Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation

Journal of Experimental Medicine

Volumn 192, Issue 2, 2000, Pages 295-302

  Read, Simon ^a   Malmström, Vivianne ^a   Powrie, Fiona ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Autoimmunity; Cd4+T lymphocyte; Inflammatory bowel disease; Interleukin 2 receptor; T lymphocyte suppressor

Indexed keywords

CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANTIGEN FUNCTION; ARTICLE; AUTOIMMUNITY; CELL FUNCTION; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; ENTERITIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; COLITIS; IMMUNOCONJUGATES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034679567     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.2.295     Document Type: Article

References (46)

1. Tlaskalova, H., V. Kamarytova, L. Mandel, L. Prokesova, J. Kruml, A. Lanc, and I. Miler. 1970. The immune response of germ-free piglets after peroral monocontamination with living Escherichia coli strain 086. I. The fate of antigen, dynamics and site of antibody formation, nature of antibodies and formation of heterohaemagglutinins. Folia Biol. (Praha). 16:177-187.
2. Powrie, F. 1995. T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity. 3:171-174.
3. Powrie, F., M.W. Leach, S. Mauze, L.B. Caddle, and R.L. Coffman. 1993. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 seid mice. Int. Immunol. 5:1461-1471.
4. + T cells. J. Exp. Med. 178:237-244.
5. high subset of CD4+ T cells. Am. J. Pathol. 148:1503-1515.
6. hi CD4+ T cells. Immunity. 1:553-562.
7. Powrie, F., S. Mauze, and R.L. Coffman. 1997. CD4+ T-cells in the regulation of inflammatory responses in the intestine. Res. Immunol. 148:576-581.
8. high T cells to SCID recipients. J. Immunol. 158:3464-3473.
9. + T cells. J. Exp. Med. 183:2669-2674.
10. Asseman, C., S. Mauze, M.W. Leach, R.L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995-1004.
11. + T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177: 627-636.
12. Saoudi, A., B. Seddon, V. Heath, D. Fowell, and D. Mason. 1996. The physiological role of regulatory T cells in the prevention of autoimmunity: the function of the thymus in the generation of the regulatory T cell subset. Immunol. Rev. 149: 1995-216.
13. Sakaguchi, S., K. Fukuma, K. Kuribayashi, and T. Masuda. 1985. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161:72-87.
14. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
15. Suri-Payer, E., A.Z. Amar, A.M. Thornton, and E.M. Shevach. 1998. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J. Immunol. 1611:1212-1218.
16. Asano, M., M. Toda, N. Sakaguchi, and S. Sakaguchi. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387-396.
17. + immunoregulatory T cells suppress polydonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
18. Takahashi, T., Y. Kuniyasu, M. Toda, N. Sakaguchi, M. Itoh. M. Iwata, J. Shimizu, and S. Sakaguchi. 1998. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction ot autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10:1969-1980.
19. Van Parijs, L., and A.K. Abbas. 1998. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science. 280:243-248.
20. Lanzavecchia, A., and F. Sallusto. 2000. From synapses to immunological memory: the role of sustained T cell stimulation. Curr. Opin. Immunol. 12:92-98.
21. Shahinian, A., K. Pfeffer, K.P. Lee, T.M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P.S. Ohashi, C.B. Thompson, and T.W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 261:609-612.
22. Allison, J.P. 1994. CD28-B7 interactions in T-cell activation. Curr. Opin. Immunol. 6:414-419.
23. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today. 15:321-331.
24. Walunas, T.L., C.Y. Bakker, and J.A. Bluestone. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541-2550.
25. Krummel, M.F., and J.P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183:2533-2540.
26. Perez, V.L., L. Van Parijs, A. Biuckians, X.X. Zheng, T.B. Strom, and A.K. Abbas. 1997. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity. 6:411-417.
27. Leach, D.R., M.F. Krummel, and J.P. Allison. 1996. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 271:1734-1736.
28. Karandikar, N.J., C.L. Vanderlugt, T.L. Walunas, S.D. Miller, and J.A. Bluestone. 1996. CTLA-4: a negative regulator of autoimmune disease. J. Exp. Med. 184:783-788.
29. Perrin, P.J., J.H. Maldonado, T.A. Davis, C.H. June, and M.K. Racke. 1996. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. J. Immunol. 157:1333-1336.
30. Luhder, F., P. Hoglund, J.P. Allison, C. Benoist, and D. Mathis. 1998. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J. Exp. Med. 187:427-432.
31. Waterhouse, P., J.M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K.P. Lee, C.B. Thompson, H. Griesser, and T.W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 270:985-988.
32. Tivol, E.A., F. Bomello, A.N. Schweitzer, W.P. Lynch, J.A. Bluestone, and A.H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 3:541-547.
33. + T cells. J. Exp. Med. 188:1849-1857.
34. Coffman, R.L. 1982. Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69:5-23.
35. Oosterwegel, M.A., D.A. Mandelbrot, S.D. Boyd, R.B. Lorsbach, D.Y. Jarrett, A.K. Abbas, and A.M. Sharpe. 1999. The role of CTLA-4 in regulating Th2 differentiation. J Immunol. 163:2634-2639.
36. Chambers, C.A., and J.P. Allison. 1999. Costimulatory regulation of T cell function. Curr. Opin. Cell Biol. 11:203-210.
37. Linsley, P.S., J. Bradshaw, J. Greene, R. Peach, K.L. Bennett, and R.S. Mittler. 1996. Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity. 4:535-543.
38. Alegre, M.L., P.J. Noel, B.J. Eisfelder, E. Chuang, M.R. Clark, S.L. Reiner, and C.B. Thompson. 1996. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J. Immunol. 157:4762-4770.
39. Krummel, M.F., and J.P. Allison. 1995. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459-465.
40. Walunas, T.L., D.J. Lenschow, C.Y. Bakker, P.S. Linsley, G.J. Freeman, J.M. Green, C.B. Thompson, and J.A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1:405-413.
41. Metzler, B., C. Burkhart, and D.C. Wraith. 1999. Phenotypic analysis of CTLA-4 and CD28 expression during transient peptide-induced T cell activation in vivo. Int. Immunol. 11:667-675.
42. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303-309.
43. McCoy, K., M. Camberis, and G.L. Gros. 1997. Protective immunity to nematode infection is induced by CTLA-4 blockade. J. Exp. Med. 186:183-187.
44. Bachmann, M.F., G. Kohler, B. Ecabert, T.W. Mak, and M. Kopf. 1999. Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J. Immunol. 163:1128-1131.
45. low CD4+ T cells: a population of T cells with immune regulatory activities in vitro. Eur. J. Immunol. 28:3435-3447.
46. - thymocytes. J. Exp. Med. 189:279-288.