36. + spinal cord T cells of Lewis rats with EAE. J. Neurosci. Res. 44:562.
37. Weinberg, A. D., D. N. Bourdette, T. J. Sullivan, M. Lemon, J. J. Wallin, R. Maziarz, M. Davey, F. Palida, W. Godfrey, E. Engleman, et al. 1996. Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat. Med. 2:183.
38. Tittle, T. V., A. D. Weinberg, C. N. Steinkeler, and R. T. Maziarz. 1997. Expression of the T-cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease. Blood 89:4652.
39. Vetto, J. T., S. Lum, A. Morris, M. Sicotte, J. Davis, M. Lemon, and A. Weinberg. 1997. Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers. Am. J. Surg. 174:258.
40. Higgins, L. M., S. A. McDonald, N. Whittle, N. Crockett, J. G. Shields, and T. T. MacDonald. 1999. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J. Immunol. 162:486.
41. Ohshima, Y., Y. Tanaka, H. Tozawa, Y. Takahashi, C. Maliszewski, and G. Delespesse. 1997. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 159:3838.
42. Imura, A., T. Hori, K. Imada, S. Kawamata, Y. Tanaka, S. Imamura, and T. Uchiyama. 1997. OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration. Blood 89: 2951.
43. Imura, A., T. Hori, K. Imada, T. Ishikawa, Y. Tanaka, M. Maeda, S. Imamura, and T. Uchiyama. 1996. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J. Exp. Med. 183:2185.
44. Stüber, E., and W. Strober. 1996. The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J. Exp. Med. 183:979.
45. Stüber, E., M. Neurath, D. Calderhead, H. P. Fell, and W. Strober. 1995. Crosslinking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2:507.
46. Birkeland, M. L., N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and A. N. Barclay. 1995. Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. Eur. J. Immunol. 25:926.
47. Connolly, A. J., H. Ishihara, M. L. Kahn, R. V. Farese, Jr., and S. R. Coughlin. 1996. Role of the thrombin receptor in development and evidence for a second receptor. Nature 381:516.
48. Hogan, B. 1994. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Plainview, NY.
49. Hodgkin, P. D., J. H. Lee, and A. B. Lyons. 1996. B cell differentiation and isotype switching is related to division cycle number. J. Exp. Med. 184:277.
50. Bird, J. J., D. R. Brown, A. C. Mullen, N. H. Moskowitz, M. A. Mahowald, J. R. Sider, T. F. Gajewski, C. R. Wang, and S. L. Reiner. 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9:229.
51. + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184:1295.
52. Rossi, C. P., M. Delcroix, I. Huitinga, A. McAllister, N. van Rooijen, E. Claassen, and M. Brahic. 1997. Role of macrophages during Theiler's virus infection. J. Virol. 71:3336.
53. Rossi, C. P., A. McAllister, M. Tanguy, D. Kagi, and M. Brahic. 1998. Theiler's virus infection of perforin-deficient mice. J. Virol. 72:4515.
54. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
55. Tedder, T. F., D. A. Steeber, and P. Pizcueta. 1995. L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. J. Exp. Med. 181: 2259.
56. Chapman, J. R., Z. Ruben, and G. M. Butchko. 1986. Histology of and quantitative assays for oxazolone-induced allergic contact dermatitis in mice. Am. J. Dermatopathol. 8:130.
57. Kearney, E. R., K. A. Pape, D. Y. Loh, and M. K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1:327.
58. Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353:858.
59. Joyner, A. L. 1993. Gene Targeting: A Practical Approach. IRL Press at Oxford University Press, Oxford.
60. + TCRIo thymocytes in vivo. Science 250: 1720.
61. Locksley, R. M., S. Pingel, D. Lacy, A. E. Wakil, M. Bix, and D. J. Fowell. 1999. Susceptibility to infectious diseases: Leishmania as a paradigm. J. Infect. Dis. 179(Suppl.) 2:S305.
62. Urban, J. F., Jr., N. Noben-Trauth, D. D. Donaldson, K. B. Madden, S. C. Morris, M. Collins, and F. D. Finkelman. 1998. IL-13, IL-4Rα, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8:255.
63. Monteyne, P., J. F. Bureau, and M. Brahic. 1997. The infection of mouse by Theiler's virus: from genetics to immunology. Immunol. Rev. 159:163.
64. + T cells. J. Immunol. 139:1303.
65. 2-microglobulin-deficient mice. J. Virol. 67:589.
66. Kurts, C., F. R. Carbone, M. F. Krummel, K. M. Koch, J. F. Miller, and W. R. Heath. 1999. Signaling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. Nature 398:341.
67. Rathmell, J. C., S. E. Townsend, J. C. Xu, R. A. Flavell, and C. C. Goodnow. 1996. Expansion or elimination of B cells in vivo: dual roles for CD40-and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell 87:319.
68. Garside, P., E. Ingulli, R. R. Merica, J. G. Johnson, R. J. Noelle, and M. K. Jenkins. 1998. Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281:96.
69. Jang, I. K., Z. H. Lee, Y. J. Kim, S. H. Kim, and B. S. Kwon. 1998. Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-κB. Biochem. Biophys. Res. Commun. 242:613.