CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1

Journal of Experimental Medicine

Volumn 188, Issue 2, 1998, Pages 297-304

  Flynn, Sarah ^a   Toellner, Kai Michael ^a   Raykundalia, Chandra ^a   Goodall, Margaret ^a   Lane, Peter ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

Cognate B cell T Cell interaction; Cytokine; OX40 OX40 ligand; T cell priming; Th1 Th2 differentiation

Indexed keywords

CD4 ANTIGEN;

ANIMAL CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; GENE EXPRESSION REGULATION; GROWTH REGULATION; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COOPERATION; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, CHEMOKINE; RECEPTORS, TUMOR NECROSIS FACTOR; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTORS;

EID: 0031872028     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.2.297     Document Type: Article

References (35)

1. Kumararatne, D.S. 1997. Tuberculosis and immunodeficiency - of mice and men. Clin. Exp. Immunol. 107:11-14.
2. Toellner, K., S. Luther, D.M.-Y. Sze, R.K.-W. Choy, D.R. Taylor, I.C.M. MacLennan, and H. Acha-Orbea. 1998. Th1 and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J. Exp. Med. 187:1193-1201.
3. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
4. Cella, M., D. Scheidegger, K. Palmer-Lehman, V. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell costimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747-752.
5. Sousa, C.R., S. Hieny, T. Scharton-Kersten, D. Jankovic, H. Charest, R.N. Germain, and A. Sher. 1997. In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J. Exp. Med. 186:1819-1829.
6. Szabo, S.J., A.S. Dighe, U. Gubler, and K.M. Murphy. 1997. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
7. Bendelac, A. 1995. Mouse NK1 + T cells. Curr. Opin. Immunol. 7:367-74.
8. - T cell population. J. Immunol. 157:4421-4427.
9. Stockinger, B., T. Zal, A. Zal, and D. Gray. 1995. B cells solicit their own help from T cells. J. Exp. Med. 183:891-899.
10. Mason, D. 1996. The role of B cells in the programming of T cells for IL-4 synthesis. J. Exp. Med. 183:717-719.
11. Stüber, E., and W. Strober. 1996. The T cell-B cell interaction via OX40-OX40L is necessary for the cell-dependent humoral immune response. J. Exp. Med. 183:979-989.
12. Gunn, M.D., V.N. Ngo, K.M. Ansel, E.H. Ekland, J.G. Cyster, and L.T. Williams. 1998. A B-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma type receptor-1. Nature. 391:799-802.
13. Traunecker, A., F. Oliveri, and K. Karjalainen. 1991. Myeloma based expression system for production of large mammalian proteins. Trends Biotechnol. 9:109-113.
14. Calderhead, D.M., J.E. Buhlmann, A.J.M. Vandeneertwegh, E. Claassen, R.J. Noelle, and H.P. Fell. 1993. Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J. Immunol. 151:5261-5271.
15. Lane, P., W. Gerhard, S. Hubele, A. Lanzavecchia, and F. McConnell. 1993. Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human γ 1. Immunology. 80:56-61.
16. Svetic, A., F.D. Finkelman, Y.C. Jian, C.W. Dieffenbach, D.E. Scott, K.F. McCarthy, A.D. Steinberg, and W.C. Gause. 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391-2397.
17. Forster, R., T. Emrich, E. Kremmer, and M. Lipp. 1994. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood. 84:830-840.
18. Weibel, E.R. 1963. Principles and methods for the morphometric study of the lung and other organs. Lab. Invest. 12: 131-155.
19. Luther, S.A., I. Maillard, F. Luthi, L. Scarpellino, H. Diggelmann, and H. Acha-Orbea. 1997. Early neutralizing antibody response against mouse mammary tumor virus: critical role of viral infection and superantigen-reactive T cells. J. Immunol. 159:2807-2814.
20. Stüber, E., M. Neurath, D. Calderhead, H.P. Fell, and W. Strober. 1995. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity. 2:507-521.
21. Austrup, F., D. Vestweber, E. Borges, M. Lohning, R. Brauer, U. Herz, H. Renz, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann. 1997. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues. Nature. 385:81-83.
22. Sallusto, F., C.R. Mackay, and A. Lanzavecchia. 1997. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Science. 277:2005-2007.
23. Forster, R., A.E. Mattis, E. Kremmer, E. Wolf, G. Brem, and M. Lipp. 1996. A putative chemokine receptor, BLR1, directs B cell migration to defined lympboid organs and specific anatomic compartments of the spleen. Cell. 87:1037-1047.
24. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-introphenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165-1175.
25. Lin, Y.J., J. Zhang, P.J. Lane, E.Y. Chan, and I.C. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951-2962.
26. + T cells. J. Exp. Med. 182:1591-1596.
27. + T cells. J. Exp. Med. 185:461-469.
28. Kopf, M., G. Legros, A.J. Coyle, M. Koscovilbois, and F. Brombacher. 1995. Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol. Rev. 148:45-69.
29. Cyster, J.G., S.B. Hartley, and C.C. Goodnow. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature. 371:389-395.
30. Ohshima, Y., Y. Tanaka, H. Tozawa, Y. Takahashi, C. Maliszewski, and G. Delespesse. 1997. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 159: 3838-3848.
31. Bonecchi, R., G. Bianchi, P.P. Bordignon, D. Dambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P.A. Gray, A. Mantovani, and F. Sinigaglia. 1998. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J. Exp. Med. 187:129-134.
32. Lens, S.M.A., R.L. Dejong, B. Hooibrink, B. Koopman, S.T. Pals, M.H.J. Vanoers, and R.A.W. Vanlier. 1996. Phenotype and function of human B-cells expressing CD70 (CD27 ligand). Eur. J. Immunol. 26:2964-2971.
33. Hilkens, C.M.U., P. Kalinski, M. deBoer, and M.L. Kapsenberg. 1997. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype. Blood. 90:1920-1926.
34. + T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J. Exp. Med. 186:421-432.
35. + T cells requires the production of gamma interferon. Infect. Immun. 66:830-834.